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Polyclonal Gene Rearrangement

MedGen UID:
618736
•Concept ID:
C0443977
•
Cell or Molecular Dysfunction

Definition

DNA sequence rearrangements that result in the creation of multiple immunoglobulins or T-cell receptors being expressed in a lymphocyte population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal Gene Rearrangement

Professional guidelines

PubMed

T-Cell Monoclonality in the Blood and the Skin Correlates With Poor Response to Treatment in Mycosis Fungoides.
Geller S, Tel-Dan SF, Solar I, Sprecher E, Goldberg I
Clin Lymphoma Myeloma Leuk 2023 Feb;23(2):123-126. Epub 2022 Nov 4 doi: 10.1016/j.clml.2022.10.011. PMID: 36424279
ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity.
Zaliova M, Potuckova E, Hovorkova L, Musilova A, Winkowska L, Fiser K, Stuchly J, Mejstrikova E, Starkova J, Zuna J, Stary J, Trka J
Haematologica 2019 Jul;104(7):1407-1416. Epub 2019 Jan 10 doi: 10.3324/haematol.2018.204487. PMID: 30630977Free PMC Article
The differential diagnosis of early gastric mucosa-associated lymphoma: polymerase chain reaction and paraffin section immunophenotyping.
El-Zimaity HM, El-Zaatari FA, Dore MP, Oweiss S, Gutierrez O, Yuksul M, Ramchatesingh J, Graham DY
Mod Pathol 1999 Sep;12(9):885-93. PMID: 10496597

Recent clinical studies

Diagnosis

Immunoglobulin and T cell antigen receptor gene arrangements indicate that the immune response in autoimmune thyroid disease is polyclonal.
Kaulfersch W, Baker JR Jr, Burman KD, Ahmann AJ, D'Avis JC, Waldmann TA
J Clin Endocrinol Metab 1988 May;66(5):958-63. doi: 10.1210/jcem-66-5-958. PMID: 3129452

Supplemental Content

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    Practice guidelines

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