U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adenomatous Polyp

MedGen UID:
61657
•Concept ID:
C0206677
•
Neoplastic Process
Synonyms: Adenomatous Polyps; Polyp, Adenomatous; Polyps, Adenomatous
SNOMED CT: Adenomatous polyp (82375006); Polypoid adenoma (82375006)

Definition

A polypoid neoplasm arising from the glandular epithelium of the gastrointestinal tract. There is proliferation of glandular cells which may display dysplastic cytologic features. Representative examples include the adenomatous polyps of the colon and rectum. [from NCI]

Professional guidelines

PubMed

The Differential Diagnosis of Colorectal Polyps Using Colon Capsule Endoscopy.
Nakazawa K, Nouda S, Kakimoto K, Kinoshita N, Tanaka Y, Tawa H, Koshiba R, Naka Y, Hirata Y, Ota K, Kawakami K, Takeuchi T, Inoue T, Miyazaki T, Sanomura M, Nakamura S, Saito Y, Higuchi K
Intern Med 2021 Jun 15;60(12):1805-1812. Epub 2021 Jan 15 doi: 10.2169/internalmedicine.6446-20. PMID: 33456043Free PMC Article
Current status and future perspectives of endoscopic diagnosis and treatment of diminutive colorectal polyps.
Matsuda T, Kawano H, Hisabe T, Ikematsu H, Kobayashi N, Mizuno K, Oka S, Takeuchi Y, Tamai N, Uraoka T, Hewett D, Chiu HM
Dig Endosc 2014 Apr;26 Suppl 2:104-8. doi: 10.1111/den.12281. PMID: 24750158
Colorectal cancer update. Prevention, screening, treatment, and surveillance for high-risk groups.
Bond JH
Med Clin North Am 2000 Sep;84(5):1163-82, viii. doi: 10.1016/s0025-7125(05)70281-9. PMID: 11026923

Recent clinical studies

Etiology

Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Koshman YE, Bielinski AL, Bird BM, Green JR, Kowalkowski KL, Lai-Zhang J, Mahalingaiah PK, Sawicki JW, Talaty NN, Wilsey AS, Zafiratos MT, Van Vleet TR
J Pharmacol Toxicol Methods 2023 Mar-Apr;120:107251. Epub 2023 Feb 13 doi: 10.1016/j.vascn.2023.107251. PMID: 36792039
Contrast-enhanced ultrasound to assess gallbladder polyps.
Zhu L, Han P, Lee R, Jiang B, Jiao Z, Li N, Tang W, Fei X
Clin Imaging 2021 Oct;78:8-13. Epub 2021 Feb 11 doi: 10.1016/j.clinimag.2021.02.015. PMID: 33706069
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Pharmacologically pertinent period of effect (PPPE).
Suissa M, LeLorier J
Pharmacoepidemiol Drug Saf 2020 Jan;29 Suppl 1(Suppl 1):61-67. Epub 2019 Jan 9 doi: 10.1002/pds.4714. PMID: 30628139Free PMC Article
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110

Diagnosis

Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps.
Feng Z, Lin H, Yang X, Cao S, Gu X, Zhang Z, Deng W
Cancer Control 2023 Jan-Dec;30:10732748231180745. doi: 10.1177/10732748231180745. PMID: 37421141Free PMC Article
Contrast-enhanced ultrasound to assess gallbladder polyps.
Zhu L, Han P, Lee R, Jiang B, Jiao Z, Li N, Tang W, Fei X
Clin Imaging 2021 Oct;78:8-13. Epub 2021 Feb 11 doi: 10.1016/j.clinimag.2021.02.015. PMID: 33706069
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
The pathology of bowel cancer screening.
Loughrey MB, Shepherd NA
Histopathology 2015 Jan;66(1):66-77. doi: 10.1111/his.12530. PMID: 25123305
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110

Therapy

Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas.
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T, Oppezzi M, Gandini S, Bonanni B, DeCensi A
Nutrients 2023 Sep 7;15(18) doi: 10.3390/nu15183894. PMID: 37764678Free PMC Article
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Koshman YE, Bielinski AL, Bird BM, Green JR, Kowalkowski KL, Lai-Zhang J, Mahalingaiah PK, Sawicki JW, Talaty NN, Wilsey AS, Zafiratos MT, Van Vleet TR
J Pharmacol Toxicol Methods 2023 Mar-Apr;120:107251. Epub 2023 Feb 13 doi: 10.1016/j.vascn.2023.107251. PMID: 36792039
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Colon cancer: preventive agents and the present status of chemoprevention.
Half E, Arber N
Expert Opin Pharmacother 2009 Feb;10(2):211-9. doi: 10.1517/14656560802560153. PMID: 19236194
Adenomatous polyp recurrence and physical activity in the Polyp Prevention Trial (United States).
Colbert LH, Lanza E, Ballard-Barbash R, Slattery ML, Tangrea JA, Caan B, Paskett ED, Iber F, Kikendall W, Lance P, Shike M, Schoen RE, Daston C, Schatzkin A; Polyp Prevention Trial Study Group
Cancer Causes Control 2002 Jun;13(5):445-53. doi: 10.1023/a:1015736524447. PMID: 12146849

