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Klatskin tumor

MedGen UID:
61664
Concept ID:
C0206702
Neoplastic Process
Synonyms: Hilar Cholangiocarcinoma; Klatskin's tumor
SNOMED CT: Klatskin's tumor (6492006); Klatskin's tumor morphology (6492006); Klatskin tumor (253017000); Klatskin tumor (6492006); Klatskin's tumor (253017000); Hilar cholangiocarcinoma (253017000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0003345
Orphanet: ORPHA99978

Definition

Klatskin tumor is an extra-hepatic cholangiocarcinoma (CCA, see this term) arising in the junction of the main right or left hepatic ducts to form the common hepatic duct. [from ORDO]

Professional guidelines

PubMed

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M
Dig Endosc 2022 Sep;34(6):1147-1156. Epub 2022 Jun 2 doi: 10.1111/den.14317. PMID: 35377509
Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article

Recent clinical studies

Etiology

Nechita VI, Moiş E, Furcea L, Nechita MA, Graur F
Medicina (Kaunas) 2022 Dec 5;58(12) doi: 10.3390/medicina58121788. PMID: 36556990Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Mueller M, Breuer E, Mizuno T, Bartsch F, Ratti F, Benzing C, Ammar-Khodja N, Sugiura T, Takayashiki T, Hessheimer A, Kim HS, Ruzzenente A, Ahn KS, Wong T, Bednarsch J, D'Silva M, Koerkamp BG, Jeddou H, López-López V, de Ponthaud C, Yonkus JA, Ismail W, Nooijen LE, Hidalgo-Salinas C, Kontis E, Wagner KC, Gunasekaran G, Higuchi R, Gleisner A, Shwaartz C, Sapisochin G, Schulick RD, Yamamoto M, Noji T, Hirano S, Schwartz M, Oldhafer KJ, Prachalias A, Fusai GK, Erdmann JI, Line PD, Smoot RL, Soubrane O, Robles-Campos R, Boudjema K, Polak WG, Han HS, Neumann UP, Lo CM, Kang KJ, Guglielmi A, Park JS, Fondevila C, Ohtsuka M, Uesaka K, Adam R, Pratschke J, Aldrighetti L, De Oliveira ML, Gores GJ, Lang H, Nagino M, Clavien PA
Ann Surg 2021 Nov 1;274(5):780-788. doi: 10.1097/SLA.0000000000005103. PMID: 34334638
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Tsalis K, Parpoudi S, Kyziridis D, Ioannidis O, Savvala NA, Antoniou N, Symeonidis S, Konstantaras D, Mantzoros I, Pramateftakis MG, Kotidis E, Angelopoulos S
Rev Esp Enferm Dig 2019 Feb;111(2):121-128. doi: 10.17235/reed.2018.5749/2018. PMID: 30421957

Diagnosis

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M
Dig Endosc 2022 Sep;34(6):1147-1156. Epub 2022 Jun 2 doi: 10.1111/den.14317. PMID: 35377509
Khan AS, Dageforde LA
Surg Clin North Am 2019 Apr;99(2):315-335. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.12.004. PMID: 30846037
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article
Brown KM, Geller DA
Surg Clin North Am 2014 Apr;94(2):311-23. Epub 2014 Feb 4 doi: 10.1016/j.suc.2013.12.003. PMID: 24679423

Therapy

Mizuno T, Ebata T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Kamei Y, Nagino M
Ann Surg 2022 Feb 1;275(2):382-390. doi: 10.1097/SLA.0000000000004322. PMID: 32976284
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Chen Y, Xu Y, Zhang Y
Biosci Trends 2020 Jul 17;14(3):168-173. Epub 2020 May 9 doi: 10.5582/bst.2020.03010. PMID: 32389939
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article
Schmeding M, Neumann UP
Ann Transplant 2013 Jan 4;18:1-8. doi: 10.12659/AOT.883789. PMID: 23792495

