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Cellular urinary casts

MedGen UID:
606002
•Concept ID:
C0427895
•
Finding
Synonym: Cellular casts
SNOMED CT: Cellular casts (250445004)
 
HPO: HP:0031197

Definition

A type of urinary cast composed of cells incorporated in a protein matrix. The cells can be those found in the urinary sediment (erythrocytes, leuklocytes, renal tubular epithelial cells). [from HPO]

Professional guidelines

PubMed

Efficacy of two cyclophosphamide regimens for the treatment of lupus nephritis in Puerto Ricans: low vs. standard dose.
Castro-Santana LE, Colón M, Molina MJ, Rodríguez VE, Mayor AM, Vilá LM
Ethn Dis 2010 Winter;20(1 Suppl 1):S1-116-21. PMID: 20521398Free PMC Article

Recent clinical studies

Etiology

Urinary Sediment Microscopy and Correlations with Kidney Biopsy: Red Flags Not To Be Missed.
Navarro D, Fonseca NM, Ferreira AC, Barata R, Góis M, Sousa H, Nolasco F
Kidney360 2023 Jan 1;4(1):32-40. Epub 2022 Dec 24 doi: 10.34067/KID.0003082022. PMID: 36700902Free PMC Article
Anticoagulant-Related Nephropathy.
Brodsky S, Eikelboom J, Hebert LA
J Am Soc Nephrol 2018 Dec;29(12):2787-2793. Epub 2018 Nov 12 doi: 10.1681/ASN.2018070741. PMID: 30420420Free PMC Article
Hemodynamic and tubular changes induced by contrast media.
Caiazza A, Russo L, Sabbatini M, Russo D
Biomed Res Int 2014;2014:578974. Epub 2014 Feb 11 doi: 10.1155/2014/578974. PMID: 24678510Free PMC Article
Assessment of asymptomatic microscopic hematuria in adults.
Sharp VJ, Barnes KT, Erickson BA
Am Fam Physician 2013 Dec 1;88(11):747-54. PMID: 24364522
Hematuria in children.
Yadin O
Pediatr Ann 1994 Sep;23(9):474-8, 481-5. doi: 10.3928/0090-4481-19940901-06. PMID: 7800423

Diagnosis

Pitfalls in anticoagulant-related nephropathy.
Kock RV, Berend K, Florquin S, Ten Cate H
Clin Nephrol 2023 Dec;100(6):284-289. doi: 10.5414/CN111156. PMID: 37877298
Glomerular Hematuria and the Utility of Urine Microscopy: A Review.
Saha MK, Massicotte-Azarniouch D, Reynolds ML, Mottl AK, Falk RJ, Jennette JC, Derebail VK
Am J Kidney Dis 2022 Sep;80(3):383-392. Epub 2022 Jun 29 doi: 10.1053/j.ajkd.2022.02.022. PMID: 35777984
Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019.
Cavanaugh C, Perazella MA
Am J Kidney Dis 2019 Feb;73(2):258-272. Epub 2018 Sep 21 doi: 10.1053/j.ajkd.2018.07.012. PMID: 30249419
Anticoagulant-Related Nephropathy.
Brodsky S, Eikelboom J, Hebert LA
J Am Soc Nephrol 2018 Dec;29(12):2787-2793. Epub 2018 Nov 12 doi: 10.1681/ASN.2018070741. PMID: 30420420Free PMC Article
Cylindruria.
Caleffi A, Lippi G
Clin Chem Lab Med 2015 Nov;53 Suppl 2:s1471-7. doi: 10.1515/cclm-2015-0480. PMID: 26079824

Therapy

Pitfalls in anticoagulant-related nephropathy.
Kock RV, Berend K, Florquin S, Ten Cate H
Clin Nephrol 2023 Dec;100(6):284-289. doi: 10.5414/CN111156. PMID: 37877298
Anticoagulant-Related Nephropathy.
Brodsky S, Eikelboom J, Hebert LA
J Am Soc Nephrol 2018 Dec;29(12):2787-2793. Epub 2018 Nov 12 doi: 10.1681/ASN.2018070741. PMID: 30420420Free PMC Article
Hemodynamic and tubular changes induced by contrast media.
Caiazza A, Russo L, Sabbatini M, Russo D
Biomed Res Int 2014;2014:578974. Epub 2014 Feb 11 doi: 10.1155/2014/578974. PMID: 24678510Free PMC Article
Evaluation of asymptomatic microhematuria.
Fracchia JA, Motta J, Miller LS, Armenakas NA, Schumann GB, Greenberg RA
Urology 1995 Oct;46(4):484-9. doi: 10.1016/s0090-4295(99)80259-3. PMID: 7571215
The effect of netilmicin and other aminoglycosides on renal function. A survey of the literature on the nephrotoxicity of netilmicin.
Dahlager JI
Scand J Infect Dis Suppl 1980;Suppl 23:96-102. PMID: 7010549

