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Radiation proctitis

MedGen UID:
586421
•Concept ID:
C0400827
•
Pathologic Function
Synonyms: Radiation induced proctitis; radiation proctitis
SNOMED CT: Radiation induced proctitis (235760009); Radiation proctitis (235760009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019084
Orphanet: ORPHA70475

Definition

Radiation proctitis is a rare rectal disease directly induced by pelvic radiotherapy and characterized by rectal bleeding, change in bowel habits, tenesmus and sepsis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation proctitis
Follow this link to review classifications for Radiation proctitis in Orphanet.

Professional guidelines

PubMed

Management of Radiation Proctitis.
Tabaja L, Sidani SM
Dig Dis Sci 2018 Sep;63(9):2180-2188. doi: 10.1007/s10620-018-5163-8. PMID: 29948565
Management of radiation proctitis.
Mendenhall WM, McKibben BT, Hoppe BS, Nichols RC, Henderson RH, Mendenhall NP
Am J Clin Oncol 2014 Oct;37(5):517-23. doi: 10.1097/COC.0b013e318271b1aa. PMID: 23241500
Management of radiation proctitis.
Sarin A, Safar B
Gastroenterol Clin North Am 2013 Dec;42(4):913-25. doi: 10.1016/j.gtc.2013.08.004. PMID: 24280407

Recent clinical studies

Etiology

Clinical Outcome and Risk Factors of Chronic Radiation Proctitis Following Pelvic Radiation Therapy.
Im CM, Cho IJ, Yu HJ, Han B, Oh HH, Seo YJ, Kim KH, Myung DS, Cho SB, Lee WS, Nam TK, Joo YE
Anticancer Res 2022 Dec;42(12):5951-5959. doi: 10.21873/anticanres.16105. PMID: 36456158
Treatment and outcomes of patients with chronic radiation proctitis. A single-center experience and review of the literature.
Gentile M, Cestaro G, Formisano C, Sivero L
Ann Ital Chir 2020;91:668-672. PMID: 33554948
Management of Radiation Proctitis.
Tabaja L, Sidani SM
Dig Dis Sci 2018 Sep;63(9):2180-2188. doi: 10.1007/s10620-018-5163-8. PMID: 29948565
Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding.
Weiner JP, Wong AT, Schwartz D, Martinez M, Aytaman A, Schreiber D
World J Gastroenterol 2016 Aug 21;22(31):6972-86. doi: 10.3748/wjg.v22.i31.6972. PMID: 27610010Free PMC Article
Chronic radiation proctitis: tricks to prevent and treat.
Vanneste BG, Van De Voorde L, de Ridder RJ, Van Limbergen EJ, Lambin P, van Lin EN
Int J Colorectal Dis 2015 Oct;30(10):1293-303. Epub 2015 Jul 23 doi: 10.1007/s00384-015-2289-4. PMID: 26198994Free PMC Article

Diagnosis

Management of Radiation Proctitis.
Tabaja L, Sidani SM
Dig Dis Sci 2018 Sep;63(9):2180-2188. doi: 10.1007/s10620-018-5163-8. PMID: 29948565
Radiation esophagitis.
Murro D, Jakate S
Arch Pathol Lab Med 2015 Jun;139(6):827-30. doi: 10.5858/arpa.2014-0111-RS. PMID: 26030254
Pathogenesis, diagnosis, and management of ulcerative proctitis, chronic radiation proctopathy, and diversion proctitis.
Wu XR, Liu XL, Katz S, Shen B
Inflamm Bowel Dis 2015 Mar;21(3):703-15. doi: 10.1097/MIB.0000000000000227. PMID: 25687266
Management of radiation proctitis.
Sarin A, Safar B
Gastroenterol Clin North Am 2013 Dec;42(4):913-25. doi: 10.1016/j.gtc.2013.08.004. PMID: 24280407
Chronic radiation proctitis.
Tagkalidis PP, Tjandra JJ
ANZ J Surg 2001 Apr;71(4):230-7. doi: 10.1046/j.1440-1622.2001.02081.x. PMID: 11355732

Therapy

Saponins regulate intestinal inflammation in colon cancer and IBD.
Dong J, Liang W, Wang T, Sui J, Wang J, Deng Z, Chen D
Pharmacol Res 2019 Jun;144:66-72. Epub 2019 Apr 5 doi: 10.1016/j.phrs.2019.04.010. PMID: 30959159
Management of Radiation Proctitis.
Tabaja L, Sidani SM
Dig Dis Sci 2018 Sep;63(9):2180-2188. doi: 10.1007/s10620-018-5163-8. PMID: 29948565
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.
Sun M, Wu W, Liu Z, Cong Y
J Gastroenterol 2017 Jan;52(1):1-8. Epub 2016 Jul 23 doi: 10.1007/s00535-016-1242-9. PMID: 27448578Free PMC Article
Radiation esophagitis.
Murro D, Jakate S
Arch Pathol Lab Med 2015 Jun;139(6):827-30. doi: 10.5858/arpa.2014-0111-RS. PMID: 26030254
Chronic radiation proctitis.
Tagkalidis PP, Tjandra JJ
ANZ J Surg 2001 Apr;71(4):230-7. doi: 10.1046/j.1440-1622.2001.02081.x. PMID: 11355732

