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Anaplastic large cell lymphoma

MedGen UID:
61533
Concept ID:
C0206180
Neoplastic Process
Synonyms: Anaplastic Large Cell Lymphoma; Anaplastic Large-Cell Lymphoma; Anaplastic Large-Cell Lymphomas; CD30 Positive Anaplastic Large Cell Lymphoma; CD30+ Anaplastic Large Cell Lymphoma; CD30+ Anaplastic Large-Cell Lymphoma; CD30-Positive Anaplastic Large-Cell Lymphoma; Ki 1 Lymphoma; Ki-1 Lymphoma; Ki-1 Lymphomas; Large-Cell Lymphoma, Anaplastic; Large-Cell Lymphomas, Anaplastic; Lymphoma, Anaplastic Large-Cell; Lymphoma, Ki-1; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Large-Cell, Ki-1; Lymphomas, Anaplastic Large-Cell; Lymphomas, Ki-1; Systemic Anaplastic Large Cell Lymphoma; Systemic Anaplastic Large-Cell Lymphoma
SNOMED CT: Anaplastic large cell lymphoma, CD30+ (53237008); Anaplastic large cell lymphoma, T cell and Null cell type (53237008); Large cell anaplastic lymphoma T cell and Null cell type (702785000); Large cell (Ki-1 positive) lymphoma (702785000); Large cell (Ki-1 positive) lymphoma (53237008); Anaplastic large cell lymphoma CD30 positive (53237008); Anaplastic large cell lymphoma CD30 positive (702785000); Anaplastic large cell lymphoma (ALCL) CD30+ (53237008)
 
HPO: HP:0012193
Monarch Initiative: MONDO:0020325

Definition

A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic large cell lymphoma

Professional guidelines

PubMed

Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216

Recent clinical studies

Etiology

Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article

Diagnosis

Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Chung EM, Pavio M
Radiol Clin North Am 2016 Jul;54(4):727-46. doi: 10.1016/j.rcl.2016.03.004. PMID: 27265605
Minoo P, Wang HY
Int J Clin Exp Pathol 2012;5(5):397-410. Epub 2012 May 23 PMID: 22808292Free PMC Article
Inghirami G, Pileri SA; European T-Cell Lymphoma Study Group
Semin Diagn Pathol 2011 Aug;28(3):190-201. doi: 10.1053/j.semdp.2011.03.002. PMID: 21850985

Therapy

Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Menne T, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Zinzani PL, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Illidge T
Ann Oncol 2022 Mar;33(3):288-298. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.002. PMID: 34921960Free PMC Article
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Horwitz S, O'Connor OA, Pro B, Illidge T, Fanale M, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Lennard A, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Iyer S, Zinzani PL, Hua Z, Little M, Rao S, Woolery J, Manley T, Trümper L; ECHELON-2 Study Group
Lancet 2019 Jan 19;393(10168):229-240. Epub 2018 Dec 4 doi: 10.1016/S0140-6736(18)32984-2. PMID: 30522922Free PMC Article
Deng C, Pan B, O'Connor OA
Clin Cancer Res 2013 Jan 1;19(1):22-7. Epub 2012 Nov 15 doi: 10.1158/1078-0432.CCR-12-0290. PMID: 23155186
van de Donk NW, Dhimolea E
MAbs 2012 Jul-Aug;4(4):458-65. Epub 2012 Jul 1 doi: 10.4161/mabs.20230. PMID: 22684302Free PMC Article

Prognosis

Lowe EJ, Reilly AF, Lim MS, Gross TG, Saguilig L, Barkauskas DA, Wu R, Alexander S, Bollard CM
Blood 2021 Jul 1;137(26):3595-3603. doi: 10.1182/blood.2020009806. PMID: 33684925Free PMC Article
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Nikolaenko L, Zain J, Rosen ST, Querfeld C
Cancer Treat Res 2019;176:249-268. doi: 10.1007/978-3-319-99716-2_12. PMID: 30596222
Kricheldorff J, Fallenberg EM, Solbach C, Gerber-Schäfer C, Rancsó C, Fritschen UV
Dtsch Arztebl Int 2018 Sep 21;115(38):628-635. doi: 10.3238/arztebl.2018.0628. PMID: 30373708Free PMC Article

Clinical prediction guides

Nakashima M, Uchimaru K
Int J Mol Sci 2023 May 13;24(10) doi: 10.3390/ijms24108731. PMID: 37240076Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Martin JM, Wu H, Barta SK
Chin Clin Oncol 2019 Feb;8(1):4. Epub 2018 Oct 11 doi: 10.21037/cco.2018.09.06. PMID: 30525751
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Recent systematic reviews

Padhi S, Panigrahi MK, Mohapatra S, Mishra P, Patra S, Sable MN, Thakur B, Nayak M, Panigrahi A
J Cancer Res Ther 2021 Oct-Dec;17(6):1297-1306. doi: 10.4103/jcrt.JCRT_1089_19. PMID: 34916357
DeCoster RC, Lynch EB, Bonaroti AR, Webster JM, Butterfield TA, Evers BM, Vasconez HC, Clemens MW
Ann Surg 2021 Mar 1;273(3):449-458. doi: 10.1097/SLA.0000000000004365. PMID: 33234792
Leberfinger AN, Behar BJ, Williams NC, Rakszawski KL, Potochny JD, Mackay DR, Ravnic DJ
JAMA Surg 2017 Dec 1;152(12):1161-1168. doi: 10.1001/jamasurg.2017.4026. PMID: 29049466
Gidengil CA, Predmore Z, Mattke S, van Busum K, Kim B
Plast Reconstr Surg 2015 Mar;135(3):713-720. doi: 10.1097/PRS.0000000000001037. PMID: 25490539
Kim B, Roth C, Chung KC, Young VL, van Busum K, Schnyer C, Mattke S
Plast Reconstr Surg 2011 Jun;127(6):2141-2150. doi: 10.1097/PRS.0b013e3182172418. PMID: 21358562

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