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Pituitary microadenoma

MedGen UID:
577355
•Concept ID:
C0346306
•
Neoplastic Process
SNOMED CT: Pituitary microadenoma (254963000)
 
HPO: HP:0025694

Definition

A pituitary adenoma that is less than 10 mm in diameter. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary microadenoma

Professional guidelines

PubMed

Bilateral inferior petrosal sinus sampling: validity, diagnostic accuracy in lateralization of pituitary microadenoma, and treatment in eleven patients with Cushing's syndrome - a single-center retrospective cohort study.
Ardakani MT, Rabizadeh S, Yadegar A, Mohammadi F, Reyhan SK, Qahremani R, Ghanaati H, Esteghamati A, Nakhjavani M
BMC Endocr Disord 2023 Oct 23;23(1):232. doi: 10.1186/s12902-023-01495-z. PMID: 37872539Free PMC Article
Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Cystic lesions of the sellar-suprasellar region - diagnosis and treatment.
Andrysiak-Mamos E, Sagan K, Sagan L, Sowińska-Przepiera E, Syrenicz A
Endokrynol Pol 2018;69(2):212-228. doi: 10.5603/EP.2018.0023. PMID: 29952427

Recent clinical studies

Etiology

Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Subclinical acromegaly: to treat or not to treat?
Shimon I, Adnan Z, Hirsch D, Duskin-Bitan H, Akirov A
Endocr J 2022 Nov 28;69(11):1323-1328. Epub 2022 Jun 22 doi: 10.1507/endocrj.EJ22-0066. PMID: 35732439
Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas.
Nakhleh A, Assaliya Naffa M, Sviri G, Shehadeh N, Hochberg I
Pituitary 2021 Aug;24(4):492-498. Epub 2021 Jan 19 doi: 10.1007/s11102-020-01124-1. PMID: 33462744
Frequency of Macroprolactin in Hyperprolactinemia.
Sherazi NA, Baig MZ, Khan AH
J Coll Physicians Surg Pak 2018 Feb;28(2):93-97. doi: 10.29271/jcpsp.2018.02.93. PMID: 29394965
Pituitary magnetic resonance imaging in Cushing's disease.
Vitale G, Tortora F, Baldelli R, Cocchiara F, Paragliola RM, Sbardella E, Simeoli C, Caranci F, Pivonello R, Colao A; A.B.C. Group
Endocrine 2017 Mar;55(3):691-696. Epub 2016 Jul 19 doi: 10.1007/s12020-016-1038-y. PMID: 27435590

Diagnosis

Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Subclinical acromegaly: to treat or not to treat?
Shimon I, Adnan Z, Hirsch D, Duskin-Bitan H, Akirov A
Endocr J 2022 Nov 28;69(11):1323-1328. Epub 2022 Jun 22 doi: 10.1507/endocrj.EJ22-0066. PMID: 35732439
Pituitary Dysfunction Among Men Presenting with Hypogonadism.
Levy S, Arguello M, Macki M, Rao SD
Curr Urol Rep 2019 Nov 16;20(11):78. doi: 10.1007/s11934-019-0935-z. PMID: 31734886
Acromegaly in Carney complex.
Cuny T, Mac TT, Romanet P, Dufour H, Morange I, Albarel F, Lagarde A, Castinetti F, Graillon T, North MO, Barlier A, Brue T
Pituitary 2019 Oct;22(5):456-466. doi: 10.1007/s11102-019-00974-8. PMID: 31264077
Pituitary magnetic resonance imaging in Cushing's disease.
Vitale G, Tortora F, Baldelli R, Cocchiara F, Paragliola RM, Sbardella E, Simeoli C, Caranci F, Pivonello R, Colao A; A.B.C. Group
Endocrine 2017 Mar;55(3):691-696. Epub 2016 Jul 19 doi: 10.1007/s12020-016-1038-y. PMID: 27435590

