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Neonatal jaundice

MedGen UID:
5923
Concept ID:
C0022353
Disease or Syndrome
Synonyms: Jaundice, Neonatal; Neonatal Jaundice
SNOMED CT: Neonatal jaundice (387712008); Icterus neonatorum (387712008)

Definition

Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Recent clinical studies

Etiology

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Diagnosis

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, Joubert G
Afr J Prim Health Care Fam Med 2018 Apr 12;10(1):e1-e6. doi: 10.4102/phcfm.v10i1.1582. PMID: 29781686Free PMC Article
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507

Therapy

Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators
N Engl J Med 2008 May 8;358(19):2003-15. doi: 10.1056/NEJMoa0707193. PMID: 18463376

Prognosis

van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Horn D, Ehret D, Gautham KS, Soll R
Cochrane Database Syst Rev 2021 Jul 6;7(7):CD013277. doi: 10.1002/14651858.CD013277.pub2. PMID: 34228352Free PMC Article
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
McKiernan P
Clin Res Hepatol Gastroenterol 2012 Jun;36(3):253-6. Epub 2012 May 18 doi: 10.1016/j.clinre.2012.03.018. PMID: 22609294

Clinical prediction guides

Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Ding J, Ma X, Han L, Zhao X, Li A, Xin Q, Lian W, Li Z, Ren H, Ren Z
Biosci Rep 2021 Apr 30;41(4) doi: 10.1042/BSR20210362. PMID: 33860293Free PMC Article
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055Free PMC Article
Evans D
BMJ Clin Evid 2007 Jun 1;2007 PMID: 19454091Free PMC Article

Recent systematic reviews

Okwundu CI, Olowoyeye A, Uthman OA, Smith J, Wiysonge CS, Bhutani VK, Fiander M, Gautham KS
Cochrane Database Syst Rev 2023 May 9;5(5):CD012660. doi: 10.1002/14651858.CD012660.pub2. PMID: 37158489Free PMC Article
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M
Arch Iran Med 2020 Feb 1;23(2):128-140. PMID: 32061076
Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618Free PMC Article

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