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Seropositive rheumatoid arthritis

MedGen UID:
592547
•Concept ID:
C0409651
•
Disease or Syndrome
Synonyms: Rheumatoid factor positive rheumatoid arthritis; Seropositive Rheumatoid Arthritis
SNOMED CT: Rheumatoid factor positive rheumatoid arthritis (239791005); Seropositive rheumatoid arthritis (239791005)

Definition

Rheumatoid arthritis in which a patient''s serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeropositive rheumatoid arthritis

Professional guidelines

PubMed

Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan.
Munir A, Khan S, Khan S, Attaullah S, Munir M, Saleem A, Ali I
PLoS One 2023;18(12):e0295124. Epub 2023 Dec 20 doi: 10.1371/journal.pone.0295124. PMID: 38117833Free PMC Article
Clinical management of seronegative and seropositive rheumatoid arthritis: A comparative study.
Choi S, Lee KH
PLoS One 2018;13(4):e0195550. Epub 2018 Apr 6 doi: 10.1371/journal.pone.0195550. PMID: 29624625Free PMC Article
Aspirin and the treatment of rheumatoid arthritis.
Csuka ME, McCarty DJ
Rheum Dis Clin North Am 1989 Aug;15(3):439-54. PMID: 2672131

Recent clinical studies

Etiology

Rheumatoid Arthritis and Risk of Lung Cancer: A Nationwide Cohort Study.
Cho MH, Cho JH, Eun Y, Han K, Jung J, Cho IY, Yoo JE, Lee H, Kim H, Park SY, Shin DW
J Thorac Oncol 2024 Feb;19(2):216-226. Epub 2023 Oct 12 doi: 10.1016/j.jtho.2023.10.006. PMID: 37838085
Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease.
Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V
Arthritis Rheumatol 2023 Nov;75(11):1910-1922. Epub 2023 Aug 3 doi: 10.1002/art.42549. PMID: 37192126
Familial risk of seropositive rheumatoid arthritis and interaction with smoking: a population-based cohort study.
Kim HJ, Swan H, Kazmi SZ, Hong G, Kim YS, Choi S, Kang T, Cha J, Eom J, Hann HJ, Choi IA, Ahn HS
Rheumatology (Oxford) 2023 Sep 1;62(9):3006-3013. doi: 10.1093/rheumatology/kead048. PMID: 36692153
Individuals at risk of seropositive rheumatoid arthritis: the evolving story.
Rantapää Dahlqvist S, Andrade F
J Intern Med 2019 Dec;286(6):627-643. Epub 2019 Oct 21 doi: 10.1111/joim.12980. PMID: 31562671Free PMC Article
Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article

Diagnosis

Rheumatoid Arthritis and Risk of Lung Cancer: A Nationwide Cohort Study.
Cho MH, Cho JH, Eun Y, Han K, Jung J, Cho IY, Yoo JE, Lee H, Kim H, Park SY, Shin DW
J Thorac Oncol 2024 Feb;19(2):216-226. Epub 2023 Oct 12 doi: 10.1016/j.jtho.2023.10.006. PMID: 37838085
Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease.
Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V
Arthritis Rheumatol 2023 Nov;75(11):1910-1922. Epub 2023 Aug 3 doi: 10.1002/art.42549. PMID: 37192126
Impact of lifestyle and comorbidities on seropositive rheumatoid arthritis risk from Korean health insurance data.
Ro J, Kim SH, Kim HR, Lee SH, Min HK
Sci Rep 2022 Feb 9;12(1):2201. doi: 10.1038/s41598-022-06194-8. PMID: 35140294Free PMC Article
Rheumatoid Arthritis in Silica-Exposed Workers.
Min YS, Kim MG, Ahn YS
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312776. PMID: 34886499Free PMC Article
Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article

Therapy

Cancers and cardiovascular diseases in patients with seropositive rheumatoid arthritis treated with JAK inhibitors, biologics and conventional synthetic DMARDs.
Ahn SS, Han M, Jung I, Kim HW
Clin Exp Rheumatol 2023 Sep;41(9):1908-1916. Epub 2023 Mar 27 doi: 10.55563/clinexprheumatol/ins2z2. PMID: 36995320
Familial risk of seropositive rheumatoid arthritis and interaction with smoking: a population-based cohort study.
Kim HJ, Swan H, Kazmi SZ, Hong G, Kim YS, Choi S, Kang T, Cha J, Eom J, Hann HJ, Choi IA, Ahn HS
Rheumatology (Oxford) 2023 Sep 1;62(9):3006-3013. doi: 10.1093/rheumatology/kead048. PMID: 36692153
Incidence of septic arthritis in patients with ankylosing spondylitis and seropositive rheumatoid arthritis following TNF inhibitor therapy.
Kim HW, Han M, Jung I, Ahn SS
Rheumatology (Oxford) 2023 Aug 1;62(8):2740-2747. doi: 10.1093/rheumatology/keac721. PMID: 36562569
Glycosylation of random IgG distinguishes seropositive and seronegative rheumatoid arthritis.
Magorivska I, Döncző B, Dumych T, Karmash A, Boichuk M, Hychka K, Mihalj M, Szabó M, Csánky E, Rech J, Guttman A, Vari SG, Bilyy R
Autoimmunity 2018 May;51(3):111-117. Epub 2018 May 7 doi: 10.1080/08916934.2018.1468886. PMID: 29733234
Clinical management of seronegative and seropositive rheumatoid arthritis: A comparative study.
Choi S, Lee KH
PLoS One 2018;13(4):e0195550. Epub 2018 Apr 6 doi: 10.1371/journal.pone.0195550. PMID: 29624625Free PMC Article

Prognosis

Incidence of seropositive rheumatoid arthritis in population-based studies in Northern Savo, Finland, during 1980-2020.
Elfving P, Kononoff A, Huhtakangas J, Kautiainen H, Savolainen E, Arstila L, Barantseva J, Rannio T, Niinisalo H, Puolitaival A, Soininen K, Kariniemi S, Oksaranta M, Kaipiainen-Seppänen O
Rheumatol Int 2023 Apr;43(4):659-666. Epub 2023 Jan 11 doi: 10.1007/s00296-022-05268-0. PMID: 36629937Free PMC Article
Incidence of septic arthritis in patients with ankylosing spondylitis and seropositive rheumatoid arthritis following TNF inhibitor therapy.
Kim HW, Han M, Jung I, Ahn SS
Rheumatology (Oxford) 2023 Aug 1;62(8):2740-2747. doi: 10.1093/rheumatology/keac721. PMID: 36562569
Differing X-ray patterns in seronegative and seropositive rheumatoid arthritis.
Gadeholt O, Hausotter K, Eberle H, Klink T, Pfeil A
Clin Rheumatol 2019 Sep;38(9):2403-2410. Epub 2019 May 23 doi: 10.1007/s10067-019-04602-5. PMID: 31123977
Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting.
Malmström V, Catrina AI, Klareskog L
Nat Rev Immunol 2017 Jan;17(1):60-75. Epub 2016 Dec 5 doi: 10.1038/nri.2016.124. PMID: 27916980

Clinical prediction guides

Incidence of septic arthritis in patients with ankylosing spondylitis and seropositive rheumatoid arthritis following TNF inhibitor therapy.
Kim HW, Han M, Jung I, Ahn SS
Rheumatology (Oxford) 2023 Aug 1;62(8):2740-2747. doi: 10.1093/rheumatology/keac721. PMID: 36562569
Rheumatoid Arthritis in Silica-Exposed Workers.
Min YS, Kim MG, Ahn YS
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312776. PMID: 34886499Free PMC Article
Assessing improved risk prediction of rheumatoid arthritis by environmental, genetic, and metabolomic factors.
Bouzit L, Malspeis S, Sparks JA, Cui J, Karlson EW, Yoshida K, Costenbader KH
Semin Arthritis Rheum 2021 Oct;51(5):1016-1022. Epub 2021 Jul 10 doi: 10.1016/j.semarthrit.2021.07.006. PMID: 34416623Free PMC Article
Differing X-ray patterns in seronegative and seropositive rheumatoid arthritis.
Gadeholt O, Hausotter K, Eberle H, Klink T, Pfeil A
Clin Rheumatol 2019 Sep;38(9):2403-2410. Epub 2019 May 23 doi: 10.1007/s10067-019-04602-5. PMID: 31123977
Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction.
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article

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