U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Endometrial stromal sarcoma(ESS)

MedGen UID:
60196
•Concept ID:
C0206630
•
Neoplastic Process
Synonyms: Endometrioid stromal sarcoma; ESS
SNOMED CT: Endometrial stromal sarcoma (699356008); Endometrial stromal sarcoma (1178986006); Endometrial sarcoma (1178986006)
 
Monarch Initiative: MONDO:0006745
Orphanet: ORPHA213711

Definition

A malignant mesenchymal neoplasm that affects the uterine corpus, and rarely, the ovaries, cervix, and vagina. In the uterine corpus it is classified as low grade or high grade endometrial stromal sarcoma. In the remainder of the anatomic sites it is classified as low grade endometrioid stromal sarcoma. [from NCI]

Professional guidelines

PubMed

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Systemic treatment in adult uterine sarcomas.
Desar IME, Ottevanger PB, Benson C, van der Graaf WTA
Crit Rev Oncol Hematol 2018 Feb;122:10-20. Epub 2017 Dec 14 doi: 10.1016/j.critrevonc.2017.12.009. PMID: 29458779
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037

Recent clinical studies

Etiology

Endometrial stromal sarcoma: A review of rare mesenchymal uterine neoplasm.
Capozzi VA, Monfardini L, Ceni V, Cianciolo A, Butera D, Gaiano M, Berretta R
J Obstet Gynaecol Res 2020 Nov;46(11):2221-2236. Epub 2020 Aug 23 doi: 10.1111/jog.14436. PMID: 32830415
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
BCOR involvement in cancer.
Astolfi A, Fiore M, Melchionda F, Indio V, Bertuccio SN, Pession A
Epigenomics 2019 May;11(7):835-855. Epub 2019 May 31 doi: 10.2217/epi-2018-0195. PMID: 31150281Free PMC Article
Uterine Mesenchymal Tumors: Update on Classification, Staging, and Molecular Features.
Parra-Herran C, Howitt BE
Surg Pathol Clin 2019 Jun;12(2):363-396. doi: 10.1016/j.path.2019.01.004. PMID: 31097109
Systemic treatment in adult uterine sarcomas.
Desar IME, Ottevanger PB, Benson C, van der Graaf WTA
Crit Rev Oncol Hematol 2018 Feb;122:10-20. Epub 2017 Dec 14 doi: 10.1016/j.critrevonc.2017.12.009. PMID: 29458779

Diagnosis

Update on Uterine Mesenchymal Neoplasms.
Kertowidjojo EC, Bennett JA
Surg Pathol Clin 2022 Jun;15(2):315-340. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.008. PMID: 35715164
Endometrial stromal tumors: Diagnostic updates and challenges.
Niu S, Zheng W
Semin Diagn Pathol 2022 May;39(3):201-212. Epub 2022 Jan 14 doi: 10.1053/j.semdp.2022.01.004. PMID: 35067405
Endometrial stromal sarcoma: A review of rare mesenchymal uterine neoplasm.
Capozzi VA, Monfardini L, Ceni V, Cianciolo A, Butera D, Gaiano M, Berretta R
J Obstet Gynaecol Res 2020 Nov;46(11):2221-2236. Epub 2020 Aug 23 doi: 10.1111/jog.14436. PMID: 32830415
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Low-Grade Endometrial Stromal Sarcoma - a Review.
Thiel FC, Halmen S
Oncol Res Treat 2018;41(11):687-692. Epub 2018 Oct 13 doi: 10.1159/000494225. PMID: 30317238

Therapy

Endometrial stromal sarcoma: A review of rare mesenchymal uterine neoplasm.
Capozzi VA, Monfardini L, Ceni V, Cianciolo A, Butera D, Gaiano M, Berretta R
J Obstet Gynaecol Res 2020 Nov;46(11):2221-2236. Epub 2020 Aug 23 doi: 10.1111/jog.14436. PMID: 32830415
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
Hensley ML, Chavan SS, Solit DB, Murali R, Soslow R, Chiang S, Jungbluth AA, Bandlamudi C, Srinivasan P, Tap WD, Rosenbaum E, Taylor BS, Donoghue MTA, Hyman DM
Clin Cancer Res 2020 Jul 15;26(14):3881-3888. Epub 2020 Apr 16 doi: 10.1158/1078-0432.CCR-19-3959. PMID: 32299819Free PMC Article
Low-Grade Endometrial Stromal Sarcoma - a Review.
Thiel FC, Halmen S
Oncol Res Treat 2018;41(11):687-692. Epub 2018 Oct 13 doi: 10.1159/000494225. PMID: 30317238
Uterine sarcoma 2008.
Lin JF, Slomovitz BM
Curr Oncol Rep 2008 Nov;10(6):512-8. doi: 10.1007/s11912-008-0077-9. PMID: 18928666
Uterine sarcomas.
Moinfar F, Azodi M, Tavassoli FA
Pathology 2007 Feb;39(1):55-71. doi: 10.1080/00313020601136146. PMID: 17365823

