U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inappropriate antidiuretic hormone secretion

MedGen UID:
5772
•Concept ID:
C0021141
•
Disease or Syndrome
Synonyms: ADH Syndrome, Inappropriate; Antidiuretic Hormone, Inappropriate Secretion; Inappropriate ADH Syndrome; Inappropriate Vasopressin Secretion Syndrome; Schwartz Bartter Syndrome; Schwartz-Bartter Syndrome; SIADH; Syndrome of Inappropriate ADH (SIADH) Secretion; Syndrome, Inappropriate ADH; Syndrome, Schwartz-Bartter
SNOMED CT: Syndrome of inappropriate secretion of antidiuretic hormone (55004003); Syndrome of inappropriate antidiuresis (55004003); Syndrome of inappropriate antidiuretic hormone secretion (55004003); SIAD - syndrome of inappropriate antidiuresis (55004003); Syndrome of inappropriate ADH (antidiuretic hormone) production (55004003); SIADH (syndrome of inappropriate antidiuretic hormone) secretion (55004003); Syndrome of inappropriate vasopressin secretion (55004003); Schwartz-Bartter syndrome (55004003)
 
HPO: HP:0031218
Monarch Initiative: MONDO:0006802
Orphanet: ORPHA83449

Definition

A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInappropriate antidiuretic hormone secretion

Professional guidelines

PubMed

Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529
Treatment of hyponatremia.
Gross P
Intern Med 2008;47(10):885-91. Epub 2008 May 15 doi: 10.2169/internalmedicine.47.0918. PMID: 18480571

Recent clinical studies

Etiology

Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial.
Bisogno G, De Salvo GL, Bergeron C, Gallego Melcón S, Merks JH, Kelsey A, Martelli H, Minard-Colin V, Orbach D, Glosli H, Chisholm J, Casanova M, Zanetti I, Devalck C, Ben-Arush M, Mudry P, Ferman S, Jenney M, Ferrari A; European paediatric Soft tissue sarcoma Study Group
Lancet Oncol 2019 Nov;20(11):1566-1575. Epub 2019 Sep 24 doi: 10.1016/S1470-2045(19)30617-5. PMID: 31562043
Endocrinopathy-induced euvolemic hyponatremia.
Diker-Cohen T, Rozen-Zvi B, Yelin D, Akirov A, Robenshtok E, Gafter-Gvili A, Shepshelovich D
Intern Emerg Med 2018 Aug;13(5):679-688. Epub 2018 May 22 doi: 10.1007/s11739-018-1872-4. PMID: 29790126
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Medication-induced SIADH: distribution and characterization according to medication class.
Shepshelovich D, Schechter A, Calvarysky B, Diker-Cohen T, Rozen-Zvi B, Gafter-Gvili A
Br J Clin Pharmacol 2017 Aug;83(8):1801-1807. Epub 2017 Mar 2 doi: 10.1111/bcp.13256. PMID: 28168757Free PMC Article
SIADH: differential diagnosis and clinical management.
Peri A, Grohé C, Berardi R, Runkle I
Endocrine 2017 Jan;55(1):311-319. Epub 2016 Mar 30 doi: 10.1007/s12020-016-0936-3. PMID: 27025948

Diagnosis

Syndrome of inappropriate antidiuretic hormone secretion.
Poch E, Molina A, Piñeiro G
Med Clin (Barc) 2022 Aug 12;159(3):139-146. Epub 2022 May 31 doi: 10.1016/j.medcli.2022.02.015. PMID: 35659417
Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients.
Harrois A, Anstey JR
Crit Care Clin 2019 Apr;35(2):187-200. Epub 2019 Jan 28 doi: 10.1016/j.ccc.2018.11.001. PMID: 30784603
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
SIADH: differential diagnosis and clinical management.
Peri A, Grohé C, Berardi R, Runkle I
Endocrine 2017 Jan;55(1):311-319. Epub 2016 Mar 30 doi: 10.1007/s12020-016-0936-3. PMID: 27025948
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529

