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Malignant epithelial tumor of ovary

MedGen UID:
577291
•Concept ID:
C0346161
•
Neoplastic Process
Synonyms: Carcinoma of ovary; Epithelial cancer of ovary; epithelial cancer of ovary; malignant epithelial tumor of ovary; malignant ovarian epithelial tumor; malignant ovarian epithelial tumour; malignant ovarian surface epithelial-stromal neoplasm; malignant ovarian surface epithelial-stromal tumor; malignant ovarian surface epithelial-stromal tumour; Ovarian epithelial cancer; ovarian epithelial cancer; ovarian epithelial tumor, malignant; Ovarian malignant epithelial tumor; ovarian malignant epithelial tumor; ovarian malignant epithelial tumour; ovarian stromal cancer
SNOMED CT: Carcinoma of ovary (254849005); Malignant epithelial tumor of ovary (254849005)
 
Monarch Initiative: MONDO:0018364
Orphanet: ORPHA398934

Definition

An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant epithelial tumor of ovary

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article

Recent clinical studies

Etiology

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Polycystic Ovary Syndrome.
Azziz R
Obstet Gynecol 2018 Aug;132(2):321-336. doi: 10.1097/AOG.0000000000002698. PMID: 29995717
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Low-grade serous tumors of ovary.
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394
Mucinous tumours of the ovary--primary and metastatic.
Heatley MK
J Clin Pathol 2012 Jul;65(7):577-9. Epub 2011 Nov 12 doi: 10.1136/jclinpath-2011-200407. PMID: 22081785
Angiogenesis and ovarian cancer.
Gómez-Raposo C, Mendiola M, Barriuso J, Casado E, Hardisson D, Redondo A
Clin Transl Oncol 2009 Sep;11(9):564-71. doi: 10.1007/s12094-009-0406-y. PMID: 19775995

Therapy

Low-grade serous ovarian cancer: expert consensus report on the state of the science.
Grisham RN, Slomovitz BM, Andrews N, Banerjee S, Brown J, Carey MS, Chui H, Coleman RL, Fader AN, Gaillard S, Gourley C, Sood AK, Monk BJ, Moore KN, Ray-Coquard I, Shih IM, Westin SN, Wong KK, Gershenson DM
Int J Gynecol Cancer 2023 Sep 4;33(9):1331-1344. doi: 10.1136/ijgc-2023-004610. PMID: 37591609Free PMC Article
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Mucinous ovarian cancer.
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Prognosis

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Low-grade serous tumors of ovary.
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394
Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?
Rittiluechai K, Wilcox R, Lisle J, Everett E, Wallace HJ 3rd, Verschraegen CF
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:25-9. Epub 2014 Jan 3 doi: 10.1016/j.ejogrb.2013.12.029. PMID: 24462393
Angiogenesis and ovarian cancer.
Gómez-Raposo C, Mendiola M, Barriuso J, Casado E, Hardisson D, Redondo A
Clin Transl Oncol 2009 Sep;11(9):564-71. doi: 10.1007/s12094-009-0406-y. PMID: 19775995

Clinical prediction guides

Clinical impact of EZH2 and its antagonist SMARCA4 in ovarian cancer.
Leitner K, Tsibulak I, Wieser V, Knoll K, Reimer D, Marth C, Fiegl H, Zeimet AG
Sci Rep 2020 Nov 23;10(1):20412. doi: 10.1038/s41598-020-77532-x. PMID: 33230143Free PMC Article
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
The Abnormal Ovary: Evolving Concepts in Diagnosis and Management.
Hack K, Glanc P
Obstet Gynecol Clin North Am 2019 Dec;46(4):607-624. Epub 2019 Sep 25 doi: 10.1016/j.ogc.2019.07.002. PMID: 31677745
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review.
Li M, Liu S, Huang W, Zhang J
Aging (Albany NY) 2021 Jun 11;13(11):15674-15687. doi: 10.18632/aging.203147. PMID: 34118792Free PMC Article
Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis.
Madeira K, Dondossola ER, Farias BF, Simon CS, Alexandre MC, Silva BR, Rosa MI
An Acad Bras Cienc 2016 May 31;88(2):923-32. doi: 10.1590/0001-3765201620150107. PMID: 27254448
Ovarian epithelial tumors and reproductive factors: a systematic review.
Schüler S, Ponnath M, Engel J, Ortmann O
Arch Gynecol Obstet 2013 Jun;287(6):1187-204. Epub 2013 Mar 17 doi: 10.1007/s00404-013-2784-1. PMID: 23503972

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