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T-Cell Chronic Lymphocytic Leukemia

MedGen UID:
6065
•Concept ID:
C0023494
•
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, Chronic, T Cell; Leukemia, Lymphocytic, Chronic, T-Cell; Leukemia, T Cell, Chronic; Leukemia, T-Cell, Chronic; Lymphocytic Leukemia, T Cell, Chronic; Lymphocytic Leukemia, T-Cell, Chronic; T-Cell Leukemia, Chronic; T-Lymphocytic Leukemia, Chronic
SNOMED CT: T-cell chronic lymphocytic leukemia (277545003); TCLL - T-cell chronic lymphocytic leukemia (277545003)

Definition

A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The T-cell is specified as the defective cell line. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-Cell Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies.
Kreitman RJ
Curr Pharm Des 2009;15(23):2652-64. doi: 10.2174/138161209788923949. PMID: 19689336Free PMC Article

Recent clinical studies

Etiology

Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia.
Calfa CJ, Lossos IS, Ruiz P, Davis JL
Am J Ophthalmol 2007 Aug;144(2):326-9. doi: 10.1016/j.ajo.2007.03.031. PMID: 17659976
T-small lymphocyte disorders.
Bartlett NL, Longo DL
Semin Hematol 1999 Apr;36(2):164-70. PMID: 10319385
Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy.
Eriksson S, Arnér E, Spasokoukotskaja T, Wang L, Karlsson A, Brosjö O, Gunvén P, Julusson G, Liliemark J
Adv Enzyme Regul 1994;34:13-25. doi: 10.1016/0065-2571(94)90006-x. PMID: 7942271
Expression of interleukin-2 receptor on T cell chronic lymphocytic leukemia cells and their response to interleukin-2.
Tsudo M, Uchiyama T, Umadome H, Wano Y, Hori T, Tamori S, Uchino H, Kita K, Chiba S, Mitsutani S
Blood 1986 Feb;67(2):316-21. PMID: 3080037
Classification of patients with T-cell chronic lymphocytic leukemia and expansions of granular lymphocytes: heterogeneity of Italian cases by a multiparameter analysis.
Pandolfi F, Mandelli F, Semenzato G, Ranucci A, Aiuti F
J Clin Immunol 1984 May;4(3):174-84. doi: 10.1007/BF00914964. PMID: 6234322

Diagnosis

T-cell chronic lymphocytic leukemia or small-cell variant of T-cell prolymphocytic leukemia: a historical perspective and search for consensus.
Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia.
Malani AK, Gupta C, Rangineni R, Singh J, Ammar H
Acta Oncol 2007;46(2):247-9. doi: 10.1080/02841860600827139. PMID: 17453377
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism.
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
T-cell chronic lymphocytic leukemia mimicking dermatomyositis.
Nousari HC, Kimyai-Asadi A, Huang CH, Tausk FA
Int J Dermatol 2000 Feb;39(2):144-6. doi: 10.1046/j.1365-4362.2000.00850.x. PMID: 10692065
T-cell chronic lymphocytic leukemia with a helper/inducer membrane phenotype: a distinct clinicopathologic subtype with a poor prognosis.
Witzig TE, Phyliky RL, Li CY, Homburger HA, Dewald GW, Handwerger BS
Am J Hematol 1986 Feb;21(2):139-55. doi: 10.1002/ajh.2830210204. PMID: 2934974

Therapy

Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia.
Calfa CJ, Lossos IS, Ruiz P, Davis JL
Am J Ophthalmol 2007 Aug;144(2):326-9. doi: 10.1016/j.ajo.2007.03.031. PMID: 17659976
Pentostatin (Nipent) in T-cell malignancies. Leukemia Cooperative Group and the European Organization for Research and Treatment of Cancer.
Ho AD, Suciu S, Stryckmans P, De Cataldo F, Willemze R, Thaler J, Peetermans M, Döhner H, Solbu G, Dardenne M, Zittoun R
Semin Oncol 2000 Apr;27(2 Suppl 5):52-7. PMID: 10877053
Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy.
Eriksson S, Arnér E, Spasokoukotskaja T, Wang L, Karlsson A, Brosjö O, Gunvén P, Julusson G, Liliemark J
Adv Enzyme Regul 1994;34:13-25. doi: 10.1016/0065-2571(94)90006-x. PMID: 7942271
Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues.
Witzig TE, Weitz JJ, Lundberg JH, Tefferi A
Leuk Lymphoma 1994 Jun;14(1-2):137-9. doi: 10.3109/10428199409049659. PMID: 7920220
Transient response of pure red cell aplasia to anti-thymocyte globulin in a patient with T-cell chronic lymphocytic leukemia.
Hocking W, Champlin R, Mitsuyasu R
Am J Hematol 1987 Mar;24(3):285-91. doi: 10.1002/ajh.2830240308. PMID: 3103427

Prognosis

T-cell chronic lymphocytic leukemia or small-cell variant of T-cell prolymphocytic leukemia: a historical perspective and search for consensus.
Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism.
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
T-cell chronic lymphocytic leukemia mimicking dermatomyositis.
Nousari HC, Kimyai-Asadi A, Huang CH, Tausk FA
Int J Dermatol 2000 Feb;39(2):144-6. doi: 10.1046/j.1365-4362.2000.00850.x. PMID: 10692065
True T-cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases.
Hoyer JD, Ross CW, Li CY, Witzig TE, Gascoyne RD, Dewald GW, Hanson CA
Blood 1995 Aug 1;86(3):1163-9. PMID: 7620169
Specific chromosomal markers in B- and T-cell chronic lymphocytic leukemia.
Gahrton G, Juliusson G, Robèrt KH, Zech L
Tumour Biol 1985;6(1):1-12. PMID: 3895368

Clinical prediction guides

T-cell chronic lymphocytic leukemia or small-cell variant of T-cell prolymphocytic leukemia: a historical perspective and search for consensus.
Rashidi A, Fisher SI
Eur J Haematol 2015 Sep;95(3):199-210. Epub 2015 Apr 24 doi: 10.1111/ejh.12560. PMID: 25846234
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism.
Magro CM, Morrison CD, Heerema N, Porcu P, Sroa N, Deng AC
J Am Acad Dermatol 2006 Sep;55(3):467-77. doi: 10.1016/j.jaad.2006.04.060. PMID: 16908353
True T-cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases.
Hoyer JD, Ross CW, Li CY, Witzig TE, Gascoyne RD, Dewald GW, Hanson CA
Blood 1995 Aug 1;86(3):1163-9. PMID: 7620169
Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.
Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC, Lennert K
Blood 1994 Jan 15;83(2):505-11. PMID: 8286748
Classification of patients with T-cell chronic lymphocytic leukemia and expansions of granular lymphocytes: heterogeneity of Italian cases by a multiparameter analysis.
Pandolfi F, Mandelli F, Semenzato G, Ranucci A, Aiuti F
J Clin Immunol 1984 May;4(3):174-84. doi: 10.1007/BF00914964. PMID: 6234322

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