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Focal epithelial hyperplasia

MedGen UID:
60066
•Concept ID:
C0206067
•
Disease or Syndrome
Synonyms: FEH, ORAL; Focal epithelial hyperplasia, oral; HECK DISEASE
SNOMED CT: Focal epithelial hyperplasia of mouth (6121001); Multifocal epithelial hyperplasia (6121001); Heck's disease (6121001); Oral focal epithelial hyperplasia (6121001); Focal epithelial hyperplasia (36949004)
 
Monarch Initiative: MONDO:0009237
OMIM®: 229045

Definition

Focal epithelial hyperplasia is a benign hyperplasia of the oral mucosa induced by human papillomavirus (HPV) (Premoli-De-Percoco et al., 1993). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal epithelial hyperplasia

Professional guidelines

PubMed

Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus.
Carmona Lorduy M, Harris Ricardo J, Hernández Arenas Y, Medina Carmona W
Gen Dent 2018 Mar-Apr;66(2):47-49. PMID: 29513235

Recent clinical studies

Etiology

Focal Epithelial Hyperplasia.
Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
CD133 Role in Oral Carcinogenesis.
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Focal epithelial hyperplasia - an update.
Said AK, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Jul;42(6):435-42. Epub 2012 Oct 14 doi: 10.1111/jop.12009. PMID: 23061874

Diagnosis

Focal Epithelial Hyperplasia.
Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Multifocal Epithelial Hyperplasia.
Agnew C, Alexander S, Prabhu N
J Dent Child (Chic) 2017 Jan 15;84(1):47-49. PMID: 28387191

Therapy

Photodynamic therapy in focal epithelial hyperplasia.
Tian X, Li Z, Dan H, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2023 Dec;44:103757. Epub 2023 Aug 20 doi: 10.1016/j.pdpdt.2023.103757. PMID: 37604219
Mechanical removal of epithelial hyperplasia leads to successful treatment of irregular astigmatism.
de Rojas Silva MV, Álvarez de Toledo J, Tobío Ruibal A
BMC Ophthalmol 2023 Mar 27;23(1):122. doi: 10.1186/s12886-023-02870-z. PMID: 36973686Free PMC Article
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod.
Méndez-Flores S, Esquivel-Pedraza L, Hernández-Salazar A, Charli-Joseph Y, Saeb-Lima M
Skinmed 2016;14(5):395-397. Epub 2016 Oct 1 PMID: 27871359
Focal epithelial hyperplasia.
Ruiz R, Silva GR, Menchaca HR
Lancet 2014 Jul 12;384(9938):173. Epub 2013 Nov 22 doi: 10.1016/S0140-6736(13)62221-7. PMID: 24269109
Primary cutaneous B-cell lymphoma.
Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M
J Am Acad Dermatol 2005 Sep;53(3):479-84. doi: 10.1016/j.jaad.2005.04.043. PMID: 16112357

Prognosis

CD133 Role in Oral Carcinogenesis.
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Unusually high incidence of multifocal epithelial hyperplasia in children of the Nahuatl population of Mexico.
Ledesma-Montes C, Mendez-Mendoza A
Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):663-666. doi: 10.4103/ijdvl.IJDVL_442_16. PMID: 28799531
Biology and pathological associations of the human papillomaviruses: a review.
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257
Heck's disease (focal epithelial hyperplasia): a longitudinal study.
Harris AM, van Wyk CW
Community Dent Oral Epidemiol 1993 Apr;21(2):82-5. doi: 10.1111/j.1600-0528.1993.tb00726.x. PMID: 8387416

Clinical prediction guides

Photodynamic therapy in focal epithelial hyperplasia.
Tian X, Li Z, Dan H, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2023 Dec;44:103757. Epub 2023 Aug 20 doi: 10.1016/j.pdpdt.2023.103757. PMID: 37604219
An update on Heck's disease-a systematic review.
Sethi S, Ali A, Ju X, Antonsson A, Logan R, Jamieson L
J Public Health (Oxf) 2022 Jun 27;44(2):269-285. doi: 10.1093/pubmed/fdaa256. PMID: 33501985
CD133 Role in Oral Carcinogenesis.
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Focal epithelial hyperplasia - an update.
Said AK, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Jul;42(6):435-42. Epub 2012 Oct 14 doi: 10.1111/jop.12009. PMID: 23061874
Clinicopathological and immunocytochemical study of multifocal epithelial hyperplasia.
Ledesma-Montes C, Garcés-Ortíz M, Hernández-Guerrero JC
J Oral Maxillofac Surg 2007 Nov;65(11):2211-7. doi: 10.1016/j.joms.2006.11.035. PMID: 17954316

Recent systematic reviews

An update on Heck's disease-a systematic review.
Sethi S, Ali A, Ju X, Antonsson A, Logan R, Jamieson L
J Public Health (Oxf) 2022 Jun 27;44(2):269-285. doi: 10.1093/pubmed/fdaa256. PMID: 33501985

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