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Leukemic infiltration

MedGen UID:
58150
•Concept ID:
C0162679
•
Neoplastic Process
Synonyms: Infiltration, Leukemic; Infiltrations, Leukemic; Leukemic Infiltration; Leukemic Infiltrations
SNOMED CT: Leukemic infiltration (446688004)

Definition

A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemic infiltration

Professional guidelines

PubMed

Unmet needs in the treatment of mantle cell lymphoma.
Rosen ST, Link BK, Fowler NH
Clin Adv Hematol Oncol 2013 Nov;11(11 Suppl 18):1-19. PMID: 24893041
The management of spinal metastasis in children.
Sinha AK, Seki JT, Moreau G, Ventureyra E, Letts RM
Can J Surg 1997 Jun;40(3):218-26. PMID: 9194784Free PMC Article
Acute leukemia: diagnosis and management of testicular involvement.
Heaney JA, Klauber GT, Conley GR
Urology 1983 Jun;21(6):573-7. doi: 10.1016/0090-4295(83)90194-2. PMID: 6575491

Recent clinical studies

Etiology

Neuro-ophthalmic Complications in Pediatric Leukemia.
Rothfield L, Falcone MM, Gaier ED, Heidary G, Gise R
J Neuroophthalmol 2023 Dec 1;43(4):520-524. Epub 2023 May 29 doi: 10.1097/WNO.0000000000001879. PMID: 37247249
What Is Different in Acute Hematologic Malignancy-Associated ARDS? An Overview of the Literature.
Cotorogea-Simion M, Pavel B, Isac S, Telecan T, Matache IM, Bobirca A, Bobirca FT, Rababoc R, Droc G
Medicina (Kaunas) 2022 Sep 3;58(9) doi: 10.3390/medicina58091215. PMID: 36143892Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Evolution of Metastases in Space and Time under Immune Selection.
Angelova M, Mlecnik B, Vasaturo A, Bindea G, Fredriksen T, Lafontaine L, Buttard B, Morgand E, Bruni D, Jouret-Mourin A, Hubert C, Kartheuser A, Humblet Y, Ceccarelli M, Syed N, Marincola FM, Bedognetti D, Van den Eynde M, Galon J
Cell 2018 Oct 18;175(3):751-765.e16. Epub 2018 Oct 11 doi: 10.1016/j.cell.2018.09.018. PMID: 30318143
Seizures caused by brain tumors in children.
Sánchez Fernández I, Loddenkemper T
Seizure 2017 Jan;44:98-107. Epub 2016 Dec 7 doi: 10.1016/j.seizure.2016.11.028. PMID: 28017579

Diagnosis

Skin changes in hairy cell leukemia.
Robak E, Jesionek-Kupnicka D, Robak T
Ann Hematol 2021 Mar;100(3):615-625. Epub 2020 Nov 20 doi: 10.1007/s00277-020-04349-z. PMID: 33216198Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
A lot of nerve.
Birnbaum FA, Meekins LC, Srinivasan A, Murchison AP
Surv Ophthalmol 2020 Mar-Apr;65(2):272-277. Epub 2019 Apr 25 doi: 10.1016/j.survophthal.2019.04.005. PMID: 31029580
The Clinical Spectrum of Hepatic Manifestations in Chronic Lymphocytic Leukemia.
Kreiniz N, Beyar Katz O, Polliack A, Tadmor T
Clin Lymphoma Myeloma Leuk 2017 Dec;17(12):863-869. Epub 2017 Jul 23 doi: 10.1016/j.clml.2017.07.008. PMID: 28803824
Leukemia cutis.
Cho-Vega JH, Medeiros LJ, Prieto VG, Vega F
Am J Clin Pathol 2008 Jan;129(1):130-42. doi: 10.1309/WYACYWF6NGM3WBRT. PMID: 18089498

