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Olfactory esthesioneuroblastoma

MedGen UID:
60217
•Concept ID:
C0206717
•
Neoplastic Process
Synonym: Esthesioneuroblastoma
SNOMED CT: Esthesioneuroepithelioma (68614005); Olfactory neuroepithelioma (68614005); Esthesioneuroblastoma (76060004); Olfactory neuroblastoma (76060004); Asthesioneuroblastoma (76060004); Olfactory neuroblastoma (422886007); Esthesioneuroblastoma (422886007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030068
Monarch Initiative: MONDO:0016029
Orphanet: ORPHA1957

Definition

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. [from HPO]

Professional guidelines

PubMed

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach.
Thompson LD
Mod Pathol 2017 Jan;30(s1):S1-S26. doi: 10.1038/modpathol.2016.119. PMID: 28060373
Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma).
Unger F, Haselsberger K, Walch C, Stammberger H, Papaefthymiou G
Acta Neurochir (Wien) 2005 Jun;147(6):595-601; discussion 601-2. Epub 2005 Apr 11 doi: 10.1007/s00701-005-0521-7. PMID: 15806328

Recent clinical studies

Etiology

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M Jr, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR Jr, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY
Eur J Cancer 2022 Feb;162:221-236. Epub 2021 Dec 31 doi: 10.1016/j.ejca.2021.09.046. PMID: 34980502Free PMC Article
Radiotherapy of sinonasal cancers.
Larnaudie A, Delaby N, Marcy PY, Leleu T, Costes-Martineau V, Vergez S, de Gabory L, Quintyn JC, Doré M, Pointreau Y, Thariat J
Cancer Radiother 2022 Feb-Apr;26(1-2):156-167. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.10.007. PMID: 34953697
Early Stage olfactory neuroblastoma and the impact of resecting dura and olfactory bulb.
Mays AC, Bell D, Ferrarotto R, Phan J, Roberts D, Fuller CD, Frank SJ, Raza SM, Kupferman ME, DeMonte F, Hanna EY, Su SY
Laryngoscope 2018 Jun;128(6):1274-1280. Epub 2017 Dec 11 doi: 10.1002/lary.26908. PMID: 29226334
Neuroendocrine neoplasms of the head and neck and olfactory neuroblastoma. Diagnosis and classification.
Uccella S, Ottini G, Facco C, Maragliano R, Asioli S, Sessa F, La Rosa S
Pathologica 2017 Mar;109(1):14-30. PMID: 28635990
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598

Diagnosis

Olfactory Neuroblastoma.
Veyrat M, Vérillaud B, Fiaux-Camous D, Froelich S, Bresson D, Nicolai P, Herman P
Adv Otorhinolaryngol 2020;84:154-167. Epub 2020 Jul 30 doi: 10.1159/000457935. PMID: 32731231
Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.
Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F
J Neurooncol 2020 Dec;150(3):367-375. Epub 2020 May 18 doi: 10.1007/s11060-020-03537-1. PMID: 32424573
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Olfactory Neuroblastoma.
Abdelmeguid AS
Curr Oncol Rep 2018 Feb 7;20(1):7. doi: 10.1007/s11912-018-0661-6. PMID: 29411144
Esthesioneuroblastoma.
Ow TJ, Bell D, Kupferman ME, Demonte F, Hanna EY
Neurosurg Clin N Am 2013 Jan;24(1):51-65. doi: 10.1016/j.nec.2012.08.005. PMID: 23174357

Therapy

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M Jr, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR Jr, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY
Eur J Cancer 2022 Feb;162:221-236. Epub 2021 Dec 31 doi: 10.1016/j.ejca.2021.09.046. PMID: 34980502Free PMC Article
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Esthesioneuroblastoma.
Klepin HD, McMullen KP, Lesser GJ
Curr Treat Options Oncol 2005 Nov;6(6):509-18. doi: 10.1007/s11864-005-0029-7. PMID: 16242055
Diagnosis and management of esthesioneuroblastoma.
Bradley PJ, Jones NS, Robertson I
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):112-8. doi: 10.1097/00020840-200304000-00009. PMID: 14515089
Esthesioneuroblastoma in children.
Kumar M, Fallon RJ, Hill JS, Davis MM
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):482-7. doi: 10.1097/00043426-200208000-00015. PMID: 12218598

