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Delayed passage of meconium

MedGen UID:
578790
•Concept ID:
C0349500
•
Pathologic Function
SNOMED CT: Delayed passage of meconium (276713004)
 
HPO: HP:6000224

Definition

Failure to pass meconium (the first stool following birth) in the first 48 hours of life. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed passage of meconium

Professional guidelines

PubMed

Endoscopic Decompression with a Transanal Drainage Tube for the Treatment of Hirschsprung's Disease in Newborns.
Zhang JS, Kong C, Li L
J Laparoendosc Adv Surg Tech A 2021 Aug;31(8):959-963. Epub 2021 May 7 doi: 10.1089/lap.2020.1035. PMID: 33970040
Glycerin laxatives for prevention or treatment of feeding intolerance in very low birth weight infants.
Anabrees J, Shah VS, AlOsaimi A, AlFaleh K
Cochrane Database Syst Rev 2015 Sep 30;2015(9):CD010464. doi: 10.1002/14651858.CD010464.pub2. PMID: 26421424Free PMC Article
Evaluation and treatment of constipation in children and adolescents.
Nurko S, Zimmerman LA
Am Fam Physician 2014 Jul 15;90(2):82-90. PMID: 25077577

Recent clinical studies

Etiology

Antenatal magnesium sulphate and delayed passage of meconium: A multicentre study.
Toledano Revenga J, Peña-Moreno A, Arriaga-Redondo M, Márquez Isidro EM, Gochi Valdovinos A, Blanco Bravo D, Sánchez Luna M
An Pediatr (Engl Ed) 2022 Dec;97(6):383-389. Epub 2022 Oct 3 doi: 10.1016/j.anpede.2022.08.012. PMID: 36202742
Chronic constipation in infants and children.
Ho JMD, How CH
Singapore Med J 2020 Feb;61(2):63-68. doi: 10.11622/smedj.2020014. PMID: 32152637Free PMC Article
Meconium Evacuation for Facilitating Feed Tolerance in Preterm Neonates: A Systematic Review and Meta-Analysis.
Deshmukh M, Balasubramanian H, Patole S
Neonatology 2016;110(1):55-65. Epub 2016 Apr 7 doi: 10.1159/000444075. PMID: 27050644
Pediatric intestinal motility disorders.
Gfroerer S, Rolle U
World J Gastroenterol 2015 Sep 7;21(33):9683-7. doi: 10.3748/wjg.v21.i33.9683. PMID: 26361414Free PMC Article
Long-segment Hirschsprung's disease.
Bickler SW, Harrison MW, Campbell TJ, Campbell JR
Arch Surg 1992 Sep;127(9):1047-50; discussion 1050-1. doi: 10.1001/archsurg.1992.01420090051008. PMID: 1514906

Diagnosis

Very early onset perinatal constipation: Can it be cow's milk protein allergy?
Arakoni R, Kamal H, Cheng SX
World J Gastroenterol 2023 Sep 7;29(33):4920-4926. doi: 10.3748/wjg.v29.i33.4920. PMID: 37731998Free PMC Article
Chronic constipation in infants and children.
Ho JMD, How CH
Singapore Med J 2020 Feb;61(2):63-68. doi: 10.11622/smedj.2020014. PMID: 32152637Free PMC Article
Pediatric intestinal motility disorders.
Gfroerer S, Rolle U
World J Gastroenterol 2015 Sep 7;21(33):9683-7. doi: 10.3748/wjg.v21.i33.9683. PMID: 26361414Free PMC Article
Evaluation and treatment of constipation in children and adolescents.
Nurko S, Zimmerman LA
Am Fam Physician 2014 Jul 15;90(2):82-90. PMID: 25077577
Long-segment Hirschsprung's disease.
Bickler SW, Harrison MW, Campbell TJ, Campbell JR
Arch Surg 1992 Sep;127(9):1047-50; discussion 1050-1. doi: 10.1001/archsurg.1992.01420090051008. PMID: 1514906

Therapy

Antenatal magnesium sulphate and delayed passage of meconium: A multicentre study.
Toledano Revenga J, Peña-Moreno A, Arriaga-Redondo M, Márquez Isidro EM, Gochi Valdovinos A, Blanco Bravo D, Sánchez Luna M
An Pediatr (Engl Ed) 2022 Dec;97(6):383-389. Epub 2022 Oct 3 doi: 10.1016/j.anpede.2022.08.012. PMID: 36202742
Meconium Evacuation for Facilitating Feed Tolerance in Preterm Neonates: A Systematic Review and Meta-Analysis.
Deshmukh M, Balasubramanian H, Patole S
Neonatology 2016;110(1):55-65. Epub 2016 Apr 7 doi: 10.1159/000444075. PMID: 27050644
Rectal biopsy for Hirschsprung's disease: a review of techniques, pathology, and complications.
Muise ED, Cowles RA
World J Pediatr 2016 May;12(2):135-41. Epub 2015 Dec 18 doi: 10.1007/s12519-015-0068-5. PMID: 26684314
Evaluation and treatment of constipation in children and adolescents.
Nurko S, Zimmerman LA
Am Fam Physician 2014 Jul 15;90(2):82-90. PMID: 25077577
Long-segment Hirschsprung's disease.
Bickler SW, Harrison MW, Campbell TJ, Campbell JR
Arch Surg 1992 Sep;127(9):1047-50; discussion 1050-1. doi: 10.1001/archsurg.1992.01420090051008. PMID: 1514906

