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Trachea carcinoma in situ

MedGen UID:
57816
•Concept ID:
C0154070
•
Neoplastic Process
Synonyms: Carcinoma in situ of the Trachea; carcinoma in situ of the trachea; Carcinoma in situ of trachea; Carcinoma in situ of Trachea; carcinoma in situ of trachea; Severe epithelial dysplasia of trachea; Severe Epithelial Dysplasia of Trachea; severe epithelial dysplasia of trachea; stage 0 trachea carcinoma; Trachea Carcinoma in situ; trachea carcinoma in situ; trachea in situ carcinoma; Tracheal Carcinoma In Situ; tracheal carcinoma in situ
SNOMED CT: Carcinoma in situ of trachea (92772005); Severe epithelial dysplasia of trachea (92772005)
 
Monarch Initiative: MONDO:0004661

Definition

A carcinoma that arises from the tracheal mucosa and is confined to the epithelial layer without evidence of further tissue invasion. [from NCI]

Professional guidelines

PubMed

Second primary cancer after treatment of invasive carcinoma of the uterine cervix, compared with those arising after treatment for in situ carcinomas. An effect of irradiation? A cancer registry study.
Pettersson F, Ryberg M, Malker B
Acta Obstet Gynecol Scand 1990;69(2):161-74. doi: 10.3109/00016349009006163. PMID: 2386020

Recent clinical studies

Etiology

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Gale N, Poljak M, Zidar N
Head Neck Pathol 2017 Mar;11(1):23-32. Epub 2017 Feb 28 doi: 10.1007/s12105-017-0788-z. PMID: 28247231Free PMC Article
Microbial colonization of tracheoesophageal voice prostheses (Provox2) following total laryngectomy.
Tićac B, Tićac R, Rukavina T, Kesovija PG, Pedisić D, Maljevac B, Starcević R
Eur Arch Otorhinolaryngol 2010 Oct;267(10):1579-86. Epub 2010 Apr 30 doi: 10.1007/s00405-010-1253-8. PMID: 20432044
Second primary cancers in patients with carcinoma in situ of the uterine cervix. The Norwegian experience 1970-1992.
Bjørge T, Hennig EM, Skare GB, Søreide O, Thoresen SO
Int J Cancer 1995 Jul 4;62(1):29-33. doi: 10.1002/ijc.2910620108. PMID: 7601563
Second primary cancer after treatment of invasive carcinoma of the uterine cervix, compared with those arising after treatment for in situ carcinomas. An effect of irradiation? A cancer registry study.
Pettersson F, Ryberg M, Malker B
Acta Obstet Gynecol Scand 1990;69(2):161-74. doi: 10.3109/00016349009006163. PMID: 2386020
Early cancer and related lesions in the bronchial epithelium in former workers of mustard gas factory.
Tokuoka S, Hayashi Y, Inai K, Egawa H, Aoki Y, Akamizu H, Eto R, Nishida T, Ohe K, Kobuke T
Acta Pathol Jpn 1986 Apr;36(4):533-42. doi: 10.1111/j.1440-1827.1986.tb01042.x. PMID: 3014812

Diagnosis

Clinical and molecular features of pulmonary NUT carcinoma characterizes diverse responses to immunotherapy, with a pathologic complete response case.
Chen M, Chen X, Zhang Y, Wang W, Jiang L
J Cancer Res Clin Oncol 2023 Aug;149(9):6361-6370. Epub 2023 Feb 8 doi: 10.1007/s00432-023-04621-5. PMID: 36752907
Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours.
Bishop JA, Thompson LDR, Siegele B, Gagan J, Mansour M, Chernock RD, Rooper LM
Histopathology 2023 Jan;82(2):305-313. Epub 2022 Oct 28 doi: 10.1111/his.14817. PMID: 36208053
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Mediastinal malignant epithelioid schwannoma.
Fukai I, Masaoka A, Yamakawa Y, Niwa H, Eimoto T
Chest 1995 Aug;108(2):574-5. doi: 10.1378/chest.108.2.574. PMID: 7634904
Second primary cancers in patients with carcinoma in situ of the uterine cervix. The Norwegian experience 1970-1992.
Bjørge T, Hennig EM, Skare GB, Søreide O, Thoresen SO
Int J Cancer 1995 Jul 4;62(1):29-33. doi: 10.1002/ijc.2910620108. PMID: 7601563

