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Inappropriate antidiuretic hormone secretion

MedGen UID:
5772
•Concept ID:
C0021141
•
Disease or Syndrome
Synonyms: ADH Syndrome, Inappropriate; Antidiuretic Hormone, Inappropriate Secretion; Inappropriate ADH Syndrome; Inappropriate Vasopressin Secretion Syndrome; Schwartz Bartter Syndrome; Schwartz-Bartter Syndrome; SIADH; Syndrome of Inappropriate ADH (SIADH) Secretion; Syndrome, Inappropriate ADH; Syndrome, Schwartz-Bartter
SNOMED CT: Syndrome of inappropriate secretion of antidiuretic hormone (55004003); Syndrome of inappropriate antidiuresis (55004003); Syndrome of inappropriate antidiuretic hormone secretion (55004003); SIAD - syndrome of inappropriate antidiuresis (55004003); Syndrome of inappropriate ADH (antidiuretic hormone) production (55004003); SIADH (syndrome of inappropriate antidiuretic hormone) secretion (55004003); Syndrome of inappropriate vasopressin secretion (55004003); Schwartz-Bartter syndrome (55004003)
 
HPO: HP:0031218
Monarch Initiative: MONDO:0006802
Orphanet: ORPHA83449

Definition

A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInappropriate antidiuretic hormone secretion

Professional guidelines

PubMed

Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529
Treatment of hyponatremia.
Gross P
Intern Med 2008;47(10):885-91. Epub 2008 May 15 doi: 10.2169/internalmedicine.47.0918. PMID: 18480571

Recent clinical studies

Etiology

Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial.
Schneider M, Narciso-Abraham M, Hadl S, McMahon R, Toepfer S, Fuchs U, Hochreiter R, Bitzer A, Kosulin K, Larcher-Senn J, Mader R, Dubischar K, Zoihsl O, Jaramillo JC, Eder-Lingelbach S, Buerger V, Wressnigg N
Lancet 2023 Jun 24;401(10394):2138-2147. Epub 2023 Jun 12 doi: 10.1016/S0140-6736(23)00641-4. PMID: 37321235Free PMC Article
Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial.
Bisogno G, De Salvo GL, Bergeron C, Gallego Melcón S, Merks JH, Kelsey A, Martelli H, Minard-Colin V, Orbach D, Glosli H, Chisholm J, Casanova M, Zanetti I, Devalck C, Ben-Arush M, Mudry P, Ferman S, Jenney M, Ferrari A; European paediatric Soft tissue sarcoma Study Group
Lancet Oncol 2019 Nov;20(11):1566-1575. Epub 2019 Sep 24 doi: 10.1016/S1470-2045(19)30617-5. PMID: 31562043
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Medication-induced SIADH: distribution and characterization according to medication class.
Shepshelovich D, Schechter A, Calvarysky B, Diker-Cohen T, Rozen-Zvi B, Gafter-Gvili A
Br J Clin Pharmacol 2017 Aug;83(8):1801-1807. Epub 2017 Mar 2 doi: 10.1111/bcp.13256. PMID: 28168757Free PMC Article
SIADH: differential diagnosis and clinical management.
Peri A, Grohé C, Berardi R, Runkle I
Endocrine 2017 Jan;55(1):311-319. Epub 2016 Mar 30 doi: 10.1007/s12020-016-0936-3. PMID: 27025948

Diagnosis

Syndrome of inappropriate antidiuretic hormone secretion.
Poch E, Molina A, Piñeiro G
Med Clin (Barc) 2022 Aug 12;159(3):139-146. Epub 2022 May 31 doi: 10.1016/j.medcli.2022.02.015. PMID: 35659417
Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients.
Harrois A, Anstey JR
Crit Care Clin 2019 Apr;35(2):187-200. Epub 2019 Jan 28 doi: 10.1016/j.ccc.2018.11.001. PMID: 30784603
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
SIADH: differential diagnosis and clinical management.
Peri A, Grohé C, Berardi R, Runkle I
Endocrine 2017 Jan;55(1):311-319. Epub 2016 Mar 30 doi: 10.1007/s12020-016-0936-3. PMID: 27025948
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529

Therapy

Syndrome of inappropriate antidiuretic hormone secretion.
Poch E, Molina A, Piñeiro G
Med Clin (Barc) 2022 Aug 12;159(3):139-146. Epub 2022 May 31 doi: 10.1016/j.medcli.2022.02.015. PMID: 35659417
Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients.
Harrois A, Anstey JR
Crit Care Clin 2019 Apr;35(2):187-200. Epub 2019 Jan 28 doi: 10.1016/j.ccc.2018.11.001. PMID: 30784603
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ
Am J Med 2013 Oct;126(10 Suppl 1):S1-42. doi: 10.1016/j.amjmed.2013.07.006. PMID: 24074529
Treatment of hyponatremia.
Gross P
Intern Med 2008;47(10):885-91. Epub 2008 May 15 doi: 10.2169/internalmedicine.47.0918. PMID: 18480571

