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T-Cell Chronic Lymphocytic Leukemia

MedGen UID:
6065
Concept ID:
C0023494
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, Chronic, T Cell; Leukemia, Lymphocytic, Chronic, T-Cell; Leukemia, T Cell, Chronic; Leukemia, T-Cell, Chronic; Lymphocytic Leukemia, T Cell, Chronic; Lymphocytic Leukemia, T-Cell, Chronic; T-Cell Leukemia, Chronic; T-Lymphocytic Leukemia, Chronic
SNOMED CT: T-cell chronic lymphocytic leukemia (277545003); TCLL - T-cell chronic lymphocytic leukemia (277545003)

Definition

A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The T-cell is specified as the defective cell line. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-Cell Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

Kreitman RJ
Curr Pharm Des 2009;15(23):2652-64. doi: 10.2174/138161209788923949. PMID: 19689336Free PMC Article

Recent clinical studies

Etiology

Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Bartlett NL, Longo DL
Semin Hematol 1999 Apr;36(2):164-70. PMID: 10319385
Eriksson S, Arnér E, Spasokoukotskaja T, Wang L, Karlsson A, Brosjö O, Gunvén P, Julusson G, Liliemark J
Adv Enzyme Regul 1994;34:13-25. doi: 10.1016/0065-2571(94)90006-x. PMID: 7942271
Tsudo M, Uchiyama T, Umadome H, Wano Y, Hori T, Tamori S, Uchino H, Kita K, Chiba S, Mitsutani S
Blood 1986 Feb;67(2):316-21. PMID: 3080037
Pandolfi F, Mandelli F, Semenzato G, Ranucci A, Aiuti F
J Clin Immunol 1984 May;4(3):174-84. doi: 10.1007/BF00914964. PMID: 6234322

Diagnosis

Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
Malani AK, Gupta C, Rangineni R, Singh J, Ammar H
Acta Oncol 2007;46(2):247-9. doi: 10.1080/02841860600827139. PMID: 17453377
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Palutke M, Eisenberg L, Kaplan J, Hussain M, Kithier K, Tabaczka P, Mirchandani I, Tenenbaum D
Blood 1983 Sep;62(3):627-34. PMID: 6224521

Therapy

Calfa CJ, Lossos IS, Ruiz P, Davis JL
Am J Ophthalmol 2007 Aug;144(2):326-9. doi: 10.1016/j.ajo.2007.03.031. PMID: 17659976
Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Eriksson S, Arnér E, Spasokoukotskaja T, Wang L, Karlsson A, Brosjö O, Gunvén P, Julusson G, Liliemark J
Adv Enzyme Regul 1994;34:13-25. doi: 10.1016/0065-2571(94)90006-x. PMID: 7942271
Witzig TE, Weitz JJ, Lundberg JH, Tefferi A
Leuk Lymphoma 1994 Jun;14(1-2):137-9. doi: 10.3109/10428199409049659. PMID: 7920220
Hocking WG, Singh R, Schroff R, Golde DW
Cancer 1983 Feb 15;51(4):631-6. doi: 10.1002/1097-0142(19830215)51:4<631::aid-cncr2820510415>3.0.co;2-e. PMID: 6600413

Prognosis

Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Bartlett NL, Longo DL
Semin Hematol 1999 Apr;36(2):164-70. PMID: 10319385
Hoyer JD, Ross CW, Li CY, Witzig TE, Gascoyne RD, Dewald GW, Hanson CA
Blood 1995 Aug 1;86(3):1163-9. PMID: 7620169

Clinical prediction guides

Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Hoyer JD, Ross CW, Li CY, Witzig TE, Gascoyne RD, Dewald GW, Hanson CA
Blood 1995 Aug 1;86(3):1163-9. PMID: 7620169
Nair KG, Han T, Minowada J
Cancer 1979 Nov;44(5):1652-5. doi: 10.1002/1097-0142(197911)44:5<1652::aid-cncr2820440518>3.0.co;2-d. PMID: 159121

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