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Myocardial stunning

MedGen UID:
61526
•Concept ID:
C0206146
•
Disease or Syndrome
Synonyms: Myocardial Stunning; Stunning, Myocardial
 
Monarch Initiative: MONDO:0004876

Definition

Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial stunning

Professional guidelines

PubMed

Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Intensive Hemodialysis and Treatment Complications and Tolerability.
Morfin JA, Fluck RJ, Weinhandl ED, Kansal S, McCullough PA, Komenda P
Am J Kidney Dis 2016 Nov;68(5S1):S43-S50. doi: 10.1053/j.ajkd.2016.05.021. PMID: 27772642
Scorpion-related cardiomyopathy: Clinical characteristics, pathophysiology, and treatment.
Abroug F, Souheil E, Ouanes I, Dachraoui F, Fekih-Hassen M, Ouanes Besbes L
Clin Toxicol (Phila) 2015 Jul;53(6):511-8. Epub 2015 Apr 8 doi: 10.3109/15563650.2015.1030676. PMID: 25851549

Recent clinical studies

Etiology

From Neurocardiology to Stroke-Heart Syndrome.
Nistor IR, Gherasim L
Rom J Intern Med 2023 Dec 1;61(4):177-185. Epub 2023 Aug 4 doi: 10.2478/rjim-2023-0020. PMID: 37540842
Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Current interpretation of myocardial stunning.
Guaricci AI, Bulzis G, Pontone G, Scicchitano P, Carbonara R, Rabbat M, De Santis D, Ciccone MM
Trends Cardiovasc Med 2018 May;28(4):263-271. Epub 2017 Nov 27 doi: 10.1016/j.tcm.2017.11.005. PMID: 29221768
Intracranial hemorrhage.
Naidech AM
Am J Respir Crit Care Med 2011 Nov 1;184(9):998-1006. doi: 10.1164/rccm.201103-0475CI. PMID: 22167847Free PMC Article
Takotsubo disease.
Nepal M
JNMA J Nepal Med Assoc 2007 Jan-Mar;46(165):44-8. PMID: 17721563

Diagnosis

Current interpretation of myocardial stunning.
Guaricci AI, Bulzis G, Pontone G, Scicchitano P, Carbonara R, Rabbat M, De Santis D, Ciccone MM
Trends Cardiovasc Med 2018 May;28(4):263-271. Epub 2017 Nov 27 doi: 10.1016/j.tcm.2017.11.005. PMID: 29221768
Cardiovascular Abnormalities in Carbon Monoxide Poisoning.
Garg J, Krishnamoorthy P, Palaniswamy C, Khera S, Ahmad H, Jain D, Aronow WS, Frishman WH
Am J Ther 2018 May/Jun;25(3):e339-e348. doi: 10.1097/MJT.0000000000000016. PMID: 24518173
Intracranial hemorrhage.
Naidech AM
Am J Respir Crit Care Med 2011 Nov 1;184(9):998-1006. doi: 10.1164/rccm.201103-0475CI. PMID: 22167847Free PMC Article
Neurogenic stunned myocardium.
Nguyen H, Zaroff JG
Curr Neurol Neurosci Rep 2009 Nov;9(6):486-91. doi: 10.1007/s11910-009-0071-0. PMID: 19818236
Myocardial hibernation.
Heusch G, Schulz R
Ital Heart J 2002 May;3(5):282-4. PMID: 12066558

Therapy

Extracorporeal Membrane Oxygenation for Hemodynamic Support.
Straube T, Cheifetz IM, Jackson KW
Clin Perinatol 2020 Sep;47(3):671-684. Epub 2020 May 26 doi: 10.1016/j.clp.2020.05.016. PMID: 32713457
Taxonomy of segmental myocardial systolic dysfunction.
McDiarmid AK, Pellicori P, Cleland JG, Plein S
Eur Heart J 2017 Apr 1;38(13):942-954. doi: 10.1093/eurheartj/ehw140. PMID: 27147609Free PMC Article
Hemodialysis-Induced Myocardial Stunning: A Review.
Brown M, Burrows L, Pruett T, Burrows T
Nephrol Nurs J 2015 Jan-Feb;42(1):59-66; quiz 67. PMID: 26290919
Catecholamine-induced cardiomyopathy.
Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM
Endocr Pract 2008 Dec;14(9):1137-49. doi: 10.4158/EP.14.9.1137. PMID: 19158054
Myocardial bridging.
Alegria JR, Herrmann J, Holmes DR Jr, Lerman A, Rihal CS
Eur Heart J 2005 Jun;26(12):1159-68. Epub 2005 Mar 11 doi: 10.1093/eurheartj/ehi203. PMID: 15764618

