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Chronic inflammation

MedGen UID:
5797
•Concept ID:
C0021376
•
Pathologic Function
Synonyms: Chronic Inflammation; Chronic inflammatory cell infiltration; Chronic inflammatory reaction
SNOMED CT: Chronic inflammation (84499006); Chronic inflammatory reaction (84499006); Chronic inflammatory cell infiltration (84499006)

Definition

An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic inflammation

Professional guidelines

PubMed

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
Iliotibial band syndrome: evaluation and management.
Strauss EJ, Kim S, Calcei JG, Park D
J Am Acad Orthop Surg 2011 Dec;19(12):728-36. doi: 10.5435/00124635-201112000-00003. PMID: 22134205

Recent clinical studies

Etiology

Macrophages, Chronic Inflammation, and Insulin Resistance.
Li H, Meng Y, He S, Tan X, Zhang Y, Zhang X, Wang L, Zheng W
Cells 2022 Sep 26;11(19) doi: 10.3390/cells11193001. PMID: 36230963Free PMC Article
Excessive intake of sugar: An accomplice of inflammation.
Ma X, Nan F, Liang H, Shu P, Fan X, Song X, Hou Y, Zhang D
Front Immunol 2022;13:988481. Epub 2022 Aug 31 doi: 10.3389/fimmu.2022.988481. PMID: 36119103Free PMC Article
Neutrophils in chronic inflammatory diseases.
Herrero-Cervera A, Soehnlein O, Kenne E
Cell Mol Immunol 2022 Feb;19(2):177-191. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00832-3. PMID: 35039631Free PMC Article
Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms.
Friedenreich CM, Ryder-Burbidge C, McNeil J
Mol Oncol 2021 Mar;15(3):790-800. Epub 2020 Aug 18 doi: 10.1002/1878-0261.12772. PMID: 32741068Free PMC Article
The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation.
Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V, Orekhov AN
Int J Mol Sci 2020 Mar 6;21(5) doi: 10.3390/ijms21051835. PMID: 32155866Free PMC Article

Diagnosis

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome.
Dabravolski SA, Nikiforov NG, Eid AH, Nedosugova LV, Starodubova AV, Popkova TV, Bezsonov EE, Orekhov AN
Int J Mol Sci 2021 Apr 10;22(8) doi: 10.3390/ijms22083923. PMID: 33920227Free PMC Article
Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms.
Friedenreich CM, Ryder-Burbidge C, McNeil J
Mol Oncol 2021 Mar;15(3):790-800. Epub 2020 Aug 18 doi: 10.1002/1878-0261.12772. PMID: 32741068Free PMC Article
Epithelial barriers in allergy and asthma.
Hellings PW, Steelant B
J Allergy Clin Immunol 2020 Jun;145(6):1499-1509. doi: 10.1016/j.jaci.2020.04.010. PMID: 32507228Free PMC Article
The Origin and Pathogenesis of Endometriosis.
Wang Y, Nicholes K, Shih IM
Annu Rev Pathol 2020 Jan 24;15:71-95. Epub 2019 Sep 3 doi: 10.1146/annurev-pathmechdis-012419-032654. PMID: 31479615Free PMC Article
Diet and inflammation.
Galland L
Nutr Clin Pract 2010 Dec;25(6):634-40. doi: 10.1177/0884533610385703. PMID: 21139128

Therapy

Targeting Interleukin-6 Signaling in Clinic.
Kang S, Tanaka T, Narazaki M, Kishimoto T
Immunity 2019 Apr 16;50(4):1007-1023. doi: 10.1016/j.immuni.2019.03.026. PMID: 30995492
Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis.
Mira TAA, Buen MM, Borges MG, Yela DA, Benetti-Pinto CL
Int J Gynaecol Obstet 2018 Oct;143(1):2-9. Epub 2018 Jul 9 doi: 10.1002/ijgo.12576. PMID: 29944729
Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease.
Weingarden AR, Vaughn BP
Gut Microbes 2017 May 4;8(3):238-252. Epub 2017 Feb 10 doi: 10.1080/19490976.2017.1290757. PMID: 28609251Free PMC Article
Endometriosis still a challenge.
Mehedintu C, Plotogea MN, Ionescu S, Antonovici M
J Med Life 2014 Sep 15;7(3):349-57. Epub 2014 Sep 25 PMID: 25408753Free PMC Article
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL
J Clin Invest 2013 Mar;123(3):966-72. Epub 2013 Mar 1 doi: 10.1172/JCI64098. PMID: 23454759Free PMC Article

