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Juxtacortical osteosarcoma

MedGen UID:
60197
•Concept ID:
C0206642
•
Neoplastic Process
Synonyms: Juxtacortical Osteosarcoma; Juxtacortical Osteosarcomas; Osteosarcoma, Juxtacortical; Osteosarcomas, Juxtacortical
SNOMED CT: Juxtacortical osteosarcoma (128918008); Parosteal osteosarcoma (128918008)
 
Monarch Initiative: MONDO:0006817

Definition

A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. Most patients are young adults and the prognosis is usually excellent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuxtacortical osteosarcoma

Professional guidelines

PubMed

Juxtacortical osteosarcoma. Diagnosis, differential diagnosis, treatment, and an analysis of eighty cases.
van der Heul RO, von Ronnen JR
J Bone Joint Surg Am 1967 Apr;49(3):415-39. PMID: 5228781

Recent clinical studies

Etiology

The value of chest and skeletal staging in parosteal osteosarcoma: two-centre experience and literature review.
Rajakulasingam R, Attard V, Botchu R, James SL, Saifuddin A
Skeletal Radiol 2021 Feb;50(2):301-309. Epub 2020 Jul 23 doi: 10.1007/s00256-020-03557-y. PMID: 32705301
Gene amplification and tumor grading in parosteal osteosarcoma.
Chen PC, Yen CC, Hung GY, Pan CC, Chen WM
J Chin Med Assoc 2019 Dec;82(12):889-894. doi: 10.1097/JCMA.0000000000000211. PMID: 31634336
Imaging recurrent parosteal osteosarcoma.
Johnson K, Davies AM, Evans N, Grimer RJ
Eur Radiol 2001;11(3):460-6. doi: 10.1007/s003300000673. PMID: 11288853
Malignant tumors of the osteogenic matrix.
Spina V, Montanari N, Romagnoli R
Eur J Radiol 1998 May;27 Suppl 1:S98-109. doi: 10.1016/s0720-048x(98)00050-3. PMID: 9652509
Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome.
Sheth DS, Yasko AW, Raymond AK, Ayala AG, Carrasco CH, Benjamin RS, Jaffe N, Murray JA
Cancer 1996 Nov 15;78(10):2136-45. PMID: 8918422

Diagnosis

Parosteal osteosarcoma of the thumb: A case report and literature review.
Rossetti A, Fily A, Dreano T, Ropars M, Maximen J
Hand Surg Rehabil 2022 Apr;41(2):273-277. Epub 2022 Jan 25 doi: 10.1016/j.hansur.2022.01.005. PMID: 35091042
Parosteal osteosarcoma.
Samardziski M, Zafiroski G, Tolevska C, Konstadinova-Kunovska S, Vasilevska V
Bratisl Lek Listy 2009;110(4):240-4. PMID: 19507652
Malignant tumors of the osteogenic matrix.
Spina V, Montanari N, Romagnoli R
Eur J Radiol 1998 May;27 Suppl 1:S98-109. doi: 10.1016/s0720-048x(98)00050-3. PMID: 9652509
Intracortical osteosarcoma.
Griffith JF, Kumta SM, Chow LT, Leung PC, Metreweli C
Skeletal Radiol 1998 Apr;27(4):228-32. doi: 10.1007/s002560050372. PMID: 9592909
Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome.
Sheth DS, Yasko AW, Raymond AK, Ayala AG, Carrasco CH, Benjamin RS, Jaffe N, Murray JA
Cancer 1996 Nov 15;78(10):2136-45. PMID: 8918422

