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Melanotic neuroectodermal tumor

MedGen UID:
60073
•Concept ID:
C0206094
•
Neoplastic Process
Synonyms: Anlage Tumor, Retinal; Anlage Tumors, Retinal; Melanoameloblastoma; Melanoameloblastomas; Melanotic Neuroectodermal Tumor; Melanotic Neuroectodermal Tumors; Melanotic Progonoma; Melanotic Progonomas; Neuroectodermal Tumor, Melanotic; Neuroectodermal Tumors, Melanotic; Progonoma, Melanotic; Progonomas, Melanotic; Retinal Anlage Tumor; Retinal Anlage Tumors; Tumor, Melanotic Neuroectodermal; Tumor, Retinal Anlage; Tumors, Melanotic Neuroectodermal; Tumors, Retinal Anlage
SNOMED CT: Pigmented neuroectodermal tumor of infancy (404042005); Retinal anlage tumor (404042005); Melanotic progonoma (404042005); Melanotic neuroectodermal tumor (1513001); Retinal anlage tumor (1513001); Melanoameloblastoma (1513001); Melanotic progonoma (1513001); Melanotic neuroectodermal tumor of infancy (767047005); MNTI - melanotic neuroectodermal tumor of infancy (767047005)
 
Monarch Initiative: MONDO:0002072

Definition

A rare neoplasm usually occurring in infants. It is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It may involve the skull and facial bones, or the epididymis. It usually has a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanotic neuroectodermal tumor

Professional guidelines

PubMed

Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777

Recent clinical studies

Etiology

Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution.
Al-Obaidy KI, Alruwaii FI, Ulbright TM, Idrees MT
Hum Pathol 2020 Sep;103:25-33. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.006. PMID: 32619438
Melanotic neuroectodermal tumor of infancy to the skull: case-based review.
Ebel F, Thieringer FM, Kunz C, Klein-Franke A, Scheinemann K, Guzman R, Soleman J
Childs Nerv Syst 2020 Apr;36(4):679-688. Epub 2020 Jan 17 doi: 10.1007/s00381-020-04509-6. PMID: 31953575
Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence.
Pontes FSC, de Souza LL, Uchôa DCC, Joaquim AMC, do Nascimento LS, da Mata Rezende DDS, Pontes HAR
Head Neck 2018 Dec;40(12):2749-2756. Epub 2018 Nov 2 doi: 10.1002/hed.25514. PMID: 30390348
Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study.
Moreau A, Galmiche L, Minard-Colin V, Rachwalski M, Belhous K, Orbach D, Joly A, Picard A, Kadlub N
J Craniomaxillofac Surg 2018 Feb;46(2):201-206. Epub 2017 Dec 12 doi: 10.1016/j.jcms.2017.12.001. PMID: 29275074
Melanotic neuroectodermal tumor of infancy: clinical, radiologic, and pathologic findings in five cases.
Mirich DR, Blaser SI, Harwood-Nash DC, Armstrong DC, Becker LE, Posnick JC
AJNR Am J Neuroradiol 1991 Jul-Aug;12(4):689-97. PMID: 1652883Free PMC Article

Diagnosis

Melanotic Neuroectodermal Tumour of Infancy.
Janardhanan M, Rakesh S, Savithri V, Aravind T, Mathew L, Ravi V
Head Neck Pathol 2023 Jun;17(2):509-514. Epub 2023 Feb 28 doi: 10.1007/s12105-023-01537-x. PMID: 36853558Free PMC Article
Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Melanotic Neuroectodermal Tumor of Infancy Arising in the Skull and Brain: A Systematic Review.
Ren Q, Chen H, Wang Y, Xu J
World Neurosurg 2019 Oct;130:170-178. Epub 2019 Jul 8 doi: 10.1016/j.wneu.2019.07.017. PMID: 31295620
Melanotic Neuroectodermal Tumor of Infancy.
Soles BS, Wilson A, Lucas DR, Heider A
Arch Pathol Lab Med 2018 Nov;142(11):1358-1363. doi: 10.5858/arpa.2018-0241-RA. PMID: 30407852

