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Multidrug-resistant tuberculosis

MedGen UID:
60163
Concept ID:
C0206526
Disease or Syndrome
Synonyms: MDR Tuberculosis; Multi-Drug Resistant Tuberculosis; Multidrug-Resistant Tuberculosis; Tuberculosis, MDR; Tuberculosis, Multi Drug Resistant; Tuberculosis, Multi-Drug Resistant; Tuberculosis, Multidrug Resistant; Tuberculosis, Multidrug-Resistant
SNOMED CT: Multidrug resistant tuberculosis (423092005)
 
Monarch Initiative: MONDO:0005861

Definition

Tuberculosis disease that is caused by a multidrug-resistant strain of Mycobacterium tuberculosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultidrug-resistant tuberculosis

Professional guidelines

PubMed

Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J
Dtsch Arztebl Int 2019 Oct 25;116(43):729-735. doi: 10.3238/arztebl.2019.0729. PMID: 31755407
Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR Jr
Lancet 2019 Sep 14;394(10202):953-966. doi: 10.1016/S0140-6736(19)31882-3. PMID: 31526739
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838

Recent clinical studies

Etiology

Pontali E, Raviglione MC, Migliori GB; and the writing group members of the Global TB Network Clinical Trials Committee
Eur Respir Rev 2019 Jun 30;28(152) Epub 2019 May 29 doi: 10.1183/16000617.0035-2019. PMID: 31142549Free PMC Article
Li Y, Sun F, Zhang W
Drug Dev Res 2019 Feb;80(1):98-105. Epub 2018 Dec 11 doi: 10.1002/ddr.21498. PMID: 30548290Free PMC Article
Ahmad S, Mokaddas E, Al-Mutairi NM
Expert Rev Anti Infect Ther 2018 Sep;16(9):709-721. Epub 2018 Sep 13 doi: 10.1080/14787210.2018.1519393. PMID: 30173588
Hargreaves S, Lönnroth K, Nellums LB, Olaru ID, Nathavitharana RR, Norredam M, Friedland JS
Clin Microbiol Infect 2017 Mar;23(3):141-146. Epub 2016 Sep 23 doi: 10.1016/j.cmi.2016.09.009. PMID: 27665703
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508

Diagnosis

Hui SYA, Lao TT
Best Pract Res Clin Obstet Gynaecol 2022 Dec;85(Pt A):34-44. Epub 2022 Jul 31 doi: 10.1016/j.bpobgyn.2022.07.006. PMID: 36002371Free PMC Article
Seaworth BJ, Griffith DE
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0042-2017. PMID: 28361737
Millard J, Ugarte-Gil C, Moore DA
BMJ 2015 Feb 26;350:h882. doi: 10.1136/bmj.h882. PMID: 25721508
Lynch JB
Med Clin North Am 2013 Jul;97(4):553-79, ix-x. doi: 10.1016/j.mcna.2013.03.012. PMID: 23809714
Pontali E, Matteelli A, Migliori GB
Curr Opin Pulm Med 2013 May;19(3):266-72. doi: 10.1097/MCP.0b013e32835f1bf3. PMID: 23422415

Therapy

Berry C, du Cros P, Fielding K, Gajewski S, Kazounis E, McHugh TD, Merle C, Motta I, Moore DAJ, Nyang'wa BT
Trials 2022 Jun 13;23(1):484. doi: 10.1186/s13063-022-06331-8. PMID: 35698158Free PMC Article
Esmail A, Oelofse S, Lombard C, Perumal R, Mbuthini L, Goolam Mahomed A, Variava E, Black J, Oluboyo P, Gwentshu N, Ngam E, Ackerman T, Marais L, Mottay L, Meier S, Pooran A, Tomasicchio M, Te Riele J, Derendinger B, Ndjeka N, Maartens G, Warren R, Martinson N, Dheda K
Am J Respir Crit Care Med 2022 May 15;205(10):1214-1227. doi: 10.1164/rccm.202107-1779OC. PMID: 35175905
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article

Prognosis

Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, Kampmann B, Graham SM, Dodd PJ, Houben RM, Denholm JT, Sawyer SM, Kranzer K
Lancet Child Adolesc Health 2020 Jan;4(1):68-79. Epub 2019 Nov 18 doi: 10.1016/S2352-4642(19)30337-2. PMID: 31753806Free PMC Article
Ahmad S, Mokaddas E, Al-Mutairi NM
Expert Rev Anti Infect Ther 2018 Sep;16(9):709-721. Epub 2018 Sep 13 doi: 10.1080/14787210.2018.1519393. PMID: 30173588
Jenkins HE, Yuen CM
Int J Tuberc Lung Dis 2018 May 1;22(5):3-6. doi: 10.5588/ijtld.17.0357. PMID: 29665947Free PMC Article
Houben RM, Dodd PJ
PLoS Med 2016 Oct;13(10):e1002152. Epub 2016 Oct 25 doi: 10.1371/journal.pmed.1002152. PMID: 27780211Free PMC Article
Jenkins HE, Tolman AW, Yuen CM, Parr JB, Keshavjee S, Pérez-Vélez CM, Pagano M, Becerra MC, Cohen T
Lancet 2014 May 3;383(9928):1572-9. Epub 2014 Mar 24 doi: 10.1016/S0140-6736(14)60195-1. PMID: 24671080Free PMC Article

Clinical prediction guides

Günther G, Ruswa N, Keller PM
Curr Opin Pulm Med 2022 May 1;28(3):211-217. Epub 2022 Feb 25 doi: 10.1097/MCP.0000000000000866. PMID: 35220372Free PMC Article
Li Y, Sun F, Zhang W
Drug Dev Res 2019 Feb;80(1):98-105. Epub 2018 Dec 11 doi: 10.1002/ddr.21498. PMID: 30548290Free PMC Article
Fox GJ, Schaaf HS, Mandalakas A, Chiappini E, Zumla A, Marais BJ
Clin Microbiol Infect 2017 Mar;23(3):147-153. Epub 2016 Aug 31 doi: 10.1016/j.cmi.2016.08.024. PMID: 27592087
Sharma SK, Mohan A
Indian J Med Res 2004 Oct;120(4):354-76. PMID: 15520486
Willcox PA
Curr Opin Pulm Med 2000 May;6(3):198-202. doi: 10.1097/00063198-200005000-00006. PMID: 10782703

Recent systematic reviews

Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG, Warren R, Theron G
Cochrane Database Syst Rev 2022 May 18;5(5):CD014841. doi: 10.1002/14651858.CD014841.pub2. PMID: 35583175Free PMC Article
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Sultana ZZ, Hoque FU, Beyene J, Akhlak-Ul-Islam M, Khan MHR, Ahmed S, Hawlader DH, Hossain A
BMC Infect Dis 2021 Jan 11;21(1):51. doi: 10.1186/s12879-020-05749-2. PMID: 33430786Free PMC Article
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856
Pradipta IS, Forsman LD, Bruchfeld J, Hak E, Alffenaar JW
J Infect 2018 Dec;77(6):469-478. Epub 2018 Oct 16 doi: 10.1016/j.jinf.2018.10.004. PMID: 30339803

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