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Esthesioneuroblastoma

MedGen UID:
60217
•Concept ID:
C0206717
•
Neoplastic Process
Synonym: Olfactory esthesioneuroblastoma
SNOMED CT: Esthesioneuroepithelioma (68614005); Olfactory neuroepithelioma (68614005); Esthesioneuroblastoma (76060004); Olfactory neuroblastoma (76060004); Asthesioneuroblastoma (76060004); Olfactory neuroblastoma (422886007); Esthesioneuroblastoma (422886007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030068
Monarch Initiative: MONDO:0016029
Orphanet: ORPHA1957

Definition

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. [from HPO]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589

Recent clinical studies

Etiology

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Esthesioneuroblastoma.
Shah JP, Feghali J
Am J Surg 1981 Oct;142(4):456-8. doi: 10.1016/0002-9610(81)90374-3. PMID: 7283046
Esthesioneuroblastoma.
Elkon D, Hightower SI, Lim ML, Cantrell RW, Constable WC
Cancer 1979 Sep;44(3):1087-94. doi: 10.1002/1097-0142(197909)44:3<1087::aid-cncr2820440343>3.0.co;2-a. PMID: 383268

Diagnosis

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Olfactory Neuroblastoma.
Abdelmeguid AS
Curr Oncol Rep 2018 Feb 7;20(1):7. doi: 10.1007/s11912-018-0661-6. PMID: 29411144
Esthesioneuroblastoma.
Ow TJ, Bell D, Kupferman ME, Demonte F, Hanna EY
Neurosurg Clin N Am 2013 Jan;24(1):51-65. doi: 10.1016/j.nec.2012.08.005. PMID: 23174357

Therapy

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Esthesioneuroblastoma.
Klepin HD, McMullen KP, Lesser GJ
Curr Treat Options Oncol 2005 Nov;6(6):509-18. doi: 10.1007/s11864-005-0029-7. PMID: 16242055
Diagnosis and management of esthesioneuroblastoma.
Bradley PJ, Jones NS, Robertson I
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):112-8. doi: 10.1097/00020840-200304000-00009. PMID: 14515089
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598

Prognosis

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
Olfactory Neuroblastoma.
Veyrat M, Vérillaud B, Fiaux-Camous D, Froelich S, Bresson D, Nicolai P, Herman P
Adv Otorhinolaryngol 2020;84:154-167. Epub 2020 Jul 30 doi: 10.1159/000457935. PMID: 32731231
Of mice and men: olfactory neuroblastoma among animals and humans.
Lubojemska A, Borejko M, Czapiewski P, Dziadziuszko R, Biernat W
Vet Comp Oncol 2016 Sep;14(3):e70-82. Epub 2014 Jul 12 doi: 10.1111/vco.12102. PMID: 25041470
Esthesioneuroblastoma.
Ow TJ, Bell D, Kupferman ME, Demonte F, Hanna EY
Neurosurg Clin N Am 2013 Jan;24(1):51-65. doi: 10.1016/j.nec.2012.08.005. PMID: 23174357
Esthesioneuroblastoma.
Elkon D, Hightower SI, Lim ML, Cantrell RW, Constable WC
Cancer 1979 Sep;44(3):1087-94. doi: 10.1002/1097-0142(197909)44:3<1087::aid-cncr2820440343>3.0.co;2-a. PMID: 383268

Clinical prediction guides

Update on olfactory neuroblastoma.
Lopez F, Agaimy A, Franchi A, Suárez C, Vander Poorten V, Mäkitie AA, Homma A, Eisbruch A, Olsen KD, Saba NF, Nuyts S, Snyderman C, Beitler JJ, Corry J, Hanna E, Hellquist H, Rinaldo A, Ferlito A
Virchows Arch 2024 Apr;484(4):567-585. Epub 2024 Feb 22 doi: 10.1007/s00428-024-03758-z. PMID: 38386106
Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.
Lechner M, Liu J, Lund VJ
Curr Oncol Rep 2020 Jul 29;22(10):106. doi: 10.1007/s11912-020-00947-2. PMID: 32725435Free PMC Article
Endoscopic management of Esthesioneuroblastoma: Our experience and review of the literature.
Klironomos G, Gonen L, Au K, Monteiro E, Mansouri A, Turel MK, Witterick I, Vescan A, Zadeh G, Gentili F
J Clin Neurosci 2018 Dec;58:117-123. Epub 2018 Oct 16 doi: 10.1016/j.jocn.2018.09.011. PMID: 30340976
Of mice and men: olfactory neuroblastoma among animals and humans.
Lubojemska A, Borejko M, Czapiewski P, Dziadziuszko R, Biernat W
Vet Comp Oncol 2016 Sep;14(3):e70-82. Epub 2014 Jul 12 doi: 10.1111/vco.12102. PMID: 25041470
MRI of esthesioneuroblastoma.
Derdeyn CP, Moran CJ, Wippold FJ 2nd, Chason DP, Koby MB, Rodriguez F
J Comput Assist Tomogr 1994 Jan-Feb;18(1):16-21. doi: 10.1097/00004728-199401000-00004. PMID: 8282874

Recent systematic reviews

Immunohistochemical Profiling and Staging in Esthesioneuroblastoma: A Single-Center Cohort Study and Systematic Review.
Henson JC, Cutler CC, Cole KL, Lucke-Wold B, Khan M, Alt JA, Karsy M
World Neurosurg 2023 Feb;170:e652-e665. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.094. PMID: 36435382
Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis.
Marinelli JP, Janus JR, Van Gompel JJ, Link MJ, Foote RL, Lohse CM, Price KA, Chintakuntlawar AV
Head Neck 2018 Oct;40(10):2295-2303. Epub 2018 May 13 doi: 10.1002/hed.25209. PMID: 29756250
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676
Comparison of outcomes for open versus endoscopic approaches for olfactory neuroblastoma: A systematic review and individual participant data meta-analysis.
Fu TS, Monteiro E, Muhanna N, Goldstein DP, de Almeida JR
Head Neck 2016 Apr;38 Suppl 1:E2306-16. Epub 2015 Oct 30 doi: 10.1002/hed.24233. PMID: 26514662
Long-term carcinologic results of advanced esthesioneuroblastoma: a systematic review.
De Bonnecaze G, Lepage B, Rimmer J, Al Hawat A, Vairel B, Serrano E, Chaput B, Vergez S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):21-6. Epub 2014 Oct 17 doi: 10.1007/s00405-014-3320-z. PMID: 25323151

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