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T-cell leukemia

MedGen UID:
6064
•Concept ID:
C0023492
•
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, T Cell; Leukemia, Lymphocytic, T-Cell; Leukemia, T Cell; Leukemia, T Lymphocytic; Leukemia, T-Cell; Leukemia, T-Cell Lymphocytic; Leukemia, T-Lymphocytic; Leukemias, T Lymphocytic; Leukemias, T-Cell; Leukemias, T-Cell Lymphocytic; Leukemias, T-Lymphocytic; Lymphocytic Leukemia, T; Lymphocytic Leukemia, T Cell; Lymphocytic Leukemia, T-Cell; Lymphocytic Leukemias, T; Lymphocytic Leukemias, T-Cell; T Cell Leukemia; T Lymphocytic Leukemia; T Lymphocytic Leukemias; T-Cell Leukemia; T-Cell Leukemias; T-Cell Lymphocytic Leukemia; T-Cell Lymphocytic Leukemias; T-Lymphocytic Leukemia; T-Lymphocytic Leukemias
 
Monarch Initiative: MONDO:0005525

Definition

A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell leukemia

Professional guidelines

PubMed

Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma.
Ureshino H, Kamachi K, Kimura S
Clin Lymphoma Myeloma Leuk 2019 Jun;19(6):326-331. Epub 2019 Mar 23 doi: 10.1016/j.clml.2019.03.004. PMID: 30981611
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Etiology

An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia 2018 Sep;32(9):1970-1983. Epub 2018 Feb 20 doi: 10.1038/s41375-018-0065-5. PMID: 29483708Free PMC Article
Management of adults with T-cell lymphoblastic leukemia.
Marks DI, Rowntree C
Blood 2017 Mar 2;129(9):1134-1142. Epub 2017 Jan 23 doi: 10.1182/blood-2016-07-692608. PMID: 28115371
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
T-small lymphocyte disorders.
Bartlett NL, Longo DL
Semin Hematol 1999 Apr;36(2):164-70. PMID: 10319385

Diagnosis

Flow Cytometry of T cells and T-cell Neoplasms.
Craig JW, Dorfman DM
Clin Lab Med 2017 Dec;37(4):725-751. Epub 2017 Oct 3 doi: 10.1016/j.cll.2017.07.002. PMID: 29128066
Human T-cell lymphotropic virus type 1 and its oncogenesis.
Zhang LL, Wei JY, Wang L, Huang SL, Chen JL
Acta Pharmacol Sin 2017 Aug;38(8):1093-1103. Epub 2017 Apr 10 doi: 10.1038/aps.2017.17. PMID: 28392570Free PMC Article
Management of adults with T-cell lymphoblastic leukemia.
Marks DI, Rowntree C
Blood 2017 Mar 2;129(9):1134-1142. Epub 2017 Jan 23 doi: 10.1182/blood-2016-07-692608. PMID: 28115371
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
Adult T-cell leukemia.
Takatsuki K
Intern Med 1995 Oct;34(10):947-52. doi: 10.2169/internalmedicine.34.947. PMID: 8563094

Therapy

Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.
Aaroe AE, Nevel KS
Curr Oncol Rep 2019 Mar 27;21(5):40. doi: 10.1007/s11912-019-0794-2. PMID: 30919085
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Prognosis

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Management of adults with T-cell lymphoblastic leukemia.
Marks DI, Rowntree C
Blood 2017 Mar 2;129(9):1134-1142. Epub 2017 Jan 23 doi: 10.1182/blood-2016-07-692608. PMID: 28115371
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
Adult T-cell leukemia.
Takatsuki K
Intern Med 1995 Oct;34(10):947-52. doi: 10.2169/internalmedicine.34.947. PMID: 8563094

Clinical prediction guides

Recent advances in T-cell lymphoid neoplasms.
Bigas A, Rodriguez-Sevilla JJ, Espinosa L, Gallardo F
Exp Hematol 2022 Feb;106:3-18. Epub 2021 Dec 5 doi: 10.1016/j.exphem.2021.12.191. PMID: 34879258
State-of-Art of Cellular Therapy for Acute Leukemia.
Lee JB, Vasic D, Kang H, Fang KK, Zhang L
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094590. PMID: 33925571Free PMC Article
CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?
Sarmento LM, Barata JT
Adv Biol Regul 2016 Jan;60:115-121. Epub 2015 Oct 24 doi: 10.1016/j.jbior.2015.10.007. PMID: 26527132
Notch and Ikaros: not only converging players in T cell leukemia.
Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Gulino A, Screpanti I
Cell Cycle 2007 Nov 15;6(22):2730-4. Epub 2007 Aug 15 doi: 10.4161/cc.6.22.4894. PMID: 18032925
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Recent systematic reviews

Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
The efficacy of anti-CD19 chimeric antigen receptor T cells for B-cell malignancies.
Cao JX, Gao WJ, You J, Wu LH, Liu JL, Wang ZX
Cytotherapy 2019 Jul;21(7):769-781. Epub 2019 May 31 doi: 10.1016/j.jcyt.2019.04.005. PMID: 31160157
Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review.
Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ
Lab Med 2015 Spring;46(2):140-5. doi: 10.1309/LMU4KMJDRM3AD6FQ. PMID: 25918193
Diseases of large granular lymphocytes.
Alekshun TJ, Sokol L
Cancer Control 2007 Apr;14(2):141-50. doi: 10.1177/107327480701400207. PMID: 17387299

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