Therapy

Melanotic neuroectodermal tumor of infancy successfully treated with metformin: A case report.
Liang Y, Tian R, Wang J, Shan Y, Gao H, Xie C, Li J, Zhang L, Xu M, Gu S
Medicine (Baltimore) 2020 Nov 6;99(45):e22303. doi: 10.1097/MD.0000000000022303. PMID: 33157911Free PMC Article
Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy.
Maroun C, Khalifeh I, Alam E, Akl PA, Saab R, Moukarbel RV
Eur Arch Otorhinolaryngol 2016 Dec;273(12):4629-4635. Epub 2016 Apr 23 doi: 10.1007/s00405-016-4066-6. PMID: 27107579
Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases.
Higashi K, Ogawa T, Onuma M, Usubuchi H, Imai Y, Takata I, Hidaka H, Watanabe M, Sasahara Y, Koyama S, Kure S, Katori Y
Auris Nasus Larynx 2016 Aug;43(4):451-4. Epub 2015 Nov 18 doi: 10.1016/j.anl.2015.10.010. PMID: 26602435
Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases.
Lambropoulos V, Neofytou A, Sfougaris D, Mouravas V, Petropoulos A
Acta Neurochir (Wien) 2010 May;152(5):869-75. Epub 2009 Aug 11 doi: 10.1007/s00701-009-0472-5. PMID: 19669690

Prognosis

Melanotic Neuroectodermal Tumor of Infancy at Skull: Rare and Rapid-Growing Tumor but Histologically Benign.
Yindeedej V, Kittisangvara L
Pediatr Neurosurg 2021;56(3):306-311. Epub 2021 Apr 16 doi: 10.1159/000515686. PMID: 33866319
Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Melanotic Neuroectodermal Tumor of Infancy: Case Report and Review of Management.
Emmerling MR, York TA, Caccamese JF
J Oral Maxillofac Surg 2019 Feb;77(2):315-320. Epub 2018 Oct 5 doi: 10.1016/j.joms.2018.09.033. PMID: 30392845
Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence.
Pontes FSC, de Souza LL, Uchôa DCC, Joaquim AMC, do Nascimento LS, da Mata Rezende DDS, Pontes HAR
Head Neck 2018 Dec;40(12):2749-2756. Epub 2018 Nov 2 doi: 10.1002/hed.25514. PMID: 30390348
Miscellaneous rare paratesticular tumors.
Henley JD, Ferry J, Ulbright TM
Semin Diagn Pathol 2000 Nov;17(4):319-39. PMID: 11202548

Clinical prediction guides

Melanotic Neuroectodermal Tumor of Infancy at Skull: Rare and Rapid-Growing Tumor but Histologically Benign.
Yindeedej V, Kittisangvara L
Pediatr Neurosurg 2021;56(3):306-311. Epub 2021 Apr 16 doi: 10.1159/000515686. PMID: 33866319
Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy.
Barrett AW, Morgan M, Ramsay AD, Farthing PM, Newman L, Speight PM
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jun;93(6):688-98. doi: 10.1067/moe.2002.124000. PMID: 12142876
Cell cycle-associated proteins in melanotic neuroectodermal tumor of infancy.
de Souza PE, Merly F, Maia DM, Castro WH, Gomez RS
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Oct;88(4):466-8. doi: 10.1016/s1079-2104(99)70063-6. PMID: 10519756
Melanotic neuroectodermal tumor of infancy. Clinicopathological, immunohistochemical, and flow cytometric study.
Kapadia SB, Frisman DM, Hitchcock CL, Ellis GL, Popek EJ
Am J Surg Pathol 1993 Jun;17(6):566-73. doi: 10.1097/00000478-199306000-00004. PMID: 8392815

Recent systematic reviews

Melanotic Neuroectodermal Tumor of Infancy Arising in the Skull and Brain: A Systematic Review.
Ren Q, Chen H, Wang Y, Xu J
World Neurosurg 2019 Oct;130:170-178. Epub 2019 Jul 8 doi: 10.1016/j.wneu.2019.07.017. PMID: 31295620
Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
Melanotic Neuroectodermal Tumor of Infancy: A Systematic Review.
Rachidi S, Sood AJ, Patel KG, Nguyen SA, Hamilton H, Neville BW, Day TA
J Oral Maxillofac Surg 2015 Oct;73(10):1946-56. Epub 2015 Apr 7 doi: 10.1016/j.joms.2015.03.061. PMID: 25936939
Melanotic neuroectodermal tumour of infancy: report of two cases and review of the literature.
Manojlović S, Virag M, Lukšić I, Müller D
J Craniomaxillofac Surg 2012 Jun;40(4):e103-7. Epub 2011 Jul 6 doi: 10.1016/j.jcms.2011.05.013. PMID: 21737290
Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.
Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug;102(2):204-16. Epub 2006 Jun 8 doi: 10.1016/j.tripleo.2005.08.010. PMID: 16876064

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