U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

T-cell leukemia

MedGen UID:
6064
•Concept ID:
C0023492
•
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, T Cell; Leukemia, Lymphocytic, T-Cell; Leukemia, T Cell; Leukemia, T Lymphocytic; Leukemia, T-Cell; Leukemia, T-Cell Lymphocytic; Leukemia, T-Lymphocytic; Leukemias, T Lymphocytic; Leukemias, T-Cell; Leukemias, T-Cell Lymphocytic; Leukemias, T-Lymphocytic; Lymphocytic Leukemia, T; Lymphocytic Leukemia, T Cell; Lymphocytic Leukemia, T-Cell; Lymphocytic Leukemias, T; Lymphocytic Leukemias, T-Cell; T Cell Leukemia; T Lymphocytic Leukemia; T Lymphocytic Leukemias; T-Cell Leukemia; T-Cell Leukemias; T-Cell Lymphocytic Leukemia; T-Cell Lymphocytic Leukemias; T-Lymphocytic Leukemia; T-Lymphocytic Leukemias
 
Monarch Initiative: MONDO:0005525

Definition

A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell leukemia

Professional guidelines

PubMed

Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma.
Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH
Blood Adv 2023 Jul 25;7(14):3416-3430. doi: 10.1182/bloodadvances.2022008327. PMID: 37058474Free PMC Article
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Etiology

What is new in mature T-cell leukemias?
Bailey NG, Elenitoba-Johnson KSJ
Semin Diagn Pathol 2020 Jan;37(1):72-78. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.001. PMID: 31917110
An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia 2018 Sep;32(9):1970-1983. Epub 2018 Feb 20 doi: 10.1038/s41375-018-0065-5. PMID: 29483708Free PMC Article
Management of adults with T-cell lymphoblastic leukemia.
Marks DI, Rowntree C
Blood 2017 Mar 2;129(9):1134-1142. Epub 2017 Jan 23 doi: 10.1182/blood-2016-07-692608. PMID: 28115371
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Diagnosis

Human T-cell Leukemia Virus Type 1 (HTLV-1)-induced Uveitis.
Terada Y, Miyata K, Shoji N, Mochizuki M
Ocul Immunol Inflamm 2023 Sep;31(7):1416-1424. Epub 2023 Feb 21 doi: 10.1080/09273948.2023.2175697. PMID: 36803501
Flow Cytometry of T cells and T-cell Neoplasms.
Craig JW, Dorfman DM
Clin Lab Med 2017 Dec;37(4):725-751. Epub 2017 Oct 3 doi: 10.1016/j.cll.2017.07.002. PMID: 29128066
Human T-cell lymphotropic virus type 1 and its oncogenesis.
Zhang LL, Wei JY, Wang L, Huang SL, Chen JL
Acta Pharmacol Sin 2017 Aug;38(8):1093-1103. Epub 2017 Apr 10 doi: 10.1038/aps.2017.17. PMID: 28392570Free PMC Article
Management of adults with T-cell lymphoblastic leukemia.
Marks DI, Rowntree C
Blood 2017 Mar 2;129(9):1134-1142. Epub 2017 Jan 23 doi: 10.1182/blood-2016-07-692608. PMID: 28115371
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Therapy

A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.
Lancho O, Singh A, da Silva-Diz V, Aleksandrova M, Khatun J, Tottone L, Nunes PR, Luo S, Zhao C, Zheng H, Chiles E, Zuo Z, Rocha PP, Su X, Khiabanian H, Herranz D
Blood Cancer Discov 2023 Jan 6;4(1):12-33. doi: 10.1158/2643-3230.BCD-22-0098. PMID: 36322781Free PMC Article
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Cutaneous T-cell lymphoma/leukemia.
Siegel RS, Kuzel TM
Curr Treat Options Oncol 2000 Apr;1(1):43-50. doi: 10.1007/s11864-000-0014-0. PMID: 12057060
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Prognosis

Human T-cell Leukemia Virus Type 1 (HTLV-1)-induced Uveitis.
Terada Y, Miyata K, Shoji N, Mochizuki M
Ocul Immunol Inflamm 2023 Sep;31(7):1416-1424. Epub 2023 Feb 21 doi: 10.1080/09273948.2023.2175697. PMID: 36803501
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
Leukemia cutis.
Ratnam KV, Khor CJ, Su WP
Dermatol Clin 1994 Apr;12(2):419-31. PMID: 8045053

Clinical prediction guides

Recent advances in T-cell lymphoid neoplasms.
Bigas A, Rodriguez-Sevilla JJ, Espinosa L, Gallardo F
Exp Hematol 2022 Feb;106:3-18. Epub 2021 Dec 5 doi: 10.1016/j.exphem.2021.12.191. PMID: 34879258
State-of-Art of Cellular Therapy for Acute Leukemia.
Lee JB, Vasic D, Kang H, Fang KK, Zhang L
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094590. PMID: 33925571Free PMC Article
CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?
Sarmento LM, Barata JT
Adv Biol Regul 2016 Jan;60:115-121. Epub 2015 Oct 24 doi: 10.1016/j.jbior.2015.10.007. PMID: 26527132
Notch and Ikaros: not only converging players in T cell leukemia.
Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Gulino A, Screpanti I
Cell Cycle 2007 Nov 15;6(22):2730-4. Epub 2007 Aug 15 doi: 10.4161/cc.6.22.4894. PMID: 18032925
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Recent systematic reviews

Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
The efficacy of anti-CD19 chimeric antigen receptor T cells for B-cell malignancies.
Cao JX, Gao WJ, You J, Wu LH, Liu JL, Wang ZX
Cytotherapy 2019 Jul;21(7):769-781. Epub 2019 May 31 doi: 10.1016/j.jcyt.2019.04.005. PMID: 31160157
Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review.
Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ
Lab Med 2015 Spring;46(2):140-5. doi: 10.1309/LMU4KMJDRM3AD6FQ. PMID: 25918193
Diseases of large granular lymphocytes.
Alekshun TJ, Sokol L
Cancer Control 2007 Apr;14(2):141-50. doi: 10.1177/107327480701400207. PMID: 17387299

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...