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Neonatal jaundice

MedGen UID:
5923
•Concept ID:
C0022353
•
Disease or Syndrome
Synonyms: Jaundice, Neonatal; Neonatal Jaundice
SNOMED CT: Neonatal jaundice (387712008); Icterus neonatorum (387712008)

Definition

Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal jaundice

Professional guidelines

PubMed

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Recent clinical studies

Etiology

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Neonatal Jaundice: awareness, perception and preventive practices in expectant mothers.
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
Breastfeeding during breast milk jaundice - a pathophysiological perspective.
Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Diagnosis

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Neonatal Jaundice: awareness, perception and preventive practices in expectant mothers.
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein.
Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, Joubert G
Afr J Prim Health Care Fam Med 2018 Apr 12;10(1):e1-e6. doi: 10.4102/phcfm.v10i1.1582. PMID: 29781686Free PMC Article
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Therapy

Intermittent phototherapy versus continuous phototherapy for neonatal jaundice.
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Metformin versus insulin for the treatment of gestational diabetes.
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators
N Engl J Med 2008 May 8;358(19):2003-15. doi: 10.1056/NEJMoa0707193. PMID: 18463376

Prognosis

Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Neonatal hyperbilirubinemia and the role of unbound bilirubin.
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
When babies turn yellow.
Ng MC, How CH
Singapore Med J 2015 Nov;56(11):599-602; quiz 603. doi: 10.11622/smedj.2015167. PMID: 26668403Free PMC Article
Neonatal jaundice.
McKiernan P
Clin Res Hepatol Gastroenterol 2012 Jun;36(3):253-6. Epub 2012 May 18 doi: 10.1016/j.clinre.2012.03.018. PMID: 22609294

Clinical prediction guides

Causal relationships of neonatal jaundice, direct bilirubin and indirect bilirubin with autism spectrum disorder: A two-sample Mendelian randomization analysis.
Chen LW, Zhang Y, Xu DD, Wang Y, Gao H
Front Public Health 2023;11:1137383. Epub 2023 Apr 13 doi: 10.3389/fpubh.2023.1137383. PMID: 37124814Free PMC Article
Neonatal hyperbilirubinemia and the role of unbound bilirubin.
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Neonatal jaundice.
Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055Free PMC Article
Neonatal jaundice.
Evans D
BMJ Clin Evid 2007 Jun 1;2007 PMID: 19454091Free PMC Article

Recent systematic reviews

Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns.
Okwundu CI, Olowoyeye A, Uthman OA, Smith J, Wiysonge CS, Bhutani VK, Fiander M, Gautham KS
Cochrane Database Syst Rev 2023 May 9;5(5):CD012660. doi: 10.1002/14651858.CD012660.pub2. PMID: 37158489Free PMC Article
Intermittent phototherapy versus continuous phototherapy for neonatal jaundice.
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Evaluation of Maternal Risk Factors in Neonatal Hyperbilirubinemia.
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Neonatal jaundice: phototherapy.
Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618Free PMC Article

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