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Myeloid Sarcoma in Remission

MedGen UID:
57803
•Concept ID:
C0153892
•
Neoplastic Process
Synonyms: Chloroma (in Remission); Chloroma in Remission; Myeloid sarcoma in remission
SNOMED CT: Myeloid sarcoma in remission (94718004)

Definition

A finding of myeloid sarcoma that is not growing and responds to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyeloid Sarcoma in Remission

Professional guidelines

PubMed

Criteria for Diagnosis and Molecular Monitoring of NPM1-Mutated AML.
Falini B, Dillon R
Blood Cancer Discov 2024 Jan 8;5(1):8-20. doi: 10.1158/2643-3230.BCD-23-0144. PMID: 37917833Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate.
Ohno R, Asou N, Ohnishi K
Leukemia 2003 Aug;17(8):1454-63. doi: 10.1038/sj.leu.2403031. PMID: 12886231

Recent clinical studies

Etiology

Criteria for Diagnosis and Molecular Monitoring of NPM1-Mutated AML.
Falini B, Dillon R
Blood Cancer Discov 2024 Jan 8;5(1):8-20. doi: 10.1158/2643-3230.BCD-23-0144. PMID: 37917833Free PMC Article
Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved.
Shallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA
Blood Rev 2021 May;47:100773. Epub 2020 Oct 30 doi: 10.1016/j.blre.2020.100773. PMID: 33213985
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
Myeloid sarcoma.
Shahin OA, Ravandi F
Curr Opin Hematol 2020 Mar;27(2):88-94. doi: 10.1097/MOH.0000000000000571. PMID: 31904666
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Diagnosis

Criteria for Diagnosis and Molecular Monitoring of NPM1-Mutated AML.
Falini B, Dillon R
Blood Cancer Discov 2024 Jan 8;5(1):8-20. doi: 10.1158/2643-3230.BCD-23-0144. PMID: 37917833Free PMC Article
Myeloid sarcoma: more and less than a distinct entity.
Loscocco GG, Vannucchi AM
Ann Hematol 2023 Aug;102(8):1973-1984. Epub 2023 Jun 7 doi: 10.1007/s00277-023-05288-1. PMID: 37286874Free PMC Article
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
Myeloid sarcoma.
Shahin OA, Ravandi F
Curr Opin Hematol 2020 Mar;27(2):88-94. doi: 10.1097/MOH.0000000000000571. PMID: 31904666
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Therapy

CPX-351 induces remission in newly diagnosed pediatric secondary myeloid malignancies.
Hu Y, Caldwell KJ, Onciu M, Federico SM, Salek M, Lewis S, Lei S, Zhang J, Nichols KE, Takemoto CM, Triplett BM, Farrar JE, Rubnitz JE, Ribeiro RC, Wlodarski MW
Blood Adv 2022 Jan 25;6(2):521-527. doi: 10.1182/bloodadvances.2021006139. PMID: 34710216Free PMC Article
Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine.
Okamoto H, Kamitsuji Y, Komori Y, Sasaki N, Tsutsumi Y, Miyashita A, Tsukamoto T, Mizutani S, Shimura Y, Kobayashi T, Uoshima N, Kuroda J
Tohoku J Exp Med 2021 Jun;254(2):101-105. doi: 10.1620/tjem.254.101. PMID: 34148918
Intracranial myeloid sarcoma presentation in distant acute myeloid leukemia remission.
Lee D, Omofoye OA, Karnati T, Graff JP, Shahlaie K
J Clin Neurosci 2021 Jul;89:158-160. Epub 2021 May 12 doi: 10.1016/j.jocn.2021.05.001. PMID: 34119261
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Prognosis

Myeloid sarcoma: more and less than a distinct entity.
Loscocco GG, Vannucchi AM
Ann Hematol 2023 Aug;102(8):1973-1984. Epub 2023 Jun 7 doi: 10.1007/s00277-023-05288-1. PMID: 37286874Free PMC Article
CPX-351 induces remission in newly diagnosed pediatric secondary myeloid malignancies.
Hu Y, Caldwell KJ, Onciu M, Federico SM, Salek M, Lewis S, Lei S, Zhang J, Nichols KE, Takemoto CM, Triplett BM, Farrar JE, Rubnitz JE, Ribeiro RC, Wlodarski MW
Blood Adv 2022 Jan 25;6(2):521-527. doi: 10.1182/bloodadvances.2021006139. PMID: 34710216Free PMC Article
Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved.
Shallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA
Blood Rev 2021 May;47:100773. Epub 2020 Oct 30 doi: 10.1016/j.blre.2020.100773. PMID: 33213985
Characteristics and prognosis of pediatric myeloid sarcoma in the cytogenetic context of t(8;21).
Hu G, Lu A, Wu J, Jia Y, Zuo Y, Ding M, Zhang L
Pediatr Hematol Oncol 2021 Feb;38(1):14-24. Epub 2020 Aug 17 doi: 10.1080/08880018.2020.1803462. PMID: 32803999
Myeloid sarcoma.
Shahin OA, Ravandi F
Curr Opin Hematol 2020 Mar;27(2):88-94. doi: 10.1097/MOH.0000000000000571. PMID: 31904666

Clinical prediction guides

Extramedullary infiltration in pediatric acute myeloid leukemia: Results from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative.
Li W, Shi M, Zhou P, Liu Y, Liu X, Xiao X, Zuo S, Bai Y, Sun K
Pediatr Blood Cancer 2024 Jul;71(7):e31014. Epub 2024 Apr 21 doi: 10.1002/pbc.31014. PMID: 38644612
Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report.
Park JH, Son Y, Hyon JY, Lee JY, Jeon HS
BMC Ophthalmol 2022 Feb 10;22(1):65. doi: 10.1186/s12886-022-02286-1. PMID: 35144564Free PMC Article
Characteristics and transplant outcome of myeloid sarcoma: a single-institute study.
Shan M, Lu Y, Yang M, Wang P, Lu S, Zhang L, Qiu H, Chen S, Xu Y, Zhang X, Wu D
Int J Hematol 2021 May;113(5):682-692. Epub 2021 Jan 28 doi: 10.1007/s12185-021-03081-2. PMID: 33511548
Clinical characteristics and prognosis of nonleukemic myeloid sarcoma.
He J, Zhu L, Ye X, Li L, Zhu J, Zhang J, Xie W, Shi J, Zheng W, Wei G, Sun J, Cai Z, He H
Am J Med Sci 2014 Jun;347(6):434-8. doi: 10.1097/MAJ.0b013e31829ca859. PMID: 23928547
Clinical significance of granulocytic sarcoma in adult patients with acute myeloid leukemia.
Shimizu H, Saitoh T, Hatsumi N, Takada S, Yokohama A, Handa H, Jimbo T, Sakura T, Tsukamoto N, Murakami H, Miyawaki S, Nojima Y
Cancer Sci 2012 Aug;103(8):1513-7. Epub 2012 Jun 21 doi: 10.1111/j.1349-7006.2012.02324.x. PMID: 22568487Free PMC Article

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