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Neonatal jaundice

MedGen UID:: 5923
•Concept ID:: C0022353
•: Disease or Syndrome

Synonyms:	Jaundice, Neonatal; Neonatal Jaundice
SNOMED CT:	Neonatal jaundice (387712008); Icterus neonatorum (387712008)

Definition

Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeonatal jaundice

Abnormality of the digestive system
- Abnormality of the abdominal organs
  - Abnormality of the liver
    - Abnormality of the biliary system
      - Cholestasis
        Jaundice
        Neonatal jaundice
        Dubin-Johnson syndrome

Professional guidelines

PubMed

Screening methods for neonatal hyperbilirubinemia: benefits, limitations, requirements, and novel developments.

Hulzebos CV, Vitek L, Coda Zabetta CD, Dvořák A, Schenk P, van der Hagen EAE, Cobbaert C, Tiribelli C
Pediatr Res 2021 Aug;90(2):272-276. Epub 2021 May 3 doi: 10.1038/s41390-021-01543-1. PMID: 33941863

Neonatal jaundice: aetiology, diagnosis and treatment.

Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Evaluation and treatment of neonatal hyperbilirubinemia.

Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

See all (171)

Recent clinical studies

Etiology

Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.

Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076

Neonatal Jaundice: awareness, perception and preventive practices in expectant mothers.

Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337 Free PMC Article

Breastfeeding during breast milk jaundice - a pathophysiological perspective.

Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480

The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein.

Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, Joubert G
Afr J Prim Health Care Fam Med 2018 Apr 12;10(1):e1-e6. doi: 10.4102/phcfm.v10i1.1582. PMID: 29781686 Free PMC Article

Neonatal jaundice: aetiology, diagnosis and treatment.

Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

See all (2032)

Diagnosis

Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.

Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076

Neonatal Jaundice: awareness, perception and preventive practices in expectant mothers.

Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337 Free PMC Article

Neonatal jaundice: aetiology, diagnosis and treatment.

Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Neonatal Cholestasis.

Lane E, Murray KF
Pediatr Clin North Am 2017 Jun;64(3):621-639. doi: 10.1016/j.pcl.2017.01.006. PMID: 28502442

Neonatal jaundice.

Simkiss D, Martin R
J Trop Pediatr 2012 Oct;58(5):339-40. doi: 10.1093/tropej/fms051. PMID: 23038698

See all (1599)

Therapy

Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.

Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364

Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.

van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237 Free PMC Article

Management of pyruvate kinase deficiency in children and adults.

Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739

Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.

Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076

Immunoglobulin for alloimmune hemolytic disease in neonates.

Zwiers C, Scheffer-Rath ME, Lopriore E, de Haas M, Liley HG
Cochrane Database Syst Rev 2018 Mar 18;3(3):CD003313. doi: 10.1002/14651858.CD003313.pub2. PMID: 29551014 Free PMC Article

See all (1203)

Prognosis

Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.

Maternal disease factors associated with neonatal jaundice: a case-control study.

Yu Y, Choi J, Lee MH, Kim K, Ryu HM, Han HW
BMC Pregnancy Childbirth 2022 Mar 24;22(1):247. doi: 10.1186/s12884-022-04566-6. PMID: 35331174 Free PMC Article

Neonatal hyperbilirubinemia and the role of unbound bilirubin.

Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902

Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta-analysis.

Kuniyoshi Y, Tsujimoto Y, Banno M, Taito S, Ariie T
Pediatr Allergy Immunol 2021 May;32(4):690-701. Epub 2021 Feb 20 doi: 10.1111/pai.13456. PMID: 33475191

Biliary atresia: A comprehensive review.

Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637

See all (855)

Clinical prediction guides

Neonatal hyperbilirubinemia and the role of unbound bilirubin.

Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902

Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta-analysis.

Kuniyoshi Y, Tsujimoto Y, Banno M, Taito S, Ariie T
Pediatr Allergy Immunol 2021 May;32(4):690-701. Epub 2021 Feb 20 doi: 10.1111/pai.13456. PMID: 33475191

The Association of Breastfeeding Practices with Neonatal Jaundice.

Ketsuwan S, Baiya N, Maelhacharoenporn K, Puapornpong P
J Med Assoc Thai 2017 Mar;100(3):255-61. PMID: 29911780

Evaluation and treatment of neonatal hyperbilirubinemia.

Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Neonatal jaundice.

Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055 Free PMC Article

See all (865)

Recent systematic reviews

Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.

Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364

Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.

Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728 Free PMC Article

Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.

Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076

Neonatal jaundice: phototherapy.

Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618 Free PMC Article

Neonatal jaundice.

Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055 Free PMC Article

See all (64)