Prognosis

From Neurocardiology to Stroke-Heart Syndrome.
Nistor IR, Gherasim L
Rom J Intern Med 2023 Dec 1;61(4):177-185. Epub 2023 Aug 4 doi: 10.2478/rjim-2023-0020. PMID: 37540842
Myocardial stunning and hibernation revisited.
Heusch G
Nat Rev Cardiol 2021 Jul;18(7):522-536. Epub 2021 Feb 2 doi: 10.1038/s41569-021-00506-7. PMID: 33531698
Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Intracranial hemorrhage.
Naidech AM
Am J Respir Crit Care Med 2011 Nov 1;184(9):998-1006. doi: 10.1164/rccm.201103-0475CI. PMID: 22167847Free PMC Article
Takotsubo disease.
Nepal M
JNMA J Nepal Med Assoc 2007 Jan-Mar;46(165):44-8. PMID: 17721563

Clinical prediction guides

Myocardial stunning and hibernation revisited.
Heusch G
Nat Rev Cardiol 2021 Jul;18(7):522-536. Epub 2021 Feb 2 doi: 10.1038/s41569-021-00506-7. PMID: 33531698
Exploring the Pathophysiology of Takotsubo Cardiomyopathy.
Chen W, Dilsizian V
Curr Cardiol Rep 2017 Jun;19(6):53. doi: 10.1007/s11886-017-0865-7. PMID: 28439851
Intracranial hemorrhage.
Naidech AM
Am J Respir Crit Care Med 2011 Nov 1;184(9):998-1006. doi: 10.1164/rccm.201103-0475CI. PMID: 22167847Free PMC Article
Neurogenic stunned myocardium.
Nguyen H, Zaroff JG
Curr Neurol Neurosci Rep 2009 Nov;9(6):486-91. doi: 10.1007/s11910-009-0071-0. PMID: 19818236
Myocardial hibernation.
Heusch G, Schulz R
Ital Heart J 2002 May;3(5):282-4. PMID: 12066558

Recent systematic reviews

Clinical features, complications, and outcomes of exogenous and endogenous catecholamine-triggered Takotsubo syndrome: A systematic review and meta-analysis of 156 published cases.
Y-Hassan S, Falhammar H
Clin Cardiol 2020 May;43(5):459-467. Epub 2020 Mar 3 doi: 10.1002/clc.23352. PMID: 32125009Free PMC Article
The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations.
Valencia-Sanchez C, Goodman BP, Carter JL, Wingerchuk DM
Mult Scler 2019 May;25(6):758-765. Epub 2019 Jan 18 doi: 10.1177/1352458518823482. PMID: 30657008
Plasma Epinephrine Level and its Causal Link to Takotsubo Syndrome Revisited: Critical Review with a Diverse Conclusion.
Y-Hassan S
Cardiovasc Revasc Med 2019 Oct;20(10):907-914. Epub 2018 Nov 7 doi: 10.1016/j.carrev.2018.10.026. PMID: 30446399
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials.
Romero J, Kahan J, Kelesidis I, Makani H, Wever-Pinzon O, Medina H, Garcia MJ
Eur Heart J Cardiovasc Imaging 2013 Nov;14(11):1080-91. Epub 2013 Apr 10 doi: 10.1093/ehjci/jet040. PMID: 23575990
CMR imaging assessing viability in patients with chronic ventricular dysfunction due to coronary artery disease: a meta-analysis of prospective trials.
Romero J, Xue X, Gonzalez W, Garcia MJ
JACC Cardiovasc Imaging 2012 May;5(5):494-508. doi: 10.1016/j.jcmg.2012.02.009. PMID: 22595157

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