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Ischemic optic neuropathy

MedGen UID:
57833
•Concept ID:
C0155305
•
Disease or Syndrome
Synonyms: Ischaemic Neuropathy, Optic; Ischemia, Optic Nerve; Ischemic Neuropathy, Optic; Ischemic Optic Neuropathies; Ischemic Optic Neuropathy; Nerve Ischemia, Optic; Neuropathy, Ischemic Optic; Neuropathy, Optic Ischaemic; Neuropathy, Optic Ischemic; Optic Ischaemic Neuropathies; Optic Ischaemic Neuropathy; Optic Ischemic Neuropathies; Optic Ischemic Neuropathy; Optic Nerve Ischemia; Optic Nerve Ischemias; Optic Neuropathy, Ischemic
SNOMED CT: ION - Ischemic optic neuropathy (14357004); Ischemic optic neuropathy (14357004)

Definition

Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIschemic optic neuropathy

Professional guidelines

PubMed

Acute ischemic optic nerve disease: Pathophysiology, clinical features and management.
Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbé A
J Fr Ophtalmol 2020 Feb;43(2):e41-e54. Epub 2020 Jan 15 doi: 10.1016/j.jfo.2019.12.002. PMID: 31952875
Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094

Recent clinical studies

Etiology

Ischemic Optic Neuropathy.
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
Perioperative visual loss.
Kla KM, Lee LA
Best Pract Res Clin Anaesthesiol 2016 Mar;30(1):69-77. Epub 2015 Nov 26 doi: 10.1016/j.bpa.2015.11.004. PMID: 27036604
Ischemic optic neuropathy.
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989
Ischemic optic neuropathies.
Luneau K, Newman NJ, Biousse V
Neurologist 2008 Nov;14(6):341-54. doi: 10.1097/NRL.0b013e318177394b. PMID: 19008740

Diagnosis

Ischemic Optic Neuropathy.
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
New concepts on acute ocular ischemia.
Sharma RA, Newman NJ, Biousse V
Curr Opin Neurol 2019 Feb;32(1):19-24. doi: 10.1097/WCO.0000000000000634. PMID: 30461463
Ischemic optic neuropathy.
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989
Ischemic optic neuropathy.
Athappilly G, Pelak VS, Mandava N, Bennett JL
Neurol Res 2008 Oct;30(8):794-800. doi: 10.1179/174313208X319107. PMID: 18826805
Ischemic optic neuropathy.
Fontal MR, Kerrison JB, Garcia R, Oria V
Semin Neurol 2007 Jul;27(3):221-32. doi: 10.1055/s-2007-979686. PMID: 17577864

Therapy

Literature Commentary.
J Neuroophthalmol 2021 Dec 1;41(4):553-559. doi: 10.1097/WNO.0000000000001447. PMID: 34788240
Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Trial of Tocilizumab in Giant-Cell Arteritis.
Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, Brouwer E, Cid MC, Dasgupta B, Rech J, Salvarani C, Schett G, Schulze-Koops H, Spiera R, Unizony SH, Collinson N
N Engl J Med 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849. PMID: 28745999
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
Atypical Optic Neuritis.
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052

Prognosis

SARS-CoV-2 Impairs Vision.
Finsterer J, Scorza FA, Scorza CA, Fiorini AC
J Neuroophthalmol 2021 Jun 1;41(2):166-169. doi: 10.1097/WNO.0000000000001273. PMID: 33999887
Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Atypical Optic Neuritis.
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052
The optic nerve.
Selhorst JB, Chen Y
Semin Neurol 2009 Feb;29(1):29-35. Epub 2009 Feb 12 doi: 10.1055/s-0028-1124020. PMID: 19214930
Ischemic optic neuropathies.
Luneau K, Newman NJ, Biousse V
Neurologist 2008 Nov;14(6):341-54. doi: 10.1097/NRL.0b013e318177394b. PMID: 19008740

Clinical prediction guides

Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Sildenafil in ophthalmology: An update.
Arora S, Surakiatchanukul T, Arora T, Cagini C, Lupidi M, Chhablani J
Surv Ophthalmol 2022 Mar-Apr;67(2):463-487. Epub 2021 Jun 25 doi: 10.1016/j.survophthal.2021.06.004. PMID: 34175342
Optic disk drusen in children.
Chang MY, Pineles SL
Surv Ophthalmol 2016 Nov-Dec;61(6):745-758. Epub 2016 Mar 29 doi: 10.1016/j.survophthal.2016.03.007. PMID: 27033945Free PMC Article
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models.
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article
Postoperative ischemic optic neuropathy.
Lee LA, Newman NJ, Wagner TA, Dettori JR, Dettori NJ
Spine (Phila Pa 1976) 2010 Apr 20;35(9 Suppl):S105-16. doi: 10.1097/BRS.0b013e3181d8344d. PMID: 20407342

Recent systematic reviews

Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Lantos K, Dömötör ZR, Farkas N, Kiss S, Szakács Z, Garami A, Varga G, Lujber L, Kanaan R, Hegyi P, Fehér G, Gaál V
Int J Environ Res Public Health 2022 Feb 26;19(5) doi: 10.3390/ijerph19052718. PMID: 35270411Free PMC Article
Cardiometabolic factors and risk of non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.
Chatziralli IP, Kazantzis D, Chatzirallis AP, Machairoudia G, Papageorgiou EG, Theodossiadis GP, Psaltopoulou T, Theodossiadis PG, Sergentanis TN
Graefes Arch Clin Exp Ophthalmol 2022 May;260(5):1445-1456. Epub 2022 Jan 24 doi: 10.1007/s00417-021-05522-4. PMID: 35067769
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
Postoperative ischemic optic neuropathy.
Lee LA, Newman NJ, Wagner TA, Dettori JR, Dettori NJ
Spine (Phila Pa 1976) 2010 Apr 20;35(9 Suppl):S105-16. doi: 10.1097/BRS.0b013e3181d8344d. PMID: 20407342

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