Prognosis

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M Jr, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR Jr, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY
Eur J Cancer 2022 Feb;162:221-236. Epub 2021 Dec 31 doi: 10.1016/j.ejca.2021.09.046. PMID: 34980502Free PMC Article
Olfactory Neuroblastoma.
Veyrat M, Vérillaud B, Fiaux-Camous D, Froelich S, Bresson D, Nicolai P, Herman P
Adv Otorhinolaryngol 2020;84:154-167. Epub 2020 Jul 30 doi: 10.1159/000457935. PMID: 32731231
Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment.
Czapiewski P, Kunc M, Haybaeck J
Oncotarget 2016 Aug 9;7(32):52584-52596. doi: 10.18632/oncotarget.9683. PMID: 27256979Free PMC Article
Of mice and men: olfactory neuroblastoma among animals and humans.
Lubojemska A, Borejko M, Czapiewski P, Dziadziuszko R, Biernat W
Vet Comp Oncol 2016 Sep;14(3):e70-82. Epub 2014 Jul 12 doi: 10.1111/vco.12102. PMID: 25041470
Esthesioneuroblastoma.
Ow TJ, Bell D, Kupferman ME, Demonte F, Hanna EY
Neurosurg Clin N Am 2013 Jan;24(1):51-65. doi: 10.1016/j.nec.2012.08.005. PMID: 23174357

Clinical prediction guides

Immunohistochemical Profiling and Staging in Esthesioneuroblastoma: A Single-Center Cohort Study and Systematic Review.
Henson JC, Cutler CC, Cole KL, Lucke-Wold B, Khan M, Alt JA, Karsy M
World Neurosurg 2023 Feb;170:e652-e665. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.094. PMID: 36435382
Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M Jr, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR Jr, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY
Eur J Cancer 2022 Feb;162:221-236. Epub 2021 Dec 31 doi: 10.1016/j.ejca.2021.09.046. PMID: 34980502Free PMC Article
Endoscopic management of Esthesioneuroblastoma: Our experience and review of the literature.
Klironomos G, Gonen L, Au K, Monteiro E, Mansouri A, Turel MK, Witterick I, Vescan A, Zadeh G, Gentili F
J Clin Neurosci 2018 Dec;58:117-123. Epub 2018 Oct 16 doi: 10.1016/j.jocn.2018.09.011. PMID: 30340976
Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment.
Czapiewski P, Kunc M, Haybaeck J
Oncotarget 2016 Aug 9;7(32):52584-52596. doi: 10.18632/oncotarget.9683. PMID: 27256979Free PMC Article
Of mice and men: olfactory neuroblastoma among animals and humans.
Lubojemska A, Borejko M, Czapiewski P, Dziadziuszko R, Biernat W
Vet Comp Oncol 2016 Sep;14(3):e70-82. Epub 2014 Jul 12 doi: 10.1111/vco.12102. PMID: 25041470

Recent systematic reviews

Immunohistochemical Profiling and Staging in Esthesioneuroblastoma: A Single-Center Cohort Study and Systematic Review.
Henson JC, Cutler CC, Cole KL, Lucke-Wold B, Khan M, Alt JA, Karsy M
World Neurosurg 2023 Feb;170:e652-e665. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.094. PMID: 36435382
Surgery as Single-Modality Treatment for Early-Stage Olfactory Neuroblastoma: An Institutional Experience, Systematic Review and Meta-analysis.
Meerwein CM, Nikolaou G, H A Binz G, Soyka MB, Holzmann D
Am J Rhinol Allergy 2021 Jul;35(4):525-534. Epub 2020 Nov 11 doi: 10.1177/1945892420973163. PMID: 33174762
Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis.
Marinelli JP, Janus JR, Van Gompel JJ, Link MJ, Foote RL, Lohse CM, Price KA, Chintakuntlawar AV
Head Neck 2018 Oct;40(10):2295-2303. Epub 2018 May 13 doi: 10.1002/hed.25209. PMID: 29756250
Comparison of outcomes for open versus endoscopic approaches for olfactory neuroblastoma: A systematic review and individual participant data meta-analysis.
Fu TS, Monteiro E, Muhanna N, Goldstein DP, de Almeida JR
Head Neck 2016 Apr;38 Suppl 1:E2306-16. Epub 2015 Oct 30 doi: 10.1002/hed.24233. PMID: 26514662
Long-term carcinologic results of advanced esthesioneuroblastoma: a systematic review.
De Bonnecaze G, Lepage B, Rimmer J, Al Hawat A, Vairel B, Serrano E, Chaput B, Vergez S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):21-6. Epub 2014 Oct 17 doi: 10.1007/s00405-014-3320-z. PMID: 25323151

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