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Epithelioid hemangioma

MedGen UID:
61449
•Concept ID:
C0205788
•
Neoplastic Process
Synonyms: Hemangioma, Histiocytoid; Hemangiomas, Histiocytoid; Histiocytoid Hemangioma; Histiocytoid Hemangiomas
SNOMED CT: Angiolymphoid hyperplasia with eosinophilia (125574005); Histiocytoid hemangioma (33929001); Epithelioid hemangioma (189869009); Epithelioid hemangioma (33929001)
 
HPO: HP:0032060
Monarch Initiative: MONDO:0021169

Definition

A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. [from HPO]

Professional guidelines

PubMed

Primary vascular tumors of bone: A comprehensive literature review on classification, diagnosis and treatment.
Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda CH
Bol Asoc Med P R 1996 Apr-Jun;88(4-6):46-51. PMID: 8916440
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Recent clinical studies

Etiology

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Epithelioid hemangioma of bone harboring FOS and FOSB gene rearrangements: A clinicopathologic and molecular study.
Tsuda Y, Suurmeijer AJH, Sung YS, Zhang L, Healey JH, Antonescu CR
Genes Chromosomes Cancer 2021 Jan;60(1):17-25. Epub 2020 Oct 9 doi: 10.1002/gcc.22898. PMID: 33034932Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature.
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821
Epithelioid hemangioendothelioma and related lesions.
Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM
Semin Diagn Pathol 1986 Nov;3(4):259-87. PMID: 3303234

Diagnosis

The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
What is new in endothelial neoplasia?
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Epithelioid Vascular Tumors: A Review.
Shon W, Billings SD
Adv Anat Pathol 2019 May;26(3):186-197. doi: 10.1097/PAP.0000000000000228. PMID: 30762622
The Molecular Diagnostics of Vascular Neoplasms.
Habeeb O, Rubin BP
Surg Pathol Clin 2019 Mar;12(1):35-49. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.002. PMID: 30709447
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Therapy

Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report.
Tang L, Chen G, Wang Q, John J, Lu C
Medicine (Baltimore) 2019 Nov;98(48):e18161. doi: 10.1097/MD.0000000000018161. PMID: 31770261Free PMC Article
Periocular epithelioid hemangioma: response to bevacizumab and vascular pathogenesis.
Kahana A, Lee BJ, Flint A, Elner VM
Arch Ophthalmol 2012 Sep;130(9):1209-12. doi: 10.1001/archophthalmol.2012.572. PMID: 22965602Free PMC Article
Epithelioid hemangioma responsive to oral propranolol.
Moss HB, Sines DT, Blatt J, Dutton JJ, Proia AD
Ophthalmic Plast Reconstr Surg 2012 Jul-Aug;28(4):e88-90. doi: 10.1097/IOP.0b013e31823645f9. PMID: 22186982
Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin.
Ogura K, Shinoda Y, Okuma T, Ushiku T, Motoi T, Kawano H
J Orthop Sci 2012 Mar;17(2):194-8. Epub 2011 May 11 doi: 10.1007/s00776-011-0081-z. PMID: 21559957
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Prognosis

Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity.
Bansal D, Pasricha S, Sharma A, Pruthi M, Tiwari A, Gupta G, Durga G, Kamboj M, Mahawar V, Jajodia A, Mehta A
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):401-405. doi: 10.4103/IJPM.IJPM_1170_20. PMID: 35435379
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Epithelioid hemangioma of the scapula treated with chemoembolization and microwave ablation: Α case report.
Tsikopoulos K, Perdikakis E, Georgiannos D, Bisbinas I
Acta Orthop Traumatol Turc 2018 Mar;52(2):157-161. Epub 2017 Jan 31 doi: 10.1016/j.aott.2017.01.003. PMID: 28159479Free PMC Article
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Epithelioid hemangioma of bone and soft tissue: a reappraisal of a controversial entity.
Errani C, Zhang L, Panicek DM, Healey JH, Antonescu CR
Clin Orthop Relat Res 2012 May;470(5):1498-506. Epub 2011 Sep 24 doi: 10.1007/s11999-011-2070-0. PMID: 21948309Free PMC Article

Clinical prediction guides

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases.
Luzar B, Ieremia E, Antonescu CR, Zhang L, Calonje E
Mod Pathol 2020 Aug;33(8):1527-1536. Epub 2020 Feb 24 doi: 10.1038/s41379-020-0505-4. PMID: 32094426Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature.
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821

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