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Comedonal acne

MedGen UID:
590448
•Concept ID:
C0406481
•
Disease or Syndrome
Synonym: Comedogenic acne
SNOMED CT: Comedonal acne (238744006)
 
HPO: HP:0040137

Definition

A type of acne in which open and closed comedones comprise the majority of the lesions, with substantially fewer papules and pustules. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComedonal acne

Conditions with this feature

Progressive retinal dystrophy due to retinol transport defect
MedGen UID:
767507
•Concept ID:
C3554593
•
Disease or Syndrome
Progressive retinal dystrophy due to retinol transport defect is a rare, genetic, metabolite absorption and transport disorder characterized by progressive rod-cone dystrophy, usually presenting with impaired night vision in childhood, progressive loss of visual acuity and severe retinol deficiency without keratomalacia. Association with ocular colobomas, severe acne and hypercholesterolemia has been reported.
See: Condition Record
Progressive retinal dystrophy due to retinol transport defect

Professional guidelines

PubMed

Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea.
Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A
G Ital Dermatol Venereol 2019 Oct;154(5):557-566. doi: 10.23736/S0392-0488.19.06434-4. PMID: 31638351
Management of comedonal acne vulgaris with fixed-combination topical therapy.
Gold MH, Baldwin H, Lin T
J Cosmet Dermatol 2018 Apr;17(2):227-231. Epub 2018 Jan 30 doi: 10.1111/jocd.12497. PMID: 29380941
Consensus-Based Acne Classification System and Treatment Algorithm for Spain.
López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123

Recent clinical studies

Etiology

Individualised Homeopathic Treatment of Acne-An Analysis of 83 Patients.
Nwabudike LC
Homeopathy 2021 Nov;110(4):271-276. Epub 2021 Jun 29 doi: 10.1055/s-0041-1728666. PMID: 34187050
Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea.
Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A
G Ital Dermatol Venereol 2019 Oct;154(5):557-566. doi: 10.23736/S0392-0488.19.06434-4. PMID: 31638351
Consensus-Based Acne Classification System and Treatment Algorithm for Spain.
López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123
Epidemiology of post-adolescence acne and adolescence acne in Singapore: a 10-year retrospective and comparative study.
Han XD, Oon HH, Goh CL
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1790-1793. Epub 2016 Jul 12 doi: 10.1111/jdv.13743. PMID: 27400809
Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study.
Lucky AW, Biro FM, Simbartl LA, Morrison JA, Sorg NW
J Pediatr 1997 Jan;130(1):30-9. doi: 10.1016/s0022-3476(97)70307-x. PMID: 9003848

Diagnosis

Acne vulgaris in black pediatric patients: clinical presentation, treatment patterns, and unique needs.
Jordan KM, Famisan DO, Myer SN, Fine J, Ren Y, Tartar DM
Dermatol Online J 2024 Jun 15;30(3) doi: 10.5070/D330363861. PMID: 39090034
Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea.
Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A
G Ital Dermatol Venereol 2019 Oct;154(5):557-566. doi: 10.23736/S0392-0488.19.06434-4. PMID: 31638351
Epidemiology of post-adolescence acne and adolescence acne in Singapore: a 10-year retrospective and comparative study.
Han XD, Oon HH, Goh CL
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1790-1793. Epub 2016 Jul 12 doi: 10.1111/jdv.13743. PMID: 27400809
Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil.
Bagatin E, Timpano DL, Guadanhim LR, Nogueira VM, Terzian LR, Steiner D, Florez M
An Bras Dermatol 2014 May-Jun;89(3):428-35. doi: 10.1590/abd1806-4841.20142100. PMID: 24937816Free PMC Article
Acne vulgaris in women: prevalence across the life span.
Perkins AC, Maglione J, Hillebrand GG, Miyamoto K, Kimball AB
J Womens Health (Larchmt) 2012 Feb;21(2):223-30. Epub 2011 Dec 15 doi: 10.1089/jwh.2010.2722. PMID: 22171979

