U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Signet ring cell carcinoma

MedGen UID:
61663
•Concept ID:
C0206696
•
Neoplastic Process
Synonym: Signet cell adenocarcinoma
SNOMED CT: Signet ring carcinoma (87737001); Signet ring cell carcinoma (87737001); Signet ring cell adenocarcinoma (87737001)
 
Monarch Initiative: MONDO:0005092

Definition

A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland. [from NCI]

Professional guidelines

PubMed

Retrospective Analysis of Diagnosis and Treatment of Gastric Cancer at Huzhou Central Hospital.
Xiang Y, Yao L
Altern Ther Health Med 2023 Nov;29(8):302-309. PMID: 37632952
Diagnosis and Management of Primary Prostatic Signet Ring Cell Carcinoma: Single-Center Experience.
Li P, Zhou Z, Bao M, Li J, Meng X, Liu B, Tang M
Am J Mens Health 2022 Mar-Apr;16(2):15579883221087839. doi: 10.1177/15579883221087839. PMID: 35315313Free PMC Article
Hereditary Diffuse Gastric Cancer: Approaches to Screening, Surveillance, and Treatment.
Pilonis ND, Tischkowitz M, Fitzgerald RC, di Pietro M
Annu Rev Med 2021 Jan 27;72:263-280. Epub 2020 Nov 20 doi: 10.1146/annurev-med-051019-103216. PMID: 33217247

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

Recent clinical studies

Etiology

Prognosis prediction in esophageal signet-ring-cell carcinoma: a competing risk analysis.
Chen C, Wang Z, Qin Y
BMC Gastroenterol 2023 May 23;23(1):178. doi: 10.1186/s12876-023-02818-z. PMID: 37221531Free PMC Article
Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.
Liu X, Huang L, Liu M, Wang Z
Medicina (Kaunas) 2022 Jun 21;58(7) doi: 10.3390/medicina58070836. PMID: 35888555Free PMC Article
Diagnosis and Management of Primary Prostatic Signet Ring Cell Carcinoma: Single-Center Experience.
Li P, Zhou Z, Bao M, Li J, Meng X, Liu B, Tang M
Am J Mens Health 2022 Mar-Apr;16(2):15579883221087839. doi: 10.1177/15579883221087839. PMID: 35315313Free PMC Article
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features.
Zhao W, Jia Y, Sun G, Yang H, Liu L, Qu X, Ding J, Yu H, Xu B, Zhao S, Xing L, Chai J
Nat Commun 2023 May 24;14(1):2985. doi: 10.1038/s41467-023-38426-4. PMID: 37225691Free PMC Article
Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Goblet cell adenocarcinoma of the appendix: an update and practical approach to diagnosis and grading.
Bell PD, Pai RK
Hum Pathol 2023 Feb;132:183-196. Epub 2022 Jun 9 doi: 10.1016/j.humpath.2022.06.002. PMID: 35691370
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Therapy

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.
Liu X, Huang L, Liu M, Wang Z
Medicina (Kaunas) 2022 Jun 21;58(7) doi: 10.3390/medicina58070836. PMID: 35888555Free PMC Article
Crohn's Disease Following Rituximab Treatment for Follicular Lymphoma in a Patient with Synchronous Gastric Signet Ring Cells Carcinoma: A Case Report and Literature Review.
Cavalcanti E, Armentano R, Lolli I
Cancer Res Treat 2020 Oct;52(4):1291-1295. Epub 2020 Jul 13 doi: 10.4143/crt.2020.406. PMID: 32683839Free PMC Article
Tailored treatment for signet ring cell gastric cancer.
Mengardo V, Treppiedi E, Bencivenga M, Dal Cero M, Giacopuzzi S
Updates Surg 2018 Jun;70(2):167-171. Epub 2018 Jun 9 doi: 10.1007/s13304-018-0550-4. PMID: 29948660
Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J
World J Gastroenterol 2015 Oct 28;21(40):11428-38. doi: 10.3748/wjg.v21.i40.11428. PMID: 26523107Free PMC Article

Prognosis

Does signet ring cell carcinoma component signify worse outcomes for patients with colorectal cancer?
Wang L, Hirano Y, Heng G, Ishii T, Kondo H, Hara K, Obara N, Asari M, Kato T, Yamaguchi S
Asian J Surg 2021 Jan;44(1):105-110. Epub 2020 Apr 12 doi: 10.1016/j.asjsur.2020.03.017. PMID: 32295719
Clinical Analysis of Primary Colorectal Signet-Ring Cell Carcinoma.
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Is signet-ring cell carcinoma a specific entity among gastric cancers?
Voron T, Messager M, Duhamel A, Lefevre J, Mabrut JY, Goere D, Meunier B, Brigand C, Hamy A, Glehen O, Mariette C, Paye F
Gastric Cancer 2016 Oct;19(4):1027-1040. Epub 2015 Nov 25 doi: 10.1007/s10120-015-0564-2. PMID: 26606931
Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J
World J Gastroenterol 2015 Oct 28;21(40):11428-38. doi: 10.3748/wjg.v21.i40.11428. PMID: 26523107Free PMC Article
Primary signet ring cell carcinoma of the colon and rectum.
Arifi S, Elmesbahi O, Amarti Riffi A
Bull Cancer 2015 Oct;102(10):880-8. Epub 2015 Sep 26 doi: 10.1016/j.bulcan.2015.07.005. PMID: 26412710

Clinical prediction guides

Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis.
Green BL, Gamble LA, Diggs LP, Nousome D, Patterson JC, Joughin BA, Gasmi B, Lux SC, Samaranayake SG, Miettinen M, Quezado M, Hernandez JM, Yaffe MB, Davis JL
Mol Cancer Res 2023 Dec 1;21(12):1356-1365. doi: 10.1158/1541-7786.MCR-23-0122. PMID: 37707375Free PMC Article
Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma.
Chen J, Liu K, Luo Y, Kang M, Wang J, Chen G, Qi J, Wu W, Wang B, Han Y, Shi L, Wang K, Han X, Ma X, Liu W, Ding Y, Wang L, Liang H, Wang L, Chen J
Gastroenterology 2023 Jul;165(1):88-103. Epub 2023 Mar 14 doi: 10.1053/j.gastro.2023.03.008. PMID: 36921674
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Recent systematic reviews

Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis.
Guo Y, Wang Q, Tian Q, Bo C, Li N, Zhang S, Li P
Comput Math Methods Med 2022;2022:3473445. Epub 2022 Aug 5 doi: 10.1155/2022/3473445. PMID: 36035278Free PMC Article
The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.
Liu X, Huang L, Liu M, Wang Z
Medicina (Kaunas) 2022 Jun 21;58(7) doi: 10.3390/medicina58070836. PMID: 35888555Free PMC Article
Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study.
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK
Oncologist 2022 Sep 2;27(9):751-759. doi: 10.1093/oncolo/oyac093. PMID: 35589098Free PMC Article
Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology: a meta-analysis.
Zhao X, Cai A, Xi H, Song Y, Wang Y, Li H, Li P, Chen L
ANZ J Surg 2017 Dec;87(12):981-986. Epub 2017 Jul 6 doi: 10.1111/ans.14089. PMID: 28681963

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...