Prognosis

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M
Dig Endosc 2022 Sep;34(6):1147-1156. Epub 2022 Jun 2 doi: 10.1111/den.14317. PMID: 35377509
Mueller M, Breuer E, Mizuno T, Bartsch F, Ratti F, Benzing C, Ammar-Khodja N, Sugiura T, Takayashiki T, Hessheimer A, Kim HS, Ruzzenente A, Ahn KS, Wong T, Bednarsch J, D'Silva M, Koerkamp BG, Jeddou H, López-López V, de Ponthaud C, Yonkus JA, Ismail W, Nooijen LE, Hidalgo-Salinas C, Kontis E, Wagner KC, Gunasekaran G, Higuchi R, Gleisner A, Shwaartz C, Sapisochin G, Schulick RD, Yamamoto M, Noji T, Hirano S, Schwartz M, Oldhafer KJ, Prachalias A, Fusai GK, Erdmann JI, Line PD, Smoot RL, Soubrane O, Robles-Campos R, Boudjema K, Polak WG, Han HS, Neumann UP, Lo CM, Kang KJ, Guglielmi A, Park JS, Fondevila C, Ohtsuka M, Uesaka K, Adam R, Pratschke J, Aldrighetti L, De Oliveira ML, Gores GJ, Lang H, Nagino M, Clavien PA
Ann Surg 2021 Nov 1;274(5):780-788. doi: 10.1097/SLA.0000000000005103. PMID: 34334638
Oliverius M, Havlůj L, Hajer J, Soumarová R, Hrudka J, Gürlich R
Cas Lek Cesk 2019 Spring;158(2):73-77. PMID: 31109167
Brown KM, Geller DA
Surg Clin North Am 2014 Apr;94(2):311-23. Epub 2014 Feb 4 doi: 10.1016/j.suc.2013.12.003. PMID: 24679423

Clinical prediction guides

Nechita VI, Moiş E, Furcea L, Nechita MA, Graur F
Medicina (Kaunas) 2022 Dec 5;58(12) doi: 10.3390/medicina58121788. PMID: 36556990Free PMC Article
Yoo J, Kim JH, Bae JS, Kang HJ
Abdom Radiol (NY) 2021 Sep;46(9):4159-4169. Epub 2021 Apr 30 doi: 10.1007/s00261-021-03101-z. PMID: 33929600
Zhang X, Liu H
Med Sci Monit 2019 Jun 17;25:4503-4512. doi: 10.12659/MSM.914987. PMID: 31204730Free PMC Article
Rizvi S, Eaton J, Yang JD, Chandrasekhara V, Gores GJ
Semin Liver Dis 2018 May;38(2):160-169. Epub 2018 Jun 5 doi: 10.1055/s-0038-1655775. PMID: 29871021Free PMC Article
Kimbrough CW, Cloyd JM, Pawlik TM
Expert Rev Anticancer Ther 2018 Jul;18(7):673-683. Epub 2018 May 11 doi: 10.1080/14737140.2018.1473039. PMID: 29726723

Recent systematic reviews

Cipriani F, Ratti F, Fiorentini G, Reineke R, Aldrighetti L
Updates Surg 2021 Apr;73(2):359-377. Epub 2021 Feb 22 doi: 10.1007/s13304-021-01006-6. PMID: 33615423
Rahnemai-Azar AA, Abbasi A, Tsilimigras DI, Weber SM, Pawlik TM
J Gastrointest Surg 2020 Sep;24(9):2143-2149. Epub 2020 May 14 doi: 10.1007/s11605-020-04639-x. PMID: 32410178
Tang Z, Yang Y, Meng W, Li X
Medicine (Baltimore) 2017 Oct;96(43):e8372. doi: 10.1097/MD.0000000000008372. PMID: 29069029Free PMC Article
Celotti A, Solaini L, Montori G, Coccolini F, Tognali D, Baiocchi G
Eur J Surg Oncol 2017 Sep;43(9):1628-1635. Epub 2017 Apr 18 doi: 10.1016/j.ejso.2017.04.001. PMID: 28477976
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465

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