Therapy

Syndrome of inappropriate antidiuretic hormone secretion.
Poch E, Molina A, Piñeiro G
Med Clin (Barc) 2022 Aug 12;159(3):139-146. Epub 2022 May 31 doi: 10.1016/j.medcli.2022.02.015. PMID: 35659417
Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients.
Harrois A, Anstey JR
Crit Care Clin 2019 Apr;35(2):187-200. Epub 2019 Jan 28 doi: 10.1016/j.ccc.2018.11.001. PMID: 30784603
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529
Treatment of hyponatremia.
Gross P
Intern Med 2008;47(10):885-91. Epub 2008 May 15 doi: 10.2169/internalmedicine.47.0918. PMID: 18480571

Prognosis

Is There a Relationship between COVID-19 and Hyponatremia?
Gheorghe G, Ilie M, Bungau S, Stoian AMP, Bacalbasa N, Diaconu CC
Medicina (Kaunas) 2021 Jan 9;57(1) doi: 10.3390/medicina57010055. PMID: 33435405Free PMC Article
Hyponatremia in Infectious Diseases-A Literature Review.
Królicka AL, Kruczkowska A, Krajewska M, Kusztal MA
Int J Environ Res Public Health 2020 Jul 23;17(15) doi: 10.3390/ijerph17155320. PMID: 32718076Free PMC Article
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Oncological emergencies: syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Matwiejczuk S, Püsküllüoğlu M, Zygulska AL
Przegl Lek 2014;71(10):541-3. PMID: 25826978

Clinical prediction guides

Frequency of diencephalic syndrome in NMOSD.
Etemadifar M, Nouri H, Khorvash R, Salari M, Ghafari K, Aghababaee A
Acta Neurol Belg 2022 Aug;122(4):961-967. Epub 2021 Sep 13 doi: 10.1007/s13760-021-01792-1. PMID: 34515964
Hyponatremia in Infectious Diseases-A Literature Review.
Królicka AL, Kruczkowska A, Krajewska M, Kusztal MA
Int J Environ Res Public Health 2020 Jul 23;17(15) doi: 10.3390/ijerph17155320. PMID: 32718076Free PMC Article
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Tolvaptan.
Plosker GL
Drugs 2010 Mar 5;70(4):443-54. doi: 10.2165/11204630-000000000-00000. PMID: 20205486
Hyponatremia-induced osteoporosis.
Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE
J Bone Miner Res 2010 Mar;25(3):554-63. doi: 10.1359/jbmr.090827. PMID: 19751154Free PMC Article

Recent systematic reviews

Postoperative complications after endoscope-assisted transsphenoidal surgery for pituitary adenomas: a case series, systematic review, and meta-analysis of the literature.
Stefanidis P, Kyriakopoulos G, Athanasouli F, Mytareli C, Τzanis G, Korfias S, Theocharis S, Angelousi A
Hormones (Athens) 2022 Sep;21(3):487-499. Epub 2022 Mar 11 doi: 10.1007/s42000-022-00362-1. PMID: 35277844
Sodium and water perturbations in patients who had an acute stroke: clinical relevance and management strategies for the neurologist.
Yuen KCJ, Sharf V, Smith E, Kim M, Yuen ASM, MacDonald PR
Stroke Vasc Neurol 2022 Jun;7(3):258-266. Epub 2021 Dec 30 doi: 10.1136/svn-2021-001230. PMID: 34969834Free PMC Article
Preeclampsia and low sodium (PALS): A case and systematic review.
Powel JE, Rosenthal E, Roman A, Chasen ST, Berghella V
Eur J Obstet Gynecol Reprod Biol 2020 Jun;249:14-20. Epub 2020 Apr 8 doi: 10.1016/j.ejogrb.2020.03.052. PMID: 32344245
Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review.
Miell J, Dhanjal P, Jamookeeah C
Int J Clin Pract 2015 Dec;69(12):1396-417. Epub 2015 Aug 19 doi: 10.1111/ijcp.12713. PMID: 26289137Free PMC Article
Hyponatremia, fluid-electrolyte disorders, and the syndrome of inappropriate antidiuretic hormone secretion: diagnosis and treatment options.
Siragy HM
Endocr Pract 2006 Jul-Aug;12(4):446-57. doi: 10.4158/EP.12.4.446. PMID: 16901803

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...