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Embryonal carcinoma

MedGen UID:
61653
Concept ID:
C0206659
Neoplastic Process
Synonyms: Carcinoma, Embryonal; Carcinomas, Embryonal; Embryonal Carcinoma; Embryonal Carcinomas
SNOMED CT: Embryonal carcinoma (1156454002); Embryonal carcinoma (28047004); Embryonal adenocarcinoma (28047004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005440
Orphanet: ORPHA180226

Definition

A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum). [from NCI]

Professional guidelines

PubMed

Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Kyritsis AP
J Neurooncol 2010 Jan;96(2):143-9. Epub 2009 Jul 9 doi: 10.1007/s11060-009-9951-z. PMID: 19588227
Heidenreich A, Srivastava S, Moul JW, Hofmann R
Eur Urol 2000 Feb;37(2):121-35. doi: 10.1159/000020128. PMID: 10705188

Recent clinical studies

Etiology

Ramalingam P
Semin Diagn Pathol 2023 Jan;40(1):22-36. Epub 2022 Jul 29 doi: 10.1053/j.semdp.2022.07.004. PMID: 36088223
Dhillon P, Watson CJ
FEBS J 2022 Jan;289(1):9-16. Epub 2021 Jul 12 doi: 10.1111/febs.16071. PMID: 34251738
Yeh CY, Huang WH, Chen HC, Meir YJ
Cells 2021 Dec 16;10(12) doi: 10.3390/cells10123558. PMID: 34944066Free PMC Article
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Oliver RT
Curr Opin Oncol 1999 May;11(3):236-41. doi: 10.1097/00001622-199905000-00017. PMID: 10328600

Diagnosis

Ramalingam P
Semin Diagn Pathol 2023 Jan;40(1):22-36. Epub 2022 Jul 29 doi: 10.1053/j.semdp.2022.07.004. PMID: 36088223
Iczkowski KA
Semin Diagn Pathol 2023 Jan;40(1):2-21. Epub 2022 Jul 7 doi: 10.1053/j.semdp.2022.07.001. PMID: 35840444
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257

Therapy

Moreira-Meyer A, Bautista-Herrera D, Hernández-González M, Navarro-Reynoso F, Cicero-Sabido R, Núñez-Pérez-Redondo C
J Bronchology Interv Pulmonol 2017 Apr;24(2):148-152. doi: 10.1097/LBR.0000000000000315. PMID: 28323728
Dai LC
World J Gastroenterol 2009 Jan 28;15(4):412-6. doi: 10.3748/wjg.15.412. PMID: 19152444Free PMC Article
Fan X, Eberhart CG
J Clin Oncol 2008 Jun 10;26(17):2821-7. doi: 10.1200/JCO.2007.15.2264. PMID: 18539960Free PMC Article
Heidenreich A, Srivastava S, Moul JW, Hofmann R
Eur Urol 2000 Feb;37(2):121-35. doi: 10.1159/000020128. PMID: 10705188
Oliver RT
Curr Opin Oncol 1999 May;11(3):236-41. doi: 10.1097/00001622-199905000-00017. PMID: 10328600

Prognosis

Reynolds JP, Liu S
Semin Diagn Pathol 2020 Jul;37(4):174-178. Epub 2020 May 13 doi: 10.1053/j.semdp.2020.04.008. PMID: 32444243
Batool A, Chen SR, Liu YX
J Proteome Res 2019 Apr 5;18(4):1819-1826. Epub 2019 Mar 12 doi: 10.1021/acs.jproteome.9b00007. PMID: 30835130
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Murray MJ, Huddart RA, Coleman N
Nat Rev Urol 2016 Dec;13(12):715-725. Epub 2016 Oct 18 doi: 10.1038/nrurol.2016.170. PMID: 27754472
Kyritsis AP
J Neurooncol 2010 Jan;96(2):143-9. Epub 2009 Jul 9 doi: 10.1007/s11060-009-9951-z. PMID: 19588227

Clinical prediction guides

Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Francis F, Zhou M
Methods Mol Biol 2021;2195:13-29. doi: 10.1007/978-1-0716-0860-9_2. PMID: 32852754
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Handa K, Hakomori SI
Glycoconj J 2017 Dec;34(6):693-699. Epub 2016 Jun 18 doi: 10.1007/s10719-016-9684-0. PMID: 27318475
Silván U, Díez-Torre A, Arluzea J, Andrade R, Silió M, Aréchaga J
Differentiation 2009 Sep-Oct;78(2-3):159-68. Epub 2009 Jul 14 doi: 10.1016/j.diff.2009.06.002. PMID: 19604622

Recent systematic reviews

Zengerling F, Beyersdorff D, Busch J, Heinzelbecker J, Pfister D, Ruf C, Winter C, Albers P, Kliesch S, Schmidt S
World J Urol 2022 Dec;40(12):2879-2887. Epub 2022 Jul 29 doi: 10.1007/s00345-022-04063-7. PMID: 35906286Free PMC Article
Blok JM, Pluim I, Daugaard G, Wagner T, Jóźwiak K, Wilthagen EA, Looijenga LHJ, Meijer RP, Bosch JLHR, Horenblas S
BJU Int 2020 Mar;125(3):355-368. Epub 2020 Jan 8 doi: 10.1111/bju.14967. PMID: 31797520Free PMC Article
Lima L, de Melo TCT, Marques D, de Araújo JNG, Leite ISF, Alves CX, Genre J, Silbiger VN
BMC Cancer 2019 Aug 30;19(1):866. doi: 10.1186/s12885-019-6081-7. PMID: 31470825Free PMC Article
Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI
Int J Androl 2011 Aug;34(4 Pt 2):e133-50; discussion e150-1. Epub 2011 Jun 9 doi: 10.1111/j.1365-2605.2011.01169.x. PMID: 21651573
Vergouwe Y, Steyerberg EW, Eijkemans MJ, Albers P, Habbema JD
J Clin Oncol 2003 Nov 15;21(22):4092-9. Epub 2003 Oct 14 doi: 10.1200/JCO.2003.01.094. PMID: 14559885

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