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Ischemic optic neuropathy

MedGen UID:
57833
•Concept ID:
C0155305
•
Disease or Syndrome
Synonyms: Ischaemic Neuropathy, Optic; Ischemia, Optic Nerve; Ischemic Neuropathy, Optic; Ischemic Optic Neuropathies; Ischemic Optic Neuropathy; Nerve Ischemia, Optic; Neuropathy, Ischemic Optic; Neuropathy, Optic Ischaemic; Neuropathy, Optic Ischemic; Optic Ischaemic Neuropathies; Optic Ischaemic Neuropathy; Optic Ischemic Neuropathies; Optic Ischemic Neuropathy; Optic Nerve Ischemia; Optic Nerve Ischemias; Optic Neuropathy, Ischemic
SNOMED CT: ION - Ischemic optic neuropathy (14357004); Ischemic optic neuropathy (14357004)

Definition

Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIschemic optic neuropathy

Professional guidelines

PubMed

Management of ocular arterial ischemic diseases: a review.
Vilares-Morgado R, Nunes HMM, Dos Reis RS, Barbosa-Breda J
Graefes Arch Clin Exp Ophthalmol 2023 Jan;261(1):1-22. Epub 2022 Jul 15 doi: 10.1007/s00417-022-05747-x. PMID: 35838806
Acute ischemic optic nerve disease: Pathophysiology, clinical features and management.
Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbé A
J Fr Ophtalmol 2020 Feb;43(2):e41-e54. Epub 2020 Jan 15 doi: 10.1016/j.jfo.2019.12.002. PMID: 31952875
Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119

Recent clinical studies

Etiology

Ischemic Optic Neuropathy.
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Perioperative visual loss.
Kla KM, Lee LA
Best Pract Res Clin Anaesthesiol 2016 Mar;30(1):69-77. Epub 2015 Nov 26 doi: 10.1016/j.bpa.2015.11.004. PMID: 27036604
Ischemic optic neuropathy.
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989
Ischemic optic neuropathies.
Luneau K, Newman NJ, Biousse V
Neurologist 2008 Nov;14(6):341-54. doi: 10.1097/NRL.0b013e318177394b. PMID: 19008740
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Diagnosis

Ischemic Optic Neuropathy.
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Ischemic optic neuropathy.
Gonzalez-Garcia A, Mendoza-Santiesteban CE, Mendoza-Santiesteban EA, Felipe DL, Echavarria OH, Santiesteban-Freixas R, Hedges TR
Semin Ophthalmol 2010 Jul;25(4):130-5. doi: 10.3109/15368378.2010.499849. PMID: 20695733
Ischemic optic neuropathy.
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989
Ischemic optic neuropathy.
Athappilly G, Pelak VS, Mandava N, Bennett JL
Neurol Res 2008 Oct;30(8):794-800. doi: 10.1179/174313208X319107. PMID: 18826805
Ischemic optic neuropathy.
Fontal MR, Kerrison JB, Garcia R, Oria V
Semin Neurol 2007 Jul;27(3):221-32. doi: 10.1055/s-2007-979686. PMID: 17577864

Therapy

Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy.
Mitchell R, Chacko J
Biomolecules 2022 Sep 14;12(9) doi: 10.3390/biom12091298. PMID: 36139137Free PMC Article
Literature Commentary.
J Neuroophthalmol 2021 Dec 1;41(4):553-559. doi: 10.1097/WNO.0000000000001447. PMID: 34788240
Trial of Tocilizumab in Giant-Cell Arteritis.
Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, Brouwer E, Cid MC, Dasgupta B, Rech J, Salvarani C, Schett G, Schulze-Koops H, Spiera R, Unizony SH, Collinson N
N Engl J Med 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849. PMID: 28745999
Atypical Optic Neuritis.
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Prognosis

SARS-CoV-2 Impairs Vision.
Finsterer J, Scorza FA, Scorza CA, Fiorini AC
J Neuroophthalmol 2021 Jun 1;41(2):166-169. doi: 10.1097/WNO.0000000000001273. PMID: 33999887
Atypical Optic Neuritis.
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052
The optic nerve.
Selhorst JB, Chen Y
Semin Neurol 2009 Feb;29(1):29-35. Epub 2009 Feb 12 doi: 10.1055/s-0028-1124020. PMID: 19214930
Ischemic optic neuropathies.
Luneau K, Newman NJ, Biousse V
Neurologist 2008 Nov;14(6):341-54. doi: 10.1097/NRL.0b013e318177394b. PMID: 19008740
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Clinical prediction guides

Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Sildenafil in ophthalmology: An update.
Arora S, Surakiatchanukul T, Arora T, Cagini C, Lupidi M, Chhablani J
Surv Ophthalmol 2022 Mar-Apr;67(2):463-487. Epub 2021 Jun 25 doi: 10.1016/j.survophthal.2021.06.004. PMID: 34175342
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models.
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article
Postoperative ischemic optic neuropathy.
Lee LA, Newman NJ, Wagner TA, Dettori JR, Dettori NJ
Spine (Phila Pa 1976) 2010 Apr 20;35(9 Suppl):S105-16. doi: 10.1097/BRS.0b013e3181d8344d. PMID: 20407342
Complications of blepharoplasty.
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Recent systematic reviews

Neuroprotective Strategies for Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review.
Budihardja BM, Anggraini E, Pratiwi RW, Nastiti AD, Nusanti S
Korean J Ophthalmol 2023 Aug;37(4):328-339. Epub 2023 Aug 5 doi: 10.3341/kjo.2022.0166. PMID: 37563973Free PMC Article
Immune Checkpoint Inhibitors and Optic Neuropathy: A Systematic Review.
Pietris J, Santhosh S, Ferdinando Cirocco G, Lam A, Bacchi S, Tan Y, Gupta AK, Kovoor JG, Chan W
Semin Ophthalmol 2023 Aug;38(6):547-558. Epub 2023 Jan 22 doi: 10.1080/08820538.2023.2168494. PMID: 36683270
Management of ocular arterial ischemic diseases: a review.
Vilares-Morgado R, Nunes HMM, Dos Reis RS, Barbosa-Breda J
Graefes Arch Clin Exp Ophthalmol 2023 Jan;261(1):1-22. Epub 2022 Jul 15 doi: 10.1007/s00417-022-05747-x. PMID: 35838806
Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Lantos K, Dömötör ZR, Farkas N, Kiss S, Szakács Z, Garami A, Varga G, Lujber L, Kanaan R, Hegyi P, Fehér G, Gaál V
Int J Environ Res Public Health 2022 Feb 26;19(5) doi: 10.3390/ijerph19052718. PMID: 35270411Free PMC Article
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article

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