Therapy

Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea.
Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A
G Ital Dermatol Venereol 2019 Oct;154(5):557-566. doi: 10.23736/S0392-0488.19.06434-4. PMID: 31638351
Management of comedonal acne vulgaris with fixed-combination topical therapy.
Gold MH, Baldwin H, Lin T
J Cosmet Dermatol 2018 Apr;17(2):227-231. Epub 2018 Jan 30 doi: 10.1111/jocd.12497. PMID: 29380941
Consensus-Based Acne Classification System and Treatment Algorithm for Spain.
López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123
Spotlight on adapalene.
Piérard GE, Piérard-Franchimont C, Paquet P, Quatresooz P
Expert Opin Drug Metab Toxicol 2009 Dec;5(12):1565-75. doi: 10.1517/17425250903386269. PMID: 19929446
Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.
Fitton A, Goa KL
Drugs 1991 May;41(5):780-98. doi: 10.2165/00003495-199141050-00007. PMID: 1712709

Prognosis

Acne treatment in the field: how guidelines and other sources can be included in daily practice.
Rzany B, Nast A
J Eur Acad Dermatol Venereol 2013 Jul;27 Suppl 2:2-5. doi: 10.1111/jdv.12167. PMID: 23731194
Facial edema induced by isotretinoin use: a case and a review of the side effects of isotretinoin.
Scheinfeld N, Bangalore S
J Drugs Dermatol 2006 May;5(5):467-8. PMID: 16703787
Topical therapy for acne vulgaris. How do you choose the best drug for each patient?
Johnson BA, Nunley JR
Postgrad Med 2000 Mar;107(3):69-70, 73-6, 79-80. doi: 10.3810/pgm.2000.03.945. PMID: 10728136
Predictive factors for failure of isotretinoin treatment in acne patients: results from a cohort of 237 patients.
Lehucher-Ceyrac D, de La Salmonière P, Chastang C, Morel P
Dermatology 1999;198(3):278-83. doi: 10.1159/000018130. PMID: 10393453
Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study.
Lucky AW, Biro FM, Simbartl LA, Morrison JA, Sorg NW
J Pediatr 1997 Jan;130(1):30-9. doi: 10.1016/s0022-3476(97)70307-x. PMID: 9003848

Clinical prediction guides

Acne vulgaris in black pediatric patients: clinical presentation, treatment patterns, and unique needs.
Jordan KM, Famisan DO, Myer SN, Fine J, Ren Y, Tartar DM
Dermatol Online J 2024 Jun 15;30(3) doi: 10.5070/D330363861. PMID: 39090034
Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris.
Mias C, Thouvenin MD, Gravier E, Dalmon S, Bouyer K, Alvarez S, Mengeaud V, Ribet V, Bessou-Touya S, Duplan H
J Eur Acad Dermatol Venereol 2023 Mar;37 Suppl 2:20-25. doi: 10.1111/jdv.18792. PMID: 36729402
The Prevalence of Malassezia Folliculitis in Patients with Papulopustular/Comedonal Acne, and Their Response to Antifungal Treatment.
Pürnak S, Durdu M, Tekindal MA, Güleç AT, Seçkin D
Skinmed 2018;16(2):99-104. Epub 2018 Apr 1 PMID: 29911526
Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris.
Tanghetti E, Dhawan S, Green L, Ling M, Downie J, Germain MA, Kasteler JS, Kircik L, Oefelein MG, Draelos Z
J Drugs Dermatol 2011 Jul;10(7):783-92. PMID: 21720661
Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study.
Lucky AW, Biro FM, Simbartl LA, Morrison JA, Sorg NW
J Pediatr 1997 Jan;130(1):30-9. doi: 10.1016/s0022-3476(97)70307-x. PMID: 9003848

Recent systematic reviews

Spotlight on adapalene.
Piérard GE, Piérard-Franchimont C, Paquet P, Quatresooz P
Expert Opin Drug Metab Toxicol 2009 Dec;5(12):1565-75. doi: 10.1517/17425250903386269. PMID: 19929446

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