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Mucoepidermoid carcinoma

MedGen UID:
61662
•Concept ID:
C0206694
•
Neoplastic Process
Synonyms: Carcinoma, Mucoepidermoid; Carcinomas, Mucoepidermoid; Mucoepidermoid Carcinoma; Mucoepidermoid Carcinomas
SNOMED CT: Mucoepidermoid carcinoma (4079000)
 
Monarch Initiative: MONDO:0003036

Definition

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucoepidermoid carcinoma

Professional guidelines

PubMed

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644

Recent clinical studies

Etiology

A molecular guide to systemic therapy in salivary gland carcinoma.
Weaver AN, Lakritz S, Mandair D, Ulanja MB, Bowles DW
Head Neck 2023 May;45(5):1315-1326. Epub 2023 Mar 1 doi: 10.1002/hed.27307. PMID: 36859797
Salivary Gland Cancers.
Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Diagnosis

Mucoepidermoid Carcinoma.
Whaley RD, Gupta S, Erickson LA
Mayo Clin Proc 2023 Sep;98(9):1427-1428. doi: 10.1016/j.mayocp.2023.07.018. PMID: 37661153
Mucoepidermoid carcinoma. An update and review of the literature.
Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644
Salivary mucoepidermoid carcinoma revisited.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Rinaldo A, Strojan P, Haigentz M Jr, Mendenhall WM, Takes RP, Vander Poorten V, Ferlito A
Eur Arch Otorhinolaryngol 2015 Apr;272(4):799-819. Epub 2014 Apr 26 doi: 10.1007/s00405-014-3053-z. PMID: 24771140
Mucoepidermoid carcinoma.
Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946Free PMC Article

Therapy

Role of fine-needle aspiration in post liver transplant patients: A clinical/cytological review.
Rohra P, Mir F, Lin DM, Furlan K, Javidiparsijani S, Lucero D, Gattuso P
Diagn Cytopathol 2019 May;47(5):434-438. Epub 2018 Dec 28 doi: 10.1002/dc.24133. PMID: 30593732
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Histopathological Assessment for Esophageal Adenocarcinoma.
Lam AK
Methods Mol Biol 2018;1756:67-76. doi: 10.1007/978-1-4939-7734-5_6. PMID: 29600360
Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Central mucoepidermoid carcinoma: An up-to-date analysis of 147 cases and review of prognostic factors.
de Souza LL, Pontes FSC, Pontes HAR, Neto NC, de Carvalho WRS, Guimarães DM
J Craniomaxillofac Surg 2018 Jan;46(1):162-167. Epub 2017 Oct 31 doi: 10.1016/j.jcms.2017.10.020. PMID: 29198377
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197
Salivary mucoepidermoid carcinoma: revisited.
Luna MA
Adv Anat Pathol 2006 Nov;13(6):293-307. doi: 10.1097/01.pap.0000213058.74509.d3. PMID: 17075295

Clinical prediction guides

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment.
Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788Free PMC Article
Clinical predictors of special type of esophageal cancer.
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis.
Keerthika R, Devi A, Kamboj M, Sivakumar N, Vijayakumar G, Narwal A, Girdhar A
Head Neck Pathol 2023 Mar;17(1):233-245. Epub 2022 Nov 10 doi: 10.1007/s12105-022-01494-x. PMID: 36357765Free PMC Article
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977

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