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Villous adenoma

MedGen UID:
60206
•Concept ID:
C0206674
•
Neoplastic Process
Synonyms: Adenoma, Villous; Adenomas, Villous; Villous Adenoma; Villous Adenomas
SNOMED CT: Villous papilloma (128859003); Villous adenoma (128859003)
 
Monarch Initiative: MONDO:0000502

Definition

An adenoma arising from the glandular epithelium of the gastrointestinal tract. It is characterized by the presence of a villous architectural pattern. Most often it occurs in the large intestine, small intestine, and the stomach. The neoplastic epithelial cells show dysplastic features. [from NCI]

Professional guidelines

PubMed

Double balloon enteroscopy in children: diagnosis, treatment, and safety.
Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M
World J Gastroenterol 2010 Jan 7;16(1):56-62. doi: 10.3748/wjg.v16.i1.56. PMID: 20039449Free PMC Article
Intraperitoneal chemotherapy for peritoneal carcinomatosis from colonic or appendiceal cystadenocarcinoma: rationale and results of treatment.
Sugarbaker PH, Landy D, Pascal R
Prog Clin Biol Res 1990;354B:141-70. PMID: 2236162
Duodenal polyps: diagnosis and management.
Reddy RR, Schuman BM, Priest RJ
J Clin Gastroenterol 1981 Jun;3(2):139-47. doi: 10.1097/00004836-198106000-00007. PMID: 7240690

Recent clinical studies

Etiology

Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study.
Pires-Luis AS, Martinek P, Alaghehbandan R, Trpkov K, Comperat EM, Perez Montiel DM, Bulimbasic S, Lobo J, Henrique R, Vanecek T, Pivovarcikova K, Michalova K, Pitra T, Hora M, Marques A, Lopes JM, Rogala J, Mareckova J, Michal M, Hes O
Adv Anat Pathol 2020 Sep;27(5):303-310. doi: 10.1097/PAP.0000000000000268. PMID: 32520749
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature.
van der Pool AEM, de Graaf EJR, Vermaas M, Barendse RM, Doornebosch PG
J Laparoendosc Adv Surg Tech A 2018 Feb;28(2):204-208. Epub 2017 Jun 28 doi: 10.1089/lap.2017.0195. PMID: 28657837
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Diagnosis

Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis.
Mitra S, Ayyanar P, Kaur G
Int J Surg Pathol 2020 Feb;28(1):4-12. Epub 2019 Aug 13 doi: 10.1177/1066896919868527. PMID: 31409167
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
The third pathway of colorectal carcinogenesis.
Rubio CA, Puppa G, de Petris G, Kis L, Schmidt PT
J Clin Pathol 2018 Jan;71(1):7-11. Epub 2017 Jul 27 doi: 10.1136/jclinpath-2017-204660. PMID: 28751521
Rectal pseudodiverticulum.
Singh S, Savage L
BMJ Case Rep 2014 Jul 8;2014 doi: 10.1136/bcr-2013-201888. PMID: 25006050Free PMC Article
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Therapy

Rectal pseudodiverticulum.
Singh S, Savage L
BMJ Case Rep 2014 Jul 8;2014 doi: 10.1136/bcr-2013-201888. PMID: 25006050Free PMC Article
Sphincter preservation in rectal cancer. Endocavitary radiation therapy.
Gerard JP, Romestaing P, Ardiet JM, Mornex F
Semin Radiat Oncol 1998 Jan;8(1):13-23. doi: 10.1016/s1053-4296(98)80032-5. PMID: 9516579
Lasers in rectosigmoid tumors.
Brunetaud JM, Maunoury V, Cochelard D
Semin Surg Oncol 1995 Jul-Aug;11(4):319-27. doi: 10.1002/ssu.2980110407. PMID: 7481369
Local resection for ampullary tumors. Is there a place for it?
Asbun HJ, Rossi RL, Munson JL
Arch Surg 1993 May;128(5):515-20. doi: 10.1001/archsurg.1993.01420170045006. PMID: 8098205
Experience with the use of the circular stapler in rectal surgery.
Kyzer S, Gordon PH
Dis Colon Rectum 1992 Jul;35(7):696-706. doi: 10.1007/BF02053764. PMID: 1611960

Prognosis

Gastric villous adenoma: a case report and review of the literature.
Sathirawich P, Pongpaibul A, Parakonthun T, Kaosombatwattana U
J Med Case Rep 2023 Apr 26;17(1):167. doi: 10.1186/s13256-023-03893-2. PMID: 37098577Free PMC Article
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Association between Helicobacter pylori infection and colorectal polyps.
Basmaci N, Karataş A, Ergin M, Dumlu GŞ
Medicine (Baltimore) 2023 Oct 20;102(42):e35591. doi: 10.1097/MD.0000000000035591. PMID: 37861565Free PMC Article
Reliability in villous tumors staging between preoperative MRI and histopathological examination.
Vogrig C, Leclerc J, Haghnejad V, Orry X, Remen T, Germain A, Laurent V
Abdom Radiol (NY) 2020 Oct;45(10):3046-3056. doi: 10.1007/s00261-020-02450-5. PMID: 32123949
Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization.
Broggi G, Piombino E, Magro G, Vecchio GM
Pathologica 2018 Sep;110(2):92-95. PMID: 30546144
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review.
Saini SD, Kim HM, Schoenfeld P
Gastrointest Endosc 2006 Oct;64(4):614-26. doi: 10.1016/j.gie.2006.06.057. PMID: 16996358
Endorectal ultrasound detection of focal carcinoma within rectal adenomas.
Worrell S, Horvath K, Blakemore T, Flum D
Am J Surg 2004 May;187(5):625-9; discussion 629. doi: 10.1016/j.amjsurg.2004.01.005. PMID: 15135679

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