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Malignant epithelial tumor of ovary

MedGen UID:
577291
Concept ID:
C0346161
Neoplastic Process
Synonyms: Carcinoma of ovary; Epithelial cancer of ovary; epithelial cancer of ovary; malignant epithelial tumor of ovary; malignant ovarian epithelial tumor; malignant ovarian epithelial tumour; malignant ovarian surface epithelial-stromal neoplasm; malignant ovarian surface epithelial-stromal tumor; malignant ovarian surface epithelial-stromal tumour; Ovarian epithelial cancer; ovarian epithelial cancer; ovarian epithelial tumor, malignant; Ovarian malignant epithelial tumor; ovarian malignant epithelial tumor; ovarian malignant epithelial tumour; ovarian stromal cancer
SNOMED CT: Carcinoma of ovary (254849005); Malignant epithelial tumor of ovary (254849005)
 
Monarch Initiative: MONDO:0018364
Orphanet: ORPHA398934

Definition

An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant epithelial tumor of ovary

Professional guidelines

PubMed

Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853

Recent clinical studies

Etiology

Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Azziz R
Obstet Gynecol 2018 Aug;132(2):321-336. doi: 10.1097/AOG.0000000000002698. PMID: 29995717
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Stein EB, Wasnik AP, Sciallis AP, Kamaya A, Maturen KE
Magn Reson Imaging Clin N Am 2017 Aug;25(3):545-562. Epub 2017 Apr 29 doi: 10.1016/j.mric.2017.03.004. PMID: 28668159
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394

Therapy

Grisham RN, Slomovitz BM, Andrews N, Banerjee S, Brown J, Carey MS, Chui H, Coleman RL, Fader AN, Gaillard S, Gourley C, Sood AK, Monk BJ, Moore KN, Ray-Coquard I, Shih IM, Westin SN, Wong KK, Gershenson DM
Int J Gynecol Cancer 2023 Sep 4;33(9):1331-1344. doi: 10.1136/ijgc-2023-004610. PMID: 37591609Free PMC Article
Santos ML, Pais AS, Almeida Santos T
Gynecol Endocrinol 2021 Jun;37(6):483-489. Epub 2021 Jan 27 doi: 10.1080/09513590.2021.1872534. PMID: 33501866
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252

Prognosis

Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394
Gómez-Raposo C, Mendiola M, Barriuso J, Casado E, Hardisson D, Redondo A
Clin Transl Oncol 2009 Sep;11(9):564-71. doi: 10.1007/s12094-009-0406-y. PMID: 19775995

Clinical prediction guides

Leitner K, Tsibulak I, Wieser V, Knoll K, Reimer D, Marth C, Fiegl H, Zeimet AG
Sci Rep 2020 Nov 23;10(1):20412. doi: 10.1038/s41598-020-77532-x. PMID: 33230143Free PMC Article
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Paleari L, DeCensi A
Curr Opin Obstet Gynecol 2018 Feb;30(1):17-22. doi: 10.1097/GCO.0000000000000423. PMID: 29176513
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Li M, Liu S, Huang W, Zhang J
Aging (Albany NY) 2021 Jun 11;13(11):15674-15687. doi: 10.18632/aging.203147. PMID: 34118792Free PMC Article
Schüler S, Ponnath M, Engel J, Ortmann O
Arch Gynecol Obstet 2013 Jun;287(6):1187-204. Epub 2013 Mar 17 doi: 10.1007/s00404-013-2784-1. PMID: 23503972

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