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Fatty dimpling of skin

MedGen UID:
603326
•Concept ID:
C0424624
•
Finding
Synonyms: Cellulite; Cellulites
SNOMED CT: Fatty dimpling of skin (248306003); Cellulite (248306003)

Definition

Skin lumpiness or skin surface dimpling often seen on the thighs, buttocks and abdomen. It is due to protrusion of SUBCUTANEOUS FAT into the DERMIS layer of skin. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFatty dimpling of skin

Professional guidelines

PubMed

Cellulite: Presentation and management.
Arora G, Patil A, Hooshanginezhad Z, Fritz K, Salavastru C, Kassir M, Goldman MP, Gold MH, Adatto M, Grabbe S, Goldust M
J Cosmet Dermatol 2022 Apr;21(4):1393-1401. Epub 2022 Feb 14 doi: 10.1111/jocd.14815. PMID: 35104044
Global Consensus Guidelines for the Injection of Diluted and Hyperdiluted Calcium Hydroxylapatite for Skin Tightening.
Goldie K, Peeters W, Alghoul M, Butterwick K, Casabona G, Chao YYY, Costa J, Eviatar J, Fabi SG, Lupo M, Sattler G, Waldorf H, Yutskovskaya Y, Lorenc P
Dermatol Surg 2018 Nov;44 Suppl 1:S32-S41. doi: 10.1097/DSS.0000000000001685. PMID: 30358631
Evidence-based treatment for gynoid lipodystrophy: A review of the recent literature.
Pérez Atamoros FM, Alcalá Pérez D, Asz Sigall D, Ávila Romay AA, Barba Gastelum JA, de la Peña Salcedo JA, Escalante Salgado PE, Gallardo Palacios GJ, Guerrero-Gonzalez GA, Morales De la Cerda R, Ponce Olivera RM, Rossano Soriano F, Solís Tinoco E, Welsh Hernández EC
J Cosmet Dermatol 2018 Dec;17(6):977-983. Epub 2018 Apr 30 doi: 10.1111/jocd.12555. PMID: 29707877

Recent clinical studies

Etiology

Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Delivery of light to the skin through ablated conduits.
Tanghetti E, Mirkov M, Sierra RA
Lasers Surg Med 2017 Jan;49(1):69-77. Epub 2016 May 19 doi: 10.1002/lsm.22533. PMID: 27197620
Cellulite: an evidence-based review.
Luebberding S, Krueger N, Sadick NS
Am J Clin Dermatol 2015 Aug;16(4):243-256. doi: 10.1007/s40257-015-0129-5. PMID: 25940753
Obesity and dermatology.
Scheinfeld NS
Clin Dermatol 2004 Jul-Aug;22(4):303-9. doi: 10.1016/j.clindermatol.2004.01.001. PMID: 15475230
Cellulite: a review.
Rossi AB, Vergnanini AL
J Eur Acad Dermatol Venereol 2000 Jul;14(4):251-62. doi: 10.1046/j.1468-3083.2000.00016.x. PMID: 11204512

Diagnosis

Cellulite: Presentation and management.
Arora G, Patil A, Hooshanginezhad Z, Fritz K, Salavastru C, Kassir M, Goldman MP, Gold MH, Adatto M, Grabbe S, Goldust M
J Cosmet Dermatol 2022 Apr;21(4):1393-1401. Epub 2022 Feb 14 doi: 10.1111/jocd.14815. PMID: 35104044
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Updates on the understanding and treatment of cellulite.
Hogan S, Velez MW, Kaminer MS
Semin Cutan Med Surg 2018 Dec;37(4):242-246. doi: 10.12788/j.sder.2018.056. PMID: 30475930
Evidence-based treatment for gynoid lipodystrophy: A review of the recent literature.
Pérez Atamoros FM, Alcalá Pérez D, Asz Sigall D, Ávila Romay AA, Barba Gastelum JA, de la Peña Salcedo JA, Escalante Salgado PE, Gallardo Palacios GJ, Guerrero-Gonzalez GA, Morales De la Cerda R, Ponce Olivera RM, Rossano Soriano F, Solís Tinoco E, Welsh Hernández EC
J Cosmet Dermatol 2018 Dec;17(6):977-983. Epub 2018 Apr 30 doi: 10.1111/jocd.12555. PMID: 29707877
Cutaneous manifestations of obesity and themetabolic syndrome.
Uzuncakmak TK, Akdeniz N, Karadag AS
Clin Dermatol 2018 Jan-Feb;36(1):81-88. Epub 2017 Sep 8 doi: 10.1016/j.clindermatol.2017.09.014. PMID: 29241757

