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Mucoepidermoid carcinoma

MedGen UID:
61662
•Concept ID:
C0206694
•
Neoplastic Process
Synonyms: Carcinoma, Mucoepidermoid; Carcinomas, Mucoepidermoid; Mucoepidermoid Carcinoma; Mucoepidermoid Carcinomas
SNOMED CT: Mucoepidermoid carcinoma (4079000)
 
Monarch Initiative: MONDO:0003036

Definition

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucoepidermoid carcinoma

Professional guidelines

PubMed

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.
Chan SA, Van Abel KM, Lewis JE, Routman DM, Garcia JJ, Karp EE, Price DL, Janus JR, Kasperbauer JL, Moore EJ
Head Neck 2021 Sep;43(9):2663-2671. Epub 2021 May 1 doi: 10.1002/hed.26735. PMID: 33931913
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644

Recent clinical studies

Etiology

Salivary mucoepidermoid carcinoma: histological variants, grading systems, CRTC1/3-MAML2 fusions, and clinicopathological features.
Nakano S, Okumura Y, Murase T, Nagao T, Kusafuka K, Urano M, Yamamoto H, Kano S, Tsukahara K, Okami K, Kawakita D, Nagao T, Hanai N, Iwai H, Kawata R, Tada Y, Nibu KI, Inagaki H
Histopathology 2022 Mar;80(4):729-735. Epub 2021 Dec 14 doi: 10.1111/his.14586. PMID: 34657306
Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.
Chan SA, Van Abel KM, Lewis JE, Routman DM, Garcia JJ, Karp EE, Price DL, Janus JR, Kasperbauer JL, Moore EJ
Head Neck 2021 Sep;43(9):2663-2671. Epub 2021 May 1 doi: 10.1002/hed.26735. PMID: 33931913
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Mucoepidermoid carcinoma of hard palate.
Gill S, Mohan A, Aggarwal S, Varshney A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):397-398. doi: 10.4103/IJPM.IJPM_617_17. PMID: 30004063

Diagnosis

Mucoepidermoid Carcinoma.
Whaley RD, Gupta S, Erickson LA
Mayo Clin Proc 2023 Sep;98(9):1427-1428. doi: 10.1016/j.mayocp.2023.07.018. PMID: 37661153
Mucoepidermoid carcinoma. An update and review of the literature.
Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266
Mucoepidermoid carcinoma of hard palate.
Gill S, Mohan A, Aggarwal S, Varshney A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):397-398. doi: 10.4103/IJPM.IJPM_617_17. PMID: 30004063
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644
Mucoepidermoid carcinoma.
Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946Free PMC Article

Therapy

Role of fine-needle aspiration in post liver transplant patients: A clinical/cytological review.
Rohra P, Mir F, Lin DM, Furlan K, Javidiparsijani S, Lucero D, Gattuso P
Diagn Cytopathol 2019 May;47(5):434-438. Epub 2018 Dec 28 doi: 10.1002/dc.24133. PMID: 30593732
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Histopathological Assessment for Esophageal Adenocarcinoma.
Lam AK
Methods Mol Biol 2018;1756:67-76. doi: 10.1007/978-1-4939-7734-5_6. PMID: 29600360
Characteristics and outcome of radiation and chemotherapy-related mucoepidermoid carcinoma of the salivary glands.
Verma J, Teh BS, Paulino AC
Pediatr Blood Cancer 2011 Dec 15;57(7):1137-41. Epub 2011 Jan 28 doi: 10.1002/pbc.22978. PMID: 21280198
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Minor salivary gland tumors of the head and neck-Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type.
Hay AJ, Migliacci J, Karassawa Zanoni D, McGill M, Patel S, Ganly I
Cancer 2019 Oct 1;125(19):3354-3366. Epub 2019 Jun 7 doi: 10.1002/cncr.32208. PMID: 31174233Free PMC Article
Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Central mucoepidermoid carcinoma: An up-to-date analysis of 147 cases and review of prognostic factors.
de Souza LL, Pontes FSC, Pontes HAR, Neto NC, de Carvalho WRS, Guimarães DM
J Craniomaxillofac Surg 2018 Jan;46(1):162-167. Epub 2017 Oct 31 doi: 10.1016/j.jcms.2017.10.020. PMID: 29198377
Bronchial adenoma.
Miller RE, Hopeman AR
Ann Thorac Surg 1975 Apr;19(4):378-85. doi: 10.1016/s0003-4975(10)64038-6. PMID: 164842

Clinical prediction guides

Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma.
Gyulai M, Harko T, Fabian K, Karsko L, Agocs L, Szigeti B, Fillinger J, Szallasi Z, Pipek O, Moldvay J
Pathol Oncol Res 2023;29:1611328. Epub 2023 Aug 9 doi: 10.3389/pore.2023.1611328. PMID: 37621953Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Minor salivary gland tumors of the head and neck-Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type.
Hay AJ, Migliacci J, Karassawa Zanoni D, McGill M, Patel S, Ganly I
Cancer 2019 Oct 1;125(19):3354-3366. Epub 2019 Jun 7 doi: 10.1002/cncr.32208. PMID: 31174233Free PMC Article
Intraosseous mucoepidermoid carcinoma: Outcome review.
Merna C, Kita A, Wester J, Diaz-Aguilar D, Goldstein JD, Palma Diaz F, Blackwell K, St John MA
Laryngoscope 2018 May;128(5):1083-1092. Epub 2017 Aug 22 doi: 10.1002/lary.26832. PMID: 28833169
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis.
Keerthika R, Devi A, Kamboj M, Sivakumar N, Vijayakumar G, Narwal A, Girdhar A
Head Neck Pathol 2023 Mar;17(1):233-245. Epub 2022 Nov 10 doi: 10.1007/s12105-022-01494-x. PMID: 36357765Free PMC Article
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977

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