U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal jaundice

MedGen UID:
5923
Concept ID:
C0022353
Finding
Synonyms: Jaundice, Neonatal; Neonatal Jaundice
SNOMED CT: Neonatal jaundice (387712008); Icterus neonatorum (387712008)

Definition

Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Recent clinical studies

Etiology

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Diagnosis

Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Amegan-Aho KH, Segbefia CI, Glover NDO, Ansa GA, Afaa TJ
Ghana Med J 2019 Dec;53(4):267-272. doi: 10.4314/gmj.v53i4.3. PMID: 32116337Free PMC Article
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Lane E, Murray KF
Pediatr Clin North Am 2017 Jun;64(3):621-639. doi: 10.1016/j.pcl.2017.01.006. PMID: 28502442
Simkiss D, Martin R
J Trop Pediatr 2012 Oct;58(5):339-40. doi: 10.1093/tropej/fms051. PMID: 23038698

Therapy

Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
McKiernan P
Clin Res Hepatol Gastroenterol 2012 Jun;36(3):253-6. Epub 2012 May 18 doi: 10.1016/j.clinre.2012.03.018. PMID: 22609294
Maisels MJ, McDonagh AF
N Engl J Med 2008 Feb 28;358(9):920-8. doi: 10.1056/NEJMct0708376. PMID: 18305267

Prognosis

van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Ng MC, How CH
Singapore Med J 2015 Nov;56(11):599-602; quiz 603. doi: 10.11622/smedj.2015167. PMID: 26668403Free PMC Article
McKiernan P
Clin Res Hepatol Gastroenterol 2012 Jun;36(3):253-6. Epub 2012 May 18 doi: 10.1016/j.clinre.2012.03.018. PMID: 22609294

Clinical prediction guides

Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055Free PMC Article
Evans D
BMJ Clin Evid 2007 Jun 1;2007 PMID: 19454091Free PMC Article
Sodeinde O
Baillieres Clin Haematol 1992 Apr;5(2):367-82. doi: 10.1016/s0950-3536(11)80024-7. PMID: 1511180

Recent systematic reviews

Okwundu CI, Olowoyeye A, Uthman OA, Smith J, Wiysonge CS, Bhutani VK, Fiander M, Gautham KS
Cochrane Database Syst Rev 2023 May 9;5(5):CD012660. doi: 10.1002/14651858.CD012660.pub2. PMID: 37158489Free PMC Article
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618Free PMC Article
Woodgate P, Jardine LA
BMJ Clin Evid 2011 Sep 15;2011 PMID: 21920055Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...