U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Serous cystadenocarcinoma

MedGen UID:
60212
•Concept ID:
C0206701
•
Neoplastic Process
Synonyms: Cystadenocarcinoma, Serous; Cystadenocarcinomas, Serous; Serous Cystadenocarcinoma; Serous Cystadenocarcinomas
SNOMED CT: Serous cystadenocarcinoma (90725004); Serous adenocarcinoma (90725004); Serous carcinoma (90725004); Papillary serous cystadenocarcinoma (90725004); Papillary serous adenocarcinoma (90725004); Serous surface papillary carcinoma (90725004)
 
Monarch Initiative: MONDO:0024621

Definition

An adenocarcinoma that is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies may be present. Representative examples include cervical serous adenocarcinoma, endometrial serous adenocarcinoma, ovarian serous adenocarcinoma, and primary peritoneal serous adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerous cystadenocarcinoma

Professional guidelines

PubMed

A Network Pharmacology-Based Analysis of Multi-Target, Multi-Pathway, Multi-Compound Treatment for Ovarian Serous Cystadenocarcinoma.
Xiong DD, Qin Y, Xu WQ, He RQ, Wu HY, Wei DM, Zeng JJ, Dang YW, Chen G
Clin Drug Investig 2018 Oct;38(10):909-925. doi: 10.1007/s40261-018-0683-8. PMID: 30097905
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Hormone replacement therapy after invasive ovarian serous cystadenocarcinoma treatment: the effect on survival.
Ursic-Vrscaj M, Bebar S, Zakelj MP
Menopause 2001 Jan-Feb;8(1):70-5. doi: 10.1097/00042192-200101000-00012. PMID: 11201519

Recent clinical studies

Etiology

Low-grade Serous Neoplasia of the Female Genital Tract.
Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112
High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints.
Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C
Int J Mol Sci 2019 Feb 22;20(4) doi: 10.3390/ijms20040952. PMID: 30813239Free PMC Article
Whence High-Grade Serous Ovarian Cancer.
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development.
Malmberg K, Klynning C, Flöter-Rådestad A, Carlson JW
Virchows Arch 2016 Jun;468(6):707-13. Epub 2016 Mar 22 doi: 10.1007/s00428-016-1928-7. PMID: 27003156
Hereditary ovarian cancer.
Neri A, Rabinerson D, Kaplan B, Levavi H
Isr J Med Sci 1995 Feb-Mar;31(2-3):172-5. PMID: 7744589

Diagnosis

HER2 Testing and Reporting in Endometrial Serous Carcinoma: Practical Recommendations for HER2 Immunohistochemistry and Fluorescent In Situ Hybridization: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting.
Buza N
Int J Gynecol Pathol 2021 Jan;40(1):17-23. doi: 10.1097/PGP.0000000000000711. PMID: 33290351
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Fallopian Tube Neoplasia and Mimics.
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer.
Freimund AE, Beach JA, Christie EL, Bowtell DDL
Hematol Oncol Clin North Am 2018 Dec;32(6):983-996. doi: 10.1016/j.hoc.2018.07.007. PMID: 30390769
Acquired chemotherapy resistance in ovarian cancer.
Christie EL, Bowtell DDL
Ann Oncol 2017 Nov 1;28(suppl_8):viii13-viii15. doi: 10.1093/annonc/mdx446. PMID: 29232469

Therapy

Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial.
Banerjee S, Moore KN, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley WH, Holmes E, Lowe ES, DiSilvestro P
Lancet Oncol 2021 Dec;22(12):1721-1731. Epub 2021 Oct 26 doi: 10.1016/S1470-2045(21)00531-3. PMID: 34715071
Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
HER2 Testing in Endometrial Serous Carcinoma: Time for Standardized Pathology Practice to Meet the Clinical Demand.
Buza N
Arch Pathol Lab Med 2021 Jun 1;145(6):687-691. doi: 10.5858/arpa.2020-0207-RA. PMID: 32649220
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
BRCA somatic mutations and epigenetic BRCA modifications in serous ovarian cancer.
Moschetta M, George A, Kaye SB, Banerjee S
Ann Oncol 2016 Aug;27(8):1449-55. Epub 2016 Mar 31 doi: 10.1093/annonc/mdw142. PMID: 27037296

Prognosis

Recommendations for diagnosing STIC: a systematic review and meta-analysis.
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial.
Banerjee S, Moore KN, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley WH, Holmes E, Lowe ES, DiSilvestro P
Lancet Oncol 2021 Dec;22(12):1721-1731. Epub 2021 Oct 26 doi: 10.1016/S1470-2045(21)00531-3. PMID: 34715071
Uterine serous carcinoma: key advances and novel treatment approaches.
Ferriss JS, Erickson BK, Shih IM, Fader AN
Int J Gynecol Cancer 2021 Aug;31(8):1165-1174. Epub 2021 Jul 1 doi: 10.1136/ijgc-2021-002753. PMID: 34210768
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR
Nat Rev Cancer 2015 Nov;15(11):668-79. doi: 10.1038/nrc4019. PMID: 26493647Free PMC Article

Clinical prediction guides

Identification of immunity- and ferroptosis-related genes for predicting the prognosis of serous ovarian cancer.
Yuan X, Zhou Q, Zhang F, Zheng W, Liu H, Chen A, Tao Y
Gene 2022 Sep 5;838:146701. Epub 2022 Jun 28 doi: 10.1016/j.gene.2022.146701. PMID: 35777713
Immuno-genomic characterisation of high-grade serous ovarian cancer reveals immune evasion mechanisms and identifies an immunological subtype with a favourable prognosis and improved therapeutic efficacy.
Sun J, Yan C, Xu D, Zhang Z, Li K, Li X, Zhou M, Hao D
Br J Cancer 2022 Jun;126(11):1570-1580. Epub 2022 Jan 11 doi: 10.1038/s41416-021-01692-4. PMID: 35017656Free PMC Article
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
Low-grade serous ovarian cancer: A review.
Kaldawy A, Segev Y, Lavie O, Auslender R, Sopik V, Narod SA
Gynecol Oncol 2016 Nov;143(2):433-438. Epub 2016 Aug 28 doi: 10.1016/j.ygyno.2016.08.320. PMID: 27581327
Serous Cystadenocarcinoma of the Pancreas: Clinical Features and Management of a Rare Tumor.
Van Dyke TJ, Johlin FC, Bellizzi AM, Howe JR
Dig Surg 2016;33(3):240-8. Epub 2016 Mar 22 doi: 10.1159/000444721. PMID: 26998825

Recent systematic reviews

Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
Incidence of omental metastasis in uterine serous carcinoma: a systematic review and meta-analysis.
Xu H, Cui SS, Ran L, Liu Y, Hu C, Xu Y, Tian Y
J Gynecol Obstet Hum Reprod 2022 Jun;51(6):102395. Epub 2022 Apr 28 doi: 10.1016/j.jogoh.2022.102395. PMID: 35489712
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Recommendations for diagnosing STIC: a systematic review and meta-analysis.
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...