Therapy

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Clinical and genetic characterization of de novo double-hit B cell precursor leukemia/lymphoma.
Stratmann JA, von Rose AB, Koschade S, Wendelin K, Köhler F, Heinsch M, Schiller K, Haferlach C, Wattad M, Rieder H, Serve H, Gökbuget N, Steffen B
Ann Hematol 2019 Mar;98(3):647-656. Epub 2019 Jan 6 doi: 10.1007/s00277-018-03590-x. PMID: 30613837
The Clinical Spectrum of Hepatic Manifestations in Chronic Lymphocytic Leukemia.
Kreiniz N, Beyar Katz O, Polliack A, Tadmor T
Clin Lymphoma Myeloma Leuk 2017 Dec;17(12):863-869. Epub 2017 Jul 23 doi: 10.1016/j.clml.2017.07.008. PMID: 28803824
CART attack.
Pillai V, Maude SL
Blood 2017 Jul 13;130(2):229. doi: 10.1182/blood-2017-04-779009. PMID: 28705860
Intrathecal chemotherapy.
Kerr JZ, Berg S, Blaney SM
Crit Rev Oncol Hematol 2001 Mar;37(3):227-36. doi: 10.1016/s1040-8428(00)00115-3. PMID: 11248578

Prognosis

Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
The leukemias.
Burke VP, Startzell JM
Oral Maxillofac Surg Clin North Am 2008 Nov;20(4):597-608. doi: 10.1016/j.coms.2008.06.011. PMID: 18940626
Leukemia cutis.
Ratnam KV, Khor CJ, Su WP
Dermatol Clin 1994 Apr;12(2):419-31. PMID: 8045053

Clinical prediction guides

Evolution of Metastases in Space and Time under Immune Selection.
Angelova M, Mlecnik B, Vasaturo A, Bindea G, Fredriksen T, Lafontaine L, Buttard B, Morgand E, Bruni D, Jouret-Mourin A, Hubert C, Kartheuser A, Humblet Y, Ceccarelli M, Syed N, Marincola FM, Bedognetti D, Van den Eynde M, Galon J
Cell 2018 Oct 18;175(3):751-765.e16. Epub 2018 Oct 11 doi: 10.1016/j.cell.2018.09.018. PMID: 30318143
Current challenges and opportunities in treating adult patients with Philadelphia-negative acute lymphoblastic leukaemia.
Wolach O, Amitai I, DeAngelo DJ
Br J Haematol 2017 Dec;179(5):705-723. Epub 2017 Oct 26 doi: 10.1111/bjh.14916. PMID: 29076138
Development and function of human innate immune cells in a humanized mouse model.
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA
Nat Biotechnol 2014 Apr;32(4):364-72. Epub 2014 Mar 16 doi: 10.1038/nbt.2858. PMID: 24633240Free PMC Article
Skin lesions in chronic lymphocytic leukemia.
Robak E, Robak T
Leuk Lymphoma 2007 May;48(5):855-65. doi: 10.1080/10428190601137336. PMID: 17487727
Molecular diagnosis of lymphocytic infiltrates of the skin.
Weinberg JM, Rook AH, Lessin SR
Arch Dermatol 1993 Nov;129(11):1491-500. PMID: 8239706

Recent systematic reviews

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review.
Gomes NR, Lima LA, Morais-Perdigão AL, de Caceres CVBL, Sant'Ana MSP, Pontes HAR, Pontes FSC, Smit C, van Heerden WFP, Robinson L, Brasileiro CB, Brennan PA, Fonseca FP
J Oral Pathol Med 2023 Apr;52(4):315-323. Epub 2023 Mar 7 doi: 10.1111/jop.13422. PMID: 36852531
Purging of malignant cell contamination prior to spermatogonia stem cell autotransplantation to preserve fertility: progress & prospects.
Abdelaal O, Barber H, Atala A, Sadri-Ardekani H
Curr Opin Endocrinol Diabetes Obes 2019 Jun;26(3):166-174. doi: 10.1097/MED.0000000000000481. PMID: 30998603
Anterior segment infiltration of acute lymphoblastic leukemia: case report and systematic review.
Yu AM, Chan SC, Iordanous Y, Padmore RF, O'Connor MD
Can J Ophthalmol 2019 Feb;54(1):20-26. Epub 2018 Apr 22 doi: 10.1016/j.jcjo.2018.02.016. PMID: 30851770

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