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Fetal acidosis

MedGen UID:
593455
•Concept ID:
C0410959
•
Disease or Syndrome
Synonyms: Fetal Acidemia; Fetal Acidosis; Foetal acidosis
SNOMED CT: Foetal acidosis (240306004); Fetal acidosis (240306004)

Definition

An abnormally high hydrogen ion concentration (umbilical arterial blood pH less than 7.00) in fetal blood or tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal acidosis

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Management of fetal distress.
Penning S, Garite TJ
Obstet Gynecol Clin North Am 1999 Jun;26(2):259-74. doi: 10.1016/s0889-8545(05)70073-5. PMID: 10399760

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Improving the interpretation of electronic fetal monitoring: the fetal reserve index.
Evans MI, Britt DW, Evans SM, Devoe LD
Am J Obstet Gynecol 2023 May;228(5S):S1129-S1143. Epub 2023 Mar 17 doi: 10.1016/j.ajog.2022.11.1275. PMID: 37164491
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Maternal obesity and the risk of fetal acidosis at birth.
Cardona-Benavides I, Mora-González P, Pineda A, Puertas A, Manzanares Galán S
J Matern Fetal Neonatal Med 2022 Feb;35(4):765-769. Epub 2020 Feb 25 doi: 10.1080/14767058.2020.1731795. PMID: 32098548
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Improving the interpretation of electronic fetal monitoring: the fetal reserve index.
Evans MI, Britt DW, Evans SM, Devoe LD
Am J Obstet Gynecol 2023 May;228(5S):S1129-S1143. Epub 2023 Mar 17 doi: 10.1016/j.ajog.2022.11.1275. PMID: 37164491
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
A Review on Magnetic Induction Spectroscopy Potential for Fetal Acidosis Examination.
Abdul Halim SF, Zakaria Z, Pusppanathan J, Mohd Noor A, Norali AN, Fazalul Rahiman MH, Mohd Muji SZ, Abdul Rahim R, Engku-Husna EI, Ali Hassan MK, Aziz Safar MJ, Salleh AF, Mat Som MH
Sensors (Basel) 2022 Feb 10;22(4) doi: 10.3390/s22041334. PMID: 35214235Free PMC Article
Reevaluation of intrapartum fetal monitoring using fetal oximetry: A review.
Uchida T, Kanayama N, Kawai K, Mukai M, Suzuki K, Itoh H, Niwayama M
J Obstet Gynaecol Res 2018 Dec;44(12):2127-2134. Epub 2018 Aug 6 doi: 10.1111/jog.13761. PMID: 30084196

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Association Between Obesity and Fetal Acidosis at Scheduled Cesarean Delivery.
DeBolt CA, Sarker M, Trejo FE, Feldman K, Kaplowitz E, Rattner P, Paul K, Jagannatham S, Ferrara L, Doulaveris G, Bernstein PS, Brustman L, Glazer KB, Stone J, Bianco A
Obstet Gynecol 2022 Dec 1;140(6):950-957. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004968. PMID: 36357997
Reevaluation of intrapartum fetal monitoring using fetal oximetry: A review.
Uchida T, Kanayama N, Kawai K, Mukai M, Suzuki K, Itoh H, Niwayama M
J Obstet Gynaecol Res 2018 Dec;44(12):2127-2134. Epub 2018 Aug 6 doi: 10.1111/jog.13761. PMID: 30084196
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.
Allanson ER, Waqar T, White C, Tunçalp Ö, Dickinson JE
BJOG 2017 Mar;124(4):584-594. Epub 2016 Oct 5 doi: 10.1111/1471-0528.14306. PMID: 27704703
Nonobstetric anesthesia during pregnancy.
Heesen M, Klimek M
Curr Opin Anaesthesiol 2016 Jun;29(3):297-303. doi: 10.1097/ACO.0000000000000311. PMID: 26859466

Prognosis

Improving the interpretation of electronic fetal monitoring: the fetal reserve index.
Evans MI, Britt DW, Evans SM, Devoe LD
Am J Obstet Gynecol 2023 May;228(5S):S1129-S1143. Epub 2023 Mar 17 doi: 10.1016/j.ajog.2022.11.1275. PMID: 37164491
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.
Allanson ER, Waqar T, White C, Tunçalp Ö, Dickinson JE
BJOG 2017 Mar;124(4):584-594. Epub 2016 Oct 5 doi: 10.1111/1471-0528.14306. PMID: 27704703
Fetal pulse oximetry.
Luttkus AK, Dudenhausen JW
Curr Opin Obstet Gynecol 1998 Dec;10(6):481-6. doi: 10.1097/00001703-199812000-00009. PMID: 9866017

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Improving the interpretation of electronic fetal monitoring: the fetal reserve index.
Evans MI, Britt DW, Evans SM, Devoe LD
Am J Obstet Gynecol 2023 May;228(5S):S1129-S1143. Epub 2023 Mar 17 doi: 10.1016/j.ajog.2022.11.1275. PMID: 37164491
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Association Between Obesity and Fetal Acidosis at Scheduled Cesarean Delivery.
DeBolt CA, Sarker M, Trejo FE, Feldman K, Kaplowitz E, Rattner P, Paul K, Jagannatham S, Ferrara L, Doulaveris G, Bernstein PS, Brustman L, Glazer KB, Stone J, Bianco A
Obstet Gynecol 2022 Dec 1;140(6):950-957. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004968. PMID: 36357997
Intrapartum Fetal Monitoring.
Arnold JJ, Gawrys BL
Am Fam Physician 2020 Aug 1;102(3):158-167. PMID: 32735438

Recent systematic reviews

Norepinephrine versus phenylephrine for postspinal hypotension in parturients undergoing cesarean section: a systematic review and meta-analysis.
Kumari K, Chaudhary K, Sethi P, Rathod D, Meshram T, Kothari N, Sharma A, Bhatia P, Singh S
Minerva Anestesiol 2022 Dec;88(12):1043-1056. Epub 2022 Jul 5 doi: 10.23736/S0375-9393.22.16654-X. PMID: 35785931
Regimens of ultrasound surveillance for twin pregnancies for improving outcomes.
Woolcock JG, Grivell RM, Dodd JM
Cochrane Database Syst Rev 2017 Nov 7;11(11):CD011371. doi: 10.1002/14651858.CD011371.pub2. PMID: 29108135Free PMC Article
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.
Allanson ER, Waqar T, White C, Tunçalp Ö, Dickinson JE
BJOG 2017 Mar;124(4):584-594. Epub 2016 Oct 5 doi: 10.1111/1471-0528.14306. PMID: 27704703
Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis.
Veeser M, Hofmann T, Roth R, Klöhr S, Rossaint R, Heesen M
Acta Anaesthesiol Scand 2012 Aug;56(7):810-6. Epub 2012 Feb 7 doi: 10.1111/j.1399-6576.2011.02646.x. PMID: 22313496
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Emmett RS, Cyna AM, Andrew M, Simmons SW
Cochrane Database Syst Rev 2002;(3):CD002251. doi: 10.1002/14651858.CD002251. PMID: 12137652

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