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Benign fibrous histiocytoma

MedGen UID:
60199
•Concept ID:
C0206644
•
Neoplastic Process
Synonyms: Benign Fibrous Histiocytoma; Benign Fibrous Histiocytomas; Fibrous Histiocytoma; Fibrous Histiocytoma, Benign; Fibrous Histiocytomas; Fibrous Histiocytomas, Benign; Histiocytoma, Benign Fibrous; Histiocytoma, Fibrous; Histiocytomas, Benign Fibrous; Histiocytomas, Fibrous
SNOMED CT: Benign fibrous histiocytoma (25889007); Fibrous histiocytoma (25889007); Xanthofibroma (25889007); Fibroxanthoma (25889007)
 
Monarch Initiative: MONDO:0002989

Definition

A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform pattern. It is characterized by the presence of foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage. [from NCI]

Professional guidelines

PubMed

Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.
Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM
Ear Nose Throat J 2010 Nov;89(11):534-40. PMID: 21086277
Treatment of proximal fibular tumors with en bloc resection.
Erler K, Demiralp B, Ozdemir MT, Basbozkurt M
Knee 2004 Dec;11(6):489-96. doi: 10.1016/j.knee.2003.10.005. PMID: 15581770

Recent clinical studies

Etiology

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Fibrohistiocytic tumors and related neoplasms in children and adolescents.
Black J, Coffin CM, Dehner LP
Pediatr Dev Pathol 2012;15(1 Suppl):181-210. doi: 10.2350/11-03-1001-PB.1. PMID: 22420728
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286
Pathology of osteosarcoma.
Dahlin DC
Clin Orthop Relat Res 1975 Sep;(111):23-32. doi: 10.1097/00003086-197509000-00004. PMID: 168999

Diagnosis

Conjunctival and Corneal Fibrous Histiocytoma: Brief review.
Singh T, Ichhpujani P
Semin Ophthalmol 2021 Oct 3;36(7):569-572. Epub 2021 Mar 25 doi: 10.1080/08820538.2021.1900286. PMID: 33764259
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Aneurysmal fibrous histiocytoma.
Serin M, Leblebici C, Aksu EK, Kurt Yazar S
BMJ Case Rep 2018 Aug 14;2018 doi: 10.1136/bcr-2018-225198. PMID: 30108116Free PMC Article
Benign fibrous histiocytoma.
Varma P, Walia S, Manglawat R
Indian J Ophthalmol 2014 Apr;62(4):464-7. doi: 10.4103/0301-4738.132104. PMID: 24817747Free PMC Article
Atypical fibroxanthoma.
Ziemer M
J Dtsch Dermatol Ges 2012 Aug;10(8):537-50. Epub 2012 Jun 19 doi: 10.1111/j.1610-0387.2012.07980.x. PMID: 22709412

Therapy

Dermatofibroma Versus Dermatofibrosarcoma Protuberans: A Nuclear Morphology Study.
Khamdan F, Brailsford C, Dirr MA, Sagut P, Nietert PJ, Elston D
Am J Dermatopathol 2023 Sep 1;45(9):631-634. doi: 10.1097/DAD.0000000000002526. PMID: 37625803Free PMC Article
When to suspect a non-melanoma skin cancer.
Smith H, Wernham A, Patel A
BMJ 2020 Mar 11;368:m692. doi: 10.1136/bmj.m692. PMID: 32161002
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Primary chemotherapy and delayed surgery for malignant fibrous histiocytoma of bone in the extremity.
Bacci G, Avella M, Picci P, Dallari D, Malaguti C, Biagini R, Ruggieri P, Balladelli A, Ferrari S, Caldora P
Tumori 1990 Dec 31;76(6):537-42. doi: 10.1177/030089169007600604. PMID: 2178284
Juvenile nasopharyngeal angiofibroma.
Wilson WR, Miller D, Lee KJ, Yules RB
Laryngoscope 1972 Jun;82(6):985-97. doi: 10.1288/00005537-197206000-00006. PMID: 4338568

Prognosis

Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review.
Kirschnick LB, Schuch LF, Silveira FM, Só BB, Martins MAT, Lopes MA, Vargas PA, Santos-Silva AR, Carrard VC, Vasconcelos ACU, Wagner VP, Martins MD
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):e43-e56. Epub 2021 Jul 15 doi: 10.1016/j.oooo.2021.07.003. PMID: 34511357
Malignant fibrous neoplasms of long bones: analysis of the surveillance, epidemiology, and end results database from 1973 to 2015.
Huang Y, Hong J, Meng J, Wu H, Shi M, Yan S, Wang W
BMC Musculoskelet Disord 2020 Jan 22;21(1):48. doi: 10.1186/s12891-019-2971-8. PMID: 31969161Free PMC Article
Aneurysmal benign fibrous histiocytoma of the anal canal: a rare differential diagnosis.
Amarnani R, Harikrishnan A
Int J Colorectal Dis 2020 Feb;35(2):347-349. Epub 2019 Dec 16 doi: 10.1007/s00384-019-03472-2. PMID: 31845025
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Malignant fibrous histiocytoma of the nasal cavity and paranasal sinuses: review of the last 30 years.
Iguchi Y, Takahashi H, Yao K, Nakayama M, Nagai H, Okamoto M
Acta Otolaryngol Suppl 2002;(547):75-8. doi: 10.1080/000164802760057635. PMID: 12212601

Clinical prediction guides

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review.
Kirschnick LB, Schuch LF, Silveira FM, Só BB, Martins MAT, Lopes MA, Vargas PA, Santos-Silva AR, Carrard VC, Vasconcelos ACU, Wagner VP, Martins MD
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):e43-e56. Epub 2021 Jul 15 doi: 10.1016/j.oooo.2021.07.003. PMID: 34511357
Aneurysmal benign fibrous histiocytoma of the anal canal: a rare differential diagnosis.
Amarnani R, Harikrishnan A
Int J Colorectal Dis 2020 Feb;35(2):347-349. Epub 2019 Dec 16 doi: 10.1007/s00384-019-03472-2. PMID: 31845025
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature.
Alsawas M, Dundar B, Prokop L, Murad MH, Swick B
Am J Dermatopathol 2022 Nov 1;44(11):822-827. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002211. PMID: 35503883
Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review.
Kirschnick LB, Schuch LF, Silveira FM, Só BB, Martins MAT, Lopes MA, Vargas PA, Santos-Silva AR, Carrard VC, Vasconcelos ACU, Wagner VP, Martins MD
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):e43-e56. Epub 2021 Jul 15 doi: 10.1016/j.oooo.2021.07.003. PMID: 34511357
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137

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