Prognosis

Efficacy and complications of argon plasma coagulation for hemorrhagic chronic radiation proctitis.
Zhong QH, Liu ZZ, Yuan ZX, Ma TH, Huang XY, Wang HM, Chen DC, Wang JP, Wang L
World J Gastroenterol 2019 Apr 7;25(13):1618-1627. doi: 10.3748/wjg.v25.i13.1618. PMID: 30983821Free PMC Article
Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management.
Mallick S, Madan R, Julka PK, Rath GK
Asian Pac J Cancer Prev 2015;16(14):5589-94. doi: 10.7314/apjcp.2015.16.14.5589. PMID: 26320421
Radiation esophagitis.
Murro D, Jakate S
Arch Pathol Lab Med 2015 Jun;139(6):827-30. doi: 10.5858/arpa.2014-0111-RS. PMID: 26030254
The use of hyperbaric oxygen for treating delayed radiation injuries in gynecologic malignancies: a review of literature and report of radiation injury incidence.
Allen S, Kilian C, Phelps J, Whelan HT
Support Care Cancer 2012 Oct;20(10):2467-72. Epub 2012 Jan 14 doi: 10.1007/s00520-012-1379-x. PMID: 22246598
Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.
Denehy TR, Eastman R, SanFilippo L, Gregori CA, Breen JL
Gynecol Oncol 1996 Jan;60(1):64-71. doi: 10.1006/gyno.1996.0013. PMID: 8557230

Clinical prediction guides

Clinical Outcome and Risk Factors of Chronic Radiation Proctitis Following Pelvic Radiation Therapy.
Im CM, Cho IJ, Yu HJ, Han B, Oh HH, Seo YJ, Kim KH, Myung DS, Cho SB, Lee WS, Nam TK, Joo YE
Anticancer Res 2022 Dec;42(12):5951-5959. doi: 10.21873/anticanres.16105. PMID: 36456158
Short and long term response to argon plasma therapy for hemorrhagic radiation proctitis.
Montes de Oca Megías E, Morera Pérez M, Noa Pedroso G, Piñol Jiménez F, Armenteros Torres M
Rev Esp Enferm Dig 2019 Nov;111(11):852-857. doi: 10.17235/reed.2019.5998/2018. PMID: 31595754
Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding.
Weiner JP, Wong AT, Schwartz D, Martinez M, Aytaman A, Schreiber D
World J Gastroenterol 2016 Aug 21;22(31):6972-86. doi: 10.3748/wjg.v22.i31.6972. PMID: 27610010Free PMC Article
Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management.
Mallick S, Madan R, Julka PK, Rath GK
Asian Pac J Cancer Prev 2015;16(14):5589-94. doi: 10.7314/apjcp.2015.16.14.5589. PMID: 26320421
Treatment of radiation proctitis.
Leiper K, Morris AI
Clin Oncol (R Coll Radiol) 2007 Nov;19(9):724-9. Epub 2007 Aug 28 doi: 10.1016/j.clon.2007.07.008. PMID: 17728120

Recent systematic reviews

Comparative efficacy of oral drugs for chronic radiation proctitis - a systematic review.
Liu L, Xiao N, Liang J
Syst Rev 2023 Aug 22;12(1):146. doi: 10.1186/s13643-023-02294-2. PMID: 37608385Free PMC Article
Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis.
McCarty TR, Garg R, Rustagi T
J Gastroenterol Hepatol 2019 Sep;34(9):1479-1485. Epub 2019 Jul 2 doi: 10.1111/jgh.14729. PMID: 31111527
Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries.
Hoggan BL, Cameron AL
Support Care Cancer 2014 Jun;22(6):1715-26. Epub 2014 Mar 29 doi: 10.1007/s00520-014-2198-z. PMID: 24794980
Hyperbaric oxygen therapy for late radiation tissue injury.
Bennett MH, Feldmeier J, Hampson N, Smee R, Milross C
Cochrane Database Syst Rev 2012 May 16;(5):CD005005. doi: 10.1002/14651858.CD005005.pub3. PMID: 22592699
Systematic review for non-surgical interventions for the management of late radiation proctitis.
Denton AS, Andreyev HJ, Forbes A, Maher EJ
Br J Cancer 2002 Jul 15;87(2):134-43. doi: 10.1038/sj.bjc.6600360. PMID: 12107832Free PMC Article

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