Therapy

A Pediatric Case of Metastatic Conventional Parosteal Osteosarcoma Treated With Multidrug Chemotherapy.
Nodomi S, Umeda K, Okamoto T, Saida S, Hiramatsu H, Watanabe K, Adachi S, Heike T
Pediatr Blood Cancer 2016 Aug;63(8):1471-3. Epub 2016 May 3 doi: 10.1002/pbc.26052. PMID: 27149276
Dedifferentiated parosteal osteosarcoma with well-differentiated metastases.
Takeuchi K, Morii T, Yabe H, Morioka H, Mukai M, Toyama Y
Skeletal Radiol 2006 Oct;35(10):778-82. Epub 2006 Mar 1 doi: 10.1007/s00256-005-0066-0. PMID: 16518652
Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute.
Bertoni F, Bacchini P, Staals EL, Davidovitz P
Cancer 2005 Jun 1;103(11):2373-82. doi: 10.1002/cncr.21039. PMID: 15852358
Telangiectatic dedifferentiation of a parosteal osteosarcoma.
Wines A, Bonar F, Lam P, McCarthy S, Stalley P
Skeletal Radiol 2000 Oct;29(10):597-600. doi: 10.1007/s002560000247. PMID: 11127684
Parosteal osteosarcoma of the posterior aspect of the distal part of the femur. Oncological and functional results following a new resection technique.
Lewis VO, Gebhardt MC, Springfield DS
J Bone Joint Surg Am 2000 Aug;82(8):1083-8. doi: 10.2106/00004623-200008000-00003. PMID: 10954096

Prognosis

Gene amplification and tumor grading in parosteal osteosarcoma.
Chen PC, Yen CC, Hung GY, Pan CC, Chen WM
J Chin Med Assoc 2019 Dec;82(12):889-894. doi: 10.1097/JCMA.0000000000000211. PMID: 31634336
Can imaging distinguish between low-grade and dedifferentiated parosteal osteosarcoma?
Lin HY, Hondar Wu HT, Wu PK, Wu CL, Chih-Hsueh Chen P, Chen WM, Guo WY
J Chin Med Assoc 2018 Oct;81(10):912-919. Epub 2018 Sep 3 doi: 10.1016/j.jcma.2018.01.014. PMID: 30190236
Malignant tumors of the osteogenic matrix.
Spina V, Montanari N, Romagnoli R
Eur J Radiol 1998 May;27 Suppl 1:S98-109. doi: 10.1016/s0720-048x(98)00050-3. PMID: 9652509
Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome.
Sheth DS, Yasko AW, Raymond AK, Ayala AG, Carrasco CH, Benjamin RS, Jaffe N, Murray JA
Cancer 1996 Nov 15;78(10):2136-45. PMID: 8918422
Juxtacortical osteosarcoma of the jaws.
Millar BG, Browne RM, Flood TR
Br J Oral Maxillofac Surg 1990 Apr;28(2):73-9. doi: 10.1016/0266-4356(90)90125-5. PMID: 2186801

Clinical prediction guides

Gene amplification and tumor grading in parosteal osteosarcoma.
Chen PC, Yen CC, Hung GY, Pan CC, Chen WM
J Chin Med Assoc 2019 Dec;82(12):889-894. doi: 10.1097/JCMA.0000000000000211. PMID: 31634336
Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features.
Kaste SC, Fuller CE, Saharia A, Neel MD, Rao BN, Daw NC
Pediatr Blood Cancer 2006 Aug;47(2):152-62. doi: 10.1002/pbc.20570. PMID: 16123997
Imaging recurrent parosteal osteosarcoma.
Johnson K, Davies AM, Evans N, Grimer RJ
Eur Radiol 2001;11(3):460-6. doi: 10.1007/s003300000673. PMID: 11288853
Parosteal osteosarcoma: value of MR imaging and CT in the prediction of histologic grade.
Jelinek JS, Murphey MD, Kransdorf MJ, Shmookler BM, Malawer MM, Hur RC
Radiology 1996 Dec;201(3):837-42. doi: 10.1148/radiology.201.3.8939240. PMID: 8939240
Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome.
Sheth DS, Yasko AW, Raymond AK, Ayala AG, Carrasco CH, Benjamin RS, Jaffe N, Murray JA
Cancer 1996 Nov 15;78(10):2136-45. PMID: 8918422

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