Therapy

Hyperprolactinemia-induced acute ischemic stroke.
Elfessi Z, Dressler D, Johnson S, Antonishina K, Suh M
Am J Emerg Med 2023 Sep;71:249.e1-249.e2. Epub 2023 Jul 13 doi: 10.1016/j.ajem.2023.07.013. PMID: 37468431
Subclinical acromegaly: to treat or not to treat?
Shimon I, Adnan Z, Hirsch D, Duskin-Bitan H, Akirov A
Endocr J 2022 Nov 28;69(11):1323-1328. Epub 2022 Jun 22 doi: 10.1507/endocrj.EJ22-0066. PMID: 35732439
Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas.
Nakhleh A, Assaliya Naffa M, Sviri G, Shehadeh N, Hochberg I
Pituitary 2021 Aug;24(4):492-498. Epub 2021 Jan 19 doi: 10.1007/s11102-020-01124-1. PMID: 33462744
Pituitary Dysfunction Among Men Presenting with Hypogonadism.
Levy S, Arguello M, Macki M, Rao SD
Curr Urol Rep 2019 Nov 16;20(11):78. doi: 10.1007/s11934-019-0935-z. PMID: 31734886
The therapy of Cushing's disease in adults and children: an update.
Juszczak A, Ertorer ME, Grossman A
Horm Metab Res 2013 Feb;45(2):109-17. Epub 2012 Dec 7 doi: 10.1055/s-0032-1330009. PMID: 23225246

Prognosis

Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas.
Nakhleh A, Assaliya Naffa M, Sviri G, Shehadeh N, Hochberg I
Pituitary 2021 Aug;24(4):492-498. Epub 2021 Jan 19 doi: 10.1007/s11102-020-01124-1. PMID: 33462744
Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience.
Thaker VV, Lage AE, Kumari G, Silvera VM, Cohen LE
J Clin Endocrinol Metab 2019 Dec 1;104(12):5906-5912. doi: 10.1210/jc.2019-01252. PMID: 31390015Free PMC Article
Incidence and Outcomes of Pituitary Microadenomas in Children with Short Stature/Growth Hormone Deficiency.
Derrick KM, Gomes WA, Gensure RC
Horm Res Paediatr 2018;90(3):151-160. Epub 2018 Sep 27 doi: 10.1159/000489456. PMID: 30261514
Diagnosis and treatment of pituitary microadenoma: report of 80 cases.
Zhang HW, Sun W, Yang J, Yan CX, Yu CJ
Neurol Res 2008 Jul;30(6):587-93. doi: 10.1179/174313208X310287. PMID: 18647498

Clinical prediction guides

Bilateral inferior petrosal sinus sampling: validity, diagnostic accuracy in lateralization of pituitary microadenoma, and treatment in eleven patients with Cushing's syndrome - a single-center retrospective cohort study.
Ardakani MT, Rabizadeh S, Yadegar A, Mohammadi F, Reyhan SK, Qahremani R, Ghanaati H, Esteghamati A, Nakhjavani M
BMC Endocr Disord 2023 Oct 23;23(1):232. doi: 10.1186/s12902-023-01495-z. PMID: 37872539Free PMC Article
Subclinical acromegaly: to treat or not to treat?
Shimon I, Adnan Z, Hirsch D, Duskin-Bitan H, Akirov A
Endocr J 2022 Nov 28;69(11):1323-1328. Epub 2022 Jun 22 doi: 10.1507/endocrj.EJ22-0066. PMID: 35732439
A study on clinical outcomes of Rathke's cleft cyst in patients managed conservatively.
Chong GYC, Tan KCB, Lau EYF, Lai AYT, Man KKY, Chan TM, Leung WKW, Leung JYY
Pituitary 2022 Apr;25(2):258-266. Epub 2021 Nov 22 doi: 10.1007/s11102-021-01194-9. PMID: 34807360
Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience.
Thaker VV, Lage AE, Kumari G, Silvera VM, Cohen LE
J Clin Endocrinol Metab 2019 Dec 1;104(12):5906-5912. doi: 10.1210/jc.2019-01252. PMID: 31390015Free PMC Article
Infrasellar pituitary gangliocytoma causing Cushing's syndrome.
Domingue ME, Marbaix E, Do Rego JL, Col V, Raftopoulos C, Duprez T, Vaudry H, Maiter D
Pituitary 2015 Oct;18(5):738-44. doi: 10.1007/s11102-014-0595-4. PMID: 25183169

Recent systematic reviews

Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review.
Roca E, Mattogno PP, Porcelli T, Poliani L, Belotti F, Schreiber A, Maffezzoni F, Fontanella MM, Doglietto F
World Neurosurg 2018 Jun;114:e158-e164. Epub 2018 Mar 6 doi: 10.1016/j.wneu.2018.02.120. PMID: 29501516

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