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Parinaud syndrome

MedGen UID:
57754
•Concept ID:
C0152222
•
Disease or Syndrome
Synonyms: Parinaud Syndrome; Parinaud's Syndrome; Parinauds Syndrome; Syndrome, Parinaud; Syndrome, Parinaud's
SNOMED CT: Dorsal midbrain syndrome (37991008); Vertical gaze palsy - Parinaud (37991008); Parinaud syndrome (37991008); Paralysis of vertical movement (37991008); Parinaud's syndrome (37991008); Parinaud's ophthalmoplegia (37991008)
 
Monarch Initiative: MONDO:0022220

Definition

A rare syndrome affecting conjugate vertical eye movement. It is often caused by a dorsal midbrain neoplasm, commonly a pinealoma, but may also be attributable to demyelinating diseases or stroke. Clinical signs include limitation of upward gaze, light-near dissociation of the pupillary response, eyelid retraction (Collier''s sign) and convergence-retraction nystagmus. Clinical course is dependent on effective treatment of underlying cause. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParinaud syndrome

Professional guidelines

PubMed

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267
Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report.
El Asri AC, Baallal H, Zoubeir Y, Sinaa M, Albouzidi A, Gazzaz M, Akhaddar A, Boucetta M, El Mostarchid B
J Neurosurg Pediatr 2015 May;15(5):506-9. Epub 2015 Feb 20 doi: 10.3171/2014.10.PEDS13388. PMID: 25700123
Symptomatic pineal cysts: clinical manifestations and management.
Michielsen G, Benoit Y, Baert E, Meire F, Caemaert J
Acta Neurochir (Wien) 2002 Mar;144(3):233-42; discussion 242. doi: 10.1007/s007010200031. PMID: 11956936

Recent clinical studies

Etiology

Minimally Invasive, Supine, Lateral Supracerebellar Infratentorial Approach for Resection of a Pineal Cyst.
Yağmurlu K, Kalani MYS
World Neurosurg 2022 Dec;168:205. Epub 2022 Sep 27 doi: 10.1016/j.wneu.2022.09.084. PMID: 36174946
Parinaud syndrome: Any clinicoradiological correlation?
Pollak L, Zehavi-Dorin T, Eyal A, Milo R, Huna-Baron R
Acta Neurol Scand 2017 Dec;136(6):721-726. Epub 2017 Jun 26 doi: 10.1111/ane.12795. PMID: 28653396
Children with dorsal midbrain syndrome as a result of pineal tumors.
Hoehn ME, Calderwood J, O'Donnell T, Armstrong GT, Gajjar A
J AAPOS 2017 Feb;21(1):34-38. Epub 2017 Jan 7 doi: 10.1016/j.jaapos.2016.09.024. PMID: 28069468Free PMC Article
Parinaud syndrome: a 25-year (1991-2016) review of 40 consecutive adult cases.
Shields M, Sinkar S, Chan W, Crompton J
Acta Ophthalmol 2017 Dec;95(8):e792-e793. Epub 2016 Oct 24 doi: 10.1111/aos.13283. PMID: 27778456
Long-term ophthalmological follow-up of children with Parinaud syndrome.
Goldenberg-Cohen N, Haber J, Ron Y, Kornreich L, Toledano H, Snir M, Cohen IJ, Michowiz S
Ophthalmic Surg Lasers Imaging 2010 Jul-Aug;41(4):467-71. doi: 10.3928/15428877-20100426-02. PMID: 20438046

Diagnosis

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267
Acute upward gaze palsy: Not always Parinaud syndrome.
Rossi S, Frisullo G, Iorio R
Eur J Ophthalmol 2020 Nov;30(6):NP5-NP6. Epub 2019 Jun 13 doi: 10.1177/1120672119855845. PMID: 31189350
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Long-term ophthalmological follow-up of children with Parinaud syndrome.
Goldenberg-Cohen N, Haber J, Ron Y, Kornreich L, Toledano H, Snir M, Cohen IJ, Michowiz S
Ophthalmic Surg Lasers Imaging 2010 Jul-Aug;41(4):467-71. doi: 10.3928/15428877-20100426-02. PMID: 20438046
Parinaud's syndrome.
Moffie D, Ongerboer de Visser BW, Stefanko SZ
J Neurol Sci 1983 Feb;58(2):175-83. doi: 10.1016/0022-510x(83)90215-0. PMID: 6834076