Prognosis

Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Koshman YE, Bielinski AL, Bird BM, Green JR, Kowalkowski KL, Lai-Zhang J, Mahalingaiah PK, Sawicki JW, Talaty NN, Wilsey AS, Zafiratos MT, Van Vleet TR
J Pharmacol Toxicol Methods 2023 Mar-Apr;120:107251. Epub 2023 Feb 13 doi: 10.1016/j.vascn.2023.107251. PMID: 36792039
Relationship Between Lesions in Adenomatous Polyp-Dysplasia-Colorectal Cancer Sequence and Neutrophil-to-Lymphocyte Ratio.
Uçmak F, Tuncel ET
Med Sci Monit 2016 Nov 24;22:4536-4541. doi: 10.12659/msm.898879. PMID: 27881836Free PMC Article
Management of Diminutive Colon Polyps Based on Endoluminal Imaging.
Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J
Clin Gastroenterol Hepatol 2015 Nov;13(11):1860-6; quiz e168-9. Epub 2015 Jul 17 doi: 10.1016/j.cgh.2015.07.011. PMID: 26192139
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas.
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T, Oppezzi M, Gandini S, Bonanni B, DeCensi A
Nutrients 2023 Sep 7;15(18) doi: 10.3390/nu15183894. PMID: 37764678Free PMC Article
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Koshman YE, Bielinski AL, Bird BM, Green JR, Kowalkowski KL, Lai-Zhang J, Mahalingaiah PK, Sawicki JW, Talaty NN, Wilsey AS, Zafiratos MT, Van Vleet TR
J Pharmacol Toxicol Methods 2023 Mar-Apr;120:107251. Epub 2023 Feb 13 doi: 10.1016/j.vascn.2023.107251. PMID: 36792039
From Mixed Hyperplastic/Adenomatous Polyp to Sessile Serrated Lesion: A Long and Winding Road for Long and Winding Crypts.
Booth AL, Taggart MW, Ono Y, Gonzalez RS
Arch Pathol Lab Med 2021 Oct 1;145(10):1289-1296. doi: 10.5858/arpa.2020-0591-RA. PMID: 33351878
Pharmacologically pertinent period of effect (PPPE).
Suissa M, LeLorier J
Pharmacoepidemiol Drug Saf 2020 Jan;29 Suppl 1(Suppl 1):61-67. Epub 2019 Jan 9 doi: 10.1002/pds.4714. PMID: 30628139Free PMC Article
Management of Diminutive Colon Polyps Based on Endoluminal Imaging.
Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J
Clin Gastroenterol Hepatol 2015 Nov;13(11):1860-6; quiz e168-9. Epub 2015 Jul 17 doi: 10.1016/j.cgh.2015.07.011. PMID: 26192139

Recent systematic reviews

The incremental yield of adenoma detection with I-Scan versus high-definition white light colonoscopy-a systematic review and meta-analysis of randomized studies.
Hussain MR, Ali FS, Tangri A, Rashtak S, Joseph-Talreja M, Mutha PR, Wadhwa V, Guha S, DaVee RT, Thosani N
Int J Colorectal Dis 2023 Sep 27;38(1):240. doi: 10.1007/s00384-023-04533-3. PMID: 37755588
Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas.
Yao Y, Suo T, Andersson R, Cao Y, Wang C, Lu J, Chui E
Cochrane Database Syst Rev 2017 Jan 8;1(1):CD003430. doi: 10.1002/14651858.CD003430.pub2. PMID: 28064440Free PMC Article
ASGE Technology Committee systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting real-time endoscopic assessment of the histology of diminutive colorectal polyps.
ASGE Technology Committee, Abu Dayyeh BK, Thosani N, Konda V, Wallace MB, Rex DK, Chauhan SS, Hwang JH, Komanduri S, Manfredi M, Maple JT, Murad FM, Siddiqui UD, Banerjee S
Gastrointest Endosc 2015 Mar;81(3):502.e1-502.e16. Epub 2015 Jan 16 doi: 10.1016/j.gie.2014.12.022. PMID: 25597420

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...