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Oncocytic Adenocarcinoma

MedGen UID:
61427
•Concept ID:
C0205642
•
Neoplastic Process
Synonyms: Adenocarcinoma, Oxyphilic; Adenocarcinomas, Oxyphilic; Oxyphilic Adenocarcinoma; Oxyphilic Adenocarcinomas
SNOMED CT: Follicular carcinoma, oxyphilic cell (57596004); Oxyphilic adenocarcinoma (443261008); Oxyphilic adenocarcinoma (57596004); Oncocytic carcinoma (57596004); Oncocytic adenocarcinoma (57596004); Hurthle cell carcinoma (57596004); Hurthle cell adenocarcinoma (57596004)

Definition

An adenocarcinoma characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast carcinoma, and salivary gland oncocytic carcinoma. [from NCI]

Professional guidelines

PubMed

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jul;69(1):182-236. Epub 2018 Apr 5 doi: 10.1016/j.jhep.2018.03.019. PMID: 29628281
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases.
Zhan KY, Lentsch EJ
Head Neck 2016 Apr;38 Suppl 1:E1981-6. Epub 2016 Feb 1 doi: 10.1002/hed.24363. PMID: 26829582
Oncocytic carcinoma of the parotid gland.
Caloglu M, Yurut-Caloglu V, Altaner S, Huseyinova G, Unlu E, Karagol H, Uzal C
Onkologie 2006 Sep;29(8-9):388-90. Epub 2006 Sep 5 doi: 10.1159/000095029. PMID: 16974117
Epithelial tumors of the lacrimal glands: a clinicopathologic study.
Paulino AF, Huvos AG
Ann Diagn Pathol 1999 Aug;3(4):199-204. doi: 10.1016/s1092-9134(99)80051-3. PMID: 10459045
Intraoperative radiotherapy of skull base cancer.
Freeman SB, Hamaker RC, Singer MI, Pugh N, Garrett P, Ross D
Laryngoscope 1991 May;101(5):507-9. doi: 10.1288/00005537-199105000-00011. PMID: 1851521
Oncocytic adenocarcinoma of salivary glands.
Goode RK, Corio RL
Oral Surg Oral Med Oral Pathol 1988 Jan;65(1):61-6. doi: 10.1016/0030-4220(88)90193-4. PMID: 3422397

Diagnosis

Primary oncocytic carcinoma of ectopic salivary gland: a unique case.
Touli E, Manganaris A, Nikolaidou C, Karasmanis I
Int J Oral Maxillofac Surg 2022 Apr;51(4):463-466. Epub 2021 Aug 25 doi: 10.1016/j.ijom.2021.08.010. PMID: 34452806
Epithelial tumors of the lacrimal glands: a clinicopathologic study.
Paulino AF, Huvos AG
Ann Diagn Pathol 1999 Aug;3(4):199-204. doi: 10.1016/s1092-9134(99)80051-3. PMID: 10459045
Oncocytic adenocarcinoma of the ovary.
Miranda D, Leite VH, de Azevedo GM Jr
Virchows Arch 1996 Oct;429(2-3):181-3. doi: 10.1007/BF00192442. PMID: 8917721
Oncocytic adenocarcinoma of the lacrimal sac: report of a case with paranasal sinus and orbital extension.
Perlman JI, Specht CS, McLean IW, Wolfe SA
Ophthalmic Surg 1995 Jul-Aug;26(4):377-9. PMID: 8532297
Oncocytic adenocarcinoma of salivary glands.
Goode RK, Corio RL
Oral Surg Oral Med Oral Pathol 1988 Jan;65(1):61-6. doi: 10.1016/0030-4220(88)90193-4. PMID: 3422397

Prognosis

Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases.
Zhan KY, Lentsch EJ
Head Neck 2016 Apr;38 Suppl 1:E1981-6. Epub 2016 Feb 1 doi: 10.1002/hed.24363. PMID: 26829582
Parietal cell (oncocytic) adenocarcinoma of the stomach in a female patient: superficial spreading and extensive nodal involvement.
Motta MP, Athanazio DA, Motta A, Studart E, Athanazio PR
Int J Surg Pathol 2008 Oct;16(4):447-9. Epub 2008 Apr 2 doi: 10.1177/1066896908315750. PMID: 18387987
Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma.
Takubo K, Honma N, Sawabe M, Arai T, Izumiyama-Shimomura N, Kammori M, Sasajima K, Esaki Y
Am J Surg Pathol 2002 Apr;26(4):458-65. doi: 10.1097/00000478-200204000-00007. PMID: 11914623
Epithelial tumors of the lacrimal glands: a clinicopathologic study.
Paulino AF, Huvos AG
Ann Diagn Pathol 1999 Aug;3(4):199-204. doi: 10.1016/s1092-9134(99)80051-3. PMID: 10459045
Oncocytic adenocarcinoma of salivary glands.
Goode RK, Corio RL
Oral Surg Oral Med Oral Pathol 1988 Jan;65(1):61-6. doi: 10.1016/0030-4220(88)90193-4. PMID: 3422397

Clinical prediction guides

Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases.
Zhan KY, Lentsch EJ
Head Neck 2016 Apr;38 Suppl 1:E1981-6. Epub 2016 Feb 1 doi: 10.1002/hed.24363. PMID: 26829582
Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours.
Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J, Barbatis C
J Laryngol Otol 2006 Apr;120(4):298-304. doi: 10.1017/S0022215106000351. PMID: 16623973
Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
Piana S, Asioli S, Foroni M
Virchows Arch 2006 Feb;448(2):228-31. Epub 2006 Feb 1 doi: 10.1007/s00428-005-0148-3. PMID: 16450120
Oncocytic cells and parenchymal tumors of the kidney.
Vecchioli Scaldazza C, Morosetti C
Arch Esp Urol 1996 Jun;49(5):538-44. PMID: 8766096

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