U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epithelioid hemangioma

MedGen UID:
61449
•Concept ID:
C0205788
•
Neoplastic Process
Synonyms: Hemangioma, Histiocytoid; Hemangiomas, Histiocytoid; Histiocytoid Hemangioma; Histiocytoid Hemangiomas
SNOMED CT: Angiolymphoid hyperplasia with eosinophilia (125574005); Histiocytoid hemangioma (33929001); Epithelioid hemangioma (189869009); Epithelioid hemangioma (33929001)
 
HPO: HP:0032060
Monarch Initiative: MONDO:0021169

Definition

A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. [from HPO]

Professional guidelines

PubMed

The multidisciplinary management of gastrointestinal cancer. The diagnostic and therapeutic approach for primary solid liver tumours in adults.
Verslype C, Libbrecht L
Best Pract Res Clin Gastroenterol 2007;21(6):983-96. doi: 10.1016/j.bpg.2007.09.006. PMID: 18070699
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda CH
Bol Asoc Med P R 1996 Apr-Jun;88(4-6):46-51. PMID: 8916440
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Recent clinical studies

Etiology

A unique epithelioid vascular neoplasm of bone characterized by EWSR1/FUS-NFATC1/2 fusions.
Dashti NK, Dickson BC, Zhang L, Xie Z, Nielsen GP, Antonescu CR
Genes Chromosomes Cancer 2021 Nov;60(11):762-771. Epub 2021 Aug 6 doi: 10.1002/gcc.22984. PMID: 34310785Free PMC Article
Epithelioid hemangioma of bone harboring FOS and FOSB gene rearrangements: A clinicopathologic and molecular study.
Tsuda Y, Suurmeijer AJH, Sung YS, Zhang L, Healey JH, Antonescu CR
Genes Chromosomes Cancer 2021 Jan;60(1):17-25. Epub 2020 Oct 9 doi: 10.1002/gcc.22898. PMID: 33034932Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature.
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821
Epithelioid hemangioendothelioma and related lesions.
Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM
Semin Diagn Pathol 1986 Nov;3(4):259-87. PMID: 3303234

Diagnosis

The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
What is new in endothelial neoplasia?
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Epithelioid Vascular Tumors: A Review.
Shon W, Billings SD
Adv Anat Pathol 2019 May;26(3):186-197. doi: 10.1097/PAP.0000000000000228. PMID: 30762622
The Molecular Diagnostics of Vascular Neoplasms.
Habeeb O, Rubin BP
Surg Pathol Clin 2019 Mar;12(1):35-49. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.002. PMID: 30709447
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Therapy

Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report.
Tang L, Chen G, Wang Q, John J, Lu C
Medicine (Baltimore) 2019 Nov;98(48):e18161. doi: 10.1097/MD.0000000000018161. PMID: 31770261Free PMC Article
Periocular epithelioid hemangioma: response to bevacizumab and vascular pathogenesis.
Kahana A, Lee BJ, Flint A, Elner VM
Arch Ophthalmol 2012 Sep;130(9):1209-12. doi: 10.1001/archophthalmol.2012.572. PMID: 22965602Free PMC Article
Epithelioid hemangioma responsive to oral propranolol.
Moss HB, Sines DT, Blatt J, Dutton JJ, Proia AD
Ophthalmic Plast Reconstr Surg 2012 Jul-Aug;28(4):e88-90. doi: 10.1097/IOP.0b013e31823645f9. PMID: 22186982
Bacillary angiomatosis affecting the oral cavity. Report of two cases and review.
López de Blanc S, Sambuelli R, Femopase F, Luna N, Gravotta M, David D, Bistoni A, Criscuolo MI
J Oral Pathol Med 2000 Feb;29(2):91-6. doi: 10.1034/j.1600-0714.2000.290207.x. PMID: 10718405
Bacillary angiomatosis: microbiology, histopathology, clinical presentation, diagnosis and management.
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Prognosis

Epithelioid haemangioma of bone: A series of four cases with a revision of this contentious entity.
Bansal D, Pasricha S, Sharma A, Pruthi M, Tiwari A, Gupta G, Durga G, Kamboj M, Mahawar V, Jajodia A, Mehta A
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):401-405. doi: 10.4103/IJPM.IJPM_1170_20. PMID: 35435379
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Epithelioid hemangioma of the scapula treated with chemoembolization and microwave ablation: Α case report.
Tsikopoulos K, Perdikakis E, Georgiannos D, Bisbinas I
Acta Orthop Traumatol Turc 2018 Mar;52(2):157-161. Epub 2017 Jan 31 doi: 10.1016/j.aott.2017.01.003. PMID: 28159479Free PMC Article
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Epithelioid hemangioma of bone and soft tissue: a reappraisal of a controversial entity.
Errani C, Zhang L, Panicek DM, Healey JH, Antonescu CR
Clin Orthop Relat Res 2012 May;470(5):1498-506. Epub 2011 Sep 24 doi: 10.1007/s11999-011-2070-0. PMID: 21948309Free PMC Article

Clinical prediction guides

Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases.
Luzar B, Ieremia E, Antonescu CR, Zhang L, Calonje E
Mod Pathol 2020 Aug;33(8):1527-1536. Epub 2020 Feb 24 doi: 10.1038/s41379-020-0505-4. PMID: 32094426Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Epithelioid hemangioma of the spine: a case series of six patients and review of the literature.
Boyaci B, Hornicek FJ, Nielsen GP, DeLaney TF, Pedlow FX Jr, Mansfield FL, Carrier CS, Harms J, Schwab JH
Spine J 2013 Dec;13(12):e7-13. Epub 2013 Sep 14 doi: 10.1016/j.spinee.2013.06.070. PMID: 24045160
Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature.
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...