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Focal epithelial hyperplasia

MedGen UID:
60066
Concept ID:
C0206067
Disease or Syndrome
Synonyms: FEH, ORAL; Focal epithelial hyperplasia, oral; HECK DISEASE
SNOMED CT: Focal epithelial hyperplasia of mouth (6121001); Multifocal epithelial hyperplasia (6121001); Heck's disease (6121001); Oral focal epithelial hyperplasia (6121001); Focal epithelial hyperplasia (36949004)
 
Monarch Initiative: MONDO:0009237
OMIM®: 229045

Definition

Focal epithelial hyperplasia is a benign hyperplasia of the oral mucosa induced by human papillomavirus (HPV) (Premoli-De-Percoco et al., 1993). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal epithelial hyperplasia

Professional guidelines

PubMed

Carmona Lorduy M, Harris Ricardo J, Hernández Arenas Y, Medina Carmona W
Gen Dent 2018 Mar-Apr;66(2):47-49. PMID: 29513235

Recent clinical studies

Etiology

Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Said AK, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Jul;42(6):435-42. Epub 2012 Oct 14 doi: 10.1111/jop.12009. PMID: 23061874

Diagnosis

Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Agnew C, Alexander S, Prabhu N
J Dent Child (Chic) 2017 Jan 15;84(1):47-49. PMID: 28387191

Therapy

Tian X, Li Z, Dan H, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2023 Dec;44:103757. Epub 2023 Aug 20 doi: 10.1016/j.pdpdt.2023.103757. PMID: 37604219
de Rojas Silva MV, Álvarez de Toledo J, Tobío Ruibal A
BMC Ophthalmol 2023 Mar 27;23(1):122. doi: 10.1186/s12886-023-02870-z. PMID: 36973686Free PMC Article
Ruiz R, Silva GR, Menchaca HR
Lancet 2014 Jul 12;384(9938):173. Epub 2013 Nov 22 doi: 10.1016/S0140-6736(13)62221-7. PMID: 24269109
Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J
SADJ 2010 May;65(4):172-5. PMID: 20632701
dos Santos-Pinto L, Giro EM, Pansani CA, Ferrari J, Massucato EM, Spolidório LC
J Dent Child (Chic) 2009 Sep-Dec;76(3):233-6. PMID: 19941767

Prognosis

Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Ledesma-Montes C, Mendez-Mendoza A
Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):663-666. doi: 10.4103/ijdvl.IJDVL_442_16. PMID: 28799531
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257
Harris AM, van Wyk CW
Community Dent Oral Epidemiol 1993 Apr;21(2):82-5. doi: 10.1111/j.1600-0528.1993.tb00726.x. PMID: 8387416

Clinical prediction guides

Tian X, Li Z, Dan H, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2023 Dec;44:103757. Epub 2023 Aug 20 doi: 10.1016/j.pdpdt.2023.103757. PMID: 37604219
Sethi S, Ali A, Ju X, Antonsson A, Logan R, Jamieson L
J Public Health (Oxf) 2022 Jun 27;44(2):269-285. doi: 10.1093/pubmed/fdaa256. PMID: 33501985
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Said AK, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Jul;42(6):435-42. Epub 2012 Oct 14 doi: 10.1111/jop.12009. PMID: 23061874
Ledesma-Montes C, Garcés-Ortíz M, Hernández-Guerrero JC
J Oral Maxillofac Surg 2007 Nov;65(11):2211-7. doi: 10.1016/j.joms.2006.11.035. PMID: 17954316

Recent systematic reviews

Sethi S, Ali A, Ju X, Antonsson A, Logan R, Jamieson L
J Public Health (Oxf) 2022 Jun 27;44(2):269-285. doi: 10.1093/pubmed/fdaa256. PMID: 33501985

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