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Idiopathic anaphylaxis

MedGen UID:
595022
•Concept ID:
C0413235
•
Disease or Syndrome
Synonyms: idiopathic anaphylaxis; Syndrome of idiopathic anaphylaxis
SNOMED CT: Idiopathic anaphylaxis (241954008); Syndrome of idiopathic anaphylaxis (241954008)
 
HPO: HP:0410148
Monarch Initiative: MONDO:0100054

Definition

A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic anaphylaxis

Professional guidelines

PubMed

Knowledge gaps in the diagnosis and management of anaphylaxis.
Wallace DV
Ann Allergy Asthma Immunol 2023 Aug;131(2):151-169. Epub 2023 May 19 doi: 10.1016/j.anai.2023.05.010. PMID: 37209836
Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Diagnosis and management of anaphylaxis in precision medicine.
Castells M
J Allergy Clin Immunol 2017 Aug;140(2):321-333. doi: 10.1016/j.jaci.2017.06.012. PMID: 28780940

Recent clinical studies

Etiology

Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Anaphylaxis.
Watts MM, Marie Ditto A
Allergy Asthma Proc 2019 Nov 1;40(6):453-456. doi: 10.2500/aap.2019.40.4270. PMID: 31690393
Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors.
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article
Diagnosis and management of anaphylaxis in precision medicine.
Castells M
J Allergy Clin Immunol 2017 Aug;140(2):321-333. doi: 10.1016/j.jaci.2017.06.012. PMID: 28780940

Diagnosis

Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Idiopathic anaphylaxis.
Bilò MB, Martini M, Tontini C, Mohamed OE, Krishna MT
Clin Exp Allergy 2019 Jul;49(7):942-952. Epub 2019 May 13 doi: 10.1111/cea.13402. PMID: 31002196
Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors.
Skypala IJ
Front Immunol 2019;10:673. Epub 2019 Apr 3 doi: 10.3389/fimmu.2019.00673. PMID: 31001275Free PMC Article
Diagnosis and management of anaphylaxis in precision medicine.
Castells M
J Allergy Clin Immunol 2017 Aug;140(2):321-333. doi: 10.1016/j.jaci.2017.06.012. PMID: 28780940

Therapy

Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Idiopathic anaphylaxis.
Guo C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):457-461. doi: 10.2500/aap.2019.40.4271. PMID: 31690394
Anaphylaxis.
Watts MM, Marie Ditto A
Allergy Asthma Proc 2019 Nov 1;40(6):453-456. doi: 10.2500/aap.2019.40.4270. PMID: 31690393
Idiopathic anaphylaxis.
Greenberger PA, Lieberman P
J Allergy Clin Immunol Pract 2014 May-Jun;2(3):243-50; quiz 251. Epub 2014 Apr 6 doi: 10.1016/j.jaip.2014.02.012. PMID: 24811012

Prognosis

Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Idiopathic anaphylaxis.
Bilò MB, Martini M, Tontini C, Mohamed OE, Krishna MT
Clin Exp Allergy 2019 Jul;49(7):942-952. Epub 2019 May 13 doi: 10.1111/cea.13402. PMID: 31002196
Idiopathic anaphylaxis.
Fenny N, Grammer LC
Immunol Allergy Clin North Am 2015 May;35(2):349-62. Epub 2015 Mar 6 doi: 10.1016/j.iac.2015.01.004. PMID: 25841556
Idiopathic anaphylaxis.
Lieberman PL
Allergy Asthma Proc 2014 Jan-Feb;35(1):17-23. doi: 10.2500/aap.2014.35.3717. PMID: 24433593
Idiopathic anaphylaxis.
Patterson R, Harris KE
Allergy Asthma Proc 1999 Sep-Oct;20(5):311-5. doi: 10.2500/108854199778251906. PMID: 10566101

Clinical prediction guides

Knowledge gaps in the diagnosis and management of anaphylaxis.
Wallace DV
Ann Allergy Asthma Immunol 2023 Aug;131(2):151-169. Epub 2023 May 19 doi: 10.1016/j.anai.2023.05.010. PMID: 37209836
Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Risk Factors and Characteristics of Biphasic Anaphylaxis.
Kraft M, Scherer Hofmeier K, Ruëff F, Pföhler C, Renaudin JM, Bilò MB, Treudler R, Lang R, Cichocka-Jarosz E, Fernandez-Rivas M, Christoff G, Papadopoulos NG, Ensina LF, Hourihane JO, Maris I, Koehli A, García BE, Jappe U, Vogelberg C, Ott H, Lange L, Spindler T, Dölle-Bierke S, Worm M
J Allergy Clin Immunol Pract 2020 Nov-Dec;8(10):3388-3395.e6. Epub 2020 Aug 4 doi: 10.1016/j.jaip.2020.07.036. PMID: 32763470
Anaphylaxis.
Janwitayanujit S
J Med Assoc Thai 2007 Jan;90(1):195-200. PMID: 17621755

Recent systematic reviews

Use of omalizumab for management of idiopathic anaphylaxis: A systematic review and retrospective case series.
Kaminsky LW, Aukstuolis K, Petroni DH, Al-Shaikhly T
Ann Allergy Asthma Immunol 2021 Oct;127(4):481-487. Epub 2021 Jun 24 doi: 10.1016/j.anai.2021.06.017. PMID: 34175498
Omalizumab in the treatment of adult patients with mastocytosis: A systematic review.
Jendoubi F, Gaudenzio N, Gallini A, Negretto M, Paul C, Bulai Livideanu C
Clin Exp Allergy 2020 Jun;50(6):654-661. Epub 2020 Mar 25 doi: 10.1111/cea.13592. PMID: 32107810
A systematic review and cost-effectiveness analysis of specialist services and adrenaline auto-injectors in anaphylaxis.
Armstrong N, Wolff R, van Mastrigt G, Martinez N, Hernandez AV, Misso K, Kleijnen J
Health Technol Assess 2013 Apr;17(17):1-117, v-vi. doi: 10.3310/hta17170. PMID: 23618619Free PMC Article

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