Prognosis

Antenatal magnesium sulphate and delayed passage of meconium: A multicentre study.
Toledano Revenga J, Peña-Moreno A, Arriaga-Redondo M, Márquez Isidro EM, Gochi Valdovinos A, Blanco Bravo D, Sánchez Luna M
An Pediatr (Engl Ed) 2022 Dec;97(6):383-389. Epub 2022 Oct 3 doi: 10.1016/j.anpede.2022.08.012. PMID: 36202742
Delayed Presentation of Meconium Ileus in an Infant With Cystic Fibrosis.
Lahiri T, Sullivan JS, Sartorelli KH, Murphy JJ
Pediatrics 2020 Oct;146(4) doi: 10.1542/peds.2019-3717. PMID: 32978295
Pediatric intestinal motility disorders.
Gfroerer S, Rolle U
World J Gastroenterol 2015 Sep 7;21(33):9683-7. doi: 10.3748/wjg.v21.i33.9683. PMID: 26361414Free PMC Article
Evaluation and treatment of constipation in children and adolescents.
Nurko S, Zimmerman LA
Am Fam Physician 2014 Jul 15;90(2):82-90. PMID: 25077577
Long-segment Hirschsprung's disease.
Bickler SW, Harrison MW, Campbell TJ, Campbell JR
Arch Surg 1992 Sep;127(9):1047-50; discussion 1050-1. doi: 10.1001/archsurg.1992.01420090051008. PMID: 1514906

Clinical prediction guides

Antenatal magnesium sulphate and delayed passage of meconium: A multicentre study.
Toledano Revenga J, Peña-Moreno A, Arriaga-Redondo M, Márquez Isidro EM, Gochi Valdovinos A, Blanco Bravo D, Sánchez Luna M
An Pediatr (Engl Ed) 2022 Dec;97(6):383-389. Epub 2022 Oct 3 doi: 10.1016/j.anpede.2022.08.012. PMID: 36202742
Pediatric intestinal motility disorders.
Gfroerer S, Rolle U
World J Gastroenterol 2015 Sep 7;21(33):9683-7. doi: 10.3748/wjg.v21.i33.9683. PMID: 26361414Free PMC Article
Prevalence of Hirschsprung's disease in premature infants: a systematic review.
Duess JW, Hofmann AD, Puri P
Pediatr Surg Int 2014 Aug;30(8):791-5. Epub 2014 Jul 2 doi: 10.1007/s00383-014-3540-8. PMID: 24986057
A new diagnostic scoring system to differentiate Hirschsprung's disease from Hirschsprung's disease-allied disorders in patients with suspected intestinal dysganglionosis.
Wu XJ, Zhang HY, Li N, Yan MS, Wei J, Yu DH, Feng JX
Int J Colorectal Dis 2013 May;28(5):689-96. Epub 2013 Apr 9 doi: 10.1007/s00384-013-1691-z. PMID: 23568714
Trypsin activity in stool and duodenal aspirate of neonates for differential diagnosis of intestinal obstruction.
Meisheri IV, Sawant VV, Gangal S, Ahuja S, Ravindran G, Nobre M
Pediatr Surg Int 2002 Mar;18(2-3):104-6. doi: 10.1007/s003830100624. PMID: 11956772

Recent systematic reviews

Meconium Evacuation for Facilitating Feed Tolerance in Preterm Neonates: A Systematic Review and Meta-Analysis.
Deshmukh M, Balasubramanian H, Patole S
Neonatology 2016;110(1):55-65. Epub 2016 Apr 7 doi: 10.1159/000444075. PMID: 27050644
Glycerin laxatives for prevention or treatment of feeding intolerance in very low birth weight infants.
Anabrees J, Shah VS, AlOsaimi A, AlFaleh K
Cochrane Database Syst Rev 2015 Sep 30;2015(9):CD010464. doi: 10.1002/14651858.CD010464.pub2. PMID: 26421424Free PMC Article
Prevalence of Hirschsprung's disease in premature infants: a systematic review.
Duess JW, Hofmann AD, Puri P
Pediatr Surg Int 2014 Aug;30(8):791-5. Epub 2014 Jul 2 doi: 10.1007/s00383-014-3540-8. PMID: 24986057
A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood.
Doodnath R, Puri P
Pediatr Surg Int 2010 Nov;26(11):1107-10. doi: 10.1007/s00383-010-2694-2. PMID: 20725836

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