Prognosis

Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms.
Friedenreich CM, Ryder-Burbidge C, McNeil J
Mol Oncol 2021 Mar;15(3):790-800. Epub 2020 Aug 18 doi: 10.1002/1878-0261.12772. PMID: 32741068Free PMC Article
Periodontitis and Cardiovascular Diseases. Consensus Report.
Sanz M, Del Castillo AM, Jepsen S, Gonzalez-Juanatey JR, D'Aiuto F, Bouchard P, Chapple I, Dietrich T, Gotsman I, Graziani F, Herrera D, Loos B, Madianos P, Michel JB, Perel P, Pieske B, Shapira L, Shechter M, Tonetti M, Vlachopoulos C, Wimmer G
Glob Heart 2020 Feb 3;15(1):1. doi: 10.5334/gh.400. PMID: 32489774Free PMC Article
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018.
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Dietary Inflammatory Index and Colorectal Cancer Risk-A Meta-Analysis.
Shivappa N, Godos J, Hébert JR, Wirth MD, Piuri G, Speciani AF, Grosso G
Nutrients 2017 Sep 20;9(9) doi: 10.3390/nu9091043. PMID: 28930191Free PMC Article
Diet and nutritional factors in inflammatory bowel diseases.
Owczarek D, Rodacki T, Domagała-Rodacka R, Cibor D, Mach T
World J Gastroenterol 2016 Jan 21;22(3):895-905. doi: 10.3748/wjg.v22.i3.895. PMID: 26811635Free PMC Article

Clinical prediction guides

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
The impact of ageing on monocytes and macrophages.
De Maeyer RPH, Chambers ES
Immunol Lett 2021 Feb;230:1-10. Epub 2020 Dec 10 doi: 10.1016/j.imlet.2020.12.003. PMID: 33309673
Clinical-stage Approaches for Imaging Chronic Inflammation and Fibrosis in Crohn's Disease.
Greer MC, Cytter-Kuint R, Pratt LT, Soboleski D, Focht G, Castro DA
Inflamm Bowel Dis 2020 Sep 18;26(10):1509-1523. doi: 10.1093/ibd/izaa218. PMID: 32946578
Dietary Inflammatory Index and Colorectal Cancer Risk-A Meta-Analysis.
Shivappa N, Godos J, Hébert JR, Wirth MD, Piuri G, Speciani AF, Grosso G
Nutrients 2017 Sep 20;9(9) doi: 10.3390/nu9091043. PMID: 28930191Free PMC Article
A reproducible grading scale for histological assessment of inflammation in ulcerative colitis.
Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Löfberg R
Gut 2000 Sep;47(3):404-9. doi: 10.1136/gut.47.3.404. PMID: 10940279Free PMC Article

Recent systematic reviews

EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update.
Hellmich B, Sanchez-Alamo B, Schirmer JH, Berti A, Blockmans D, Cid MC, Holle JU, Hollinger N, Karadag O, Kronbichler A, Little MA, Luqmani RA, Mahr A, Merkel PA, Mohammad AJ, Monti S, Mukhtyar CB, Musial J, Price-Kuehne F, Segelmark M, Teng YKO, Terrier B, Tomasson G, Vaglio A, Vassilopoulos D, Verhoeven P, Jayne D
Ann Rheum Dis 2024 Jan 2;83(1):30-47. doi: 10.1136/ard-2022-223764. PMID: 36927642
A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging.
Fernandes A, Rodrigues PM, Pintado M, Tavaria FK
Phytomedicine 2023 Jul;115:154824. Epub 2023 Apr 18 doi: 10.1016/j.phymed.2023.154824. PMID: 37119762
Endometriosis and irritable bowel syndrome: a systematic review and meta-analysis.
Chiaffarino F, Cipriani S, Ricci E, Mauri PA, Esposito G, Barretta M, Vercellini P, Parazzini F
Arch Gynecol Obstet 2021 Jan;303(1):17-25. Epub 2020 Sep 19 doi: 10.1007/s00404-020-05797-8. PMID: 32949284
Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis.
Mira TAA, Buen MM, Borges MG, Yela DA, Benetti-Pinto CL
Int J Gynaecol Obstet 2018 Oct;143(1):2-9. Epub 2018 Jul 9 doi: 10.1002/ijgo.12576. PMID: 29944729
Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

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