Prognosis

Glomerular Hematuria and the Utility of Urine Microscopy: A Review.
Saha MK, Massicotte-Azarniouch D, Reynolds ML, Mottl AK, Falk RJ, Jennette JC, Derebail VK
Am J Kidney Dis 2022 Sep;80(3):383-392. Epub 2022 Jun 29 doi: 10.1053/j.ajkd.2022.02.022. PMID: 35777984
A practical approach to the pathology of renal intratubular casts.
Dvanajscak Z, Cossey LN, Larsen CP
Semin Diagn Pathol 2020 May;37(3):127-134. Epub 2020 Feb 14 doi: 10.1053/j.semdp.2020.02.001. PMID: 32147230
Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019.
Cavanaugh C, Perazella MA
Am J Kidney Dis 2019 Feb;73(2):258-272. Epub 2018 Sep 21 doi: 10.1053/j.ajkd.2018.07.012. PMID: 30249419
Dysproteinemia and the kidney.
Markowitz GS
Adv Anat Pathol 2004 Jan;11(1):49-63. doi: 10.1097/00125480-200401000-00005. PMID: 14676640
Hematuria in children.
Yadin O
Pediatr Ann 1994 Sep;23(9):474-8, 481-5. doi: 10.3928/0090-4481-19940901-06. PMID: 7800423

Clinical prediction guides

Pathophysiology of Red Blood Cell Trapping in Ischemic Acute Kidney Injury.
McLarnon SR
Compr Physiol 2023 Dec 29;14(1):5325-5343. doi: 10.1002/cphy.c230010. PMID: 38158367
Urinary Sediment Microscopy and Correlations with Kidney Biopsy: Red Flags Not To Be Missed.
Navarro D, Fonseca NM, Ferreira AC, Barata R, Góis M, Sousa H, Nolasco F
Kidney360 2023 Jan 1;4(1):32-40. Epub 2022 Dec 24 doi: 10.34067/KID.0003082022. PMID: 36700902Free PMC Article
Glomerular Hematuria and the Utility of Urine Microscopy: A Review.
Saha MK, Massicotte-Azarniouch D, Reynolds ML, Mottl AK, Falk RJ, Jennette JC, Derebail VK
Am J Kidney Dis 2022 Sep;80(3):383-392. Epub 2022 Jun 29 doi: 10.1053/j.ajkd.2022.02.022. PMID: 35777984
Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum.
Liapis H, Boils C, Hennigar R, Silva F
Hum Pathol 2016 Aug;54:25-30. Epub 2016 Mar 30 doi: 10.1016/j.humpath.2016.02.026. PMID: 27038680
Pneumonia-associated acute glomerulonephritis.
Srivastava T, Warady, Alon US
Clin Nephrol 2002 Mar;57(3):175-82. doi: 10.5414/cnp57175. PMID: 11924750

Recent systematic reviews

Differences in the Clinical Manifestations and Mortality of Systemic Lupus Erythematosus Onset in Children and Adults: A Systematic Review and Meta-Analysis.
Huang X, Jia N, Xiao F, Sun C, Zhu J, Lai J, Cui X
Int Arch Allergy Immunol 2022;183(1):116-126. Epub 2021 Sep 27 doi: 10.1159/000518321. PMID: 34818238
Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis.
Livingston B, Bonner A, Pope J
Lupus 2011 Nov;20(13):1345-55. Epub 2011 Sep 27 doi: 10.1177/0961203311416694. PMID: 21951943
Acute tubular necrosis and pre-renal acute kidney injury: utility of urine microscopy in their evaluation- a systematic review.
Kanbay M, Kasapoglu B, Perazella MA
Int Urol Nephrol 2010 Jun;42(2):425-33. Epub 2009 Nov 17 doi: 10.1007/s11255-009-9673-3. PMID: 19921458
Urinary biochemistry and microscopy in septic acute renal failure: a systematic review.
Bagshaw SM, Langenberg C, Bellomo R
Am J Kidney Dis 2006 Nov;48(5):695-705. doi: 10.1053/j.ajkd.2006.07.017. PMID: 17059988

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