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Skin appendage carcinoma

MedGen UID:
60209
•Concept ID:
C0206697
•
Neoplastic Process
Synonyms: Appendage Carcinoma, Skin; Appendage Carcinomas, Skin; Carcinoma, Skin Appendage; Carcinomas, Skin Appendage; Skin Appendage Carcinoma; Skin Appendage Carcinomas
SNOMED CT: Skin appendage carcinoma (64000002); Adnexal carcinoma (64000002)
 
Monarch Initiative: MONDO:0006973

Definition

A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma. [from NCI]

Professional guidelines

PubMed

Microcystic adnexal carcinoma of the head and neck: Characteristics, treatment, and survival statistics.
Behbahani S, Yeh CJ, Pinto JO, Wassef D, Povolotskiy R, Joseph N, Lambert WC, Schwartz RA
Dermatol Ther 2021 Jan;34(1):e14559. Epub 2020 Dec 3 doi: 10.1111/dth.14559. PMID: 33210380
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
On the differential diagnosis of clear cell tumours of the head and neck.
Eversole LR
Eur J Cancer B Oral Oncol 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b. PMID: 8298420

Recent clinical studies

Etiology

Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study.
Ronen S, Aguilera-Barrantes I, Giorgadze T, Šteiner P, Grossmann P, Suster S
Am J Dermatopathol 2018 Aug;40(8):580-587. doi: 10.1097/DAD.0000000000001128. PMID: 29533280
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck.
Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ
Am J Clin Oncol 2017 Aug;40(4):429-432. doi: 10.1097/COC.0000000000000178. PMID: 25599317Free PMC Article
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R
J Am Acad Dermatol 2005 Feb;52(2):295-300. doi: 10.1016/j.jaad.2004.10.868. PMID: 15692477

Diagnosis

Endocrine Mucin-Producing Sweat Gland Carcinoma and Primary Cutaneous Mucinous Carcinoma: A Case Series.
Grushchak S, Barlow T, Palla B, Mannor GE, Greenway HT, Kelley BF
Cutis 2023 Sep;112(3):E6-E10. doi: 10.12788/cutis.0856. PMID: 37903397
Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Update on Malignant Sweat Gland Tumors.
van der Horst MPJ, Brenn T
Surg Pathol Clin 2017 Jun;10(2):383-397. Epub 2017 Mar 27 doi: 10.1016/j.path.2017.01.010. PMID: 28477887
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300

Therapy

Increasing incidence and survival of a rare skin cancer in the Netherlands. A population-based study of 2,220 cases of skin adnexal carcinoma.
Stam H, Lohuis PJ, Zupan-Kajcovski B, Wouters MW, van der Hage JA, Visser O
J Surg Oncol 2013 Jun;107(8):822-7. Epub 2013 Mar 15 doi: 10.1002/jso.23331. PMID: 23505050
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
Appendageal malignancies.
Harwood CA, Proby CM, Cerio R
Cancer Treat Res 2009;146:353-74. doi: 10.1007/978-0-387-78574-5_29. PMID: 19415216
Microcystic adnexal carcinoma arising in the setting of previous radiation therapy.
Antley CA, Carney M, Smoller BR
J Cutan Pathol 1999 Jan;26(1):48-50. doi: 10.1111/j.1600-0560.1999.tb01790.x. PMID: 10189245
Intraoperative fire with electrocautery.
Brechtelsbauer PB, Carroll WR, Baker S
Otolaryngol Head Neck Surg 1996 Feb;114(2):328-31. doi: 10.1016/S0194-59989670197-3. PMID: 8637764

Prognosis

Skin adnexal carcinoma with BRD3-NUTM2B fusion.
Rubio Gonzalez B, Ortiz MV, Ross DS, Busam KJ
J Cutan Pathol 2021 Dec;48(12):1508-1513. Epub 2021 Aug 3 doi: 10.1111/cup.14107. PMID: 34296453Free PMC Article
Update on Molecular Genetic Alterations of Cutaneous Adnexal Neoplasms.
Hile G, Harms PW
Surg Pathol Clin 2021 Jun;14(2):251-272. doi: 10.1016/j.path.2021.03.004. PMID: 34023104
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck.
Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ
Am J Clin Oncol 2017 Aug;40(4):429-432. doi: 10.1097/COC.0000000000000178. PMID: 25599317Free PMC Article
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
Appendageal malignancies.
Harwood CA, Proby CM, Cerio R
Cancer Treat Res 2009;146:353-74. doi: 10.1007/978-0-387-78574-5_29. PMID: 19415216

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.
Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909
A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck.
Portelli F, Salvati L, Projetto E, Gori A, Scarfì F, Trane L, Lo Russo G, Innocenti A, De Giorgi V
Australas J Dermatol 2020 May;61(2):e189-e195. Epub 2019 Nov 17 doi: 10.1111/ajd.13199. PMID: 31736065
Role of immunohistochemistry in diagnosing tumors of cutaneous appendages.
Hoang MP
Am J Dermatopathol 2011 Dec;33(8):765-71; quiz 772-4. doi: 10.1097/DAD.0b013e31820a4837. PMID: 22112636
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Wetter R, Goldstein GD
Dermatol Ther 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x. PMID: 19076623
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446

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