Prognosis

Pituitary and SARS CoV-2: An unremitting conundrum.
Capatina C, Poiana C, Fleseriu M
Best Pract Res Clin Endocrinol Metab 2023 Jul;37(4):101752. Epub 2023 Feb 27 doi: 10.1016/j.beem.2023.101752. PMID: 36878774Free PMC Article
A profile of SGLT-2 inhibitors in hyponatremia: The evidence to date.
Tang H, Xu C, Zhang P, Luo T, Huang Y, Yang X
Eur J Pharm Sci 2023 May 1;184:106415. Epub 2023 Mar 2 doi: 10.1016/j.ejps.2023.106415. PMID: 36870579
Is There a Relationship between COVID-19 and Hyponatremia?
Gheorghe G, Ilie M, Bungau S, Stoian AMP, Bacalbasa N, Diaconu CC
Medicina (Kaunas) 2021 Jan 9;57(1) doi: 10.3390/medicina57010055. PMID: 33435405Free PMC Article
Hyponatremia in the elderly: challenges and solutions.
Filippatos TD, Makri A, Elisaf MS, Liamis G
Clin Interv Aging 2017;12:1957-1965. Epub 2017 Nov 14 doi: 10.2147/CIA.S138535. PMID: 29180859Free PMC Article
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834

Clinical prediction guides

Hyponatremia in Infectious Diseases-A Literature Review.
Królicka AL, Kruczkowska A, Krajewska M, Kusztal MA
Int J Environ Res Public Health 2020 Jul 23;17(15) doi: 10.3390/ijerph17155320. PMID: 32718076Free PMC Article
Renal Considerations in the Treatment of Hypertension.
Palmer BF, Clegg DJ
Am J Hypertens 2018 Mar 10;31(4):394-401. doi: 10.1093/ajh/hpy013. PMID: 29373638
Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
Rajagopal R, Swaminathan G, Nair S, Joseph M
World Neurosurg 2017 Dec;108:529-533. Epub 2017 Sep 9 doi: 10.1016/j.wneu.2017.09.013. PMID: 28899834
Tolvaptan.
Plosker GL
Drugs 2010 Mar 5;70(4):443-54. doi: 10.2165/11204630-000000000-00000. PMID: 20205486
Hyponatremia-induced osteoporosis.
Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE
J Bone Miner Res 2010 Mar;25(3):554-63. doi: 10.1359/jbmr.090827. PMID: 19751154Free PMC Article

Recent systematic reviews

Postoperative complications after endoscope-assisted transsphenoidal surgery for pituitary adenomas: a case series, systematic review, and meta-analysis of the literature.
Stefanidis P, Kyriakopoulos G, Athanasouli F, Mytareli C, Τzanis G, Korfias S, Theocharis S, Angelousi A
Hormones (Athens) 2022 Sep;21(3):487-499. Epub 2022 Mar 11 doi: 10.1007/s42000-022-00362-1. PMID: 35277844
Sodium and water perturbations in patients who had an acute stroke: clinical relevance and management strategies for the neurologist.
Yuen KCJ, Sharf V, Smith E, Kim M, Yuen ASM, MacDonald PR
Stroke Vasc Neurol 2022 Jun;7(3):258-266. Epub 2021 Dec 30 doi: 10.1136/svn-2021-001230. PMID: 34969834Free PMC Article
Preeclampsia and low sodium (PALS): A case and systematic review.
Powel JE, Rosenthal E, Roman A, Chasen ST, Berghella V
Eur J Obstet Gynecol Reprod Biol 2020 Jun;249:14-20. Epub 2020 Apr 8 doi: 10.1016/j.ejogrb.2020.03.052. PMID: 32344245
Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review.
Miell J, Dhanjal P, Jamookeeah C
Int J Clin Pract 2015 Dec;69(12):1396-417. Epub 2015 Aug 19 doi: 10.1111/ijcp.12713. PMID: 26289137Free PMC Article
Hyponatremia, fluid-electrolyte disorders, and the syndrome of inappropriate antidiuretic hormone secretion: diagnosis and treatment options.
Siragy HM
Endocr Pract 2006 Jul-Aug;12(4):446-57. doi: 10.4158/EP.12.4.446. PMID: 16901803

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