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Uterine cancer

MedGen UID:
57791
•Concept ID:
C0153567
•
Neoplastic Process
Synonyms: Cancer of the Uterus; Cancer of Uterus; Cancer, Uterine; Cancer, Uterus; Cancers, Uterine; Cancers, Uterus; Uterine Cancer; Uterine Cancers; Uterus Cancer; Uterus Cancers
SNOMED CT: Malignant neoplasm of uterus (371973000); Malignant tumor of uterus (371973000); CA - Cancer of uterus (371973000); Cancer of uterus (371973000); Uterine cancer (371973000)
 
Monarch Initiative: MONDO:0002715

Definition

Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix. [from NCI]

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma.
Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann J, Bosse T, Chargari C, Fagotti A, Fotopoulou C, Gonzalez Martin A, Lax S, Lorusso D, Marth C, Morice P, Nout RA, O'Donnell D, Querleu D, Raspollini MR, Sehouli J, Sturdza A, Taylor A, Westermann A, Wimberger P, Colombo N, Planchamp F, Creutzberg CL
Int J Gynecol Cancer 2021 Jan;31(1):12-39. Epub 2020 Dec 18 doi: 10.1136/ijgc-2020-002230. PMID: 33397713
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).
Katoh M
Int J Mol Med 2018 Aug;42(2):713-725. Epub 2018 May 17 doi: 10.3892/ijmm.2018.3689. PMID: 29786110Free PMC Article

Recent clinical studies

Etiology

Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities.
Chambers LM, Bussies P, Vargas R, Esakov E, Tewari S, Reizes O, Michener C
Curr Oncol Rep 2021 Jun 14;23(8):92. doi: 10.1007/s11912-021-01079-x. PMID: 34125319
p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification.
Jamieson A, Thompson EF, Huvila J, Gilks CB, McAlpine JN
Int J Gynecol Cancer 2021 Jun;31(6):907-913. Epub 2021 Feb 15 doi: 10.1136/ijgc-2020-002256. PMID: 33589443
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Current recommendations and recent progress in endometrial cancer.
Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Tatebe K, Veneris JL
CA Cancer J Clin 2019 Jul;69(4):258-279. Epub 2019 May 10 doi: 10.3322/caac.21561. PMID: 31074865

Diagnosis

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities.
Chambers LM, Bussies P, Vargas R, Esakov E, Tewari S, Reizes O, Michener C
Curr Oncol Rep 2021 Jun 14;23(8):92. doi: 10.1007/s11912-021-01079-x. PMID: 34125319
What next in cervical cancer screening?
Sehnal B, Sláma J
Ceska Gynekol 2020 Winter;85(4):236-243. PMID: 33562978
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article

Therapy

Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
Current recommendations and recent progress in endometrial cancer.
Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Tatebe K, Veneris JL
CA Cancer J Clin 2019 Jul;69(4):258-279. Epub 2019 May 10 doi: 10.3322/caac.21561. PMID: 31074865
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Prognosis

Trends and age-period-cohort effects on mortality of the three major gynecologic cancers in China from 1990 to 2019: Cervical, ovarian and uterine cancer.
Wang Z, Guo E, Yang B, Xiao R, Lu F, You L, Chen G
Gynecol Oncol 2021 Nov;163(2):358-363. Epub 2021 Sep 8 doi: 10.1016/j.ygyno.2021.08.029. PMID: 34507827
Uterine serous carcinoma: key advances and novel treatment approaches.
Ferriss JS, Erickson BK, Shih IM, Fader AN
Int J Gynecol Cancer 2021 Aug;31(8):1165-1174. Epub 2021 Jul 1 doi: 10.1136/ijgc-2021-002753. PMID: 34210768
Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes.
Gardner AB, Charo LM, Mann AK, Kapp DS, Eskander RN, Chan JK
Clin Exp Metastasis 2020 Feb;37(1):107-113. Epub 2019 Nov 22 doi: 10.1007/s10585-019-10007-0. PMID: 31758289
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875

Clinical prediction guides

Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.
Vithayathil M, Carter P, Kar S, Mason AM, Burgess S, Larsson SC
PLoS Med 2021 Jul;18(7):e1003706. Epub 2021 Jul 29 doi: 10.1371/journal.pmed.1003706. PMID: 34324486Free PMC Article
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875

Recent systematic reviews

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Sleep deprivation and quality of life among uterine cancer survivors: systematic review.
Alanazi MT, Alanazi NT, Alfadeel MA, Bugis BA
Support Care Cancer 2022 Mar;30(3):2891-2900. Epub 2021 Sep 30 doi: 10.1007/s00520-021-06589-9. PMID: 34595604
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Endometrial Cancer in Germline BRCA Mutation Carriers: A Systematic Review and Meta-analysis.
Matanes E, Volodarsky-Perel A, Eisenberg N, Rottenstreich M, Yasmeen A, Mitric C, Lau S, Salvador S, Gotlieb WH, Kogan L
J Minim Invasive Gynecol 2021 May;28(5):947-956. Epub 2020 Nov 27 doi: 10.1016/j.jmig.2020.11.023. PMID: 33249269
Pelvic floor disorders in women with gynecologic malignancies: a systematic review.
Ramaseshan AS, Felton J, Roque D, Rao G, Shipper AG, Sanses TVD
Int Urogynecol J 2018 Apr;29(4):459-476. Epub 2017 Sep 19 doi: 10.1007/s00192-017-3467-4. PMID: 28929201Free PMC Article

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