Prognosis

Clinical characteristics and prognosis analysis of uterine sarcoma: a single-institution retrospective study.
Wang F, Dai X, Chen H, Hu X, Wang Y
BMC Cancer 2022 Oct 7;22(1):1050. doi: 10.1186/s12885-022-10129-x. PMID: 36207687Free PMC Article
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Low-Grade Endometrial Stromal Sarcoma - a Review.
Thiel FC, Halmen S
Oncol Res Treat 2018;41(11):687-692. Epub 2018 Oct 13 doi: 10.1159/000494225. PMID: 30317238
Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma.
Tsuyoshi H, Yoshida Y
Cancer Sci 2018 Jun;109(6):1743-1752. Epub 2018 May 23 doi: 10.1111/cas.13613. PMID: 29660202Free PMC Article

Clinical prediction guides

Clinical characteristics and prognosis analysis of uterine sarcoma: a single-institution retrospective study.
Wang F, Dai X, Chen H, Hu X, Wang Y
BMC Cancer 2022 Oct 7;22(1):1050. doi: 10.1186/s12885-022-10129-x. PMID: 36207687Free PMC Article
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
Hensley ML, Chavan SS, Solit DB, Murali R, Soslow R, Chiang S, Jungbluth AA, Bandlamudi C, Srinivasan P, Tap WD, Rosenbaum E, Taylor BS, Donoghue MTA, Hyman DM
Clin Cancer Res 2020 Jul 15;26(14):3881-3888. Epub 2020 Apr 16 doi: 10.1158/1078-0432.CCR-19-3959. PMID: 32299819Free PMC Article
Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma.
Ludovisi M, Moro F, Pasciuto T, Di Noi S, Giunchi S, Savelli L, Pascual MA, Sladkevicius P, Alcazar JL, Franchi D, Mancari R, Moruzzi MC, Jurkovic D, Chiappa V, Guerriero S, Exacoustos C, Epstein E, Frühauf F, Fischerova D, Fruscio R, Ciccarone F, Zannoni GF, Scambia G, Valentin L, Testa AC
Ultrasound Obstet Gynecol 2019 Nov;54(5):676-687. Epub 2019 Oct 7 doi: 10.1002/uog.20270. PMID: 30908820
Molecular characteristics of uterine sarcomas.
Davidson B, Micci F
Expert Rev Mol Diagn 2017 May;17(5):515-522. Epub 2017 Apr 3 doi: 10.1080/14737159.2017.1311790. PMID: 28335657

Recent systematic reviews

Prognostic significance of lymphadenectomy in uterine leiomyosarcomas and endometrial stromal sarcomas: Systematic review and meta-analysis.
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Extrauterine endometrial stromal sarcoma: A systematic review and outcome analysis.
Deb PQ, Heller DS
Ann Diagn Pathol 2022 Aug;59:151966. Epub 2022 May 10 doi: 10.1016/j.anndiagpath.2022.151966. PMID: 35569210
Endometrial stromal sarcoma: A review of rare mesenchymal uterine neoplasm.
Capozzi VA, Monfardini L, Ceni V, Cianciolo A, Butera D, Gaiano M, Berretta R
J Obstet Gynaecol Res 2020 Nov;46(11):2221-2236. Epub 2020 Aug 23 doi: 10.1111/jog.14436. PMID: 32830415
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Endometrial stromal sarcoma: a systematic review.
Rauh-Hain JA, del Carmen MG
Obstet Gynecol 2013 Sep;122(3):676-83. doi: 10.1097/AOG.0b013e3182a189ac. PMID: 23921879

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...