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Spitz nevus

MedGen UID:
61671
•Concept ID:
C0206739
•
Neoplastic Process
Synonyms: Spitz naevus; Spitz nevi
SNOMED CT: Epithelioid and spindle cell nevus (88082008); Juvenile nevus (88082008); Juvenile melanoma (88082008); Spitz nevus (88082008); Pigmented spindle cell nevus of Reed (88082008); Juvenila nevus (88082008); Juvenila melanoma (88082008); Juvenile melanoma (254811006); Juvenile nevus (254811006); Spitz nevus (254811006); Spindle and epithelioid nevus (254811006); Epithelioid and spindle cell nevus (254811006)
 
Monarch Initiative: MONDO:0044793
OMIM®: 137550

Definition

A benign, acquired or congenital, usually single skin lesion. It can occur on any area of the body, but most commonly occurs on the face of children and the thighs of young females. It is characterized by a proliferation of large spindle, oval, or large epithelioid melanocytes in the dermal-epidermal junction. The melanocytic proliferation subsequently extends into the dermis. [from NCI]

Professional guidelines

PubMed

Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment.
Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A
Actas Dermosifiliogr (Engl Ed) 2020 Jan 2;111(1):20-25. Epub 2019 Nov 15 doi: 10.1016/j.ad.2019.02.010. PMID: 31739993
Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
Ritter A, Tronnier M, Vaske B, Mitteldorf C
Arch Dermatol Res 2018 May;310(4):329-342. Epub 2018 Feb 7 doi: 10.1007/s00403-018-1818-8. PMID: 29417221
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829

Recent clinical studies

Etiology

The Morpho-Molecular Landscape of Spitz Neoplasms.
Dal Pozzo CA, Cappellesso R
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084211. PMID: 35457030Free PMC Article
Atypical melanocytic lesions: a historical overview.
Manchi M, Canzonieri V
Pol J Pathol 2019;70(1):26-32. doi: 10.5114/pjp.2019.84459. PMID: 31556548
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Spitz Tumors of the Skin.
Menezes FD, Mooi WJ
Surg Pathol Clin 2017 Jun;10(2):281-298. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.004. PMID: 28477881
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Diagnosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Spitz Tumors of the Skin.
Menezes FD, Mooi WJ
Surg Pathol Clin 2017 Jun;10(2):281-298. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.004. PMID: 28477881
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042
Spitz nevi.
Casso EM, Grin-Jorgensen CM, Grant-Kels JM
J Am Acad Dermatol 1992 Dec;27(6 Pt 1):901-13. doi: 10.1016/0190-9622(92)70286-o. PMID: 1479095

Therapy

Spitz nevus and infliximab: association or coincidence?
Queirós CS, Laureano-Oliveira A, Lopéz-Presa D, Filipe P
An Bras Dermatol 2020 Sep-Oct;95(5):615-618. Epub 2020 Jul 12 doi: 10.1016/j.abd.2020.01.008. PMID: 32711929Free PMC Article
A Diagnostic Algorithm Combining Immunohistochemistry and Molecular Cytogenetics to Diagnose Challenging Melanocytic Tumors.
Redon S, Guibourg B, Talagas M, Marcorelles P, Uguen A
Appl Immunohistochem Mol Morphol 2018 Nov/Dec;26(10):714-720. doi: 10.1097/PAI.0000000000000511. PMID: 28362709
Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.
Kraft S, Moore JB, Muzikansky A, Scott KL, Duncan LM
J Cutan Pathol 2017 Oct;44(10):843-850. Epub 2017 Jul 21 doi: 10.1111/cup.12997. PMID: 28657121
Pediatric melanoma, moles, and sun safety.
Hawryluk EB, Liang MG
Pediatr Clin North Am 2014 Apr;61(2):279-91. Epub 2014 Jan 28 doi: 10.1016/j.pcl.2013.11.004. PMID: 24636646
Angiogenesis and the skin: a primer.
Arbiser JL
J Am Acad Dermatol 1996 Mar;34(3):486-97. doi: 10.1016/s0190-9622(96)90444-2. PMID: 8609264

Prognosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Spitz nevus and atypical spitzoid neoplasm.
Miteva M, Lazova R
Semin Cutan Med Surg 2010 Sep;29(3):165-73. doi: 10.1016/j.sder.2010.06.003. PMID: 21051010
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042
Spitz nevi.
Casso EM, Grin-Jorgensen CM, Grant-Kels JM
J Am Acad Dermatol 1992 Dec;27(6 Pt 1):901-13. doi: 10.1016/0190-9622(92)70286-o. PMID: 1479095

Clinical prediction guides

PRAME immunohistochemistry of spitzoid neoplasms.
Koh SS, Lau SK, Scapa JV, Cassarino DS
J Cutan Pathol 2022 Aug;49(8):709-716. Epub 2022 May 24 doi: 10.1111/cup.14245. PMID: 35488519
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.
Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201Free PMC Article
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829
Spitz nevus and atypical spitzoid neoplasm.
Miteva M, Lazova R
Semin Cutan Med Surg 2010 Sep;29(3):165-73. doi: 10.1016/j.sder.2010.06.003. PMID: 21051010

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