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Blastomycosis

MedGen UID:
597
•Concept ID:
C0005716
•
Disease or Syndrome
Synonyms: Gilchrist's disease; North American blastomycosis
SNOMED CT: Blastomycosis (69996000); Infection by Blastomyces (69996000); Blastomycotic infection (69996000)
 
Monarch Initiative: MONDO:0005672

Definition

A fungal infection caused by inhalation of spores of Blastomyces dermatitidis. It presents with flu-like symptoms including fever, chills, cough, pleuritic chest pain and myalgias. It may lead to a chronic granulomatous pulmonary infection and disseminate to other anatomic sites including skin, nervous system and bones. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlastomycosis

Professional guidelines

PubMed

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Clinical Manifestations and Treatment of Blastomycosis.
McBride JA, Gauthier GM, Klein BS
Clin Chest Med 2017 Sep;38(3):435-449. Epub 2017 Jun 12 doi: 10.1016/j.ccm.2017.04.006. PMID: 28797487Free PMC Article
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785

Recent clinical studies

Etiology

The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.
Mazi PB, Sahrmann JM, Olsen MA, Coler-Reilly A, Rauseo AM, Pullen M, Zuniga-Moya JC, Powderly WG, Spec A
Clin Infect Dis 2023 Apr 3;76(7):1295-1301. doi: 10.1093/cid/ciac882. PMID: 36366776Free PMC Article
Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
The Changing Epidemiology of Invasive Fungal Infections.
Enoch DA, Yang H, Aliyu SH, Micallef C
Methods Mol Biol 2017;1508:17-65. doi: 10.1007/978-1-4939-6515-1_2. PMID: 27837497
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785

Diagnosis

Blastomycosis.
Tat J, Nadarajah J, Kus JV
CMAJ 2023 Jul 31;195(29):E984. doi: 10.1503/cmaj.230269. PMID: 37524399Free PMC Article
Blastomycosis.
Mazi PB, Rauseo AM, Spec A
Infect Dis Clin North Am 2021 Jun;35(2):515-530. doi: 10.1016/j.idc.2021.03.013. PMID: 34016289
Blastomycosis.
Schwartz IS, Kauffman CA
Semin Respir Crit Care Med 2020 Feb;41(1):31-41. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400281. PMID: 32000282
Blastomycosis.
Castillo CG, Kauffman CA, Miceli MH
Infect Dis Clin North Am 2016 Mar;30(1):247-64. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.002. PMID: 26739607
Blastomycosis.
López-Martínez R, Méndéz-Tovar LJ
Clin Dermatol 2012 Nov-Dec;30(6):565-72. doi: 10.1016/j.clindermatol.2012.01.002. PMID: 23068144

Therapy

Cutaneous Blastomycosis.
Caldito EG, Antia C, Petronic-Rosic V
JAMA Dermatol 2022 Sep 1;158(9):1064. doi: 10.1001/jamadermatol.2022.3151. PMID: 35947397
Blastomycosis.
Mazi PB, Rauseo AM, Spec A
Infect Dis Clin North Am 2021 Jun;35(2):515-530. doi: 10.1016/j.idc.2021.03.013. PMID: 34016289
Blastomycosis.
Schwartz IS, Kauffman CA
Semin Respir Crit Care Med 2020 Feb;41(1):31-41. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400281. PMID: 32000282
Blastomycosis.
Castillo CG, Kauffman CA, Miceli MH
Infect Dis Clin North Am 2016 Mar;30(1):247-64. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.002. PMID: 26739607
Blastomycosis.
López-Martínez R, Méndéz-Tovar LJ
Clin Dermatol 2012 Nov-Dec;30(6):565-72. doi: 10.1016/j.clindermatol.2012.01.002. PMID: 23068144

Prognosis

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
The Changing Epidemiology of Invasive Fungal Infections.
Enoch DA, Yang H, Aliyu SH, Micallef C
Methods Mol Biol 2017;1508:17-65. doi: 10.1007/978-1-4939-6515-1_2. PMID: 27837497
Blastomycosis.
Castillo CG, Kauffman CA, Miceli MH
Infect Dis Clin North Am 2016 Mar;30(1):247-64. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.002. PMID: 26739607
Neurologic infections in diabetes mellitus.
Jay CA, Solbrig MV
Handb Clin Neurol 2014;126:175-94. doi: 10.1016/B978-0-444-53480-4.00014-X. PMID: 25410222
Pustular blastomycosis.
Fisher KR, Baselski V, Beard G, Chesney TM, Threlkeld SC, Skinner RB
J Am Acad Dermatol 2009 Aug;61(2):355-8. doi: 10.1016/j.jaad.2008.12.014. PMID: 19615547

Clinical prediction guides

Recent advances in fungal serine protease inhibitors.
Burchacka E, Pięta P, Łupicka-Słowik A
Biomed Pharmacother 2022 Feb;146:112523. Epub 2021 Dec 10 doi: 10.1016/j.biopha.2021.112523. PMID: 34902742
Systemic mycoses in immunodepressed patients (AIDS).
Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S
Clin Dermatol 2012 Nov-Dec;30(6):616-27. doi: 10.1016/j.clindermatol.2012.01.008. PMID: 23068149
Pulmonary paracoccidioidomycosis.
Restrepo A, Benard G, de Castro CC, Agudelo CA, Tobón AM
Semin Respir Crit Care Med 2008 Apr;29(2):182-97. doi: 10.1055/s-2008-1063857. PMID: 18366000
Role of cell surface molecules of Blastomyces dermatitidis in the pathogenesis and immunobiology of blastomycosis.
Klein BS
Semin Respir Infect 1997 Sep;12(3):198-205. PMID: 9313291
Treatment of tropical mycoses.
Restrepo A
J Am Acad Dermatol 1994 Sep;31(3 Pt 2):S91-102. doi: 10.1016/s0190-9622(08)81277-7. PMID: 8077517

Recent systematic reviews

Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.
Zerbato V, Di Bella S, Pol R, D'Aleo F, Angheben A, Farina C, Conte M, Luzzaro F; Gianluigi Lombardi on behalf of the AMCLI Mycology Committee, Luzzati R, Principe L
Mycopathologia 2023 Aug;188(4):307-334. Epub 2023 Jun 9 doi: 10.1007/s11046-023-00735-z. PMID: 37294504Free PMC Article
Mortality associated with Blastomyces dermatitidis infection: A systematic review of the literature and meta-analysis.
Carignan A, Denis M, Abou Chakra CN
Med Mycol 2020 Jan 1;58(1):1-10. doi: 10.1093/mmy/myz048. PMID: 31111911
Diagnosis of Fungal Infections. A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline.
Haydour Q, Hage CA, Carmona EM, Epelbaum O, Evans SE, Gabe LM, Knox KS, Kolls JK, Wengenack NL, Prokop LJ, Limper AH, Murad MH
Ann Am Thorac Soc 2019 Sep;16(9):1179-1188. doi: 10.1513/AnnalsATS.201811-766OC. PMID: 31219341

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