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Polyclonal Gene Rearrangement

MedGen UID:
618736
Concept ID:
C0443977
Cell or Molecular Dysfunction

Definition

DNA sequence rearrangements that result in the creation of multiple immunoglobulins or T-cell receptors being expressed in a lymphocyte population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal Gene Rearrangement

Professional guidelines

PubMed

Geller S, Tel-Dan SF, Solar I, Sprecher E, Goldberg I
Clin Lymphoma Myeloma Leuk 2023 Feb;23(2):123-126. Epub 2022 Nov 4 doi: 10.1016/j.clml.2022.10.011. PMID: 36424279
Zaliova M, Potuckova E, Hovorkova L, Musilova A, Winkowska L, Fiser K, Stuchly J, Mejstrikova E, Starkova J, Zuna J, Stary J, Trka J
Haematologica 2019 Jul;104(7):1407-1416. Epub 2019 Jan 10 doi: 10.3324/haematol.2018.204487. PMID: 30630977Free PMC Article
Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Tóth E, Chira L, Jung I
Rom J Morphol Embryol 2009;50(3):399-406. PMID: 19690765

Recent clinical studies

Diagnosis

Kaulfersch W, Baker JR Jr, Burman KD, Ahmann AJ, D'Avis JC, Waldmann TA
J Clin Endocrinol Metab 1988 May;66(5):958-63. doi: 10.1210/jcem-66-5-958. PMID: 3129452

Supplemental Content

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