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Chronic neutrophilic leukemia(CNL)

MedGen UID:
6061
Concept ID:
C0023481
Neoplastic Process
Synonym: CNL
SNOMED CT: Chronic neutrophilic leukemia (128834007); Chronic neutrophilic leukemia (188734009)
 
Monarch Initiative: MONDO:0019451
Orphanet: ORPHA86829

Definition

A rare myeloproliferative neoplasm characterized by sustained peripheral blood neutrophilia, bone marrow hypercellularity due to neutrophilic granulocyte proliferation, and hepatosplenomegaly. Other organs may be infiltrated in addition. Microscopically, the bone marrow shows an increase in proportion of myelocytes and mature neutrophils, but no significant dysplasia in any of the cell lineages. Peripheral blood neutrophils are mostly segmented, although band forms may also be substantially increased. Cytogenetic abnormalities are absent in most cases. The disease is slowly progressive with progredient neutrophilia followed by anemia and thrombocytopenia. Transformation to acute myeloid leukemia may occur. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic neutrophilic leukemia
Follow this link to review classifications for Chronic neutrophilic leukemia in Orphanet.

Professional guidelines

PubMed

Szuber N, Elliott M, Tefferi A
Am J Hematol 2022 Apr;97(4):491-505. Epub 2022 Feb 9 doi: 10.1002/ajh.26481. PMID: 35089603
Szuber N, Tefferi A
Curr Treat Options Oncol 2021 Jun 7;22(7):59. doi: 10.1007/s11864-021-00856-x. PMID: 34097138
Szuber N, Elliott M, Tefferi A
Am J Hematol 2020 Feb;95(2):212-224. Epub 2019 Dec 30 doi: 10.1002/ajh.25688. PMID: 31769070

Recent clinical studies

Etiology

Li N, Chen M, Yin CC
Semin Diagn Pathol 2023 May;40(3):187-194. Epub 2023 Apr 13 doi: 10.1053/j.semdp.2023.04.007. PMID: 37087305
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW
Blood 2019 Sep 12;134(11):867-879. Epub 2019 Jul 31 doi: 10.1182/blood.2019000611. PMID: 31366621Free PMC Article
Elliott MA, Tefferi A
Am J Hematol 2018 Aug;93(4):578-587. doi: 10.1002/ajh.24983. PMID: 29512199
Dao KT, Tyner JW, Gotlib J
Curr Hematol Malig Rep 2017 Oct;12(5):432-441. doi: 10.1007/s11899-017-0413-y. PMID: 28983816

Diagnosis

Baba Y, Nakamaki T, Sakai H, Fukuchi K, Kabasawa N, Hattori N, Harada H
Int J Hematol 2023 Nov;118(5):636-641. Epub 2023 Jul 13 doi: 10.1007/s12185-023-03636-5. PMID: 37439996
Szuber N, Elliott M, Tefferi A
Am J Hematol 2022 Apr;97(4):491-505. Epub 2022 Feb 9 doi: 10.1002/ajh.26481. PMID: 35089603
Szuber N, Elliott M, Tefferi A
Am J Hematol 2020 Feb;95(2):212-224. Epub 2019 Dec 30 doi: 10.1002/ajh.25688. PMID: 31769070
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW
Blood 2019 Sep 12;134(11):867-879. Epub 2019 Jul 31 doi: 10.1182/blood.2019000611. PMID: 31366621Free PMC Article
Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW
N Engl J Med 2013 May 9;368(19):1781-90. doi: 10.1056/NEJMoa1214514. PMID: 23656643Free PMC Article

Therapy

Szuber N, Tefferi A
Curr Treat Options Oncol 2021 Jun 7;22(7):59. doi: 10.1007/s11864-021-00856-x. PMID: 34097138
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Szuber N, Elliott M, Tefferi A
Am J Hematol 2020 Feb;95(2):212-224. Epub 2019 Dec 30 doi: 10.1002/ajh.25688. PMID: 31769070
Maxson JE, Tyner JW
Blood 2017 Feb 9;129(6):715-722. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695981. PMID: 28028025Free PMC Article
Muxí PJ, Oliver AC
Curr Treat Options Oncol 2014 Jun;15(2):147-56. doi: 10.1007/s11864-014-0279-3. PMID: 24627006

Prognosis

Szuber N, Elliott M, Tefferi A
Am J Hematol 2022 Apr;97(4):491-505. Epub 2022 Feb 9 doi: 10.1002/ajh.26481. PMID: 35089603
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Szuber N, Elliott M, Tefferi A
Am J Hematol 2020 Feb;95(2):212-224. Epub 2019 Dec 30 doi: 10.1002/ajh.25688. PMID: 31769070
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW
Blood 2019 Sep 12;134(11):867-879. Epub 2019 Jul 31 doi: 10.1182/blood.2019000611. PMID: 31366621Free PMC Article
Venugopal S, Mascarenhas J
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):129-134. Epub 2018 Nov 29 doi: 10.1016/j.clml.2018.11.012. PMID: 30581159

Clinical prediction guides

Baba Y, Nakamaki T, Sakai H, Fukuchi K, Kabasawa N, Hattori N, Harada H
Int J Hematol 2023 Nov;118(5):636-641. Epub 2023 Jul 13 doi: 10.1007/s12185-023-03636-5. PMID: 37439996
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW
Blood 2019 Sep 12;134(11):867-879. Epub 2019 Jul 31 doi: 10.1182/blood.2019000611. PMID: 31366621Free PMC Article
Elliott MA, Tefferi A
Am J Hematol 2018 Aug;93(4):578-587. doi: 10.1002/ajh.24983. PMID: 29512199
Bain BJ, Ahmad S
Br J Haematol 2015 Nov;171(3):400-10. Epub 2015 Jul 27 doi: 10.1111/bjh.13600. PMID: 26218186

Recent systematic reviews

Guastafierro V, Ubezio M, Manes N, Milanesi C, Della Porta M, Bonometti A
Leuk Lymphoma 2023 Sep;64(9):1566-1573. Epub 2023 Jul 3 doi: 10.1080/10428194.2023.2227750. PMID: 37395413

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