Therapy

Cellulite: Presentation and management.
Arora G, Patil A, Hooshanginezhad Z, Fritz K, Salavastru C, Kassir M, Goldman MP, Gold MH, Adatto M, Grabbe S, Goldust M
J Cosmet Dermatol 2022 Apr;21(4):1393-1401. Epub 2022 Feb 14 doi: 10.1111/jocd.14815. PMID: 35104044
Radiofrequency Microneedling: A Comprehensive and Critical Review.
Tan MG, Jo CE, Chapas A, Khetarpal S, Dover JS
Dermatol Surg 2021 Jun 1;47(6):755-761. doi: 10.1097/DSS.0000000000002972. PMID: 33577211
Insights Into the Pathophysiology of Cellulite: A Review.
Bass LS, Kaminer MS
Dermatol Surg 2020 Oct;46 Suppl 1(1):S77-S85. doi: 10.1097/DSS.0000000000002388. PMID: 32976174Free PMC Article
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA
J Drugs Dermatol 2019 Jan 1;18(1):9-16. PMID: 30681787
Caffeine's mechanisms of action and its cosmetic use.
Herman A, Herman AP
Skin Pharmacol Physiol 2013;26(1):8-14. Epub 2012 Oct 11 doi: 10.1159/000343174. PMID: 23075568

Prognosis

Use of a microwave device for the treatment of cellulite and localized fat adiposity: a 1-year follow-up study.
Salsi B, Coli F, Ronconi L, Fusco I, Zingoni T, Bonan P
Skin Res Technol 2023 Jul;29(7):e13408. doi: 10.1111/srt.13408. PMID: 37522509Free PMC Article
Global trends in research on extracorporeal shock wave therapy (ESWT) from 2000 to 2021.
Zhang X, Ma Y
BMC Musculoskelet Disord 2023 Apr 20;24(1):312. doi: 10.1186/s12891-023-06407-9. PMID: 37081473Free PMC Article
Skin Tightening With Hyperdilute CaHA: Dilution Practices and Practical Guidance for Clinical Practice.
Lorenc ZP, Black JM, Cheung JS, Chiu A, Del Campo R, Durkin AJ, Graivier M, Green JB, Kwok GP, Marcus K, Rammos CB, Werschler WP
Aesthet Surg J 2022 Jan 1;42(1):NP29-NP37. doi: 10.1093/asj/sjab269. PMID: 34192299Free PMC Article
Delivery of light to the skin through ablated conduits.
Tanghetti E, Mirkov M, Sierra RA
Lasers Surg Med 2017 Jan;49(1):69-77. Epub 2016 May 19 doi: 10.1002/lsm.22533. PMID: 27197620
Obesity and dermatology.
Scheinfeld NS
Clin Dermatol 2004 Jul-Aug;22(4):303-9. doi: 10.1016/j.clindermatol.2004.01.001. PMID: 15475230

Clinical prediction guides

Global trends in research on extracorporeal shock wave therapy (ESWT) from 2000 to 2021.
Zhang X, Ma Y
BMC Musculoskelet Disord 2023 Apr 20;24(1):312. doi: 10.1186/s12891-023-06407-9. PMID: 37081473Free PMC Article
Carboxytherapy in dermatology: A systematic review.
Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
A clinical evaluation of noninvasive and contactless radiofrequency technique in the treatment of abdominal fat.
Qin J, Guo ME, Xu XG, Zhang C, Yu CQ, Li YH, Chen HD
J Cosmet Dermatol 2021 Sep;20(9):2765-2768. Epub 2021 Jan 4 doi: 10.1111/jocd.13892. PMID: 33356001
Fractional radiofrequency in the treatment of skin aging: an evidence-based treatment protocol.
Kleidona IA, Karypidis D, Lowe N, Myers S, Ghanem A
J Cosmet Laser Ther 2020;22(1):9-25. Epub 2019 Dec 11 doi: 10.1080/14764172.2019.1674448. PMID: 31825296
An Observational Study of the Safety and Efficacy of Tissue Stabilized-Guided Subcision.
Geronemus RG, Kilmer SL, Wall SH Jr, Green JB, Cohen JL, Weiss RA, Alster TS, Kaminer MS, Gupta A
Dermatol Surg 2019 Aug;45(8):1057-1062. doi: 10.1097/DSS.0000000000001911. PMID: 30893161

Recent systematic reviews

Carboxytherapy in dermatology: A systematic review.
Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA
J Drugs Dermatol 2019 Jan 1;18(1):9-16. PMID: 30681787
Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat-Systematic review.
Modena DAO, da Silva CN, Grecco C, Guidi RM, Moreira RG, Coelho AA, Sant'Ana E, de Souza JR
J Cosmet Laser Ther 2017 Oct;19(6):314-319. Epub 2017 Jun 7 doi: 10.1080/14764172.2017.1334928. PMID: 28590827
Cellulite: an evidence-based review.
Luebberding S, Krueger N, Sadick NS
Am J Clin Dermatol 2015 Aug;16(4):243-256. doi: 10.1007/s40257-015-0129-5. PMID: 25940753
Efficacy of cosmetic products in cellulite reduction: systematic review and meta-analysis.
Turati F, Pelucchi C, Marzatico F, Ferraroni M, Decarli A, Gallus S, La Vecchia C, Galeone C
J Eur Acad Dermatol Venereol 2014 Jan;28(1):1-15. Epub 2013 Jun 14 doi: 10.1111/jdv.12193. PMID: 23763635

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