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Benign neoplasm of lacrimal gland

MedGen UID:
57813
•Concept ID:
C0154024
•
Neoplastic Process
Synonyms: Benign Lacrimal Gland Neoplasm; benign lacrimal gland neoplasm; Benign Lacrimal Gland Tumor; benign lacrimal gland tumor; benign lacrimal gland tumour; Benign Neoplasm of Lacrimal Gland; benign neoplasm of lacrimal gland; Benign Neoplasm of the Lacrimal Gland; benign neoplasm of the lacrimal gland; Benign tumor of lacrimal gland; Benign Tumor of Lacrimal Gland; benign tumor of lacrimal gland; Benign Tumor of the Lacrimal Gland; benign tumor of the lacrimal gland; benign tumour of lacrimal gland; benign tumour of the lacrimal gland; lacrimal gland benign neoplasm
SNOMED CT: Benign tumor of lacrimal gland (92169007); Benign neoplasm of lacrimal gland (92169007)
 
Monarch Initiative: MONDO:0021488

Definition

A neoplasm that arises from the lacrimal gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of lacrimal gland

Professional guidelines

PubMed

Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Clinical features and management of dacryops.
Ozgonul C, Uysal Y, Ayyildiz O, Kucukevcilioglu M
Orbit 2018 Aug;37(4):262-265. Epub 2018 Jan 4 doi: 10.1080/01676830.2017.1423081. PMID: 29300516
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588

Recent clinical studies

Etiology

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
A single-institution review of lacrimal gland biopsies between 1962 and 2017.
Choi CJ, Tran AQ, Anagnostopoulos AG, Zhou HW, Tse DT, Dubovy SR
Orbit 2023 Apr;42(2):148-156. Epub 2022 Mar 17 doi: 10.1080/01676830.2022.2052113. PMID: 35298320
Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Lacrimal Sac Tumors--A Review.
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337

Diagnosis

A single-institution review of lacrimal gland biopsies between 1962 and 2017.
Choi CJ, Tran AQ, Anagnostopoulos AG, Zhou HW, Tse DT, Dubovy SR
Orbit 2023 Apr;42(2):148-156. Epub 2022 Mar 17 doi: 10.1080/01676830.2022.2052113. PMID: 35298320
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Lacrimal Sac Tumors--A Review.
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Therapy

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Comparison of Internal Dosimetry of 18 F-PSMA-1007 and 68 Ga-PSMA-11-HBED-CC.
Sharma P, Watts A, Singh H
Clin Nucl Med 2022 Nov 1;47(11):948-953. Epub 2022 Aug 16 doi: 10.1097/RLU.0000000000004353. PMID: 35961365
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Early and late toxicity of radioiodine therapy: detection and management.
Hyer SL, Newbold K, Harmer CL
Endocr Pract 2010 Nov-Dec;16(6):1064-70. doi: 10.4158/EP10170.RA. PMID: 20634173
Lateral orbitotomy--a review.
McNab AA, Wright JE
Aust N Z J Ophthalmol 1990 Aug;18(3):281-6. PMID: 2261175

Prognosis

Molecular characterisation of tumours of the lacrimal apparatus.
Vibert R, Cyrta J, Girard E, Vacher S, Dupain C, Antonio S, Wong J, Baulande S, De Sousa JMF, Vincent-Salomon A, Masliah-Planchon J, Girard N, Le Tourneau C, Kamal M, Bièche I
Histopathology 2023 Dec;83(6):925-935. Epub 2023 Sep 14 doi: 10.1111/his.15040. PMID: 37706251
Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Lacrimal Sac Tumors--A Review.
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Clinical prediction guides

Dacryops and clinical diagnostic challenges.
Alsarhani WK, Al-Sharif EM, Al-Faky YH, Alkatan HM, Maktabi AM, Alsuhaibani AH
Can J Ophthalmol 2022 Dec;57(6):388-393. Epub 2021 Jul 26 doi: 10.1016/j.jcjo.2021.06.014. PMID: 34324876
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
IgG4-related orbital disease.
Flores Balverdi J, Baenas DF, Riscanevo NC, Sánchez AV, Figueroa Rosales R, Alvarellos A
Arch Soc Esp Oftalmol (Engl Ed) 2018 Oct;93(10):494-496. Epub 2018 Jun 1 doi: 10.1016/j.oftal.2018.04.003. PMID: 29866378
Clinical features and management of dacryops.
Ozgonul C, Uysal Y, Ayyildiz O, Kucukevcilioglu M
Orbit 2018 Aug;37(4):262-265. Epub 2018 Jan 4 doi: 10.1080/01676830.2017.1423081. PMID: 29300516
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445

Recent systematic reviews

Recurrence rate of pleomorphic adenoma of the lacrimal gland: systematic review and meta-analysis.
Van Swol EG, Gupta A, Nguyen SA, Eiseman AS
Orbit 2024 Apr;43(2):208-216. Epub 2023 Oct 23 doi: 10.1080/01676830.2023.2269252. PMID: 37870812
Holding back the tears: is there a role for marsupialisation?
Chiu SJ, Currie ZI, Tan JH
BMJ Open Ophthalmol 2022 Aug;7(1) doi: 10.1136/bmjophth-2022-000985. PMID: 36161857Free PMC Article
Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM
Cancer Treat Rev 2015 Dec;41(10):925-34. Epub 2015 Sep 10 doi: 10.1016/j.ctrv.2015.09.001. PMID: 26421813

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