Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Keratoderma

MedGen UID:: 5955
•Concept ID:: C0022579
•: Congenital Abnormality

SNOMED CT:

Keratoderma (707209001)

Definition

A skin disorder consisting of hypertrophy of the stratum corneum of the skin. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVKeratoderma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Site
        Non-Neoplastic Skin Disorder
        Keratoderma
        Acquired keratosis
        Palmoplantar keratoderma
        Diffuse palmoplantar hyperkeratosis
        Diffuse palmoplantar keratoderma of Thost-Unna
        Epidermolytic palmoplantar keratoderma
        Palmoplantar keratoderma with leukoplakia
        Type A Tylosis
        Type B Tylosis
        Papillon-Lefèvre syndrome

Professional guidelines

PubMed

Aquagenic Keratoderma: Treatment Update.

Carbonell Pradas M, Grimalt Santacana R
Actas Dermosifiliogr 2022 Mar;113(3):254-260. Epub 2021 Jun 12 doi: 10.1016/j.ad.2021.05.016. PMID: 34126071

Nagashima-Type Palmoplantar Keratosis: Clinical Characteristics, Genetic Characterization, and Clinical Management.

Huang C, Yang Y, Huang X, Zhou Z
Biomed Res Int 2021;2021:8841994. Epub 2021 Jan 27 doi: 10.1155/2021/8841994. PMID: 33575348 Free PMC Article

Diagnosis and Management of Inherited Palmoplantar Keratodermas.

Thomas BR, O'Toole EA
Acta Derm Venereol 2020 Mar 25;100(7):adv00094. doi: 10.2340/00015555-3430. PMID: 32147745 Free PMC Article

See all (42)

Recent clinical studies

Etiology

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Wilson disease.

Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896

Cutaneous paraneoplastic syndromes.

Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994

Arrhythmogenic cardiomyopathy.

Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C
Orphanet J Rare Dis 2016 Apr 2;11:33. doi: 10.1186/s13023-016-0407-1. PMID: 27038780 Free PMC Article

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (330)

Diagnosis

Olmsted Syndrome.

Huang YY, Li JH
JAMA Dermatol 2024 Feb 1;160(2):218-219. doi: 10.1001/jamadermatol.2023.4152. PMID: 38055272

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

Diagnosis and Management of Inherited Palmoplantar Keratodermas.

Thomas BR, O'Toole EA
Acta Derm Venereol 2020 Mar 25;100(7):adv00094. doi: 10.2340/00015555-3430. PMID: 32147745 Free PMC Article

Acquired palmoplantar keratoderma.

Patel S, Zirwas M, English JC 3rd
Am J Clin Dermatol 2007;8(1):1-11. doi: 10.2165/00128071-200708010-00001. PMID: 17298101

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (792)

Therapy

Aquagenic Keratoderma: Treatment Update.

Carbonell Pradas M, Grimalt Santacana R
Actas Dermosifiliogr 2022 Mar;113(3):254-260. Epub 2021 Jun 12 doi: 10.1016/j.ad.2021.05.016. PMID: 34126071

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Wilson disease.

Aggarwal A, Bhatt M
Curr Opin Neurol 2020 Aug;33(4):534-542. doi: 10.1097/WCO.0000000000000837. PMID: 32657896

A Review on Pityriasis Rubra Pilaris.

Wang D, Chong VC, Chong WS, Oon HH
Am J Clin Dermatol 2018 Jun;19(3):377-390. doi: 10.1007/s40257-017-0338-1. PMID: 29302927

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (385)

Prognosis

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

Naxos disease - a narrative review.

Leopoulou M, Mattsson G, LeQuang JA, Pergolizzi JV, Varrassi G, Wallhagen M, Magnusson P
Expert Rev Cardiovasc Ther 2020 Nov;18(11):801-808. Epub 2020 Oct 8 doi: 10.1080/14779072.2020.1828064. PMID: 32966140

A Review on Pityriasis Rubra Pilaris.

Wang D, Chong VC, Chong WS, Oon HH
Am J Clin Dermatol 2018 Jun;19(3):377-390. doi: 10.1007/s40257-017-0338-1. PMID: 29302927

Cutaneous paraneoplasia.

Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730

Acrokeratoelastoidosis.

Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

See all (254)

Clinical prediction guides

Aquagenic keratoderma.

Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021

Olmsted syndrome: clinical, molecular and therapeutic aspects.

Duchatelet S, Hovnanian A
Orphanet J Rare Dis 2015 Mar 17;10:33. doi: 10.1186/s13023-015-0246-5. PMID: 25886873 Free PMC Article

Keratins and skin disease.

Knöbel M, O'Toole EA, Smith FJ
Cell Tissue Res 2015 Jun;360(3):583-9. Epub 2015 Jan 27 doi: 10.1007/s00441-014-2105-4. PMID: 25620412

Clinical and pathological features of pachyonychia congenita.

Leachman SA, Kaspar RL, Fleckman P, Florell SR, Smith FJ, McLean WH, Lunny DP, Milstone LM, van Steensel MA, Munro CS, O'Toole EA, Celebi JT, Kansky A, Lane EB
J Investig Dermatol Symp Proc 2005 Oct;10(1):3-17. doi: 10.1111/j.1087-0024.2005.10202.x. PMID: 16250204

Olmsted syndrome.

Perry HO, Su WP
Semin Dermatol 1995 Jun;14(2):145-51. doi: 10.1016/s1085-5629(05)80011-2. PMID: 7640195

See all (338)

Recent systematic reviews

Is punctate palmoplantar keratoderma type 1 associated with malignancy? A systematic review of the literature.

Gram SB, Bjerrelund J, Jelsig AM, Bygum A, Leboeuf-Yde C, Ousager LB
Orphanet J Rare Dis 2023 Sep 13;18(1):290. doi: 10.1186/s13023-023-02862-8. PMID: 37705065 Free PMC Article

Acitretin-induced periungual pyogenic granulomas and review.

Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.

Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846 Free PMC Article

Loricrin downregulation and epithelial-related disorders: a systematic review.

Catunda R, Rekhi U, Clark D, Levin L, Febbraio M
J Dtsch Dermatol Ges 2019 Dec;17(12):1227-1238. Epub 2019 Dec 17 doi: 10.1111/ddg.14001. PMID: 31846220

Combination of palmoplantar keratoderma and hair shaft anomalies, the warning signal of severe arrhythmogenic cardiomyopathy: a systematic review on genetic desmosomal diseases.

Polivka L, Bodemer C, Hadj-Rabia S
J Med Genet 2016 May;53(5):289-95. Epub 2015 Sep 23 doi: 10.1136/jmedgenet-2015-103403. PMID: 26399581

See all (8)

MedGen

National Center for Biotechnology Information

Send to:

Keratoderma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity