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Keratoderma

MedGen UID:
5955
•Concept ID:
C0022579
•
Congenital Abnormality
SNOMED CT: Keratoderma (707209001)

Definition

A skin disorder consisting of hypertrophy of the stratum corneum of the skin. [from NCI]

Professional guidelines

PubMed

Treatment of a chronic skin lesion in the lower limb in Meleda disease.
Nebbioso G, Nebbioso V, Petrella F
J Wound Care 2022 Mar 2;31(3):224-228. doi: 10.12968/jowc.2022.31.3.224. PMID: 35199600
Treatment of Keratin 16 Palmoplantar Keratoderma With Topical Erlotinib.
Lee G, Lowe PM
JAMA Dermatol 2022 Feb 1;158(2):216-217. doi: 10.1001/jamadermatol.2021.5302. PMID: 34985526
Dental management of Rapp-Hodgkin syndrome associated with oral cleft and hypodontia.
Karthikeyani S, Thirumurthy VR, Yuvaraja BA
J Indian Soc Pedod Prev Dent 2016 Apr-Jun;34(2):192-5. doi: 10.4103/0970-4388.180453. PMID: 27080974

Recent clinical studies

Etiology

Clinical and Molecular Aspects of Naxos Disease.
Protonotarios I, Asimaki A, Xylouri Z, Protonotarios A, Tsatsopoulou A
Heart Fail Clin 2022 Jan;18(1):89-99. Epub 2021 Oct 22 doi: 10.1016/j.hfc.2021.07.010. PMID: 34776086
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Cutaneous paraneoplasia.
Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730
Palmoplantar keratodermas.
Itin PH, Fistarol SK
Clin Dermatol 2005 Jan-Feb;23(1):15-22. doi: 10.1016/j.clindermatol.2004.09.005. PMID: 15708285
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Diagnosis

Olmsted Syndrome.
Huang YY, Li JH
JAMA Dermatol 2024 Feb 1;160(2):218-219. doi: 10.1001/jamadermatol.2023.4152. PMID: 38055272
Keratoderma and dental involvement.
Navarro-Triviño FJ, Moreno-Higueras M
Rev Clin Esp (Barc) 2022 Jan;222(1):54-55. Epub 2021 Jul 28 doi: 10.1016/j.rceng.2021.07.001. PMID: 34330664
Spiny keratoderma.
Corral M, Paret C, Iglesias M, Amores E, Fernández MT, Salleras M
Dermatol Online J 2020 Sep 15;26(9) PMID: 33054945
Palmoplantar keratodermas.
Itin PH, Fistarol SK
Clin Dermatol 2005 Jan-Feb;23(1):15-22. doi: 10.1016/j.clindermatol.2004.09.005. PMID: 15708285
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Therapy

A Review on Pityriasis Rubra Pilaris.
Wang D, Chong VC, Chong WS, Oon HH
Am J Clin Dermatol 2018 Jun;19(3):377-390. doi: 10.1007/s40257-017-0338-1. PMID: 29302927
Keratoderma blennorrhagica.
Coelho I, Costa S, Mendes SS, Gomes GC
BMJ Case Rep 2017 Nov 16;2017 doi: 10.1136/bcr-2017-222475. PMID: 29146729Free PMC Article
Acitretin Use in Dermatology.
Guenther LC, Kunynetz R, Lynde CW, Sibbald RG, Toole J, Vender R, Zip C
J Cutan Med Surg 2017 Nov/Dec;21(3_suppl):2S-12S. Epub 2017 Sep 27 doi: 10.1177/1203475417733414. PMID: 28952335
KID syndrome.
Abdollahi A, Hallaji Z, Esmaili N, Valikhani M, Barzegari M, Akhyani M, Toosi S, Miresmaili A
Dermatol Online J 2007 Oct 13;13(4):11. PMID: 18319008
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Prognosis

Cutaneous paraneoplasia.
Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730
Adult onset pityriasis rubra pilaris.
Sehgal VN, Srivastava G, Dogra S
Indian J Dermatol Venereol Leprol 2008 Jul-Aug;74(4):311-21. doi: 10.4103/0378-6323.42889. PMID: 18797049
Naxos disease.
Adhisivam B, Mahadevan S
Indian J Pediatr 2006 Apr;73(4):359-60. doi: 10.1007/BF02825834. PMID: 16816500
Palmoplantar keratodermas.
Itin PH, Fistarol SK
Clin Dermatol 2005 Jan-Feb;23(1):15-22. doi: 10.1016/j.clindermatol.2004.09.005. PMID: 15708285
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Clinical prediction guides

Huriez syndrome: Additional pathogenic variants supporting allelism to SMARCAD syndrome.
Loh AYT, Špoljar S, Neo GYW, Escande-Beillard N, Leushacke M, Luijten MNH, Venkatesh B, Bonnard C, van Steensel MAM, Hamm H, Carmichael A, Rajan N, Carney TJ, Reversade B
Am J Med Genet A 2022 Jun;188(6):1752-1760. Epub 2022 Feb 25 doi: 10.1002/ajmg.a.62703. PMID: 35212137
Mutations in PERP Cause Dominant and Recessive Keratoderma.
Duchatelet S, Boyden LM, Ishida-Yamamoto A, Zhou J, Guibbal L, Hu R, Lim YH, Bole-Feysot C, Nitschké P, Santos-Simarro F, de Lucas R, Milstone LM, Gildenstern V, Helfrich YR, Attardi LD, Lifton RP, Choate KA, Hovnanian A
J Invest Dermatol 2019 Feb;139(2):380-390. Epub 2018 Oct 12 doi: 10.1016/j.jid.2018.08.026. PMID: 30321533Free PMC Article
KID syndrome.
Abdollahi A, Hallaji Z, Esmaili N, Valikhani M, Barzegari M, Akhyani M, Toosi S, Miresmaili A
Dermatol Online J 2007 Oct 13;13(4):11. PMID: 18319008
Olmsted syndrome.
Fonseca E, Peña C, Del Pozo J, Almagro M, Yebra MT, Cuevas J, Contreras F
J Cutan Pathol 2001 May;28(5):271-5. doi: 10.1034/j.1600-0560.2001.028005271.x. PMID: 11401671
Arsenic and cancer.
Jackson R, Grainge JW
Can Med Assoc J 1975 Sep 6;113(5):396-401. PMID: 125622Free PMC Article

Recent systematic reviews

Is punctate palmoplantar keratoderma type 1 associated with malignancy? A systematic review of the literature.
Gram SB, Bjerrelund J, Jelsig AM, Bygum A, Leboeuf-Yde C, Ousager LB
Orphanet J Rare Dis 2023 Sep 13;18(1):290. doi: 10.1186/s13023-023-02862-8. PMID: 37705065Free PMC Article
Acitretin-induced periungual pyogenic granulomas and review.
Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333
Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review.
Martina E, Diotallevi F, Radi G, Campanati A, Offidani A
Toxins (Basel) 2021 Feb 5;13(2) doi: 10.3390/toxins13020120. PMID: 33562846Free PMC Article
Loricrin downregulation and epithelial-related disorders: a systematic review.
Catunda R, Rekhi U, Clark D, Levin L, Febbraio M
J Dtsch Dermatol Ges 2019 Dec;17(12):1227-1238. Epub 2019 Dec 17 doi: 10.1111/ddg.14001. PMID: 31846220
Combination of palmoplantar keratoderma and hair shaft anomalies, the warning signal of severe arrhythmogenic cardiomyopathy: a systematic review on genetic desmosomal diseases.
Polivka L, Bodemer C, Hadj-Rabia S
J Med Genet 2016 May;53(5):289-95. Epub 2015 Sep 23 doi: 10.1136/jmedgenet-2015-103403. PMID: 26399581

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