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Overlap syndrome

MedGen UID:
592755
•Concept ID:
C0410000
•
Disease or Syndrome
Synonym: Overlap Syndrome
SNOMED CT: Overlap syndrome (276657008)

Definition

An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOverlap syndrome

Professional guidelines

PubMed

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article

Recent clinical studies

Etiology

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Antimitochondrial Antibodies: from Bench to Bedside.
Colapietro F, Lleo A, Generali E
Clin Rev Allergy Immunol 2022 Oct;63(2):166-177. Epub 2021 Sep 29 doi: 10.1007/s12016-021-08904-y. PMID: 34586589Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995

Diagnosis

Bronchiectasis and Chronic Obstructive Pulmonary Disease Overlap Syndrome.
Sobala R, De Soyza A
Clin Chest Med 2022 Mar;43(1):61-70. doi: 10.1016/j.ccm.2021.11.005. PMID: 35236561
Autoimmune Hepatitis, Sclerosing Cholangitis, and Autoimmune Sclerosing Cholangitis or Overlap Syndrome.
Kerkar N, Chan A
Clin Liver Dis 2018 Nov;22(4):689-702. doi: 10.1016/j.cld.2018.06.005. PMID: 30266157
Primary Biliary Cholangitis and Autoimmune Hepatitis.
Gonzalez RS, Washington K
Surg Pathol Clin 2018 Jun;11(2):329-349. doi: 10.1016/j.path.2018.02.010. PMID: 29751878
COPD-OSA Overlap Syndrome: Evolving Evidence Regarding Epidemiology, Clinical Consequences, and Management.
McNicholas WT
Chest 2017 Dec;152(6):1318-1326. Epub 2017 Apr 23 doi: 10.1016/j.chest.2017.04.160. PMID: 28442310
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995

Therapy

Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis.
Shah AJ, Quek E, Alqahtani JS, Hurst JR, Mandal S
Sleep Med Rev 2022 Jun;63:101627. Epub 2022 Mar 22 doi: 10.1016/j.smrv.2022.101627. PMID: 35413500
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Neuromuscular junction disorders beyond myasthenia gravis.
Oh SJ
Curr Opin Neurol 2021 Oct 1;34(5):648-657. doi: 10.1097/WCO.0000000000000972. PMID: 34914667
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Primary Biliary Cholangitis and Autoimmune Hepatitis.
Gonzalez RS, Washington K
Surg Pathol Clin 2018 Jun;11(2):329-349. doi: 10.1016/j.path.2018.02.010. PMID: 29751878

Prognosis

Pediatric Autoimmune Liver Diseases: Autoimmune Hepatitis and Primary Sclerosing Cholangitis.
Kemme S, Mack CL
Pediatr Clin North Am 2021 Dec;68(6):1293-1307. doi: 10.1016/j.pcl.2021.07.006. PMID: 34736590
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Autoimmune Hepatitis, Sclerosing Cholangitis, and Autoimmune Sclerosing Cholangitis or Overlap Syndrome.
Kerkar N, Chan A
Clin Liver Dis 2018 Nov;22(4):689-702. doi: 10.1016/j.cld.2018.06.005. PMID: 30266157
Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article
Primary Biliary Cholangitis and Autoimmune Hepatitis.
Gonzalez RS, Washington K
Surg Pathol Clin 2018 Jun;11(2):329-349. doi: 10.1016/j.path.2018.02.010. PMID: 29751878

Clinical prediction guides

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
Anti-Ro/SSA and La/SSB antibodies.
Franceschini F, Cavazzana I
Autoimmunity 2005 Feb;38(1):55-63. doi: 10.1080/08916930400022954. PMID: 15804706

Recent systematic reviews

Prevalence and impact of Sjögren's syndrome in primary biliary cholangitis: a systematic review and meta-analysis.
Deng X, Li J, Hou S, Ci B, Liu B, Xu K
Ann Hepatol 2022 Nov-Dec;27(6):100746. Epub 2022 Aug 13 doi: 10.1016/j.aohep.2022.100746. PMID: 35970319
Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis.
Shah AJ, Quek E, Alqahtani JS, Hurst JR, Mandal S
Sleep Med Rev 2022 Jun;63:101627. Epub 2022 Mar 22 doi: 10.1016/j.smrv.2022.101627. PMID: 35413500
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Inflammatory myopathies overlapping with systemic sclerosis: a systematic review.
Júnior JG, Mugii N, Inaoka PT, Sampaio-Barros PD, Shinjo SK
Clin Rheumatol 2022 Jul;41(7):1951-1963. Epub 2022 Feb 27 doi: 10.1007/s10067-022-06115-0. PMID: 35220464
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article

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