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Idiopathic anaphylaxis

MedGen UID:
595022
Concept ID:
C0413235
Disease or Syndrome
Synonyms: idiopathic anaphylaxis; Syndrome of idiopathic anaphylaxis
SNOMED CT: Idiopathic anaphylaxis (241954008); Syndrome of idiopathic anaphylaxis (241954008)
 
HPO: HP:0410148
Monarch Initiative: MONDO:0100054

Definition

A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic anaphylaxis

Professional guidelines

PubMed

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Wallace DV
Ann Allergy Asthma Immunol 2023 Aug;131(2):151-169. Epub 2023 May 19 doi: 10.1016/j.anai.2023.05.010. PMID: 37209836
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743

Recent clinical studies

Etiology

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article
Schuch A, Brockow K
Immunol Allergy Clin North Am 2017 Feb;37(1):153-164. Epub 2016 Oct 28 doi: 10.1016/j.iac.2016.08.017. PMID: 27886904

Diagnosis

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Bilò MB, Martini M, Tontini C, Mohamed OE, Krishna MT
Clin Exp Allergy 2019 Jul;49(7):942-952. Epub 2019 May 13 doi: 10.1111/cea.13402. PMID: 31002196
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article

Therapy

Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Guo C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):457-461. doi: 10.2500/aap.2019.40.4271. PMID: 31690394
Watts MM, Marie Ditto A
Allergy Asthma Proc 2019 Nov 1;40(6):453-456. doi: 10.2500/aap.2019.40.4270. PMID: 31690393

Prognosis

Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Bilò MB, Martini M, Tontini C, Mohamed OE, Krishna MT
Clin Exp Allergy 2019 Jul;49(7):942-952. Epub 2019 May 13 doi: 10.1111/cea.13402. PMID: 31002196
Fenny N, Grammer LC
Immunol Allergy Clin North Am 2015 May;35(2):349-62. Epub 2015 Mar 6 doi: 10.1016/j.iac.2015.01.004. PMID: 25841556
Lieberman PL
Allergy Asthma Proc 2014 Jan-Feb;35(1):17-23. doi: 10.2500/aap.2014.35.3717. PMID: 24433593

Clinical prediction guides

Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Wallace DV
Ann Allergy Asthma Immunol 2023 Aug;131(2):151-169. Epub 2023 May 19 doi: 10.1016/j.anai.2023.05.010. PMID: 37209836
Rama TA, Torrado I, Henriques AF, Sánchez-Muñoz L, Jara-Acevedo M, Navarro-Navarro P, Caldas C, Mayado A, Muñoz-González J, García-Montero A, Mollejo M, Redondo E, Garbán A, Moreira A, Órfão A, Álvarez-Twose I
J Allergy Clin Immunol Pract 2023 Mar;11(3):908-919.e4. Epub 2022 Dec 16 doi: 10.1016/j.jaip.2022.11.042. PMID: 36535520
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734

Recent systematic reviews

Kaminsky LW, Aukstuolis K, Petroni DH, Al-Shaikhly T
Ann Allergy Asthma Immunol 2021 Oct;127(4):481-487. Epub 2021 Jun 24 doi: 10.1016/j.anai.2021.06.017. PMID: 34175498
Jendoubi F, Gaudenzio N, Gallini A, Negretto M, Paul C, Bulai Livideanu C
Clin Exp Allergy 2020 Jun;50(6):654-661. Epub 2020 Mar 25 doi: 10.1111/cea.13592. PMID: 32107810
Armstrong N, Wolff R, van Mastrigt G, Martinez N, Hernandez AV, Misso K, Kleijnen J
Health Technol Assess 2013 Apr;17(17):1-117, v-vi. doi: 10.3310/hta17170. PMID: 23618619Free PMC Article

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