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Adenomatoid tumor

MedGen UID:
60207
•Concept ID:
C0206675
•
Neoplastic Process
Synonyms: Adenomatoid Tumor; Adenomatoid Tumors; Tumor, Adenomatoid; Tumors, Adenomatoid
SNOMED CT: Benign mesothelioma (41183007); Adenomatoid tumor (2348006); Mesothelioma, benign (41183007)
 
Monarch Initiative: MONDO:0004230

Definition

A benign neoplasm arising from mesothelial cells. It is characterized by the formation of glandular and tubular patterns. It can occur in several anatomic sites including the pleura, peritoneum, and epididymis. [from NCI]

Professional guidelines

PubMed

Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis.
Chekol SS, Sun CC
Arch Pathol Lab Med 2012 Jan;136(1):113-7. doi: 10.5858/arpa.2010-0550-RS. PMID: 22208496

Recent clinical studies

Etiology

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution.
Al-Obaidy KI, Alruwaii FI, Ulbright TM, Idrees MT
Hum Pathol 2020 Sep;103:25-33. Epub 2020 Jun 30 doi: 10.1016/j.humpath.2020.06.006. PMID: 32619438
Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review.
Matsuhashi T, Matsui R, Hasegawa C, Hatori T, Kamoi S, Takeshita T
J Nippon Med Sch 2017;84(3):139-143. doi: 10.1272/jnms.84.139. PMID: 28724848
The adenomatoid odontogenic tumour: an update of selected issues.
Philipsen HP, Khongkhunthiang P, Reichart PA
J Oral Pathol Med 2016 Jul;45(6):394-8. Epub 2016 Feb 11 doi: 10.1111/jop.12418. PMID: 26865435
Adenomatoid paratesticular tumor: report of 5 new cases and literature review.
Cordeiro González P, Pérez Fentes DA, Carrera Álvarez JJ, Puñal Pererira A
Arch Esp Urol 2014 Oct;67(8):722-5. PMID: 25306994

Diagnosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Fallopian Tube Neoplasia and Mimics.
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Benign intrascrotal lesions.
Rubenstein RA, Dogra VS, Seftel AD, Resnick MI
J Urol 2004 May;171(5):1765-72. doi: 10.1097/01.ju.0000123083.98845.88. PMID: 15076274

Therapy

Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases.
Malpica A, Euscher ED, Marques-Piubelli ML, Miranda RN, Raghav KP, Fournier KF, Ramalingam P
Am J Surg Pathol 2022 Oct 1;46(10):1352-1363. Epub 2022 Jun 20 doi: 10.1097/PAS.0000000000001924. PMID: 35713639
Non-random adenomatoid tumours of the female genital system: A comparative clinicopathologic analysis of 14 cases.
Ersan Erdem B, Yaprak Bayrak B, Vural C, Muezzinoglu B
Ann Diagn Pathol 2020 Aug;47:151553. Epub 2020 Jun 17 doi: 10.1016/j.anndiagpath.2020.151553. PMID: 32580034
Respiratory Epithelial Adenomatoid Hamartoma is Frequent in Olfactory Cleft After Nasalization.
Nguyen DT, Jankowski R, Bey A, Gauchotte G, Casse JM, Gondim Teixeira PA, Gallet P, Rumeau C
Laryngoscope 2020 Sep;130(9):2098-2104. Epub 2019 Sep 5 doi: 10.1002/lary.28298. PMID: 31487047
Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression.
Tamura D, Maeda D, Halimi SA, Okimura M, Kudo-Asabe Y, Ito S, Sato N, Shibahara J, Nanjo H, Terada Y, Goto A
Histopathology 2018 Dec;73(6):1013-1022. Epub 2018 Oct 22 doi: 10.1111/his.13726. PMID: 30099776
Adenomatoid tumor of the uterus in a patient with chronic renal failure.
Bülent Tiras M, Noyan V, Süer O, Bali M, Edali N, Yildirim M
Eur J Obstet Gynecol Reprod Biol 2000 Oct;92(2):205-7. doi: 10.1016/s0301-2115(99)00290-0. PMID: 10996682

Prognosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature.
Guan J, Zhao C, Li H, Zhang W, Lin W, Tang L, Chen J
Front Endocrinol (Lausanne) 2021;12:692553. Epub 2021 Jun 23 doi: 10.3389/fendo.2021.692553. PMID: 34248850Free PMC Article
TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma.
Itami H, Fujii T, Nakai T, Takeda M, Kishi Y, Taniguchi F, Terada C, Okada F, Nitta Y, Matsuoka M, Sasaki S, Sugimoto S, Uchiyama T, Morita K, Kasai T, Kawaguchi R, Ohbayashi C
Hum Pathol 2021 May;111:59-66. Epub 2021 Mar 2 doi: 10.1016/j.humpath.2021.02.007. PMID: 33667423
Primary adenomatoid tumor of the testis: report of a case and review of literature.
Sheng B, Zhang YP, Wei HH, Ma M, Nan X
Int J Clin Exp Pathol 2015;8(5):5914-8. Epub 2015 May 1 PMID: 26191318Free PMC Article
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082

Clinical prediction guides

Peritoneal adenomatoid (microcystic) mesothelioma.
Mori D, Kido S, Hiraki M, Sumi K, Ureshino N, Masuda M, Nabeshima K, Akashi M
Pathol Int 2020 Nov;70(11):876-880. Epub 2020 Sep 3 doi: 10.1111/pin.13006. PMID: 32881200
Clonality assessment of adenomatoid tumor supports its neoplastic nature.
Wang W, Zhu H, Wang J, Wang S, Wang D, Zhao J, Zhu H
Hum Pathol 2016 Feb;48:88-94. Epub 2015 Oct 23 doi: 10.1016/j.humpath.2015.09.032. PMID: 26772404
Primary adenomatoid tumor of the testis: report of a case and review of literature.
Sheng B, Zhang YP, Wei HH, Ma M, Nan X
Int J Clin Exp Pathol 2015;8(5):5914-8. Epub 2015 May 1 PMID: 26191318Free PMC Article
From the radiologic pathology archives: Adrenal tumors and tumor-like conditions in the adult: radiologic-pathologic correlation.
Lattin GE Jr, Sturgill ED, Tujo CA, Marko J, Sanchez-Maldonado KW, Craig WD, Lack EE
Radiographics 2014 May-Jun;34(3):805-29. doi: 10.1148/rg.343130127. PMID: 24819798
Adenomatoid tumor of the adrenal gland: a clinicopathologic study of five cases and review of the literature.
Isotalo PA, Keeney GL, Sebo TJ, Riehle DL, Cheville JC
Am J Surg Pathol 2003 Jul;27(7):969-77. doi: 10.1097/00000478-200307000-00012. PMID: 12826889

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