Therapy

Infiltration of nanocarbon suspension into the tracheal cavity during surgical treatment of papillary thyroid carcinoma: a case report.
Zhu LB, Zhu F, Li PF, Zhang PB
J Int Med Res 2020 Apr;48(4):300060520919251. doi: 10.1177/0300060520919251. PMID: 32314626Free PMC Article
Effect of photodynamic therapy and external beam radiation therapy on juvenile laryngotracheobronchial papillomatosis.
Kavuru MS, Mehta AC, Eliachar I
Am Rev Respir Dis 1990 Feb;141(2):509-10. doi: 10.1164/ajrccm/141.2.509. PMID: 2137317
Early cancer and related lesions in the bronchial epithelium in former workers of mustard gas factory.
Tokuoka S, Hayashi Y, Inai K, Egawa H, Aoki Y, Akamizu H, Eto R, Nishida T, Ohe K, Kobuke T
Acta Pathol Jpn 1986 Apr;36(4):533-42. doi: 10.1111/j.1440-1827.1986.tb01042.x. PMID: 3014812

Prognosis

Clinical and molecular features of pulmonary NUT carcinoma characterizes diverse responses to immunotherapy, with a pathologic complete response case.
Chen M, Chen X, Zhang Y, Wang W, Jiang L
J Cancer Res Clin Oncol 2023 Aug;149(9):6361-6370. Epub 2023 Feb 8 doi: 10.1007/s00432-023-04621-5. PMID: 36752907
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Gale N, Poljak M, Zidar N
Head Neck Pathol 2017 Mar;11(1):23-32. Epub 2017 Feb 28 doi: 10.1007/s12105-017-0788-z. PMID: 28247231Free PMC Article
Mediastinal malignant epithelioid schwannoma.
Fukai I, Masaoka A, Yamakawa Y, Niwa H, Eimoto T
Chest 1995 Aug;108(2):574-5. doi: 10.1378/chest.108.2.574. PMID: 7634904
Second primary cancers in patients with carcinoma in situ of the uterine cervix. The Norwegian experience 1970-1992.
Bjørge T, Hennig EM, Skare GB, Søreide O, Thoresen SO
Int J Cancer 1995 Jul 4;62(1):29-33. doi: 10.1002/ijc.2910620108. PMID: 7601563

Clinical prediction guides

Clinical and molecular features of pulmonary NUT carcinoma characterizes diverse responses to immunotherapy, with a pathologic complete response case.
Chen M, Chen X, Zhang Y, Wang W, Jiang L
J Cancer Res Clin Oncol 2023 Aug;149(9):6361-6370. Epub 2023 Feb 8 doi: 10.1007/s00432-023-04621-5. PMID: 36752907
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Cell migration leads to spatially distinct but clonally related airway cancer precursors.
Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE, Carroll B, Navani N, McCaughan F, George JP, Giangreco A, Wright NA, McDonald SA, Graham TA, Janes SM
Thorax 2014 Jun;69(6):548-57. Epub 2014 Feb 18 doi: 10.1136/thoraxjnl-2013-204198. PMID: 24550057Free PMC Article
Second primary cancers in patients with carcinoma in situ of the uterine cervix. The Norwegian experience 1970-1992.
Bjørge T, Hennig EM, Skare GB, Søreide O, Thoresen SO
Int J Cancer 1995 Jul 4;62(1):29-33. doi: 10.1002/ijc.2910620108. PMID: 7601563
Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization.
Obara T, Baba M, Yamaguchi Y, Fuchs E, Resau JH, Trump BF, Klein-Szanto AJ
Am J Pathol 1988 Jun;131(3):519-29. PMID: 2454581Free PMC Article

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