Therapy

Parinaud syndrome due to cofirmed neurotuberculosis in a lupus eritematosis systemic patient.
Tavares-Júnior JWL, Teles Júnior JN, Magalhães SC, Cavalcante TT, Coimbra PPA, Luiz RDSS
Eur J Ophthalmol 2023 Jul;33(4):NP138-NP142. Epub 2022 Apr 28 doi: 10.1177/11206721221098284. PMID: 35482349
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267
Global Rostral Midbrain Syndrome (GRMS) and Corpus callosum infarction in the context of shunt overdrainage.
Villamil F, Varela F, Caffaratti G, Ricciardi M, Cammarota A, Cervio A
Clin Neurol Neurosurg 2022 Feb;213:107098. Epub 2021 Dec 26 doi: 10.1016/j.clineuro.2021.107098. PMID: 34973650
Children with dorsal midbrain syndrome as a result of pineal tumors.
Hoehn ME, Calderwood J, O'Donnell T, Armstrong GT, Gajjar A
J AAPOS 2017 Feb;21(1):34-38. Epub 2017 Jan 7 doi: 10.1016/j.jaapos.2016.09.024. PMID: 28069468Free PMC Article
Ocular Whipple's disease: therapeutic strategy and long-term follow-up.
Touitou V, Fenollar F, Cassoux N, Merle-Beral H, LeHoang P, Amoura Z, Drancourt M, Bodaghi B
Ophthalmology 2012 Jul;119(7):1465-9. Epub 2012 Mar 13 doi: 10.1016/j.ophtha.2012.01.024. PMID: 22420960

Prognosis

Parinaud syndrome: Any clinicoradiological correlation?
Pollak L, Zehavi-Dorin T, Eyal A, Milo R, Huna-Baron R
Acta Neurol Scand 2017 Dec;136(6):721-726. Epub 2017 Jun 26 doi: 10.1111/ane.12795. PMID: 28653396
Parinaud syndrome: a 25-year (1991-2016) review of 40 consecutive adult cases.
Shields M, Sinkar S, Chan W, Crompton J
Acta Ophthalmol 2017 Dec;95(8):e792-e793. Epub 2016 Oct 24 doi: 10.1111/aos.13283. PMID: 27778456
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Ocular Whipple's disease: therapeutic strategy and long-term follow-up.
Touitou V, Fenollar F, Cassoux N, Merle-Beral H, LeHoang P, Amoura Z, Drancourt M, Bodaghi B
Ophthalmology 2012 Jul;119(7):1465-9. Epub 2012 Mar 13 doi: 10.1016/j.ophtha.2012.01.024. PMID: 22420960
Long-term ophthalmological follow-up of children with Parinaud syndrome.
Goldenberg-Cohen N, Haber J, Ron Y, Kornreich L, Toledano H, Snir M, Cohen IJ, Michowiz S
Ophthalmic Surg Lasers Imaging 2010 Jul-Aug;41(4):467-71. doi: 10.3928/15428877-20100426-02. PMID: 20438046

Clinical prediction guides

Spontaneous involution of a large pineal cyst: Case report and narrative review.
Bouttelgier RM, Sie M, Hallaert GG
Headache 2022 Sep;62(8):1059-1062. Epub 2022 Aug 26 doi: 10.1111/head.14378. PMID: 36017961
Surgical treatment of pineal cysts in non-hydrocephalic and neurologically intact patients: selection of surgical candidates and clinical outcome.
Koziarski A, Podgórski A, Zieliński GM
Br J Neurosurg 2019 Feb;33(1):37-42. Epub 2018 Nov 19 doi: 10.1080/02688697.2018.1530731. PMID: 30450990
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Long-term ophthalmological follow-up of children with Parinaud syndrome.
Goldenberg-Cohen N, Haber J, Ron Y, Kornreich L, Toledano H, Snir M, Cohen IJ, Michowiz S
Ophthalmic Surg Lasers Imaging 2010 Jul-Aug;41(4):467-71. doi: 10.3928/15428877-20100426-02. PMID: 20438046
Parinaud's syndrome.
Moffie D, Ongerboer de Visser BW, Stefanko SZ
J Neurol Sci 1983 Feb;58(2):175-83. doi: 10.1016/0022-510x(83)90215-0. PMID: 6834076

Recent systematic reviews

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267

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