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Benign neoplasm of tonsil

MedGen UID:
57804
•Concept ID:
C0153936
•
Neoplastic Process
Synonyms: Benign neoplasm of palatine tonsil; Benign Neoplasm of the Tonsil; benign neoplasm of the tonsil; Benign Neoplasm of Tonsil; benign neoplasm of tonsil; Benign Tonsil Neoplasm; benign tonsil neoplasm; Benign Tonsil Tumor; benign tonsil tumor; benign tonsil tumour; Benign Tonsillar Neoplasm; benign tonsillar neoplasm; Benign Tonsillar Tumor; benign tonsillar tumor; benign tonsillar tumour; Benign tumor of faucial tonsil; Benign tumor of palatine tonsil; Benign Tumor of the Tonsil; benign tumor of the tonsil; Benign tumor of tonsil; Benign Tumor of Tonsil; benign tumor of tonsil; benign tumour of the tonsil; benign tumour of tonsil; tonsil benign neoplasm; Tonsillar Neoplasm, Benign; tonsillar neoplasm, benign
SNOMED CT: Benign neoplasm of tonsil (92263001); Benign neoplasm of palatine tonsil (92263001); Benign tumor of palatine tonsil (92263001); Benign tumor of faucial tonsil (92263001); Benign tumor of tonsil (92263001)
 
Monarch Initiative: MONDO:0021513

Definition

A neoplasm that arises from the tonsil and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of tonsil

Professional guidelines

PubMed

Psychosocial Oncology: Optimizing Outcomes through Interdisciplinary Care in Head and Neck Oncology.
Henry M
Curr Oncol 2023 Jul 19;30(7):6859-6861. doi: 10.3390/curroncol30070501. PMID: 37504361Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent clinical studies

Etiology

Lymphomas of the head-and-neck region.
Kamiński B
J Cancer Res Ther 2021 Oct-Dec;17(6):1347-1350. doi: 10.4103/jcrt.JCRT_213_20. PMID: 34916364
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
History of tonsillectomy and risk of oropharyngeal cancer.
Combes JD, Voisin N, Périé S, Malard O, Jegoux F, Nadjingar R, Buiret G, Philouze P, Garrel R, Vergez S, Fakhry N, Righini C, Mirghani H, Lerat J, Saroul N, Verillaud B, Bartaire E, Céruse P, Clifford GM, Franceschi S, Lacau St Guily J
Oral Oncol 2021 Jun;117:105302. Epub 2021 Apr 24 doi: 10.1016/j.oraloncology.2021.105302. PMID: 33905915
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Gamma-delta t-cell lymphomas.
Foppoli M, Ferreri AJ
Eur J Haematol 2015 Mar;94(3):206-18. Epub 2014 Oct 1 doi: 10.1111/ejh.12439. PMID: 25154298

Diagnosis

History of tonsillectomy and risk of oropharyngeal cancer.
Combes JD, Voisin N, Périé S, Malard O, Jegoux F, Nadjingar R, Buiret G, Philouze P, Garrel R, Vergez S, Fakhry N, Righini C, Mirghani H, Lerat J, Saroul N, Verillaud B, Bartaire E, Céruse P, Clifford GM, Franceschi S, Lacau St Guily J
Oral Oncol 2021 Jun;117:105302. Epub 2021 Apr 24 doi: 10.1016/j.oraloncology.2021.105302. PMID: 33905915
Pediatric Lymphoid and Histiocytic Lesions in the Head and Neck.
Auerbach A, Schmieg JJ, Aguilera NS
Head Neck Pathol 2021 Mar;15(1):41-58. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01257-6. PMID: 33723759Free PMC Article
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Gamma-delta t-cell lymphomas.
Foppoli M, Ferreri AJ
Eur J Haematol 2015 Mar;94(3):206-18. Epub 2014 Oct 1 doi: 10.1111/ejh.12439. PMID: 25154298
The broad spectrum of lymphatic health and disease.
Rockson SG
Lymphat Res Biol 2010 Jun;8(2):101. doi: 10.1089/lrb.2010.8203. PMID: 20583871

Therapy

Obesity and risk for respiratory diseases: a Mendelian randomization study.
Yang W, Yang Y, Guo Y, Guo J, Ma M, Han B
Front Endocrinol (Lausanne) 2023;14:1197730. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1197730. PMID: 37711902Free PMC Article
Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Anti-PD1/PDL1 induced psoriasis.
Voudouri D, Nikolaou V, Laschos K, Charpidou A, Soupos N, Triantafyllopoulou I, Panoutsopoulou I, Aravantinos G, Syrigos K, Stratigos A
Curr Probl Cancer 2017 Nov-Dec;41(6):407-412. Epub 2017 Oct 18 doi: 10.1016/j.currproblcancer.2017.10.003. PMID: 29096940
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Lymphoma of the thyroid and head and neck.
Beasley MJ
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):345-51. Epub 2012 Apr 2 doi: 10.1016/j.clon.2012.02.010. PMID: 22475637

Prognosis

Lymphomas of the head-and-neck region.
Kamiński B
J Cancer Res Ther 2021 Oct-Dec;17(6):1347-1350. doi: 10.4103/jcrt.JCRT_213_20. PMID: 34916364
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP
Blood 2019 Mar 7;133(10):1119-1129. Epub 2018 Dec 27 doi: 10.1182/blood-2018-08-862292. PMID: 30591526Free PMC Article
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Clinical prediction guides

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP
Blood 2019 Mar 7;133(10):1119-1129. Epub 2018 Dec 27 doi: 10.1182/blood-2018-08-862292. PMID: 30591526Free PMC Article
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature.
Wojtera M, Paradis J, Husein M, Nichols AC, Barrett JW, Salvadori MI, Strychowsky JE
J Otolaryngol Head Neck Surg 2018 Jan 30;47(1):8. doi: 10.1186/s40463-018-0255-1. PMID: 29378664Free PMC Article

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