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Ischemic optic neuropathy

MedGen UID:
57833
Concept ID:
C0155305
Disease or Syndrome
Synonyms: Ischaemic Neuropathy, Optic; Ischemia, Optic Nerve; Ischemic Neuropathy, Optic; Ischemic Optic Neuropathies; Ischemic Optic Neuropathy; Nerve Ischemia, Optic; Neuropathy, Ischemic Optic; Neuropathy, Optic Ischaemic; Neuropathy, Optic Ischemic; Optic Ischaemic Neuropathies; Optic Ischaemic Neuropathy; Optic Ischemic Neuropathies; Optic Ischemic Neuropathy; Optic Nerve Ischemia; Optic Nerve Ischemias; Optic Neuropathy, Ischemic
SNOMED CT: ION - Ischemic optic neuropathy (14357004); Ischemic optic neuropathy (14357004)

Definition

Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIschemic optic neuropathy

Professional guidelines

PubMed

Zhou P, Zhang J, Qi Y
Comput Math Methods Med 2022;2022:2935992. Epub 2022 Mar 18 doi: 10.1155/2022/2935992. PMID: 35341003Free PMC Article
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Yafi FA, Sharlip ID, Becher EF
Sex Med Rev 2018 Apr;6(2):242-252. Epub 2017 Oct 12 doi: 10.1016/j.sxmr.2017.08.001. PMID: 28923561

Recent clinical studies

Etiology

Shew W, Wang MTM, Danesh-Meyer HV
J Neuroophthalmol 2023 Mar 1;43(1):17-28. Epub 2022 Jun 23 doi: 10.1097/WNO.0000000000001625. PMID: 36166807
Aghsaei Fard M, Ghahvechian H, Subramanian PS
J Neuroophthalmol 2021 Dec 1;41(4):e433-e439. doi: 10.1097/WNO.0000000000000997. PMID: 34788242
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989
Waller EA, Bendel RE, Kaplan J
Mayo Clin Proc 2008 Nov;83(11):1251-61. doi: 10.4065/83.11.1251. PMID: 18990324

Diagnosis

Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Weng CY, Khimani KS, Foroozan R, Gospe SM 3rd, Bhatti MT
Surv Ophthalmol 2018 Sep-Oct;63(5):736-744. Epub 2018 Apr 27 doi: 10.1016/j.survophthal.2018.04.004. PMID: 29705174
Patel HR, Margo CE
Arch Pathol Lab Med 2017 Jan;141(1):162-166. doi: 10.5858/arpa.2016-0027-RS. PMID: 28029908
Sousa DC, Rodrigues FB, Duarte G, Campos F, Pinto F, Vaz-Carneiro A
Can J Ophthalmol 2016 Dec;51(6):459-466. Epub 2016 Sep 14 doi: 10.1016/j.jcjo.2016.05.018. PMID: 27938958
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989

Therapy

J Neuroophthalmol 2021 Dec 1;41(4):553-559. doi: 10.1097/WNO.0000000000001447. PMID: 34788240
Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, Brouwer E, Cid MC, Dasgupta B, Rech J, Salvarani C, Schett G, Schulze-Koops H, Spiera R, Unizony SH, Collinson N
N Engl J Med 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849. PMID: 28745999
Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, Finetti M, Cumetti D, Carobbio A, Ruperto N, Marcolongo R, Lorini M, Rimini A, Valenti A, Erre GL, Sormani MP, Belli R, Gaita F, Martini A
JAMA 2016 Nov 8;316(18):1906-1912. doi: 10.1001/jama.2016.15826. PMID: 27825009
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
Waller EA, Bendel RE, Kaplan J
Mayo Clin Proc 2008 Nov;83(11):1251-61. doi: 10.4065/83.11.1251. PMID: 18990324

Prognosis

Chapman JJ, Heidary G, Gise R
Curr Opin Ophthalmol 2022 Nov 1;33(6):494-500. Epub 2022 Sep 8 doi: 10.1097/ICU.0000000000000897. PMID: 36094020
Aghsaei Fard M, Ghahvechian H, Subramanian PS
J Neuroophthalmol 2021 Dec 1;41(4):e433-e439. doi: 10.1097/WNO.0000000000000997. PMID: 34788242
Finsterer J, Scorza FA, Scorza CA, Fiorini AC
J Neuroophthalmol 2021 Jun 1;41(2):166-169. doi: 10.1097/WNO.0000000000001273. PMID: 33999887
Chang MY, Pineles SL
Surv Ophthalmol 2016 Nov-Dec;61(6):745-758. Epub 2016 Mar 29 doi: 10.1016/j.survophthal.2016.03.007. PMID: 27033945Free PMC Article
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article

Clinical prediction guides

Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Aghsaei Fard M, Ghahvechian H, Subramanian PS
J Neuroophthalmol 2021 Dec 1;41(4):e433-e439. doi: 10.1097/WNO.0000000000000997. PMID: 34788242
Colombo L, Caretti A, Dei Cas M, Luciano F, Romano D, Paroni R, Patelli F, Ghidoni R, Rossetti L
Exp Eye Res 2021 Jun;207:108601. Epub 2021 Apr 25 doi: 10.1016/j.exer.2021.108601. PMID: 33910035
Chang MY, Pineles SL
Surv Ophthalmol 2016 Nov-Dec;61(6):745-758. Epub 2016 Mar 29 doi: 10.1016/j.survophthal.2016.03.007. PMID: 27033945Free PMC Article
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Recent systematic reviews

Shew W, Wang MTM, Danesh-Meyer HV
J Neuroophthalmol 2023 Mar 1;43(1):17-28. Epub 2022 Jun 23 doi: 10.1097/WNO.0000000000001625. PMID: 36166807
Vilares-Morgado R, Nunes HMM, Dos Reis RS, Barbosa-Breda J
Graefes Arch Clin Exp Ophthalmol 2023 Jan;261(1):1-22. Epub 2022 Jul 15 doi: 10.1007/s00417-022-05747-x. PMID: 35838806
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Allegrini D, Pagano L, Ferrara M, Borgia A, Sorrentino T, Montesano G, Angi M, Romano MR
Int Ophthalmol 2020 Aug;40(8):2119-2127. Epub 2020 May 7 doi: 10.1007/s10792-020-01365-w. PMID: 32383130
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article

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