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Drug-induced akathisia

MedGen UID:
57937
•Concept ID:
C0162550
•
Disease or Syndrome
Synonyms: Acathisia, Drug Induced; Acathisia, Drug-Induced; Akathisia, Drug Induced; Akathisia, Drug-Induced; Drug Induced Akathisia; Drug-Induced Acathisia; Drug-Induced Akathisia
SNOMED CT: Drug-induced akathisia (230333002); Akathisia caused by drug (230333002)
 
Monarch Initiative: MONDO:0006731

Definition

An uncomfortable feeling of inner restlessness and inability to stay still. It can be a side effect of psychotropic medications. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced akathisia

Professional guidelines

PubMed

Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic.
Kumsa A, Agenagnew L, Alemu B, Girma S
PLoS One 2020;15(7):e0235365. Epub 2020 Jul 2 doi: 10.1371/journal.pone.0235365. PMID: 32614868Free PMC Article
Differential diagnosis of psychotropic side effects and symptoms and signs of psychiatric disorders.
Mihanović M, Bodor D, Kezić S, Restek-Petrović B, Silić A
Psychiatr Danub 2009 Dec;21(4):570-4. PMID: 19935495
SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.
Lane RM
J Psychopharmacol 1998;12(2):192-214. doi: 10.1177/026988119801200212. PMID: 9694033

Recent clinical studies

Etiology

Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Memantine for dementia.
McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J
Cochrane Database Syst Rev 2019 Mar 20;3(3):CD003154. doi: 10.1002/14651858.CD003154.pub6. PMID: 30891742Free PMC Article
Tardive syndromes.
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Pericyazine for schizophrenia.
Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P
Cochrane Database Syst Rev 2014 May 13;2014(5):CD007479. doi: 10.1002/14651858.CD007479.pub2. PMID: 24825770Free PMC Article
Drug-induced movement disorders.
Jiménez-Jiménez FJ, García-Ruiz PJ, Molina JA
Drug Saf 1997 Mar;16(3):180-204. doi: 10.2165/00002018-199716030-00004. PMID: 9098656

Diagnosis

Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Ertapenem-induced encephalopathy.
Adams R, Chopra P, Miranda R, Calderon A
BMJ Case Rep 2020 Jun 1;13(6) doi: 10.1136/bcr-2019-231875. PMID: 32487528Free PMC Article
Tardive syndromes.
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Revisiting Antipsychotic-induced Akathisia: Current Issues and Prospective Challenges.
Salem H, Nagpal C, Pigott T, Teixeira AL
Curr Neuropharmacol 2017;15(5):789-798. doi: 10.2174/1570159X14666161208153644. PMID: 27928948Free PMC Article
Medicinal-Induced Behavior Disorders.
Munjampalli SK, Davis DE
Neurol Clin 2016 Feb;34(1):133-69. doi: 10.1016/j.ncl.2015.08.006. PMID: 26613997

Therapy

Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Memantine for dementia.
McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J
Cochrane Database Syst Rev 2019 Mar 20;3(3):CD003154. doi: 10.1002/14651858.CD003154.pub6. PMID: 30891742Free PMC Article
Revisiting Antipsychotic-induced Akathisia: Current Issues and Prospective Challenges.
Salem H, Nagpal C, Pigott T, Teixeira AL
Curr Neuropharmacol 2017;15(5):789-798. doi: 10.2174/1570159X14666161208153644. PMID: 27928948Free PMC Article
Pericyazine for schizophrenia.
Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P
Cochrane Database Syst Rev 2014 May 13;2014(5):CD007479. doi: 10.1002/14651858.CD007479.pub2. PMID: 24825770Free PMC Article
Drug-induced movement disorders.
Jiménez-Jiménez FJ, García-Ruiz PJ, Molina JA
Drug Saf 1997 Mar;16(3):180-204. doi: 10.2165/00002018-199716030-00004. PMID: 9098656

Prognosis

Struggling to find Effective Pharmacologic Options for Akathisia? B-CALM!
Thippaiah SM, Fargason RE, Birur B
Psychopharmacol Bull 2021 Jun 1;51(3):72-78. PMID: 34421146Free PMC Article
Ertapenem-induced encephalopathy.
Adams R, Chopra P, Miranda R, Calderon A
BMJ Case Rep 2020 Jun 1;13(6) doi: 10.1136/bcr-2019-231875. PMID: 32487528Free PMC Article
Tardive syndromes.
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.
Luft MJ, Lamy M, DelBello MP, McNamara RK, Strawn JR
Curr Probl Pediatr Adolesc Health Care 2018 Feb;48(2):50-62. Epub 2018 Jan 19 doi: 10.1016/j.cppeds.2017.12.001. PMID: 29358037Free PMC Article
The epidemiology of drug-induced akathisia: Part II. Chronic, tardive, and withdrawal akathisias.
Sachdev P
Schizophr Bull 1995;21(3):451-61. doi: 10.1093/schbul/21.3.451. PMID: 7481575

Clinical prediction guides

Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Safety and effectiveness of oral blonanserin for schizophrenia: A review of Japanese post-marketing surveillances.
Inoue Y, Tsuchimori K, Nakamura H
J Pharmacol Sci 2021 Jan;145(1):42-51. Epub 2020 Oct 8 doi: 10.1016/j.jphs.2020.09.006. PMID: 33357778
Ertapenem-induced encephalopathy.
Adams R, Chopra P, Miranda R, Calderon A
BMJ Case Rep 2020 Jun 1;13(6) doi: 10.1136/bcr-2019-231875. PMID: 32487528Free PMC Article
Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.
Luft MJ, Lamy M, DelBello MP, McNamara RK, Strawn JR
Curr Probl Pediatr Adolesc Health Care 2018 Feb;48(2):50-62. Epub 2018 Jan 19 doi: 10.1016/j.cppeds.2017.12.001. PMID: 29358037Free PMC Article
Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.
Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF 3rd
Lancet 2015 Dec 12;386(10011):2404-12. Epub 2015 Sep 27 doi: 10.1016/S0140-6736(15)00308-6. PMID: 26423182Free PMC Article

Recent systematic reviews

Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Memantine for dementia.
McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J
Cochrane Database Syst Rev 2019 Mar 20;3(3):CD003154. doi: 10.1002/14651858.CD003154.pub6. PMID: 30891742Free PMC Article
Chlorpromazine versus penfluridol for schizophrenia.
Nikvarz N, Vahedian M, Khalili N
Cochrane Database Syst Rev 2017 Sep 23;9(9):CD011831. doi: 10.1002/14651858.CD011831.pub2. PMID: 28940256Free PMC Article
Antipsychotic-induced akathisia in delirium: A systematic review.
Forcen FE, Matsoukas K, Alici Y
Palliat Support Care 2016 Feb;14(1):77-84. Epub 2015 Jun 19 doi: 10.1017/S1478951515000784. PMID: 26087817Free PMC Article
Pericyazine for schizophrenia.
Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P
Cochrane Database Syst Rev 2014 May 13;2014(5):CD007479. doi: 10.1002/14651858.CD007479.pub2. PMID: 24825770Free PMC Article

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